The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population.
Diabetologia
Wedekind, Lauren E LE; Mahajan, Anubha A; Hsueh, Wen-Chi WC; Chen, Peng P; Olaiya, Muideen T MT; Kobes, Sayuko S; Sinha, Madhumita M; Baier, Leslie J LJ; Knowler, William C WC; McCarthy, Mark I MI; Hanson, Robert L RL
The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population.
Journal Of Personalized Medicine
Verma, Anurag A; Damrauer, Scott M SM; Naseer, Nawar N; Weaver, JoEllen J; Kripke, Colleen M CM; Guare, Lindsay L; Sirugo, Giorgio G; Kember, Rachel L RL; Drivas, Theodore G TG; Dudek, Scott M SM; Bradford, Yuki Y; Lucas, Anastasia A; Judy, Renae R; Verma, Shefali S SS; Meagher, Emma E; Nathanson, Katherine L KL; Feldman, Michael M; Ritchie, Marylyn D MD; Rader, Daniel J DJ; For The Penn Medicine BioBank,
Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea.
Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.
Jama Psychiatry
Kappelmann, Nils N; Arloth, Janine J; Georgakis, Marios K MK; Czamara, Darina D; Rost, Nicolas N; Ligthart, Symen S; Khandaker, Golam M GM; Binder, Elisabeth B EB
Identification of type 2 diabetes loci in 433,540 East Asian individuals.
Nature
Spracklen, Cassandra N CN; Horikoshi, Momoko M; Kim, Young Jin YJ; Lin, Kuang K; Bragg, Fiona F; Moon, Sanghoon S; Suzuki, Ken K; Tam, Claudia H T CHT; Tabara, Yasuharu Y; Kwak, Soo-Heon SH; Takeuchi, Fumihiko F; Long, Jirong J; Lim, Victor J Y VJY; Chai, Jin-Fang JF; Chen, Chien-Hsiun CH; Nakatochi, Masahiro M; Yao, Jie J; Choi, Hyeok Sun HS; Iyengar, Apoorva K AK; Perrin, Hannah J HJ; Brotman, Sarah M SM; van de Bunt, Martijn M; Gloyn, Anna L AL; Below, Jennifer E JE; Boehnke, Michael M; Bowden, Donald W DW; Chambers, John C JC; Mahajan, Anubha A; McCarthy, Mark I MI; Ng, Maggie C Y MCY; Petty, Lauren E LE; Zhang, Weihua W; Morris, Andrew P AP; Adair, Linda S LS; Akiyama, Masato M; Bian, Zheng Z; Chan, Juliana C N JCN; Chang, Li-Ching LC; Chee, Miao-Li ML; Chen, Yii-Der Ida YI; Chen, Yuan-Tsong YT; Chen, Zhengming Z; Chuang, Lee-Ming LM; Du, Shufa S; Gordon-Larsen, Penny P; Gross, Myron M; Guo, Xiuqing X; Guo, Yu Y; Han, Sohee S; Howard, Annie-Green AG; Huang, Wei W; Hung, Yi-Jen YJ; Hwang, Mi Yeong MY; Hwu, Chii-Min CM; Ichihara, Sahoko S; Isono, Masato M; Jang, Hye-Mi HM; Jiang, Guozhi G; Jonas, Jost B JB; Kamatani, Yoichiro Y; Katsuya, Tomohiro T; Kawaguchi, Takahisa T; Khor, Chiea-Chuen CC; Kohara, Katsuhiko K; Lee, Myung-Shik MS; Lee, Nanette R NR; Li, Liming L; Liu, Jianjun J; Luk, Andrea O AO; Lv, Jun J; Okada, Yukinori Y; Pereira, Mark A MA; Sabanayagam, Charumathi C; Shi, Jinxiu J; Shin, Dong Mun DM; So, Wing Yee WY; Takahashi, Atsushi A; Tomlinson, Brian B; Tsai, Fuu-Jen FJ; van Dam, Rob M RM; Xiang, Yong-Bing YB; Yamamoto, Ken K; Yamauchi, Toshimasa T; Yoon, Kyungheon K; Yu, Canqing C; Yuan, Jian-Min JM; Zhang, Liang L; Zheng, Wei W; Igase, Michiya M; Cho, Yoon Shin YS; Rotter, Jerome I JI; Wang, Ya-Xing YX; Sheu, Wayne H H WHH; Yokota, Mitsuhiro M; Wu, Jer-Yuarn JY; Cheng, Ching-Yu CY; Wong, Tien-Yin TY; Shu, Xiao-Ou XO; Kato, Norihiro N; Park, Kyong-Soo KS; Tai, E-Shyong ES; Matsuda, Fumihiko F; Koh, Woon-Puay WP; Ma, Ronald C W RCW; Maeda, Shiro S; Millwood, Iona Y IY; Lee, Juyoung J; Kadowaki, Takashi T; Walters, Robin G RG; Kim, Bong-Jo BJ; Mohlke, Karen L KL; Sim, Xueling X
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle.
