Publications:

Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer.

Journal Of Translational Medicine

Mezynski, M Janusz MJ; Farrelly, Angela M AM; Cremona, Mattia M; Carr, Aoife A; Morgan, Clare C; Workman, Julie J; Armstrong, Paul P; McAuley, Jennifer J; Madden, Stephen S; Fay, Joanna J; Sheehan, Katherine M KM; Kay, Elaine W EW; Holohan, Ciara C; Elamin, Yasir Y; Rafee, Shereen S; Morris, Patrick G PG; Breathnach, Oscar O; Grogan, Liam L; Hennessy, Bryan T BT; Toomey, Sinead S

Publication Date: 2021-05-01

Variant appearance in text: ERBB2: L436V

PubMed Link: 33933113

Variant Present in the following documents:

• Main text

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The HER2 S310F Mutant Can Form an Active Heterodimer with the EGFR, Which Can Be Inhibited by Cetuximab but Not by Trastuzumab as well as Pertuzumab.

Biomolecules

Shin, Jung Won JW; Kim, Soohyun S; Ha, Suji S; Choi, Byungsan B; Kim, Seongyeong S; Im, Seock-Ah SA; Yoon, Tae-Young TY; Chung, Junho J

Publication Date: 2019-10-19

Variant appearance in text: HER2: L436V

PubMed Link: 31635022

Variant Present in the following documents:

• Main text
• biomolecules-09-00629.pdf

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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports

Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS

Publication Date: 2018-04-03

Variant appearance in text: ERBB2: 1306C>G

PubMed Link: 29617658

Variant Present in the following documents:

• NIHMS958974-supplement-6.xlsx, sheet 1
• NIHMS958974-supplement-5.xlsx, sheet 1

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Effects of trastuzumab and afatinib on kinase activity in gastric cancer cell lines.

Molecular Oncology

Keller, Simone S; Zwingenberger, Gwen G; Ebert, Karolin K; Hasenauer, Jan J; Wasmuth, Jacqueline J; Maier, Dieter D; Haffner, Ivonne I; Schierle, Katrin K; Weirich, Gregor G; Luber, Birgit B

Publication Date: 2018-04

Variant appearance in text: ERBB2: L436V

PubMed Link: 29325228

Variant Present in the following documents:

• MOL2-12-441-s001.pdf

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