Deciphering the Impact of HER2 Alterations on Non-Small-Cell Lung Cancer: From Biological Mechanisms to Therapeutic Approaches.
Journal Of Personalized Medicine
Bontoux, Christophe C; Benzaquen, Jonathan J; Hofman, Véronique V; Heeke, Simon S; Hannetel, Paul P; Capela-Brosseau-Laborde, Pierre P; Marquette, Charles-Hugo CH; Ilié, Marius M; Hofman, Paul P
Increased blood-based intratumor heterogeneity (bITH) is associated with unfavorable outcomes of immune checkpoint inhibitors plus chemotherapy in non-small cell lung cancer.
Bmc Medicine
Zhou, Juan J; Bao, Minwei M; Gao, Guanghui G; Cai, Yiran Y; Wu, Lihong L; Lei, Lei L; Zhao, Jing J; Ji, Xianxiu X; Huang, Ying Y; Su, Chunxia C
Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.
Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach.
Advances In Protein Chemistry And Structural Biology
Thirumal Kumar, D D; Shree Devi, M S MS; Udhaya Kumar, S S; Sherlin, Annie A; Mathew, Aishwarya A; Lakshmipriya, M M; Sathiyarajeswaran, P P; Gnanasambandan, R R; Siva, R R; Magesh, R R; George Priya Doss, C C
KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.
Plos One
Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW
KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.
Plos One
Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW
Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers.
Poziotinib in Non-Small-Cell Lung Cancer Harboring HER2 Exon 20 Insertion Mutations After Prior Therapies: ZENITH20-2 Trial.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Le, Xiuning X; Cornelissen, Robin R; Garassino, Marina M; Clarke, Jeffrey M JM; Tchekmedyian, Nishan N; Goldman, Jonathan W JW; Leu, Szu-Yun SY; Bhat, Gajanan G; Lebel, Francois F; Heymach, John V JV; Socinski, Mark A MA
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Targeting HER2 in non-small-cell lung cancer (NSCLC): a glimpse of hope? An updated review on therapeutic strategies in NSCLC harbouring HER2 alterations.
Esmo Open
Riudavets, M M; Sullivan, I I; Abdayem, P P; Planchard, D D
Biomarker Analysis of the Phase III NALA Study of Neratinib + Capecitabine versus Lapatinib + Capecitabine in Patients with Previously Treated Metastatic Breast Cancer.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Saura, Cristina C; Matito, Judit J; Oliveira, Mafalda M; Wildiers, Hans H; Brufksy, Adam M AM; Waters, Simon H SH; Hurvitz, Sara A SA; Moy, Beverly B; Kim, Sung-Bae SB; Gradishar, William J WJ; Queiroz, Geraldo Silva GS; Cronemberger, Eduardo E; Wallweber, Gerald J GJ; Bebchuk, Judith J; Keyvanjah, Kiana K; Lalani, Alshad S AS; Bryce, Richard R; Vivancos, Ana A; Eli, Lisa D LD; Delaloge, Suzette S
Exon 20 YVMA insertion is associated with high incidence of brain metastasis and inferior outcome of chemotherapy in advanced non-small cell lung cancer patients with HER2 kinase domain mutations.
Identifying ERBB2 Activating Mutations in HER2-Negative Breast Cancer: Clinical Impact of Institute-Wide Genomic Testing and Enrollment in Matched Therapy Trials.
Jco Precision Oncology
Exman, Pedro P; Garrido-Castro, Ana C AC; Hughes, Melissa E ME; Freedman, Rachel A RA; Li, Tianyu T; Trippa, Lorenzo L; Bychkovsky, Brittany L BL; Barroso-Sousa, Romualdo R; Di Lascio, Simona S; Mackichan, Colin C; Lloyd, Max R MR; Krevalin, Max M; Cerami, Ethan E; Merrill, Margaret S MS; Santiago, Rebecca R; Crowley, Lindsey L; Kuhnly, Nicole N; Files, Janet J; Lindeman, Neal I NI; MacConaill, Laura E LE; Kumari, Priti P; Tolaney, Sara M SM; Krop, Ian E IE; Bose, Ron R; Johnson, Bruce E BE; Ma, Cynthia X CX; Dillon, Deborah A DA; Winer, Eric P EP; Wagle, Nikhil N; Lin, Nancy U NU
ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia.
