Publications:

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Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma.

Nature Communications

Berko, Esther R ER; Witek, Gabriela M GM; Matkar, Smita S; Petrova, Zaritza O ZO; Wu, Megan A MA; Smith, Courtney M CM; Daniels, Alex A; Kalna, Joshua J; Kennedy, Annie A; Gostuski, Ivan I; Casey, Colleen C; Krytska, Kateryna K; Gerelus, Mark M; Pavlick, Dean D; Ghazarian, Susan S; Park, Julie R JR; Marachelian, Araz A; Maris, John M JM; Goldsmith, Kelly C KC; Radhakrishnan, Ravi R; Lemmon, Mark A MA; Mossé, Yaël P YP

Publication Date: 2023-05-05

Variant appearance in text: ERBB2: G776C

PubMed Link: 37147298

Variant Present in the following documents:

• 41467_2023_38195_MOESM3_ESM.xlsx, sheet 1

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Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers.

Nature Communications

Harding, James J JJ; Piha-Paul, Sarina A SA; Shah, Ronak H RH; Murphy, Jessica J JJ; Cleary, James M JM; Shapiro, Geoffrey I GI; Quinn, David I DI; Braña, Irene I; Moreno, Victor V; Borad, Mitesh M; Loi, Sherene S; Spanggaard, Iben I; Park, Haeseong H; Ford, James M JM; Arnedos, Mónica M; Stemmer, Salomon M SM; de la Fouchardiere, Christelle C; Fountzilas, Christos C; Zhang, Jie J; DiPrimeo, Daniel D; Savin, Casey C; Duygu Selcuklu, S S; Berger, Michael F MF; Eli, Lisa D LD; Meric-Bernstam, Funda F; Jhaveri, Komal K; Solit, David B DB; Abou-Alfa, Ghassan K GK

Publication Date: 2023-02-06

Variant appearance in text: ERBB2: G776C

PubMed Link: 36746967

Variant Present in the following documents:

• 41467_2023_36399_MOESM3_ESM.xlsx, sheet 5
• 41467_2023_36399_MOESM1_ESM.pdf

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Targeting the EGF receptor family in non-small cell lung cancer-increased complexity and future perspectives.

Cancer Biology & Medicine

Boch, Tobias T; Köhler, Jens J; Janning, Melanie M; Loges, Sonja S

Publication Date: 2022-12-05

Variant appearance in text: HER2: G776C

PubMed Link: 36476337

Variant Present in the following documents:

• Main text
• cbm-19-1543.pdf

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Emerging strategies to overcome resistance to third-generation EGFR inhibitors.

Journal Of Hematology & Oncology

Shi, Kunyu K; Wang, Guan G; Pei, Junping J; Zhang, Jifa J; Wang, Jiaxing J; Ouyang, Liang L; Wang, Yuxi Y; Li, Weimin W

Publication Date: 2022-07-15

Variant appearance in text: HER2: G776C

PubMed Link: 35840984

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1311.pdf

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The efficacy of afatinib in patients with HER2 mutant non-small cell lung cancer: a meta-analysis.

Translational Cancer Research

Zhou, Niya N; Zhao, Jie J; Huang, Xiu X; Shen, Hui H; Li, Wen W; Xu, Zhihao Z; Xia, Yang Y

Publication Date: 2020-05

Variant appearance in text: HER2: G776C

PubMed Link: 35117726

Variant Present in the following documents:

• Main text
• tcr-09-05-3634.pdf

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HER2 Aberrations in Non-Small Cell Lung Cancer: From Pathophysiology to Targeted Therapy.

Pharmaceuticals (Basel, Switzerland)

Vathiotis, Ioannis A IA; Charpidou, Andriani A; Gavrielatou, Niki N; Syrigos, Konstantinos N KN

Publication Date: 2021-12-14

Variant appearance in text: HER2: G776C

PubMed Link: 34959700

Variant Present in the following documents:

• Main text
• pharmaceuticals-14-01300.pdf

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HER2 Aberrations in Non-Small Cell Lung Cancer: From Pathophysiology to Targeted Therapy.

