Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50.
Frontiers In Immunology
Fliegauf, Manfred M; Kinnunen, Matias M; Posadas-Cantera, Sara S; Camacho-Ordonez, Nadezhda N; Abolhassani, Hassan H; Alsina, Laia L; Atschekzei, Faranaz F; Bogaert, Delfien J DJ; Burns, Siobhan O SO; Church, Joseph A JA; Dückers, Gregor G; Freeman, Alexandra F AF; Hammarström, Lennart L; Hanitsch, Leif Gunnar LG; Kerre, Tessa T; Kobbe, Robin R; Sharapova, Svetlana O SO; Siepermann, Kathrin K; Speckmann, Carsten C; Steiner, Sophie S; Verma, Nisha N; Walter, Jolan E JE; Westermann-Clark, Emma E; Goldacker, Sigune S; Warnatz, Klaus K; Varjosalo, Markku M; Grimbacher, Bodo B
Mild motor impairment as prodromal state in amyotrophic lateral sclerosis: a new diagnostic entity.
Brain : A Journal Of Neurology
Benatar, Michael M; Granit, Volkan V; Andersen, Peter M PM; Grignon, Anne-Laure AL; McHutchison, Caroline C; Cosentino, Stephanie S; Malaspina, Andrea A; Wuu, Joanne J
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
Nature Genetics
van Rheenen, Wouter W; van der Spek, Rick A A RAA; Bakker, Mark K MK; van Vugt, Joke J F A JJFA; Hop, Paul J PJ; Zwamborn, Ramona A J RAJ; de Klein, Niek N; Westra, Harm-Jan HJ; Bakker, Olivier B OB; Deelen, Patrick P; Shireby, Gemma G; Hannon, Eilis E; Moisse, Matthieu M; Baird, Denis D; Restuadi, Restuadi R; Dolzhenko, Egor E; Dekker, Annelot M AM; Gawor, Klara K; Westeneng, Henk-Jan HJ; Tazelaar, Gijs H P GHP; van Eijk, Kristel R KR; Kooyman, Maarten M; Byrne, Ross P RP; Doherty, Mark M; Heverin, Mark M; Al Khleifat, Ahmad A; Iacoangeli, Alfredo A; Shatunov, Aleksey A; Ticozzi, Nicola N; Cooper-Knock, Johnathan J; Smith, Bradley N BN; Gromicho, Marta M; Chandran, Siddharthan S; Pal, Suvankar S; Morrison, Karen E KE; Shaw, Pamela J PJ; Hardy, John J; Orrell, Richard W RW; Sendtner, Michael M; Meyer, Thomas T; Başak, Nazli N; van der Kooi, Anneke J AJ; Ratti, Antonia A; Fogh, Isabella I; Gellera, Cinzia C; Lauria, Giuseppe G; Corti, Stefania S; Cereda, Cristina C; Sproviero, Daisy D; D'Alfonso, Sandra S; Sorarù, Gianni G; Siciliano, Gabriele G; Filosto, Massimiliano M; Padovani, Alessandro A; Chiò, Adriano A; Calvo, Andrea A; Moglia, Cristina C; Brunetti, Maura M; Canosa, Antonio A; Grassano, Maurizio M; Beghi, Ettore E; Pupillo, Elisabetta E; Logroscino, Giancarlo G; Nefussy, Beatrice B; Osmanovic, Alma A; Nordin, Angelica A; Lerner, Yossef Y; Zabari, Michal M; Gotkine, Marc M; Baloh, Robert H RH; Bell, Shaughn S; Vourc'h, Patrick P; Corcia, Philippe P; Couratier, Philippe P; Millecamps, Stéphanie S; Meininger, Vincent V; Salachas, François F; Mora Pardina, Jesus S JS; Assialioui, Abdelilah A; Rojas-García, Ricardo R; Dion, Patrick A PA; Ross, Jay P JP; Ludolph, Albert C AC; Weishaupt, Jochen H JH; Brenner, David D; Freischmidt, Axel A; Bensimon, Gilbert G; Brice, Alexis A; Durr, Alexandra A; Payan, Christine A M CAM; Saker-Delye, Safa S; Wood, Nicholas W NW; Topp, Simon S; Rademakers, Rosa R; Tittmann, Lukas L; Lieb, Wolfgang W; Franke, Andre A; Ripke, Stephan S; Braun, Alice A; Kraft, Julia J; Whiteman, David C DC; Olsen, Catherine M CM; Uitterlinden, Andre G AG; Hofman, Albert A; Rietschel, Marcella M; Cichon, Sven S; Nöthen, Markus M MM; Amouyel, Philippe P; , ; , ; , ; , ; Traynor, Bryan J BJ; Singleton, Andrew B AB; Mitne Neto, Miguel M; Cauchi, Ruben J RJ; Ophoff, Roel A RA; Wiedau-Pazos, Martina M; Lomen-Hoerth, Catherine C; van