FTO c.46-40829G>A

Variant ID: 16-53803223-G-A

NM_001080432.2(FTO):c.46-40829G>A

This variant was identified in 20 publications

View GRCh38 version.




Publications:


Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program.

Translational Psychiatry
Cheng, Youshu Y; Dao, Cecilia C; Zhou, Hang H; Li, Boyang B; Kember, Rachel L RL; Toikumo, Sylvanus S; Zhao, Hongyu H; Gelernter, Joel J; Kranzler, Henry R HR; Justice, Amy C AC; Xu, Ke K
Publication Date: 2023-05-05

Variant appearance in text: rs62048402
PubMed Link: 37147289
Variant Present in the following documents:
  • Main text
  • 41398_2023_Article_2409.pdf
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A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus.

Frontiers In Endocrinology
Chen, Simin S; Yan, Shikang S; Aiheti, Nuerbiyamu N; Kuribanjiang, Kaidiriyan K; Yao, Xuemei X; Wang, Qian Q; Zhou, Tao T; Yang, Lei L
Publication Date: 2023

Variant appearance in text: rs62048402
PubMed Link: 36967750
Variant Present in the following documents:
  • Main text
  • fendo-14-1109800.pdf
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Assessing the causality between thyroid and breast neoplasms: A bidirectional Mendelian randomization study.

Frontiers In Oncology
Li, Zhenqi Z; Xia, Lu L; Li, Xiangzhi X; He, Hongyang H
Publication Date: 2022

Variant appearance in text: rs62048402
PubMed Link: 36544708
Variant Present in the following documents:
  • Main text
  • fonc-12-973161.pdf
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Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population.

Plos Genetics
Wong, Henry Sung-Ching HS; Tsai, Szu-Yi SY; Chu, Hou-Wei HW; Lin, Min-Rou MR; Lin, Gan-Hong GH; Tai, Yu-Ting YT; Shen, Chen-Yang CY; Chang, Wei-Chiao WC
Publication Date: 2022-01

Variant appearance in text: rs62048402
PubMed Link: 35051171
Variant Present in the following documents:
  • Main text
  • pgen.1009952.pdf
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Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population.

Plos Genetics
Wong, Henry Sung-Ching HS; Tsai, Szu-Yi SY; Chu, Hou-Wei HW; Lin, Min-Rou MR; Lin, Gan-Hong GH; Tai, Yu-Ting YT; Shen, Chen-Yang CY; Chang, Wei-Chiao WC
Publication Date: 2022-01-20

Variant appearance in text: rs62048402
PubMed Link: 35051171
Variant Present in the following documents:
  • Main text
  • pgen.1009952.pdf
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Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea.

Cancer Research And Treatment
Hoang, Tung T; Song, Dayoung D; Lee, Jeonghee J; Lee, Eun Kyung EK; Hwangbo, Yul Y; Kim, Jeongseon J
Publication Date: 2021-07

Variant appearance in text: rs62048402
PubMed Link: 33285050
Variant Present in the following documents:
  • Main text
  • crt-2020-720.pdf
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The Parkinson's Disease Mendelian Randomization Research Portal.

Movement Disorders : Official Journal Of The Movement Disorder Society
Noyce, Alastair J AJ; Bandres-Ciga, Sara S; Kim, Jonggeol J; Heilbron, Karl K; Kia, Demis D; Hemani, Gibran G; Xue, Angli A; Lawlor, Debbie A DA; Smith, George Davey GD; Duran, Raquel R; Gan-Or, Ziv Z; Blauwendraat, Cornelis C; Gibbs, J Raphael JR; , ; Hinds, David A DA; Yang, Jian J; Visscher, Peter P; Cuzick, Jack J; Morris, Huw H; Hardy, John J; Wood, Nicholas W NW; Nalls, Mike A MA; Singleton, Andrew B AB
Publication Date: 2019-12

Variant appearance in text: rs62048402
PubMed Link: 31659794
Variant Present in the following documents:
  • Main text
  • MDS-34-1864.pdf
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Functional genomic characterization of the FTO locus in African Americans.

Physiological Genomics
Gill, Richard R; Stratigopoulos, George G; Lee, Joseph H JH; Leibel, Rudolph L RL
Publication Date: 2019-11-01

Variant appearance in text: rs62048402
PubMed Link: 31530225
Variant Present in the following documents:
  • Main text
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Genetics of Obesity in Diverse Populations.