Pharmaceuticals (Basel, Switzerland)

Vathiotis, Ioannis A IA; Charpidou, Andriani A; Gavrielatou, Niki N; Syrigos, Konstantinos N KN

Publication Date: 2021-12-14

Variant appearance in text: HER2: G776C

PubMed Link: 34959700

Variant Present in the following documents:

• Main text
• pharmaceuticals-14-01300.pdf

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Serial monitoring of genomic alterations in circulating tumor cells of ER-positive/HER2-negative advanced breast cancer: feasibility of precision oncology biomarker detection.

Molecular Oncology

Cani, Andi K AK; Dolce, Emily M EM; Darga, Elizabeth P EP; Hu, Kevin K; Liu, Chia-Jen CJ; Pierce, Jackie J; Bradbury, Kieran K; Kilgour, Elaine E; Aung, Kimberly K; Schiavon, Gaia G; Carroll, Danielle D; Carr, T Hedley TH; Klinowska, Teresa T; Lindemann, Justin J; Marshall, Gayle G; Rowlands, Vicky V; Harrington, Elizabeth A EA; Barrett, J Carl JC; Sathiyayogan, Nitharsan N; Morrow, Christopher C; Sero, Valeria V; Armstrong, Anne C AC; Baird, Richard R; Hamilton, Erika E; Im, Seock-Ah SA; Jhaveri, Komal K; Patel, Manish R MR; Dive, Caroline C; Tomlins, Scott A SA; Udager, Aaron M AM; Hayes, Daniel F DF; Paoletti, Costanza C

Publication Date: 2022-05

Variant appearance in text: ERBB2: G776C

PubMed Link: 34866317

Variant Present in the following documents:

• MOL2-16-1969-s001.pdf

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Targeting HER2 in non-small-cell lung cancer (NSCLC): a glimpse of hope? An updated review on therapeutic strategies in NSCLC harbouring HER2 alterations.

Esmo Open

Riudavets, M M; Sullivan, I I; Abdayem, P P; Planchard, D D

Publication Date: 2021-10

Variant appearance in text: HER2: G776C

PubMed Link: 34479034

Variant Present in the following documents:

• Main text
• main.pdf

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Exon 20 YVMA insertion is associated with high incidence of brain metastasis and inferior outcome of chemotherapy in advanced non-small cell lung cancer patients with HER2 kinase domain mutations.

Translational Lung Cancer Research

Yang, Shuo S; Wang, Yan Y; Zhao, Chao C; Li, Xuefei X; Liu, Qian Q; Mao, Shiqi S; Liu, Yiwei Y; Yu, Xiaofei X; Wang, Wanying W; Tian, Qinrun Q; Pan, Yingying Y; Xiong, Anwen A; Chen, Bin B; Gao, Guanghui G; Li, Wei W; He, Yayi Y; Wu, Fengying F; Chen, Xiaoxia X; Su, Chunxia C; Ren, Shengxiang S; Zhou, Caicun C

Publication Date: 2021-02

Variant appearance in text: HER2: G776C

PubMed Link: 33718019

Variant Present in the following documents:

• Main text
• tlcr-10-02-753.pdf

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[Research Progress of Targeted Therapy for HER2 Gene 
in Advanced Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Kong, Lingping L; Zhong, Diansheng D

Publication Date: 2020-12-20

Variant appearance in text: HER2: G776C

PubMed Link: 33357319

Variant Present in the following documents:

• Main text
• zgfazz-23-12-1108.pdf

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Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing.

