Mechanism-based traps enable protease and hydrolase substrate discovery.
Nature
Tang, Shan S; Beattie, Adam T AT; Kafkova, Lucie L; Petris, Gianluca G; Huguenin-Dezot, Nicolas N; Fiedler, Marc M; Freeman, Matthew M; Chin, Jason W JW
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Nature Communications
Garnish, Sarah E SE; Meng, Yanxiang Y; Koide, Akiko A; Sandow, Jarrod J JJ; Denbaum, Eric E; Jacobsen, Annette V AV; Yeung, Wayland W; Samson, Andre L AL; Horne, Christopher R CR; Fitzgibbon, Cheree C; Young, Samuel N SN; Smith, Phoebe P C PPC; Webb, Andrew I AI; Petrie, Emma J EJ; Hildebrand, Joanne M JM; Kannan, Natarajan N; Czabotar, Peter E PE; Koide, Shohei S; Murphy, James M JM
Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-L-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link.
Biochemistry
Bruender, Nathan A NA; Wilcoxen, Jarett J; Britt, R David RD; Bandarian, Vahe V