Current Diabetes Reports
Young, Kristin L KL; Graff, Mariaelisa M; Fernandez-Rhodes, Lindsay L; North, Kari E KE
Publication Date: 2018-11-19

Variant appearance in text: rs62048402
PubMed Link: 30456705
Variant Present in the following documents:
  • Main text
View BVdb publication page



Overweight and Obesity in Schoolchildren: Hierarchical Analysis of Associated Demographic, Behavioral, and Biological Factors.

Journal Of Obesity
Reuter, Cézane P CP; de Mello, Elza D ED; da Silva, Priscila T PT; Borges, Tássia S TS; Klinger, Elisa I EI; Franke, Silvia I R SIR; Valim, Andréia R de M ARM
Publication Date: 2018

Variant appearance in text: rs62048402
PubMed Link: 30254759
Variant Present in the following documents:
  • Main text
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Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Risk of Intervertebral Disc Degeneration in Chinese Han Population: A Case Control Study.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
Chen, Jia J; Zhu, Qiankun Q; Liu, Gang G; Yang, Xinzhuang X; Zhao, Sen S; Chen, Weisheng W; Wu, Zhihong Z; Wu, Nan N; Qiu, Guixing G
Publication Date: 2018-08-12

Variant appearance in text: rs62048402
PubMed Link: 30099472
Variant Present in the following documents:
  • Main text
  • medscimonit-24-5598.pdf
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Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank.

Bmj (Clinical Research Ed.)
Carreras-Torres, Robert R; Johansson, Mattias M; Haycock, Philip C PC; Relton, Caroline L CL; Davey Smith, George G; Brennan, Paul P; Martin, Richard M RM
Publication Date: 2018-05-16

Variant appearance in text: rs62048402
PubMed Link: 29769355
Variant Present in the following documents:
  • Main text
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Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci.

Human Genetics
Fernández-Rhodes, Lindsay L; Gong, Jian J; Haessler, Jeffrey J; Franceschini, Nora N; Graff, Mariaelisa M; Nishimura, Katherine K KK; Wang, Yujie Y; Highland, Heather M HM; Yoneyama, Sachiko S; Bush, William S WS; Goodloe, Robert R; Ritchie, Marylyn D MD; Crawford, Dana D; Gross, Myron M; Fornage, Myriam M; Buzkova, Petra P; Tao, Ran R; Isasi, Carmen C; Avilés-Santa, Larissa L; Daviglus, Martha M; Mackey, Rachel H RH; Houston, Denise D; Gu, C Charles CC; Ehret, Georg G; Nguyen, Khanh-Dung H KH; Lewis, Cora E CE; Leppert, Mark M; Irvin, Marguerite R MR; Lim, Unhee U; Haiman, Christopher A CA; Le Marchand, Loic L; Schumacher, Fredrick F; Wilkens, Lynne L; Lu, Yingchang Y; Bottinger, Erwin P EP; Loos, Ruth J L RJL; Sheu, Wayne H-H WH; Guo, Xiuqing X; Lee, Wen-Jane WJ; Hai, Yang Y; Hung, Yi-Jen YJ; Absher, Devin D; Wu, I-Chien IC; Taylor, Kent D KD; Lee, I-Te IT; Liu, Yeheng Y; Wang, Tzung-Dau TD; Quertermous, Thomas T; Juang, Jyh-Ming J JJ; Rotter, Jerome I JI; Assimes, Themistocles T; Hsiung, Chao A CA; Chen, Yii-Der Ida YI; Prentice, Ross R; Kuller, Lewis H LH; Manson, JoAnn E JE; Kooperberg, Charles C; Smokowski, Paul P; Robinson, Whitney R WR; Gordon-Larsen, Penny P; Li, Rongling R; Hindorff, Lucia L; Buyske, Steven S; Matise, Tara C TC; Peters, Ulrike U; North, Kari E KE
Publication Date: 2017-06