Nature Communications

Lang, Guan-Tian GT; Jiang, Yi-Zhou YZ; Shi, Jin-Xiu JX; Yang, Fan F; Li, Xiao-Guang XG; Pei, Yu-Chen YC; Zhang, Chen-Hui CH; Ma, Ding D; Xiao, Yi Y; Hu, Peng-Chen PC; Wang, Hai H; Yang, Yun-Song YS; Guo, Lin-Wei LW; Lu, Xun-Xi XX; Xue, Meng-Zhu MZ; Wang, Peng P; Cao, A-Yong AY; Ling, Hong H; Wang, Zhong-Hua ZH; Yu, Ke-Da KD; Di, Gen-Hong GH; Li, Da-Qiang DQ; Wang, Yun-Jin YJ; Yu, Ying Y; Shi, Le-Ming LM; Hu, Xin X; Huang, Wei W; Shao, Zhi-Ming ZM

Publication Date: 2020-11-10

Variant appearance in text: ERBB2: G776C

PubMed Link: 33173047

Variant Present in the following documents:

• 41467_2020_19342_MOESM7_ESM.xlsx, sheet 1

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HER2 Exon 20 Insertion Mutations in Lung Adenocarcinoma: Case Series and Response to Pyrotinib.

Frontiers In Oncology

Zhang, Xinyong X; Lv, Jialin J; Wu, Yuhua Y; Qin, Na N; Ma, Li L; Li, Xi X; Nong, Jingying J; Zhang, Hui H; Zhang, Quan Q; Yang, Xinjie X; Shi, Huibo H; Wang, Jinghui J; Zhang, Shucai S

Publication Date: 2020

Variant appearance in text: HER2: G776C

PubMed Link: 32850330

Variant Present in the following documents:

• Main text
• fonc-10-01162.pdf

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Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment.

Cancers

Li, Junnan J; Kwok, Hang Fai HF

Publication Date: 2020-06-15

Variant appearance in text: HER2: G776C

PubMed Link: 32549388

Variant Present in the following documents:

• Main text
• cancers-12-01587.pdf

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Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity.

Cancer Cell

Robichaux, Jacqulyne P JP; Elamin, Yasir Y YY; Vijayan, R S K RSK; Nilsson, Monique B MB; Hu, Lemei L; He, Junqin J; Zhang, Fahao F; Pisegna, Marlese M; Poteete, Alissa A; Sun, Huiying H; Li, Shuai S; Chen, Ting T; Han, Han H; Negrao, Marcelo Vailati MV; Ahnert, Jordi Rodon JR; Diao, Lixia L; Wang, Jing J; Le, Xiuning X; Meric-Bernstam, Funda F; Routbort, Mark M; Roeck, Brent B; Yang, Zane Z; Raymond, Victoria M VM; Lanman, Richard B RB; Frampton, Garrett M GM; Miller, Vincent A VA; Schrock, Alexa B AB; Albacker, Lee A LA; Wong, Kwok-Kin KK; Cross, Jason B JB; Heymach, John V JV

Publication Date: 2019-10-14

Variant appearance in text: ERBB2: 2326G>T

PubMed Link: 31588020

Variant Present in the following documents:

• Main text

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Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study.

The Lancet. Oncology

Meric-Bernstam, Funda F; Hurwitz, Herbert H; Raghav, Kanwal Pratap Singh KPS; McWilliams, Robert R RR; Fakih, Marwan M; VanderWalde, Ari A; Swanton, Charles C; Kurzrock, Razelle R; Burris, Howard H; Sweeney, Christopher C; Bose, Ron R; Spigel, David R DR; Beattie, Mary S MS; Blotner, Steven S; Stone, Alyssa A; Schulze, Katja K; Cuchelkar, Vaikunth V; Hainsworth, John J

Publication Date: 2019-04

Variant appearance in text: HER2: G776C

PubMed Link: 30857956

Variant Present in the following documents:

• Main text

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HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Wang, Y Y; Jiang, T T; Qin, Z Z; Jiang, J J; Wang, Q Q; Yang, S S; Rivard, C C; Gao, G G; Ng, T L TL; Tu, M M MM; Yu, H H; Ji, H H; Zhou, C C; Ren, S S; Zhang, J J; Bunn, P P; Doebele, R C RC; Camidge, D R DR; Hirsch, F R FR

Publication Date: 2019-03-01

Variant appearance in text: HER2: G776C

PubMed Link: 30596880

Variant Present in the following documents:

• Main text

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Identification of a Water-Coordinating HER2 Inhibitor by Virtual Screening Using Similarity-Based Scoring.

