Publications:

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Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model.

Iscience

Jacob, Jennifer B JB; Wei, Kuang-Chung KC; Bepler, Gerold G; Reyes, Joyce D JD; Cani, Andi A; Polin, Lisa L; White, Kathryn K; Kim, Seongho S; Viola, Nerissa N; McGrath, Julie J; Guastella, Anthony A; Yin, CongCong C; Mi, Qing-Shen QS; Kidder, Benjamin L BL; Wagner, Kay-Uwe KU; Ratner, Stuart S; Phillips, Victoria V; Xiu, Joanne J; Parajuli, Prahlad P; Wei, Wei-Zen WZ

Publication Date: 2023-04-21

Variant appearance in text: HER2: V664E

PubMed Link: 36968078

Variant Present in the following documents:

• Main text
• main.pdf

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Identification of Activating Mutations in the Transmembrane and Extracellular Domains of EGFR.

Biochemistry

Wagner, Anja A; Galicia-Andrés, Edgar E; Teufl, Magdalena M; Gold, Lukas L; Obinger, Christian C; Sykacek, Peter P; Oostenbrink, Chris C; Traxlmayr, Michael W MW

Publication Date: 2022-10-04

Variant appearance in text: HER2: V664E

PubMed Link: 36148499

Variant Present in the following documents:

• Main text
• bi2c00384.pdf

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HER Tyrosine Kinase Family and Rhabdomyosarcoma: Role in Onset and Targeted Therapy.

Cells

De Giovanni, Carla C; Landuzzi, Lorena L; Palladini, Arianna A; Nicoletti, Giordano G; Nanni, Patrizia P; Lollini, Pier-Luigi PL

Publication Date: 2021-07-16

Variant appearance in text: HER2: V664E

PubMed Link: 34359977

Variant Present in the following documents:

• Main text
• cells-10-01808.pdf

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Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion.

Molecular Oncology

Villodre, Emilly S ES; Hu, Xiaoding X; Larson, Richard R; Finetti, Pascal P; Gomez, Kristen K; Balema, Wintana W; Stecklein, Shane R SR; Santiago-Sanchez, Ginette G; Krishnamurthy, Savitri S; Song, Juhee J; Su, Xiaoping X; Ueno, Naoto T NT; Tripathy, Debu D; Van Laere, Steven S; Bertucci, François F; Vivas-Mejía, Pablo P; Woodward, Wendy A WA; Debeb, Bisrat G BG

Publication Date: 2021-10

Variant appearance in text: ERBB2: V664E

PubMed Link: 34342930

Variant Present in the following documents:

• Main text
• MOL2-15-2752.pdf

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Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion.

Molecular Oncology

Villodre, Emilly S ES; Hu, Xiaoding X; Larson, Richard R; Finetti, Pascal P; Gomez, Kristen K; Balema, Wintana W; Stecklein, Shane R SR; Santiago-Sanchez, Ginette G; Krishnamurthy, Savitri S; Song, Juhee J; Su, Xiaoping X; Ueno, Naoto T NT; Tripathy, Debu D; Van Laere, Steven S; Bertucci, François F; Vivas-Mejía, Pablo P; Woodward, Wendy A WA; Debeb, Bisrat G BG

Publication Date: 2021-10

Variant appearance in text: ERBB2: V664E

PubMed Link: 34342930

Variant Present in the following documents:

• Main text
• MOL2-15-2752.pdf

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Reduction of fibrosis and immune suppressive cells in ErbB2-dependent tumorigenesis by an LXR agonist.

Plos One

Sheng, Gao G; Yuan, Hongyan H; Jin, Lu L; Ranjit, Suman S; Panov, Julia J; Lu, Xun X; Levi, Moshe M; Glazer, Robert I RI

Publication Date: 2021

Variant appearance in text: HER2: V664E

PubMed Link: 33780491

Variant Present in the following documents:

• Main text
• pone.0248996.pdf

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A small molecule inhibitor of HER3: a proof-of-concept study.

The Biochemical Journal

Colomba, Audrey A; Fitzek, Martina M; George, Roger R; Weitsman, Gregory G; Roberts, Selene S; Zanetti-Domingues, Laura L; Hirsch, Michael M; Rolfe, Daniel J DJ; Mehmood, Shahid S; Madin, Andrew A; Claus, Jeroen J; Kjaer, Svend S; Snijders, Ambrosius P AP; Ng, Tony T; Martin-Fernandez, Marisa M; Smith, David M DM; Parker, Peter J PJ

Publication Date: 2020-09-18

Variant appearance in text: HER2: V664E

PubMed Link: 32815546

Variant Present in the following documents:

• Main text
• BCJ-477-3329.pdf

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Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer.