Variant appearance in text: rs62048402
PubMed Link: 28391526
Variant Present in the following documents:
  • Main text
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Nature Communications
Lu, Yingchang Y; Day, Felix R FR; Gustafsson, Stefan S; Buchkovich, Martin L ML; Na, Jianbo J; Bataille, Veronique V; Cousminer, Diana L DL; Dastani, Zari Z; Drong, Alexander W AW; Esko, Tõnu T; Evans, David M DM; Falchi, Mario M; Feitosa, Mary F MF; Ferreira, Teresa T; Hedman, Åsa K ÅK; Haring, Robin R; Hysi, Pirro G PG; Iles, Mark M MM; Justice, Anne E AE; Kanoni, Stavroula S; Lagou, Vasiliki V; Li, Rui R; Li, Xin X; Locke, Adam A; Lu, Chen C; Mägi, Reedik R; Perry, John R B JR; Pers, Tune H TH; Qi, Qibin Q; Sanna, Marianna M; Schmidt, Ellen M EM; Scott, William R WR; Shungin, Dmitry D; Teumer, Alexander A; Vinkhuyzen, Anna A E AA; Walker, Ryan W RW; Westra, Harm-Jan HJ; Zhang, Mingfeng M; Zhang, Weihua W; Zhao, Jing Hua JH; Zhu, Zhihong Z; Afzal, Uzma U; Ahluwalia, Tarunveer Singh TS; Bakker, Stephan J L SJ; Bellis, Claire C; Bonnefond, Amélie A; Borodulin, Katja K; Buchman, Aron S AS; Cederholm, Tommy T; Choh, Audrey C AC; Choi, Hyung Jin HJ; Curran, Joanne E JE; de Groot, Lisette C P G M LC; De Jager, Philip L PL; Dhonukshe-Rutten, Rosalie A M RA; Enneman, Anke W AW; Eury, Elodie E; Evans, Daniel S DS; Forsen, Tom T; Friedrich, Nele N; Fumeron, Frédéric F; Garcia, Melissa E ME; Gärtner, Simone S; Han, Bok-Ghee BG; Havulinna, Aki S AS; Hayward, Caroline C; Hernandez, Dena D; Hillege, Hans H; Ittermann, Till T; Kent, Jack W JW; Kolcic, Ivana I; Laatikainen, Tiina T; Lahti, Jari J; Mateo Leach, Irene I; Lee, Christine G CG; Lee, Jong-Young JY; Liu, Tian T; Liu, Youfang Y; Lobbens, Stéphane S; Loh, Marie M; Lyytikäinen, Leo-Pekka LP; Medina-Gomez, Carolina C; Michaëlsson, Karl K; Nalls, Mike A MA; Nielson, Carrie M CM; Oozageer, Laticia L; Pascoe, Laura L; Paternoster, Lavinia L; Polašek, Ozren O; Ripatti, Samuli S; Sarzynski, Mark A MA; Shin, Chan Soo CS; Narančić, Nina Smolej NS; Spira, Dominik D; Srikanth, Priya P; Steinhagen-Thiessen, Elisabeth E; Sung, Yun Ju YJ; Swart, Karin M A KM; Taittonen, Leena L; Tanaka, Toshiko T; Tikkanen, Emmi E; van der Velde, Nathalie N; van Schoor, Natasja M NM; Verweij, Niek N; Wright, Alan F AF; Yu, Lei L; Zmuda, Joseph M JM; Eklund, Niina N; Forrester, Terrence T; Grarup, Niels N; Jackson, Anne U AU; Kristiansson, Kati K; Kuulasmaa, Teemu T; Kuusisto, Johanna J; Lichtner, Peter P; Luan, Jian'an J; Mahajan, Anubha A; Männistö, Satu S; Palmer, Cameron D CD; Ried, Janina S JS; Scott, Robert A RA; Stancáková, Alena A; Wagner, Peter J PJ; Demirkan, Ayse A; Döring, Angela A; Gudnason, Vilmundur V; Kiel, Douglas P DP; Kühnel, Brigitte B; Mangino, Massimo M; Mcknight, Barbara B; Menni, Cristina C; O'Connell, Jeffrey R JR; Oostra, Ben A BA; Shuldiner, Alan R AR; Song, Kijoung K; Vandenput, Liesbeth L; van Duijn, Cornelia M CM; Vollenweider, Peter P; White, Charles C CC; Boehnke, Michael M; Boettcher, Yvonne Y; Cooper, Richard S RS; Forouhi, Nita G NG; Gieger, Christian C; Grallert, Harald H; Hingorani, Aroon A; Jørgensen, Torben T; Jousilahti, Pekka P; Kivimaki, Mika M; Kumari, Meena M; Laakso, Markku M; Langenberg, Claudia C; Linneberg, Allan A; Luke, Amy A; Mckenzie, Colin A CA; Palotie, Aarno A; Pedersen, Oluf O; Peters, Annette A; Strauch, Konstantin K; Tayo, Bamidele O BO; Wareham, Nicholas J NJ; Bennett, David A DA; Bertram, Lars L; Blangero, John J; Blüher, Matthias M; Bouchard, Claude C; Campbell, Harry H; Cho, Nam H NH; Cummings, Steven R SR; Czerwinski, Stefan A SA; Demuth, Ilja I; Eckardt, Rahel R; Eriksson, Johan G JG; Ferrucci, Luigi L; Franco, Oscar H OH; Froguel, Philippe P; Gansevoort, Ron T RT; Hansen, Torben T; Harris, Tamara B TB; Hastie, Nicholas N; Heliövaara, Markku M; Hofman, Albert A; Jordan, Joanne M JM; Jula, Antti A; Kähönen, Mika M; Kajantie, Eero E; Knekt, Paul B PB; Koskinen, Seppo S; Kovacs, Peter P; Lehtimäki, Terho T; Lind, Lars L; Liu, Yongmei Y; Orwoll, Eric S ES; Osmond, Clive C; Perola, Markus M; Pérusse, Louis L; Raitakari, Olli T OT; Rankinen, Tuomo T; Rao, D C DC; Rice, Treva K TK; Rivadeneira, Fernando F; Rudan, Igor I; Salomaa, Veikko V; Sørensen, Thorkild I A TI; Stumvoll, Michael M; Tönjes, Anke A; Towne, Bradford B; Tranah, Gregory J GJ; Tremblay, Angelo A; Uitterlinden, André G AG; van der Harst, Pim P; Vartiainen, Erkki E; Viikari, Jorma S JS; Vitart, Veronique V; Vohl, Marie-Claude MC; Völzke, Henry H; Walker, Mark M; Wallaschofski, Henri H; Wild, Sarah S; Wilson, James F JF; Yengo, Loïc L; Bishop, D Timothy DT; Borecki, Ingrid B IB; Chambers, John C JC; Cupples, L Adrienne LA; Dehghan, Abbas A; Deloukas, Panos P; Fatemifar, Ghazaleh G; Fox, Caroline C; Furey, Terrence S TS; Franke, Lude L; Han, Jiali J; Hunter, David J DJ; Karjalainen, Juha J; Karpe, Fredrik F; Kaplan, Robert C RC; Kooner, Jaspal S JS; McCarthy, Mark I MI; Murabito, Joanne M JM; Morris, Andrew P AP; Bishop, Julia A N JA; North, Kari E KE; Ohlsson, Claes C; Ong, Ken K KK; Prokopenko, Inga I; Richards, J Brent JB; Schadt, Eric E EE; Spector, Tim D TD; Widén, Elisabeth E; Willer, Cristen J CJ; Yang, Jian J; Ingelsson, Erik E; Mohlke, Karen L KL; Hirschhorn, Joel N JN; Pospisilik, John Andrew JA; Zillikens, M Carola MC; Lindgren, Cecilia C; Kilpeläinen, Tuomas Oskari TO; Loos, Ruth J F RJ
Publication Date: 2016-02-01

