Constructing a polygenic risk score for childhood obesity using functional data analysis.
Econometrics And Statistics
Craig, Sarah J C SJC; Kenney, Ana M AM; Lin, Junli J; Paul, Ian M IM; Birch, Leann L LL; Savage, Jennifer S JS; Marini, Michele E ME; Chiaromonte, Francesca F; Reimherr, Matthew L ML; Makova, Kateryna D KD
Simulated distributions from negative experiments highlight the importance of the body mass index distribution in explaining depression-body mass index genetic risk score interactions.
International Journal Of Epidemiology
Casanova, Francesco F; O'Loughlin, Jessica J; Lewis, Cathryn C; Frayling, Timothy M TM; Wood, Andrew R AR; Tyrrell, Jessica J
Genetic risk of obesity as a modifier of associations between neighbourhood environment and body mass index: an observational study of 335 046 UK Biobank participants.
Bmj Nutrition, Prevention & Health
Mason, Kate E KE; Palla, Luigi L; Pearce, Neil N; Phelan, Jody J; Cummins, Steven S
The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease.
Obesity (Silver Spring, Md.)
Kalaoja, Marita M; Corbin, Laura J LJ; Tan, Vanessa Y VY; Ahola-Olli, Ari V AV; Havulinna, Aki S AS; Santalahti, Kristiina K; Pitkänen, Niina N; Lehtimäki, Terho T; Lyytikäinen, Leo-Pekka LP; Raitoharju, Emma E; Seppälä, Ilkka I; Kähönen, Mika M; Ripatti, Samuli S; Palotie, Aarno A; Perola, Markus M; Viikari, Jorma S JS; Jalkanen, Sirpa S; Maksimow, Mikael M; Salomaa, Veikko V; Salmi, Marko M; Raitakari, Olli T OT; Kettunen, Johannes J; Timpson, Nicholas J NJ
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses.
Bmj (Clinical Research Ed.)
Sun, Yi-Qian YQ; Burgess, Stephen S; Staley, James R JR; Wood, Angela M AM; Bell, Steven S; Kaptoge, Stephen K SK; Guo, Qi Q; Bolton, Thomas R TR; Mason, Amy M AM; Butterworth, Adam S AS; Di Angelantonio, Emanuele E; Vie, Gunnhild Å GÅ; Bjørngaard, Johan H JH; Kinge, Jonas Minet JM; Chen, Yue Y; Mai, Xiao-Mei XM
Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses.
Circulation
Wade, Kaitlin H KH; Chiesa, Scott T ST; Hughes, Alun D AD; Chaturvedi, Nish N; Charakida, Marietta M; Rapala, Alicja A; Muthurangu, Vivek V; Khan, Tauseef T; Finer, Nicholas N; Sattar, Naveed N; Howe, Laura D LD; Fraser, Abigail A; Lawlor, Debbie A DA; Davey Smith, George G; Deanfield, John E JE; Timpson, Nicholas J NJ
Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.
Journal Of The National Cancer Institute
Qian, Frank F; Wang, Shengfeng S; Mitchell, Jonathan J; McGuffog, Lesley L; Barrowdale, Daniel D; Leslie, Goska G; Oosterwijk, Jan C JC; Chung, Wendy K WK; Evans, D Gareth DG; Engel, Christoph C; Kast, Karin K; Aalfs, Cora M CM; Adank, Muriel A MA; Adlard, Julian J; Agnarsson, Bjarni A BA; Aittomäki, Kristiina K; Alducci, Elisa E; Andrulis, Irene L IL; Arun, Banu K BK; Ausems, Margreet G E M MGEM; Azzollini, Jacopo J; Barouk-Simonet, Emmanuelle E; Barwell, Julian J; Belotti, Muriel M; Benitez, Javier J; Berger, Andreas A; Borg, Ake A; Bradbury, Angela R AR; Brunet, Joan J; Buys, Saundra S SS; Caldes, Trinidad T; Caligo, Maria A MA; Campbell, Ian I; Caputo, Sandrine M SM; Chiquette, Jocelyne J; Claes, Kathleen B M KBM; Margriet Collée, J J; Couch, Fergus J FJ; Coupier, Isabelle I; Daly, Mary B MB; Davidson, Rosemarie R; Diez, Orland O; Domchek, Susan M SM; Donaldson, Alan A; Dorfling, Cecilia M CM; Eeles, Ros R; Feliubadaló, Lidia L; Foretova, Lenka L; Fowler, Jeffrey J; Friedman, Eitan