Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Pharmacokinetics and Genetic Factors of Atorvastatin in Healthy Korean Subjects.
Frontiers In Genetics
Kim, Serim S; Seo, Jong Do JD; Yun, Yeo-Min YM; Kim, Hanah H; Kim, Tae-Eun TE; Lee, Taeheon T; Lee, Tae-Rim TR; Lee, Jun Hyung JH; Cho, Eun-Hae EH; Ki, Chang-Seok CS
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.
Nature Communications
Schmidt, Amand F AF; Hunt, Nicholas B NB; Gordillo-Marañón, Maria M; Charoen, Pimphen P; Drenos, Fotios F; Kivimaki, Mika M; Lawlor, Deborah A DA; Giambartolomei, Claudia C; Papacosta, Olia O; Chaturvedi, Nishi N; Bis, Joshua C JC; O'Donnell, Christopher J CJ; Wannamethee, Goya G; Wong, Andrew A; Price, Jackie F JF; Hughes, Alun D AD; Gaunt, Tom R TR; Franceschini, Nora N; Mook-Kanamori, Dennis O DO; Zwierzyna, Magdalena M; Sofat, Reecha R; Hingorani, Aroon D AD; Finan, Chris C
Drug-Drug Interactions and Pharmacogenomic Evaluation in Colorectal Cancer Patients: The New Drug-PIN® System Comprehensive Approach.
Pharmaceuticals (Basel, Switzerland)
Roberto, Michela M; Rossi, Alessandro A; Panebianco, Martina M; Pomes, Leda Marina LM; Arrivi, Giulia G; Ierinò, Debora D; Simmaco, Maurizio M; Marchetti, Paolo P; Mazzuca, Federica F
Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias.
Bmc Medical Genomics
Dron, Jacqueline S JS; Wang, Jian J; McIntyre, Adam D AD; Iacocca, Michael A MA; Robinson, John F JF; Ban, Matthew R MR; Cao, Henian H; Hegele, Robert A RA
The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations.
Genes
Piko, Peter P; Fiatal, Szilvia S; Werissa, Nardos Abebe NA; Bekele, Bayu Begashaw BB; Racz, Gabor G; Kosa, Zsigmond Z; Sandor, Janos J; Adany, Roza R
Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia.
Biomolecules
Semaev, Sergey S; Shakhtshneider, Elena E; Orlov, Pavel P; Ivanoshchuk, Dinara D; Malyutina, Sophia S; Gafarov, Valery V; Ragino, Yuliya Y; Voevoda, Mikhail M
Introducing the first whole genomes of nationals from the United Arab Emirates.
Scientific Reports
AlSafar, Habiba S HS; Al-Ali, Mariam M; Elbait, Gihan Daw GD; Al-Maini, Mustafa H MH; Ruta, Dymitr D; Peramo, Braulio B; Henschel, Andreas A; Tay, Guan K GK
Relationship between CETP gene polymorphisms with coronary artery disease in Polish population.
Molecular Biology Reports
Iwanicka, Joanna J; Iwanicki, Tomasz T; Niemiec, Paweł P; Balcerzyk, Anna A; Krauze, Jolanta J; Górczyńska-Kosiorz, Sylwia S; Ochalska-Tyka, Anna A; Grzeszczak, Władysław W; Żak, Iwona I
Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease: a systematic review.
PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies.
Nature Communications
Hall, Molly A MA; Wallace, John J; Lucas, Anastasia A; Kim, Dokyoon D; Basile, Anna O AO; Verma, Shefali S SS; McCarty, Cathy A CA; Brilliant, Murray H MH; Peissig, Peggy L PL; Kitchner, Terrie E TE; Verma, Anurag A; Pendergrass, Sarah A SA; Dudek, Scott M SM; Moore, Jason H JH; Ritchie, Marylyn D MD
Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos.
Lipids In Health And Disease
Graff, Mariaelisa M; Emery, Leslie S LS; Justice, Anne E AE; Parra, Esteban E; Below, Jennifer E JE; Palmer, Nicholette D ND; Gao, Chuan C; Duan, Qing Q; Valladares-Salgado, Adan A; Cruz, Miguel M; Morrison, Alanna C AC; Boerwinkle, Eric E; Whitsel, Eric A EA; Kooperberg, Charles C; Reiner, Alex A; Li, Yun Y; Rodriguez, Carlos Jose CJ; Talavera, Gregory A GA; Langefeld, Carl D CD; Wagenknecht, Lynne E LE; Norris, Jill M JM; Taylor, Kent D KD; Papanicolaou, George G; Kenny, Eimear E; Loos, Ruth J F RJF; Chen, Yii-Der Ida YI; Laurie, Cathy C; Sofer, Tamar T; North, Kari E KE
Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C.