Molecular Psychiatry
Meddens, S Fleur W SFW; de Vlaming, Ronald R; Bowers, Peter P; Burik, Casper A P CAP; Linnér, Richard Karlsson RK; Lee, Chanwook C; Okbay, Aysu A; Turley, Patrick P; Rietveld, Cornelius A CA; Fontana, Mark Alan MA; Ghanbari, Mohsen M; Imamura, Fumiaki F; McMahon, George G; van der Most, Peter J PJ; Voortman, Trudy T; Wade, Kaitlin H KH; Anderson, Emma L EL; Braun, Kim V E KVE; Emmett, Pauline M PM; Esko, Tonũ T; Gonzalez, Juan R JR; Kiefte-de Jong, Jessica C JC; Langenberg, Claudia C; Luan, Jian'an J; Muka, Taulant T; Ring, Susan S; Rivadeneira, Fernando F; Snieder, Harold H; van Rooij, Frank J A FJA; Wolffenbuttel, Bruce H R BHR; , ; , ; , ; Smith, George Davey GD; Franco, Oscar H OH; Forouhi, Nita G NG; Ikram, M Arfan MA; Uitterlinden, Andre G AG; van Vliet-Ostaptchouk, Jana V JV; Wareham, Nick J NJ; Cesarini, David D; Harden, K Paige KP; Lee, James J JJ; Benjamin, Daniel J DJ; Chow, Carson C CC; Koellinger, Philipp D PD
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle.
Molecular Psychiatry
Meddens, S Fleur W SFW; de Vlaming, Ronald R; Bowers, Peter P; Burik, Casper A P CAP; Linnér, Richard Karlsson RK; Lee, Chanwook C; Okbay, Aysu A; Turley, Patrick P; Rietveld, Cornelius A CA; Fontana, Mark Alan MA; Ghanbari, Mohsen M; Imamura, Fumiaki F; McMahon, George G; van der Most, Peter J PJ; Voortman, Trudy T; Wade, Kaitlin H KH; Anderson, Emma L EL; Braun, Kim V E KVE; Emmett, Pauline M PM; Esko, Tonũ T; Gonzalez, Juan R JR; Kiefte-de Jong, Jessica C JC; Langenberg, Claudia C; Luan, Jian'an J; Muka, Taulant T; Ring, Susan S; Rivadeneira, Fernando F; Snieder, Harold H; van Rooij, Frank J A FJA; Wolffenbuttel, Bruce H R BHR; , ; , ; , ; Smith, George Davey GD; Franco, Oscar H OH; Forouhi, Nita G NG; Ikram, M Arfan MA; Uitterlinden, Andre G AG; van Vliet-Ostaptchouk, Jana V JV; Wareham, Nick J NJ; Cesarini, David D; Harden, K Paige KP; Lee, James J JJ; Benjamin, Daniel J DJ; Chow, Carson C CC; Koellinger, Philipp D PD
Functional validity, role, and implications of heavy alcohol consumption genetic loci.
Science Advances
Thompson, Andrew A; Cook, James J; Choquet, Hélène H; Jorgenson, Eric E; Yin, Jie J; Kinnunen, Tarja T; Barclay, Jeff J; Morris, Andrew P AP; Pirmohamed, Munir M
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
American Journal Of Human Genetics
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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
Plos One
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Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.
International Journal Of Obesity (2005)
Klimentidis, Yann C YC; Raichlen, David A DA; Bea, Jennifer J; Garcia, David O DO; Wineinger, Nathan E NE; Mandarino, Lawrence J LJ; Alexander, Gene E GE; Chen, Zhao Z; Going, Scott B SB
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts.