Deerlin, Vivianna M VM; Grosskreutz, Julian J; Roediger, Annekathrin A; Gaur, Nayana N; Jörk, Alexander A; Barthel, Tabea T; Theele, Erik E; Ilse, Benjamin B; Stubendorff, Beatrice B; Witte, Otto W OW; Steinbach, Robert R; Hübner, Christian A CA; Graff, Caroline C; Brylev, Lev L; Fominykh, Vera V; Demeshonok, Vera V; Ataulina, Anastasia A; Rogelj, Boris B; Koritnik, Blaž B; Zidar, Janez J; Ravnik-Glavač, Metka M; Glavač, Damjan D; Stević, Zorica Z; Drory, Vivian V; Povedano, Monica M; Blair, Ian P IP; Kiernan, Matthew C MC; Benyamin, Beben B; Henderson, Robert D RD; Furlong, Sarah S; Mathers, Susan S; McCombe, Pamela A PA; Needham, Merrilee M; Ngo, Shyuan T ST; Nicholson, Garth A GA; Pamphlett, Roger R; Rowe, Dominic B DB; Steyn, Frederik J FJ; Williams, Kelly L KL; Mather, Karen A KA; Sachdev, Perminder S PS; Henders, Anjali K AK; Wallace, Leanne L; de Carvalho, Mamede M; Pinto, Susana S; Petri, Susanne S; Weber, Markus M; Rouleau, Guy A GA; Silani, Vincenzo V; Curtis, Charles J CJ; Breen, Gerome G; Glass, Jonathan D JD; Brown, Robert H RH; Landers, John E JE; Shaw, Christopher E CE; Andersen, Peter M PM; Groen, Ewout J N EJN; van Es, Michael A MA; Pasterkamp, R Jeroen RJ; Fan, Dongsheng D; Garton, Fleur C FC; McRae, Allan F AF; Davey Smith, George G; Gaunt, Tom R TR; Eberle, Michael A MA; Mill, Jonathan J; McLaughlin, Russell L RL; Hardiman, Orla O; Kenna, Kevin P KP; Wray, Naomi R NR; Tsai, Ellen E; Runz, Heiko H; Franke, Lude L; Al-Chalabi, Ammar A; Van Damme, Philip P; van den Berg, Leonard H LH; Veldink, Jan H JH
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
Nature Genetics
van Rheenen, Wouter W; van der Spek, Rick A A RAA; Bakker, Mark K MK; van Vugt, Joke J F A JJFA; Hop, Paul J PJ; Zwamborn, Ramona A J RAJ; de Klein, Niek N; Westra, Harm-Jan HJ; Bakker, Olivier B OB; Deelen, Patrick P; Shireby, Gemma G; Hannon, Eilis E; Moisse, Matthieu M; Baird, Denis D; Restuadi, Restuadi R; Dolzhenko, Egor E; Dekker, Annelot M AM; Gawor, Klara K; Westeneng, Henk-Jan HJ; Tazelaar, Gijs H P GHP; van Eijk, Kristel R KR; Kooyman, Maarten M; Byrne, Ross P RP; Doherty, Mark M; Heverin, Mark M; Al Khleifat, Ahmad A; Iacoangeli, Alfredo A; Shatunov, Aleksey A; Ticozzi, Nicola N; Cooper-Knock, Johnathan J; Smith, Bradley N BN; Gromicho, Marta M; Chandran, Siddharthan S; Pal, Suvankar S; Morrison, Karen E KE; Shaw, Pamela J PJ; Hardy, John J; Orrell, Richard W RW; Sendtner, Michael M; Meyer, Thomas T; Başak, Nazli N; van der Kooi, Anneke J AJ; Ratti, Antonia A; Fogh, Isabella I; Gellera, Cinzia C; Lauria, Giuseppe G; Corti, Stefania S; Cereda, Cristina C; Sproviero, Daisy D; D'Alfonso, Sandra S; Sorarù, Gianni G; Siciliano, Gabriele G; Filosto, Massimiliano M; Padovani, Alessandro A; Chiò, Adriano A; Calvo, Andrea A; Moglia, Cristina C; Brunetti, Maura M; Canosa, Antonio A; Grassano, Maurizio M; Beghi, Ettore E; Pupillo, Elisabetta E; Logroscino, Giancarlo G; Nefussy, Beatrice B; Osmanovic, Alma A; Nordin, Angelica A; Lerner, Yossef Y; Zabari, Michal M; Gotkine, Marc M; Baloh, Robert H RH; Bell, Shaughn S; Vourc'h, Patrick P; Corcia, Philippe P; Couratier, Philippe P; Millecamps, Stéphanie S; Meininger, Vincent V; Salachas, François F; Mora Pardina, Jesus S JS; Assialioui, Abdelilah A; Rojas-García, Ricardo R; Dion, Patrick A PA; Ross, Jay P JP; Ludolph, Albert C AC; Weishaupt, Jochen H JH; Brenner, David D; Freischmidt, Axel A; Bensimon, Gilbert G; Brice, Alexis