E; Frost, Debra D; Ganz, Patricia A PA; Garber, Judy J; Garcia-Barberan, Vanesa V; Glendon, Gord G; Godwin, Andrew K AK; Gómez Garcia, Encarna B EB; Gronwald, Jacek J; Hahnen, Eric E; Hamann, Ute U; Henderson, Alex A; Hendricks, Carolyn B CB; Hopper, John L JL; Hulick, Peter J PJ; Imyanitov, Evgeny N EN; Isaacs, Claudine C; Izatt, Louise L; Izquierdo, Ángel Á; Jakubowska, Anna A; Kaczmarek, Katarzyna K; Kang, Eunyoung E; Karlan, Beth Y BY; Kets, Carolien M CM; Kim, Sung-Won SW; Kim, Zisun Z; Kwong, Ava A; Laitman, Yael Y; Lasset, Christine C; Hyuk Lee, Min M; Won Lee, Jong J; Lee, Jihyoun J; Lester, Jenny J; Lesueur, Fabienne F; Loud, Jennifer T JT; Lubinski, Jan J; Mebirouk, Noura N; Meijers-Heijboer, Hanne E J HEJ; Meindl, Alfons A; Miller, Austin A; Montagna, Marco M; Mooij, Thea M TM; Morrison, Patrick J PJ; Mouret-Fourme, Emmanuelle E; Nathanson, Katherine L KL; Neuhausen, Susan L SL; Nevanlinna, Heli H; Niederacher, Dieter D; Nielsen, Finn C FC; Nussbaum, Robert L RL; Offit, Kenneth K; Olah, Edith E; Ong, Kai-Ren KR; Ottini, Laura L; Park, Sue K SK; Peterlongo, Paolo P; Pfeiler, Georg G; Phelan, Catherine M CM; Poppe, Bruce B; Pradhan, Nisha N; Radice, Paolo P; Ramus, Susan J SJ; Rantala, Johanna J; Robson, Mark M; Rodriguez, Gustavo C GC; Schmutzler, Rita K RK; Hutten Selkirk, Christina G CG; Shah, Payal D PD; Simard, Jacques J; Singer, Christian F CF; Sokolowska, Johanna J; Stoppa-Lyonnet, Dominique D; Sutter, Christian C; Yen Tan, Yen Y; Teixeira, R Manuel RM; Teo, Soo H SH; Terry, Mary Beth MB; Thomassen, Mads M; Tischkowitz, Marc M; Toland, Amanda E AE; Tucker, Katherine M KM; Tung, Nadine N; van Asperen, Christi J CJ; van Engelen, Klaartje K; van Rensburg, Elizabeth J EJ; Wang-Gohrke, Shan S; Wappenschmidt, Barbara B; Weitzel, Jeffrey N JN; Yannoukakos, Drakoulis D; , ; , ; , ; Greene, Mark H MH; Rookus, Matti A MA; Easton, Douglas F DF; Chenevix-Trench, Georgia G; Antoniou, Antonis C AC; Goldgar, David E DE; Olopade, Olufunmilayo I OI; Rebbeck, Timothy R TR; Huo, Dezheng D
Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study.
Bmj (Clinical Research Ed.)
Wootton, Robyn E RE; Lawn, Rebecca B RB; Millard, Louise A C LAC; Davies, Neil M NM; Taylor, Amy E AE; Munafò, Marcus R MR; Timpson, Nicholas J NJ; Davis, Oliver S P OSP; Davey Smith, George G; Haworth, Claire M A CMA
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses.
Plos Genetics
Baranski, Thomas J TJ; Kraja, Aldi T AT; Fink, Jill L JL; Feitosa, Mary M; Lenzini, Petra A PA; Borecki, Ingrid B IB; Liu, Ching-Ti CT; Cupples, L Adrienne LA; North, Kari E KE; Province, Michael A MA
A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders.
Journal Of Human Genetics
Ghanbari, Mohsen M; Peters, Marjolein J MJ; de Vries, Paul S PS; Boer, Cindy G CG; van Rooij, Jeroen G J JGJ; Lee, Yu-Chi YC; Kumar, Vinod V; Uitterlinden, André G AG; Ikram, M Arfan MA; Wijmenga, Cisca C; Ordovas, Jose M JM; Smith, Caren E CE; van Meurs, Joyce B J JBJ; Erkeland, Stefan J SJ; Franco, Oscar H OH; Dehghan, Abbas A
Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study.
Jama Cardiology
Lyall, Donald M DM; Celis-Morales, Carlos C; Ward, Joey J; Iliodromiti, Stamatina S; Anderson, Jana J JJ; Gill, Jason M R JMR; Smith, Daniel J DJ; Ntuk, Uduakobong Efanga UE; Mackay, Daniel F DF; Holmes, Michael V MV; Sattar, Naveed N; Pell, Jill P JP
Gene-obesogenic environment interactions in the UK Biobank study.