Scientific Reports

Oh, Sangphil S; Shin, Sook S; Song, Hoogeun H; Grande, Joseph P JP; Janknecht, Ralf R

Publication Date: 2019-06-03

Variant appearance in text: HER2: V664E

PubMed Link: 31160676

Variant Present in the following documents:

• Main text
• 41598_2019_Article_44685.pdf

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The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation.

Cancers

Nami, Babak B; Maadi, Hamid H; Wang, Zhixiang Z

Publication Date: 2019-03-16

Variant appearance in text: HER2: Val664Glu

PubMed Link: 30884851

Variant Present in the following documents:

• Main text
• cancers-11-00375.pdf

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Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.

Cancer Cell

Pahuja, Kanika Bajaj KB; Nguyen, Thong T TT; Jaiswal, Bijay S BS; Prabhash, Kumar K; Thaker, Tarjani M TM; Senger, Kate K; Chaudhuri, Subhra S; Kljavin, Noelyn M NM; Antony, Aju A; Phalke, Sameer S; Kumar, Prasanna P; Mravic, Marco M; Stawiski, Eric W EW; Vargas, Derek D; Durinck, Steffen S; Gupta, Ravi R; Khanna-Gupta, Arati A; Trabucco, Sally E SE; Sokol, Ethan S ES; Hartmaier, Ryan J RJ; Singh, Ashish A; Chougule, Anuradha A; Trivedi, Vaishakhi V; Dutt, Amit A; Patil, Vijay V; Joshi, Amit A; Noronha, Vanita V; Ziai, James J; Banavali, Sripad D SD; Ramprasad, Vedam V; DeGrado, William F WF; Bueno, Raphael R; Jura, Natalia N; Seshagiri, Somasekar S

Publication Date: 2018-11-12

Variant appearance in text: HER2: V664E

PubMed Link: 30449325

Variant Present in the following documents:

• Main text

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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Cell Metabolism

Hulea, Laura L; Gravel, Simon-Pierre SP; Morita, Masahiro M; Cargnello, Marie M; Uchenunu, Oro O; Im, Young Kyuen YK; Lehuédé, Camille C; Ma, Eric H EH; Leibovitch, Matthew M; McLaughlan, Shannon S; Blouin, Marie-José MJ; Parisotto, Maxime M; Papavasiliou, Vasilios V; Lavoie, Cynthia C; Larsson, Ola O; Ohh, Michael M; Ferreira, Tiago T; Greenwood, Celia C; Bridon, Gaëlle G; Avizonis, Daina D; Ferbeyre, Gerardo G; Siegel, Peter P; Jones, Russell G RG; Muller, William W; Ursini-Siegel, Josie J; St-Pierre, Julie J; Pollak, Michael M; Topisirovic, Ivan I

Publication Date: 2018-12-04

Variant appearance in text: HER2: V664E

PubMed Link: 30244971

Variant Present in the following documents:

• Main text

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Genomic alterations of ERBB receptors in cancer: clinical implications.

Oncotarget

Mishra, Rosalin R; Hanker, Ariella B AB; Garrett, Joan T JT

Publication Date: 2017-12-26

Variant appearance in text: HER2: V664E

PubMed Link: 29371993

Variant Present in the following documents:

• Main text
• oncotarget-08-114371.pdf

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Cell cycle proteins as promising targets in cancer therapy.

Nature Reviews. Cancer

Otto, Tobias T; Sicinski, Piotr P

Publication Date: 2017-01-27

Variant appearance in text: ERBB2: V664E

PubMed Link: 28127048

Variant Present in the following documents:

• Main text

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Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.

Cell Reports

Zhang, Zheng Z; Christin, John R JR; Wang, Chunhui C; Ge, Kai K; Oktay, Maja H MH; Guo, Wenjun W

Publication Date: 2016-09-20

Variant appearance in text: ERBB2: V664E

PubMed Link: 27653681

Variant Present in the following documents:

• Main text

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Recent developments in receptor tyrosine kinases targeted anticancer therapy.

Veterinary World

Raval, Samir H SH; Singh, Ratn D RD; Joshi, Dilip V DV; Patel, Hitesh B HB; Mody, Shailesh K SK

Publication Date: 2016-01

Variant appearance in text: ERBB2: Val664Glu

PubMed Link: 27051190

Variant Present in the following documents:

• Main text
• VetWorld-9-80.pdf

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[Role of HER2 in NSCLC].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Zhang, Kun K; Wang, Hong H

Publication Date: 2015-10-20

Variant appearance in text: HER2: V664E

PubMed Link: 26483338

Variant Present in the following documents:

• Main text
• zgfazz-18-10-644.pdf

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Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib.

Cancer Biology & Therapy

de Martino, Michela M; Zhuang, Dazhong D; Klatte, Tobias T; Rieken, Malte M; Rouprêt, Morgan M; Xylinas, Evanguelos E; Clozel, Thomas T; Krzywinski, Martin M; Elemento, Olivier O; Shariat, Shahrokh F SF

Publication Date: 2014-09

Variant appearance in text: ERBB2: V664E

PubMed Link: 24971884

Variant Present in the following documents:

• Main text

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Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.