Npj Aging And Mechanisms Of Disease
van Leeuwen, Elisabeth M EM; Huffman, Jennifer E JE; Bis, Joshua C JC; Isaacs, Aaron A; Mulder, Monique M; Sabo, Aniko A; Smith, Albert V AV; Demissie, Serkalem S; Manichaikul, Ani A; Brody, Jennifer A JA; Feitosa, Mary F MF; Duan, Qing Q; Schraut, Katharina E KE; Navarro, Pau P; van Vliet-Ostaptchouk, Jana V JV; Zhu, Gu G; Mbarek, Hamdi H; Trompet, Stella S; Verweij, Niek N; Lyytikäinen, Leo-Pekka LP; Deelen, Joris J; Nolte, Ilja M IM; van der Laan, Sander W SW; Davies, Gail G; Vermeij-Verdoold, Andrea Jm AJ; van Oosterhout, Andy Alj AA; Vergeer-Drop, Jeannette M JM; Arking, Dan E DE; Trochet, Holly H; , ; Medina-Gomez, Carolina C; Rivadeneira, Fernando F; Uitterlinden, Andre G AG; Dehghan, Abbas A; Franco, Oscar H OH; Sijbrands, Eric J EJ; Hofman, Albert A; White, Charles C CC; Mychaleckyj, Josyf C JC; Peloso, Gina M GM; Swertz, Morris A MA; , ; Willemsen, Gonneke G; de Geus, Eco J EJ; Milaneschi, Yuri Y; Penninx, Brenda Wjh BW; Ford, Ian I; Buckley, Brendan M BM; de Craen, Anton Jm AJ; Starr, John M JM; Deary, Ian J IJ; Pasterkamp, Gerard G; Oldehinkel, Albertine J AJ; Snieder, Harold H; Slagboom, P Eline PE; Nikus, Kjell K; Kähönen, Mika M; Lehtimäki, Terho T; Viikari, Jorma S JS; Raitakari, Olli T OT; van der Harst, Pim P; Jukema, J Wouter JW; Hottenga, Jouke-Jan JJ; Boomsma, Dorret I DI; Whitfield, John B JB; Montgomery, Grant G; Martin, Nicholas G NG; , ; Polasek, Ozren O; Vitart, Veronique V; Hayward, Caroline C; Kolcic, Ivana I; Wright, Alan F AF; Rudan, Igor I; Joshi, Peter K PK; Wilson, James F JF; Lange, Leslie A LA; Wilson, James G JG; Gudnason, Vilmundur V; Harris, Tamar B TB; Morrison, Alanna C AC; Borecki, Ingrid B IB; Rich, Stephen S SS; Padmanabhan, Sandosh S; Psaty, Bruce M BM; Rotter, Jerome I JI; Smith, Blair H BH; Boerwinkle, Eric E; Cupples, L Adrienne LA; van Duijn, Cornelia C
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.
American Journal Of Human Genetics
Civelek, Mete M; Wu, Ying Y; Pan, Calvin C; Raulerson, Chelsea K CK; Ko, Arthur A; He, Aiqing A; Tilford, Charles C; Saleem, Niyas K NK; Stančáková, Alena A; Scott, Laura J LJ; Fuchsberger, Christian C; Stringham, Heather M HM; Jackson, Anne U AU; Narisu, Narisu N; Chines, Peter S PS; Small, Kerrin S KS; Kuusisto, Johanna J; Parks, Brian W BW; Pajukanta, Päivi P; Kirchgessner, Todd T; Collins, Francis S FS; Gargalovic, Peter S PS; Boehnke, Michael M; Laakso, Markku M; Mohlke, Karen L KL; Lusis, Aldons J AJ
Analysis with the exome array identifies multiple new independent variants in lipid loci.