International Journal Of Epidemiology
Tyrrell, Jessica J; Wood, Andrew R AR; Ames, Ryan M RM; Yaghootkar, Hanieh H; Beaumont, Robin N RN; Jones, Samuel E SE; Tuke, Marcus A MA; Ruth, Katherine S KS; Freathy, Rachel M RM; Davey Smith, George G; Joost, Stéphane S; Guessous, Idris I; Murray, Anna A; Strachan, David P DP; Kutalik, Zoltán Z; Weedon, Michael N MN; Frayling, Timothy M TM
Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.
Plos Genetics
Jones, Samuel E SE; Tyrrell, Jessica J; Wood, Andrew R AR; Beaumont, Robin N RN; Ruth, Katherine S KS; Tuke, Marcus A MA; Yaghootkar, Hanieh H; Hu, Youna Y; Teder-Laving, Maris M; Hayward, Caroline C; Roenneberg, Till T; Wilson, James F JF; Del Greco, Fabiola F; Hicks, Andrew A AA; Shin, Chol C; Yun, Chang-Ho CH; Lee, Seung Ku SK; Metspalu, Andres A; Byrne, Enda M EM; Gehrman, Philip R PR; Tiemeier, Henning H; Allebrandt, Karla V KV; Freathy, Rachel M RM; Murray, Anna A; Hinds, David A DA; Frayling, Timothy M TM; Weedon, Michael N MN
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.
Diabetes
Yaghootkar, Hanieh H; Lotta, Luca A LA; Tyrrell, Jessica J; Smit, Roelof A J RA; Jones, Sam E SE; Donnelly, Louise L; Beaumont, Robin R; Campbell, Archie A; Tuke, Marcus A MA; Hayward, Caroline C; Ruth, Katherine S KS; Padmanabhan, Sandosh S; Jukema, J Wouter JW; Palmer, Colin C CC; Hattersley, Andrew A; Freathy, Rachel M RM; Langenberg, Claudia C; Wareham, Nicholas J NJ; Wood, Andrew R AR; Murray, Anna A; Weedon, Michael N MN; Sattar, Naveed N; Pearson, Ewan E; Scott, Robert A RA; Frayling, Timothy M TM
Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank.
Bmj (Clinical Research Ed.)
Tyrrell, Jessica J; Jones, Samuel E SE; Beaumont, Robin R; Astley, Christina M CM; Lovell, Rebecca R; Yaghootkar, Hanieh H; Tuke, Marcus M; Ruth, Katherine S KS; Freathy, Rachel M RM; Hirschhorn, Joel N JN; Wood, Andrew R AR; Murray, Anna A; Weedon, Michael N MN; Frayling, Timothy M TM
Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study.
Scientific Reports
Konttinen, Hanna H; Llewellyn, Clare C; Wardle, Jane J; Silventoinen, Karri K; Joensuu, Anni A; Männistö, Satu S; Salomaa, Veikko V; Jousilahti, Pekka P; Kaprio, Jaakko J; Perola, Markus M; Haukkala, Ari A
Genetic studies of body mass index yield new insights for obesity biology.
Nature
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Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Lancet (London, England)
Perera, Minoli A MA; Cavallari, Larisa H LH; Limdi, Nita A NA; Gamazon, Eric R ER; Konkashbaev, Anuar A; Daneshjou, Roxana R; Pluzhnikov, Anna A; Crawford, Dana C DC; Wang, Jelai J; Liu, Nianjun N; Tatonetti, Nicholas N; Bourgeois, Stephane S; Takahashi, Harumi H; Bradford, Yukiko Y; Burkley, Benjamin M BM; Desnick, Robert J RJ; Halperin, Jonathan L JL; Khalifa, Sherief I SI; Langaee, Taimour Y TY; Lubitz, Steven A SA; Nutescu, Edith A EA; Oetjens, Matthew M; Shahin, Mohamed H MH; Patel, Shitalben R SR; Sagreiya, Hersh H; Tector, Matthew M; Weck, Karen E KE; Rieder, Mark J MJ; Scott, Stuart A SA; Wu, Alan H B AH; Burmester, James K JK; Wadelius, Mia M; Deloukas, Panos P; Wagner, Michael J MJ; Mushiroda, Taisei T; Kubo, Michiaki M; Roden, Dan M DM; Cox, Nancy J NJ; Altman, Russ B RB; Klein, Teri E TE; Nakamura, Yusuke Y; Johnson, Julie A JA