Variant appearance in text: rs62048402
PubMed Link: 26833246
Variant Present in the following documents:
  • ncomms10495-s1.pdf
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Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools.

Molecular Metabolism
Teo, Adrian Kee Keong AK; Gupta, Manoj K MK; Doria, Alessandro A; Kulkarni, Rohit N RN
Publication Date: 2015-09

Variant appearance in text: rs62048402
PubMed Link: 26413465
Variant Present in the following documents:
  • Main text
  • main.pdf
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Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index.

Frontiers In Genetics
Cronin, Robert M RM; Field, Julie R JR; Bradford, Yuki Y; Shaffer, Christian M CM; Carroll, Robert J RJ; Mosley, Jonathan D JD; Bastarache, Lisa L; Edwards, Todd L TL; Hebbring, Scott J SJ; Lin, Simon S; Hindorff, Lucia A LA; Crane, Paul K PK; Pendergrass, Sarah A SA; Ritchie, Marylyn D MD; Crawford, Dana C DC; Pathak, Jyotishman J; Bielinski, Suzette J SJ; Carrell, David S DS; Crosslin, David R DR; Ledbetter, David H DH; Carey, David J DJ; Tromp, Gerard G; Williams, Marc S MS; Larson, Eric B EB; Jarvik, Gail P GP; Peissig, Peggy L PL; Brilliant, Murray H MH; McCarty, Catherine A CA; Chute, Christopher G CG; Kullo, Iftikhar J IJ; Bottinger, Erwin E; Chisholm, Rex R; Smith, Maureen E ME; Roden, Dan M DM; Denny, Joshua C JC
Publication Date: 2014

Variant appearance in text: rs62048402
PubMed Link: 25177340
Variant Present in the following documents:
  • Main text
  • fgene-05-00250.pdf
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Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index.

