Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.
Frontiers In Pharmacology
Silgado-Guzmán, Daniel Felipe DF; Angulo-Aguado, Mariana M; Morel, Adrien A; Niño-Orrego, María José MJ; Ruiz-Torres, Daniel-Armando DA; Contreras Bravo, Nora Constanza NC; Restrepo, Carlos Martin CM; Ortega-Recalde, Oscar O; Fonseca-Mendoza, Dora Janeth DJ
Publication Date: 2022
Variant appearance in text: VKORC1: 106G>T; Asp36Tyr; rs61742245
Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement.
Frontiers In Cardiovascular Medicine
Shafique, Huma H; Ashraf, Naeem Mahmood NM; Rashid, Amir A; Majeed, Asifa A; Afsar, Tayyaba T; Daly, Ann K AK; Almajwal, Ali A; Alruwaili, Nawaf W NW; Khan, Azmat Ullah AU; Razak, Suhail S
Profiling of warfarin pharmacokinetics-associated genetic variants: Black Africans portray unique genetic markers important for an African specific warfarin pharmacogenetics-dosing algorithm.
Journal Of Thrombosis And Haemostasis : Jth
Ndadza, Arinao A; Muyambo, Sarudzai S; Mntla, Pindile P; Wonkam, Ambroise A; Chimusa, Emile E; Kengne, Andre P AP; Ntsekhe, Mpiko M; Dandara, Collet C
A study of elective genome sequencing and pharmacogenetic testing in an unselected population.
Molecular Genetics & Genomic Medicine
Cochran, Meagan M; East, Kelly K; Greve, Veronica V; Kelly, Melissa M; Kelley, Whitley W; Moore, Troy T; Myers, Richard M RM; Odom, Katherine K; Schroeder, Molly C MC; Bick, David D
Publication Date: 2021-09
Variant appearance in text: VKORC1: 106G>T; Asp36Tyr
A study of elective genome sequencing and pharmacogenetic testing in an unselected population.
Molecular Genetics & Genomic Medicine
Cochran, Meagan M; East, Kelly K; Greve, Veronica V; Kelly, Melissa M; Kelley, Whitley W; Moore, Troy T; Myers, Richard M RM; Odom, Katherine K; Schroeder, Molly C MC; Bick, David D
Publication Date: 2021-09
Variant appearance in text: VKORC1: 106G>T; Asp36Tyr
Gene variants of coagulation related proteins that interact with SARS-CoV-2.
Plos Computational Biology
Holcomb, David D; Alexaki, Aikaterini A; Hernandez, Nancy N; Hunt, Ryan R; Laurie, Kyle K; Kames, Jacob J; Hamasaki-Katagiri, Nobuko N; Komar, Anton A AA; DiCuccio, Michael M; Kimchi-Sarfaty, Chava C
Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2.
Biorxiv : The Preprint Server For Biology
Holcomb, David D; Alexaki, Aikaterini A; Hernandez, Nancy N; Laurie, Kyle K; Kames, Jacob J; Hamasaki-Katagiri, Nobuko N; Komar, Anton A AA; DiCuccio, Michael M; Kimchi-Sarfaty, Chava C
Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection.
Clinical And Translational Science
Scott, Stuart A SA; Scott, Erick R ER; Seki, Yoshinori Y; Chen, Annette J AJ; Wallsten, Richard R; Owusu Obeng, Aniwaa A; Botton, Mariana R MR; Cody, Neal N; Shi, Huanzhi H; Zhao, Geping G; Brake, Paul P; Nicoletti, Paola P; Yang, Yao Y; Delio, Maria M; Shi, Lisong L; Kornreich, Ruth R; Schadt, Eric E EE; Edelmann, Lisa L
Publication Date: 2021-01
Variant appearance in text: VKORC1: 106G>T; rs61742245
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.
Elife
Chiasson, Melissa A MA; Rollins, Nathan J NJ; Stephany, Jason J JJ; Sitko, Katherine A KA; Matreyek, Kenneth A KA; Verby, Marta M; Sun, Song S; Roth, Frederick P FP; DeSloover, Daniel D; Marks, Debora S DS; Rettie, Allan E AE; Fowler, Douglas M DM
Recommendations for Clinical Warfarin Genotyping Allele Selection: A Report of the Association for Molecular Pathology and the College of American Pathologists.
The Journal Of Molecular Diagnostics : Jmd
Pratt, Victoria M VM; Cavallari, Larisa H LH; Del Tredici, Andria L AL; Hachad, Houda H; Ji, Yuan Y; Kalman, Lisa V LV; Ly, Reynold C RC; Moyer, Ann M AM; Scott, Stuart A SA; Whirl-Carrillo, Michelle M; Weck, Karen E KE
Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting.
American Journal Of Human Genetics
Wright, Caroline F CF; West, Ben B; Tuke, Marcus M; Jones, Samuel E SE; Patel, Kashyap K; Laver, Thomas W TW; Beaumont, Robin N RN; Tyrrell, Jessica J; Wood, Andrew R AR; Frayling, Timothy M TM; Hattersley, Andrew T AT; Weedon, Michael N MN
Publication Date: 2019-02-07
Variant appearance in text: VKORC1: D36Y; rs61742245
Impact of CYP2C9 and VKORC1 Polymorphisms on Warfarin Sensitivity and Responsiveness in Jordanian Cardiovascular Patients during the Initiation Therapy.
Genes
Al-Eitan, Laith N LN; Almasri, Ayah Y AY; Khasawneh, Rame H RH
Publication Date: 2018-11-27
Variant appearance in text: VKORC1: Asp36Tyr; rs61742245
Institutional profile: translational pharmacogenomics at the Icahn School of Medicine at Mount Sinai.
Pharmacogenomics
Scott, Stuart A SA; Owusu Obeng, Aniwaa A; Botton, Mariana R MR; Yang, Yao Y; Scott, Erick R ER; Ellis, Stephen B SB; Wallsten, Richard R; Kaszemacher, Tom T; Zhou, Xiang X; Chen, Rong R; Nicoletti, Paola P; Naik, Hetanshi H; Kenny, Eimear E EE; Vega, Aida A; Waite, Eva E; Diaz, George A GA; Dudley, Joel J; Halperin, Jonathan L JL; Edelmann, Lisa L; Kasarskis, Andrew A; Hulot, Jean-Sébastien JS; Peter, Inga I; Bottinger, Erwin P EP; Hirschhorn, Kurt K; Sklar, Pamela P; Cho, Judy H JH; Desnick, Robert J RJ; Schadt, Eric E EE
Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature.
Experimental And Therapeutic Medicine
Ma, Xiao-Wei XW; Hao, Chang-Ning CN; Gu, Zhi-Chun ZC; Ye, Meng M; Li, Min M; Zhang, Lan L
Frequency of Common VKORC1 Polymorphisms and Their Impact on Warfarin Dose Requirement in Pakistani Population.
Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The International Academy Of Clinical And Applied Thrombosis/Hemostasis
Qayyum, Aisha A; Najmi, Muzammil Hasan MH; Mansoor, Qaisar Q; Irfan, Muhammad M; Naveed, Abdul Khaliq AK; Hanif, Andleeb A; Kazmi, Ali Raza AR; Ismail, Muhammad M