Plos One

Dow, Lukas E LE; Nasr, Zeina Z; Saborowski, Michael M; Ebbesen, Saya H SH; Manchado, Eusebio E; Tasdemir, Nilgun N; Lee, Teresa T; Pelletier, Jerry J; Lowe, Scott W SW

Publication Date: 2014

Variant appearance in text: ERBB2: V664E

PubMed Link: 24743474

Variant Present in the following documents:

• Main text

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Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.

Journal Of The National Cancer Institute

Yamamoto, Hiromasa H; Higasa, Koichiro K; Sakaguchi, Masakiyo M; Shien, Kazuhiko K; Soh, Junichi J; Ichimura, Koichi K; Furukawa, Masashi M; Hashida, Shinsuke S; Tsukuda, Kazunori K; Takigawa, Nagio N; Matsuo, Keitaro K; Kiura, Katsuyuki K; Miyoshi, Shinichiro S; Matsuda, Fumihiko F; Toyooka, Shinichi S

Publication Date: 2014-01

Variant appearance in text: HER2: V664E

PubMed Link: 24317180

Variant Present in the following documents:

• Main text
• djt338.pdf

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Immunogenicity and therapeutic efficacy of a dual-component genetic cancer vaccine cotargeting carcinoembryonic antigen and HER2/neu in preclinical models.

Human Gene Therapy

Aurisicchio, Luigi L; Peruzzi, Daniela D; Koo, Gloria G; Wei, Wei-Zen WZ; La Monica, Nicola N; Ciliberto, Gennaro G

Publication Date: 2014-02

Variant appearance in text: HER2: V664E

PubMed Link: 24195644

Variant Present in the following documents:

• Main text

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Cellular iron metabolism in prognosis and therapy of breast cancer.

Critical Reviews In Oncogenesis

Torti, Suzy V SV; Torti, Frank M FM

Publication Date: 2013

Variant appearance in text: HER2: V664E

PubMed Link: 23879588

Variant Present in the following documents:

• Main text

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Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Matsushita, Chihiro C; Tamagaki, Hiroko H; Miyazawa, Yudai Y; Aimoto, Saburo S; Smith, Steven O SO; Sato, Takeshi T

Publication Date: 2013-01-29

Variant appearance in text: HER2: V664E

PubMed Link: 23319611

Variant Present in the following documents:

• Main text

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Molecular Mechanisms of Trastuzumab-Based Treatment in HER2-Overexpressing Breast Cancer.

Isrn Oncology

Nahta, Rita R

Publication Date: 2012

Variant appearance in text: HER2: V664E

PubMed Link: 23227361

Variant Present in the following documents:

• Main text
• ISRN.ONCOLOGY2012-428062.pdf

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ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis.

The Journal Of Clinical Investigation

Worzfeld, Thomas T; Swiercz, Jakub M JM; Looso, Mario M; Straub, Beate K BK; Sivaraj, Kishor K KK; Offermanns, Stefan S

Publication Date: 2012-04

Variant appearance in text: ERBB2: V664E

PubMed Link: 22378040

Variant Present in the following documents:

• Main text

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Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.

Oncogene

Meng, L L; Gabai, V L VL; Sherman, M Y MY

Publication Date: 2010-09-16

Variant appearance in text: HER2: V664E

PubMed Link: 20622894

Variant Present in the following documents:

• Main text
• nihms212745.pdf

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Targeting the function of the HER2 oncogene in human cancer therapeutics.

Oncogene

Moasser, M M MM

Publication Date: 2007-10-11

Variant appearance in text: HER2: V664E

PubMed Link: 17486079

Variant Present in the following documents:

• Main text

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The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis.

Oncogene

Moasser, M M MM

Publication Date: 2007-10-04

Variant appearance in text: HER2: V664E

PubMed Link: 17471238

Variant Present in the following documents:

• Main text

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655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations.

Cellular Oncology : The Official Journal Of The International Society For Cellular Oncology

Tommasi, Stefania S; Fedele, Vita V; Lacalamita, Rosanna R; Bruno, Michele M; Schittulli, Francesco F; Ginzinger, David D; Scott, Gery G; Eppenberger-Castori, Serenella S; Calistri, Daniele D; Casadei, Silvia S; Seymour, Ian I; Longo, Salvatore S; Giannelli, Gianluigi G; Pilato, Brunella B; Simone, Giovanni G; Benz, Christopher C CC; Paradiso, Angelo A

Publication Date: 2007

Variant appearance in text: ERBB2: Val664Glu

PubMed Link: 17452776

Variant Present in the following documents:

• ACP-2007-29-3-512518.pdf

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