Biochemistry

Guo, Jiaye J; Collins, Stephen S; Miller, W Todd WT; Rizzo, Robert C RC

Publication Date: 2018-08-14

Variant appearance in text: HER2: G776C

PubMed Link: 29975516

Variant Present in the following documents:

• Main text
• bi8b00524.pdf

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Outcomes of Pemetrexed-based chemotherapies in HER2-mutant lung cancers.

Bmc Cancer

Wang, Yan Y; Zhang, Shijia S; Wu, Fengying F; Zhao, Jing J; Li, Xuefei X; Zhao, Chao C; Ren, Shengxiang S; Zhou, Caicun C

Publication Date: 2018-03-27

Variant appearance in text: HER2: G776C

PubMed Link: 29587667

Variant Present in the following documents:

• Main text
• 12885_2018_Article_4277.pdf

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Efficacy of Afatinib in a Previously-Treated Patient with Non-Small Cell Lung Cancer Harboring HER2 Mutation: Case Report.

Journal Of Korean Medical Science

Park, Cheol Kyu CK; Hur, Jae Young JY; Choi, Chang Min CM; Kim, Tae Ok TO; Cho, Hyun Ju HJ; Shin, Hong Joon HJ; Lim, Jung Hwan JH; Choi, Yoo Duk YD; Kim, Young Chul YC; Oh, In Jae IJ

Publication Date: 2018-01-01

Variant appearance in text: HER2: G776C

PubMed Link: 29215816

Variant Present in the following documents:

• Main text
• jkms-33-e7.pdf

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: ERBB2: 2326G>T; G776C

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

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Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children's Oncology Group.

Scientific Reports

Xu, Lin L; Wilson, Raphael A RA; Laetsch, Theodore W TW; Oliver, Dwight D; Spunt, Sheri L SL; Hawkins, Douglas S DS; Skapek, Stephen X SX

Publication Date: 2016-09-19

Variant appearance in text: ERBB2: G776C

PubMed Link: 27642091

Variant Present in the following documents:

• srep33429-s1.pdf

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Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations.

Cancer Science

Suzawa, Ken K; Toyooka, Shinichi S; Sakaguchi, Masakiyo M; Morita, Mizuki M; Yamamoto, Hiromasa H; Tomida, Shuta S; Ohtsuka, Tomoaki T; Watanabe, Mototsugu M; Hashida, Shinsuke S; Maki, Yuho Y; Soh, Junichi J; Asano, Hiroaki H; Tsukuda, Kazunori K; Miyoshi, Shinichiro S

Publication Date: 2016-01

Variant appearance in text: HER2: G776C

PubMed Link: 26545934

Variant Present in the following documents:

• Main text
• CAS-107-45.pdf

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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Greulich, Heidi H; Kaplan, Bethany B; Mertins, Philipp P; Chen, Tzu-Hsiu TH; Tanaka, Kumiko E KE; Yun, Cai-Hong CH; Zhang, Xiaohong X; Lee, Se-Hoon SH; Cho, Jeonghee J; Ambrogio, Lauren L; Liao, Rachel R; Imielinski, Marcin M; Banerji, Shantanu S; Berger, Alice H AH; Lawrence, Michael S MS; Zhang, Jinghui J; Pho, Nam H NH; Walker, Sarah R SR; Winckler, Wendy W; Getz, Gad G; Frank, David D; Hahn, William C WC; Eck, Michael J MJ; Mani, D R DR; Jaffe, Jacob D JD; Carr, Steven A SA; Wong, Kwok-Kin KK; Meyerson, Matthew M

Publication Date: 2012-09-04

Variant appearance in text: ERBB2: G776C

PubMed Link: 22908275

Variant Present in the following documents:

• Main text

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