Biomedical Reports
Han, Liyuan L; Tang, Linlin L; Wang, Changyi C; Chen, Zhongwei Z; Zhang, Tao T; Chen, Sihan S; Liu, Shengyuan S; Peng, Xiaolin X; Mai, Yifeng Y; Duan, Shiwei S
Publication Date: 2014-09

Variant appearance in text: rs62048402
PubMed Link: 25054011
Variant Present in the following documents:
  • Main text
View BVdb publication page



Low copy number of the salivary amylase gene predisposes to obesity.

Nature Genetics
Falchi, Mario M; El-Sayed Moustafa, Julia Sarah JS; Takousis, Petros P; Pesce, Francesco F; Bonnefond, Amélie A; Andersson-Assarsson, Johanna C JC; Sudmant, Peter H PH; Dorajoo, Rajkumar R; Al-Shafai, Mashael Nedham MN; Bottolo, Leonardo L; Ozdemir, Erdal E; So, Hon-Cheong HC; Davies, Robert W RW; Patrice, Alexandre A; Dent, Robert R; Mangino, Massimo M; Hysi, Pirro G PG; Dechaume, Aurélie A; Huyvaert, Marlène M; Skinner, Jane J; Pigeyre, Marie M; Caiazzo, Robert R; Raverdy, Violeta V; Vaillant, Emmanuel E; Field, Sarah S; Balkau, Beverley B; Marre, Michel M; Visvikis-Siest, Sophie S; Weill, Jacques J; Poulain-Godefroy, Odile O; Jacobson, Peter P; Sjostrom, Lars L; Hammond, Christopher J CJ; Deloukas, Panos P; Sham, Pak Chung PC; McPherson, Ruth R; Lee, Jeannette J; Tai, E Shyong ES; Sladek, Robert R; Carlsson, Lena M S LM; Walley, Andrew A; Eichler, Evan E EE; Pattou, Francois F; Spector, Timothy D TD; Froguel, Philippe P
Publication Date: 2014-05

Variant appearance in text: rs62048402
PubMed Link: 24686848
Variant Present in the following documents:
  • NIHMS57335-supplement-1.pdf
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Fine Mapping and Identification of BMI Loci in African Americans.

American Journal Of Human Genetics
Gong, Jian J; Schumacher, Fredrick F; Lim, Unhee U; Hindorff, Lucia A LA; Haessler, Jeff J; Buyske, Steven S; Carlson, Christopher S CS; Rosse, Stephanie S; Bůžková, Petra P; Fornage, Myriam M; Gross, Myron M; Pankratz, Nathan N; Pankow, James S JS; Schreiner, Pamela J PJ; Cooper, Richard R; Ehret, Georg G; Gu, C Charles CC; Houston, Denise D; Irvin, Marguerite R MR; Jackson, Rebecca R; Kuller, Lew L; Henderson, Brian B; Cheng, Iona I; Wilkens, Lynne L; Leppert, Mark M; Lewis, Cora E CE; Li, Rongling R; Nguyen, Khanh-Dung H KD; Goodloe, Robert R; Farber-Eger, Eric E; Boston, Jonathan J; Dilks, Holli H HH; Ritchie, Marylyn D MD; Fowke, Jay J; Pooler, Loreall L; Graff, Misa M; Fernandez-Rhodes, Lindsay L; Cochrane, Barbara B; Boerwinkle, Eric E; Kooperberg, Charles C; Matise, Tara C TC; Le Marchand, Loic L; Crawford, Dana C DC; Haiman, Christopher A CA; North, Kari E KE; Peters, Ulrike U
Publication Date: 2013-10-03

Variant appearance in text: rs62048402
PubMed Link: 24094743
Variant Present in the following documents:
  • Main text
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Genome-wide association analysis implicates elastic microfibrils in the development of nonsyndromic striae distensae.

The Journal Of Investigative Dermatology
Tung, Joyce Y JY; Kiefer, Amy K AK; Mullins, Meghan M; Francke, Uta U; Eriksson, Nicholas N
Publication Date: 2013-11

Variant appearance in text: rs62048402
PubMed Link: 23633020
Variant Present in the following documents:
  • jid2013196x1.pdf
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Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children.

International Journal Of Obesity (2005)
Sällman Almén, M M; Rask-Andersen, M M; Jacobsson, J A JA; Ameur, A A; Kalnina, I I; Moschonis, G G; Juhlin, S S; Bringeland, N N; Hedberg, L A LA; Ignatovica, V V; Chrousos, G P GP; Manios, Y Y; Klovins, J J; Marcus, C C; Gyllensten, U U; Fredriksson, R R; Schiöth, H B HB
Publication Date: 2013-03

Variant appearance in text: rs62048402
PubMed Link: 22531089
Variant Present in the following documents:
  • Main text
  • ijo201257a.pdf
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