Human Molecular Genetics
Kanoni, Stavroula S; Masca, Nicholas G D NG; Stirrups, Kathleen E KE; Varga, Tibor V TV; Warren, Helen R HR; Scott, Robert A RA; Southam, Lorraine L; Zhang, Weihua W; Yaghootkar, Hanieh H; Müller-Nurasyid, Martina M; Couto Alves, Alexessander A; Strawbridge, Rona J RJ; Lataniotis, Lazaros L; An Hashim, Nikman N; Besse, Céline C; Boland, Anne A; Braund, Peter S PS; Connell, John M JM; Dominiczak, Anna A; Farmaki, Aliki-Eleni AE; Franks, Stephen S; Grallert, Harald H; Jansson, Jan-Håkan JH; Karaleftheri, Maria M; Keinänen-Kiukaanniemi, Sirkka S; Matchan, Angela A; Pasko, Dorota D; Peters, Annette A; Poulter, Neil N; Rayner, Nigel W NW; Renström, Frida F; Rolandsson, Olov O; Sabater-Lleal, Maria M; Sennblad, Bengt B; Sever, Peter P; Shields, Denis D; Silveira, Angela A; Stanton, Alice V AV; Strauch, Konstantin K; Tomaszewski, Maciej M; Tsafantakis, Emmanouil E; Waldenberger, Melanie M; Blakemore, Alexandra I F AI; Dedoussis, George G; Escher, Stefan A SA; Kooner, Jaspal S JS; McCarthy, Mark I MI; Palmer, Colin N A CN; , ; Hamsten, Anders A; Caulfield, Mark J MJ; Frayling, Timothy M TM; Tobin, Martin D MD; Jarvelin, Marjo-Riitta MR; Zeggini, Eleftheria E; Gieger, Christian C; Chambers, John C JC; Wareham, Nick J NJ; Munroe, Patricia B PB; Franks, Paul W PW; Samani, Nilesh J NJ; Deloukas, Panos P
Resequencing of the CETP gene in American whites and African blacks: Association of rare and common variants with HDL-cholesterol levels.
Metabolism: Clinical And Experimental
Pirim, Dilek D; Wang, Xingbin X; Niemsiri, Vipavee V; Radwan, Zaheda H ZH; Bunker, Clareann H CH; Hokanson, John E JE; Hamman, Richard F RF; Barmada, M Michael MM; Demirci, F Yesim FY; Kamboh, M Ilyas MI
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem Cell Reports
Garate, Zita Z; Quintana-Bustamante, Oscar O; Crane, Ana M AM; Olivier, Emmanuel E; Poirot, Laurent L; Galetto, Roman R; Kosinski, Penelope P; Hill, Collin C; Kung, Charles C; Agirre, Xabi X; Orman, Israel I; Cerrato, Laura L; Alberquilla, Omaira O; Rodriguez-Fornes, Fatima F; Fusaki, Noemi N; Garcia-Sanchez, Felix F; Maia, Tabita M TM; Ribeiro, Maria L ML; Sevilla, Julian J; Prosper, Felipe F; Jin, Shengfang S; Mountford, Joanne J; Guenechea, Guillermo G; Gouble, Agnes A; Bueren, Juan A JA; Davis, Brian R BR; Segovia, Jose C JC
The Rotterdam Study: 2016 objectives and design update.
European Journal Of Epidemiology
Hofman, Albert A; Brusselle, Guy G O GG; Darwish Murad, Sarwa S; van Duijn, Cornelia M CM; Franco, Oscar H OH; Goedegebure, André A; Ikram, M Arfan MA; Klaver, Caroline C W CC; Nijsten, Tamar E C TE; Peeters, Robin P RP; Stricker, Bruno H Ch BH; Tiemeier, Henning W HW; Uitterlinden, André G AG; Vernooij, Meike W MW
Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models.
Human Molecular Genetics
Spiliopoulou, Athina A; Nagy, Reka R; Bermingham, Mairead L ML; Huffman, Jennifer E JE; Hayward, Caroline C; Vitart, Veronique V; Rudan, Igor I; Campbell, Harry H; Wright, Alan F AF; Wilson, James F JF; Pong-Wong, Ricardo R; Agakov, Felix F; Navarro, Pau P; Haley, Chris S CS
Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk.
Genetic Epidemiology
Hellwege, Jacklyn N JN; Palmer, Nicholette D ND; Raffield, Laura M LM; Ng, Maggie C Y MC; Hawkins, Gregory A GA; Long, Jirong J; Lorenzo, Carlos C; Norris, Jill M JM; Ida Chen, Y-D YD; Speliotes, Elizabeth K EK; Rotter, Jerome I JI; Langefeld, Carl D CD; Wagenknecht, Lynne E LE; Bowden, Donald W DW
A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.
Nature Communications
Tachmazidou, Ioanna I; Dedoussis, George G; Southam, Lorraine L; Farmaki, Aliki-Eleni AE; Ritchie, Graham R S GR; Xifara, Dionysia K DK; Matchan, Angela A; Hatzikotoulas, Konstantinos K; Rayner, Nigel W NW; Chen, Yuan Y; Pollin, Toni I TI; O'Connell, Jeffrey R JR; Yerges-Armstrong, Laura M LM; Kiagiadaki, Chrysoula C; Panoutsopoulou, Kalliope K; Schwartzentruber, Jeremy J; Moutsianas, Loukas L; , ; Tsafantakis, Emmanouil E; Tyler-Smith, Chris C; McVean, Gil G; Xue, Yali Y; Zeggini, Eleftheria E
Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data.
Plos One
Bryzgalov, Leonid O LO; Antontseva, Elena V EV; Matveeva, Marina Yu MY; Shilov, Alexander G AG; Kashina, Elena V EV; Mordvinov, Viatcheslav A VA; Merkulova, Tatyana I TI
Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study.