Plos One
Lindström, Sara S; Loomis, Stephanie S; Turman, Constance C; Huang, Hongyan H; Huang, Jinyan J; Aschard, Hugues H; Chan, Andrew T AT; Choi, Hyon H; Cornelis, Marilyn M; Curhan, Gary G; De Vivo, Immaculata I; Eliassen, A Heather AH; Fuchs, Charles C; Gaziano, Michael M; Hankinson, Susan E SE; Hu, Frank F; Jensen, Majken M; Kang, Jae H JH; Kabrhel, Christopher C; Liang, Liming L; Pasquale, Louis R LR; Rimm, Eric E; Stampfer, Meir J MJ; Tamimi, Rulla M RM; Tworoger, Shelley S SS; Wiggs, Janey L JL; Hunter, David J DJ; Kraft, Peter P
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
Genome Medicine
Nagy, Reka R; Boutin, Thibaud S TS; Marten, Jonathan J; Huffman, Jennifer E JE; Kerr, Shona M SM; Campbell, Archie A; Evenden, Louise L; Gibson, Jude J; Amador, Carmen C; Howard, David M DM; Navarro, Pau P; Morris, Andrew A; Deary, Ian J IJ; Hocking, Lynne J LJ; Padmanabhan, Sandosh S; Smith, Blair H BH; Joshi, Peter P; Wilson, James F JF; Hastie, Nicholas D ND; Wright, Alan F AF; McIntosh, Andrew M AM; Porteous, David J DJ; Haley, Chris S CS; Vitart, Veronique V; Hayward, Caroline C
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Nature Communications
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Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index.
Frontiers In Genetics
Cronin, Robert M RM; Field, Julie R JR; Bradford, Yuki Y; Shaffer, Christian M CM; Carroll, Robert J RJ; Mosley, Jonathan D JD; Bastarache, Lisa L; Edwards, Todd L TL; Hebbring, Scott J SJ; Lin, Simon S; Hindorff, Lucia A LA; Crane, Paul K PK; Pendergrass, Sarah A SA; Ritchie, Marylyn D MD; Crawford, Dana C DC; Pathak, Jyotishman J; Bielinski, Suzette J SJ; Carrell, David S DS; Crosslin, David R DR; Ledbetter, David H DH; Carey, David J DJ; Tromp, Gerard G; Williams, Marc S MS; Larson, Eric B EB; Jarvik, Gail P GP; Peissig, Peggy L PL; Brilliant, Murray H MH; McCarty, Catherine A CA; Chute, Christopher G CG; Kullo, Iftikhar J IJ; Bottinger, Erwin E; Chisholm, Rex R; Smith, Maureen E ME; Roden, Dan M DM; Denny, Joshua C JC
Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index.
Biomedical Reports
Han, Liyuan L; Tang, Linlin L; Wang, Changyi C; Chen, Zhongwei Z; Zhang, Tao T; Chen, Sihan S; Liu, Shengyuan S; Peng, Xiaolin X; Mai, Yifeng Y; Duan, Shiwei S
Low copy number of the salivary amylase gene predisposes to obesity.
Nature Genetics
Falchi, Mario M; El-Sayed Moustafa, Julia Sarah JS; Takousis, Petros P; Pesce, Francesco F; Bonnefond, Amélie A; Andersson-Assarsson, Johanna C JC; Sudmant, Peter H PH; Dorajoo, Rajkumar R; Al-Shafai, Mashael Nedham MN; Bottolo, Leonardo L; Ozdemir, Erdal E; So, Hon-Cheong HC; Davies, Robert W RW; Patrice, Alexandre A; Dent, Robert R; Mangino, Massimo M; Hysi, Pirro G PG; Dechaume, Aurélie A; Huyvaert, Marlène M; Skinner, Jane J; Pigeyre, Marie M; Caiazzo, Robert R; Raverdy, Violeta V; Vaillant, Emmanuel E; Field, Sarah S; Balkau, Beverley B; Marre, Michel M; Visvikis-Siest, Sophie S; Weill, Jacques J; Poulain-Godefroy, Odile O; Jacobson, Peter P; Sjostrom, Lars L; Hammond, Christopher J CJ; Deloukas, Panos P; Sham, Pak Chung PC; McPherson, Ruth R; Lee, Jeannette J; Tai, E Shyong ES; Sladek, Robert R; Carlsson, Lena M S LM; Walley, Andrew A; Eichler, Evan E EE; Pattou, Francois F; Spector, Timothy D TD; Froguel, Philippe P
Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children.
International Journal Of Obesity (2005)
Sällman Almén, M M; Rask-Andersen, M M; Jacobsson, J A JA; Ameur, A A; Kalnina, I I; Moschonis, G G; Juhlin, S S; Bringeland, N N; Hedberg, L A LA; Ignatovica, V V; Chrousos, G P GP; Manios, Y Y; Klovins, J J; Marcus, C C; Gyllensten, U U; Fredriksson, R R; Schiöth, H B HB