Leukemia
Joshi, Sunil K SK; Keck, Jamie M JM; Eide, Christopher A CA; Bottomly, Daniel D; Traer, Elie E; Tyner, Jeffrey W JW; McWeeney, Shannon K SK; Tognon, Cristina E CE; Druker, Brian J BJ
Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.
Cancer
Mack, Philip C PC; Banks, Kimberly C KC; Espenschied, Carin R CR; Burich, Rebekah A RA; Zill, Oliver A OA; Lee, Christine E CE; Riess, Jonathan W JW; Mortimer, Stefanie A SA; Talasaz, AmirAli A; Lanman, Richard B RB; Gandara, David R DR
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers.
Cancer Discovery
Li, Bob T BT; Michelini, Flavia F; Misale, Sandra S; Cocco, Emiliano E; Baldino, Laura L; Cai, Yanyan Y; Shifman, Sophie S; Tu, Hai-Yan HY; Myers, Mackenzie L ML; Xu, Chongrui C; Mattar, Marissa M; Khodos, Inna I; Little, Megan M; Qeriqi, Besnik B; Weitsman, Gregory G; Wilhem, Clare J CJ; Lalani, Alshad S AS; Diala, Irmina I; Freedman, Rachel A RA; Lin, Nancy U NU; Solit, David B DB; Berger, Michael F MF; Barber, Paul R PR; Ng, Tony T; Offin, Michael M; Isbell, James M JM; Jones, David R DR; Yu, Helena A HA; Thyparambil, Sheeno S; Liao, Wei-Li WL; Bhalkikar, Anuja A; Cecchi, Fabiola F; Hyman, David M DM; Lewis, Jason S JS; Buonocore, Darren J DJ; Ho, Alan L AL; Makker, Vicky V; Reis-Filho, Jorge S JS; Razavi, Pedram P; Arcila, Maria E ME; Kris, Mark G MG; Poirier, John T JT; Shen, Ronglai R; Tsurutani, Junji J; Ulaner, Gary A GA; de Stanchina, Elisa E; Rosen, Neal N; Rudin, Charles M CM; Scaltriti, Maurizio M
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity.
Cancer Cell
Robichaux, Jacqulyne P JP; Elamin, Yasir Y YY; Vijayan, R S K RSK; Nilsson, Monique B MB; Hu, Lemei L; He, Junqin J; Zhang, Fahao F; Pisegna, Marlese M; Poteete, Alissa A; Sun, Huiying H; Li, Shuai S; Chen, Ting T; Han, Han H; Negrao, Marcelo Vailati MV; Ahnert, Jordi Rodon JR; Diao, Lixia L; Wang, Jing J; Le, Xiuning X; Meric-Bernstam, Funda F; Routbort, Mark M; Roeck, Brent B; Yang, Zane Z; Raymond, Victoria M VM; Lanman, Richard B RB; Frampton, Garrett M GM; Miller, Vincent A VA; Schrock, Alexa B AB; Albacker, Lee A LA; Wong, Kwok-Kin KK; Cross, Jason B JB; Heymach, John V JV
Targeted Gene Next-Generation Sequencing Panel in Patients with Advanced Lung Adenocarcinoma: Paving the Way for Clinical Implementation.
Cancers
Fernandes, Maria Gabriela O MGO; Jacob, Maria M; Martins, Natália N; Moura, Conceição Souto CS; Guimarães, Susana S; Reis, Joana Pereira JP; Justino, Ana A; Pina, Maria João MJ; Cirnes, Luís L; Sousa, Catarina C; Pinto, Josué J; Marques, José Agostinho JA; Machado, José Carlos JC; Hespanhol, Venceslau V; Costa, José Luis JL
Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer.
Cancers
Collins, Denis M DM; Conlon, Neil T NT; Kannan, Srinivasaraghavan S; Verma, Chandra S CS; Eli, Lisa D LD; Lalani, Alshad S AS; Crown, John J