Circulation. Cardiovascular Genetics
Huggins, Gordon S GS; Papandonatos, George D GD; Erar, Bahar B; Belalcazar, L Maria LM; Brautbar, Ariel A; Ballantyne, Christie C; Kitabchi, Abbas E AE; Wagenknecht, Lynne E LE; Knowler, William C WC; Pownall, Henry J HJ; Wing, Rena R RR; Peter, Inga I; McCaffery, Jeanne M JM; ,
Investigation of genetic risk factors for chronic adult diseases for association with preterm birth.
Human Genetics
Falah, Nadia N; McElroy, Jude J; Snegovskikh, Victoria V; Lockwood, Charles J CJ; Norwitz, Errol E; Murray, Jeffey C JC; Kuczynski, Edward E; Menon, Ramkumar R; Teramo, Kari K; Muglia, Louis J LJ; Morgan, Thomas T
Advances in exercise, fitness, and performance genomics in 2011.
Medicine And Science In Sports And Exercise
Roth, Stephen M SM; Rankinen, Tuomo T; Hagberg, James M JM; Loos, Ruth J F RJ; Pérusse, Louis L; Sarzynski, Mark A MA; Wolfarth, Bernd B; Bouchard, Claude C
GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.
Human Molecular Genetics
Benyamin, Beben B; Middelberg, Rita P RP; Lind, Penelope A PA; Valle, Anne M AM; Gordon, Scott S; Nyholt, Dale R DR; Medland, Sarah E SE; Henders, Anjali K AK; Heath, Andrew C AC; Madden, Pamela A F PA; Visscher, Peter M PM; O'Connor, Daniel T DT; Montgomery, Grant W GW; Martin, Nicholas G NG; Whitfield, John B JB
Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.
Plos One
Turner, Stephen D SD; Berg, Richard L RL; Linneman, James G JG; Peissig, Peggy L PL; Crawford, Dana C DC; Denny, Joshua C JC; Roden, Dan M DM; McCarty, Catherine A CA; Ritchie, Marylyn D MD; Wilke, Russell A RA
Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry.
Circulation. Cardiovascular Genetics
Ahmad, Tariq T; Chasman, Daniel I DI; Buring, Julie E JE; Lee, I-Min IM; Ridker, Paul M PM; Everett, Brendan M BM
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
Plos Genetics
Smith, Erin N EN; Chen, Wei W; Kähönen, Mika M; Kettunen, Johannes J; Lehtimäki, Terho T; Peltonen, Leena L; Raitakari, Olli T OT; Salem, Rany M RM; Schork, Nicholas J NJ; Shaw, Marian M; Srinivasan, Sathanur R SR; Topol, Eric J EJ; Viikari, Jorma S JS; Berenson, Gerald S GS; Murray, Sarah S SS
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
Plos One
Zeller, Tanja T; Wild, Philipp P; Szymczak, Silke S; Rotival, Maxime M; Schillert, Arne A; Castagne, Raphaele R; Maouche, Seraya S; Germain, Marine M; Lackner, Karl K; Rossmann, Heidi H; Eleftheriadis, Medea M; Sinning, Christoph R CR; Schnabel, Renate B RB; Lubos, Edith E; Mennerich, Detlev D; Rust, Werner W; Perret, Claire C; Proust, Carole C; Nicaud, Viviane V; Loscalzo, Joseph J; Hübner, Norbert N; Tregouet, David D; Münzel, Thomas T; Ziegler, Andreas A; Tiret, Laurence L; Blankenberg, Stefan S; Cambien, François F
Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.
Plos Genetics
Igl, Wilmar W; Johansson, Asa A; Wilson, James F JF; Wild, Sarah H SH; Polasek, Ozren O; Hayward, Caroline C; Vitart, Veronique V; Hastie, Nicholas N; Rudan, Pavao P; Gnewuch, Carsten C; Schmitz, Gerd G; Meitinger, Thomas T; Pramstaller, Peter P PP; Hicks, Andrew A AA; Oostra, Ben A BA; van Duijn, Cornelia M CM; Rudan, Igor I; Wright, Alan A; Campbell, Harry H; Gyllensten, Ulf U; ,
Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study.
Circulation. Cardiovascular Genetics
Ridker, Paul M PM; Paré, Guillaume G; Parker, Alex N AN; Zee, Robert Y L RY; Miletich, Joseph P JP; Chasman, Daniel I DI
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
Lipids In Health And Disease
Ronald, James J; Rajagopalan, Ramakrishnan R; Ranchalis, Jane E JE; Marshall, Julieann K JK; Hatsukami, Thomas S TS; Heagerty, Patrick J PJ; Jarvik, Gail P GP