A; Durr, Alexandra A; Payan, Christine A M CAM; Saker-Delye, Safa S; Wood, Nicholas W NW; Topp, Simon S; Rademakers, Rosa R; Tittmann, Lukas L; Lieb, Wolfgang W; Franke, Andre A; Ripke, Stephan S; Braun, Alice A; Kraft, Julia J; Whiteman, David C DC; Olsen, Catherine M CM; Uitterlinden, Andre G AG; Hofman, Albert A; Rietschel, Marcella M; Cichon, Sven S; Nöthen, Markus M MM; Amouyel, Philippe P; , ; , ; , ; , ; Traynor, Bryan J BJ; Singleton, Andrew B AB; Mitne Neto, Miguel M; Cauchi, Ruben J RJ; Ophoff, Roel A RA; Wiedau-Pazos, Martina M; Lomen-Hoerth, Catherine C; van Deerlin, Vivianna M VM; Grosskreutz, Julian J; Roediger, Annekathrin A; Gaur, Nayana N; Jörk, Alexander A; Barthel, Tabea T; Theele, Erik E; Ilse, Benjamin B; Stubendorff, Beatrice B; Witte, Otto W OW; Steinbach, Robert R; Hübner, Christian A CA; Graff, Caroline C; Brylev, Lev L; Fominykh, Vera V; Demeshonok, Vera V; Ataulina, Anastasia A; Rogelj, Boris B; Koritnik, Blaž B; Zidar, Janez J; Ravnik-Glavač, Metka M; Glavač, Damjan D; Stević, Zorica Z; Drory, Vivian V; Povedano, Monica M; Blair, Ian P IP; Kiernan, Matthew C MC; Benyamin, Beben B; Henderson, Robert D RD; Furlong, Sarah S; Mathers, Susan S; McCombe, Pamela A PA; Needham, Merrilee M; Ngo, Shyuan T ST; Nicholson, Garth A GA; Pamphlett, Roger R; Rowe, Dominic B DB; Steyn, Frederik J FJ; Williams, Kelly L KL; Mather, Karen A KA; Sachdev, Perminder S PS; Henders, Anjali K AK; Wallace, Leanne L; de Carvalho, Mamede M; Pinto, Susana S; Petri, Susanne S; Weber, Markus M; Rouleau, Guy A GA; Silani, Vincenzo V; Curtis, Charles J CJ; Breen, Gerome G; Glass, Jonathan D JD; Brown, Robert H RH; Landers, John E JE; Shaw, Christopher E CE; Andersen, Peter M PM; Groen, Ewout J N EJN; van Es, Michael A MA; Pasterkamp, R Jeroen RJ; Fan, Dongsheng D; Garton, Fleur C FC; McRae, Allan F AF; Davey Smith, George G; Gaunt, Tom R TR; Eberle, Michael A MA; Mill, Jonathan J; McLaughlin, Russell L RL; Hardiman, Orla O; Kenna, Kevin P KP; Wray, Naomi R NR; Tsai, Ellen E; Runz, Heiko H; Franke, Lude L; Al-Chalabi, Ammar A; Van Damme, Philip P; van den Berg, Leonard H LH; Veldink, Jan H JH
Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
Elife
Bacic, Luka L; Gaullier, Guillaume G; Sabantsev, Anton A; Lehmann, Laura C LC; Brackmann, Klaus K; Dimakou, Despoina D; Halic, Mario M; Hewitt, Graeme G; Boulton, Simon J SJ; Deindl, Sebastian S
Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Cell Reports
Lehmann, Laura C LC; Bacic, Luka L; Hewitt, Graeme G; Brackmann, Klaus K; Sabantsev, Anton A; Gaullier, Guillaume G; Pytharopoulou, Sofia S; Degliesposti, Gianluca G; Okkenhaug, Hanneke H; Tan, Song S; Costa, Alessandro A; Skehel, J Mark JM; Boulton, Simon J SJ; Deindl, Sebastian S
Biomarkers in Motor Neuron Disease: A State of the Art Review.
Frontiers In Neurology
Verber, Nick S NS; Shepheard, Stephanie R SR; Sassani, Matilde M; McDonough, Harry E HE; Moore, Sophie A SA; Alix, James J P JJP; Wilkinson, Iain D ID; Jenkins, Tom M TM; Shaw, Pamela J PJ
Amyotrophic lateral sclerosis: one or multiple causes?
Neurology International
Bastos, Aline Furtado AF; Orsini, Marco M; Machado, Dionis D; Mello, Mariana Pimentel MP; Nader, Sergio S; Silva, Júlio Guilherme JG; da Silva Catharino, Antonio M AM; de Freitas, Marcos R G MR; Pereira, Alessandra A; Pessoa, Luciane Lacerda LL; Sztajnbok, Flavio R FR; Leite, Marco Araújo MA; Nascimento, Osvaldo J M OJ; Bastos, Victor Hugo VH