Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Journal Of Medicinal Chemistry
Willis, Nicky J NJ; Mahy, William W; Sipthorp, James J; Zhao, Yuguang Y; Woodward, Hannah L HL; Atkinson, Benjamin N BN; Bayle, Elliott D ED; Svensson, Fredrik F; Frew, Sarah S; Jeganathan, Fiona F; Monaghan, Amy A; Benvegnù, Stefano S; Jolly, Sarah S; Vecchia, Luca L; Ruza, Reinis R RR; Kjær, Svend S; Howell, Steven S; Snijders, Ambrosius P AP; Bictash, Magda M; Salinas, Patricia C PC; Vincent, Jean-Paul JP; Jones, E Yvonne EY; Whiting, Paul P; Fish, Paul V PV
Galiellalactone inhibits the STAT3/AR signaling axis and suppresses Enzalutamide-resistant Prostate Cancer.
Scientific Reports
Thaper, Daksh D; Vahid, Sepideh S; Kaur, Ramandeep R; Kumar, Sahil S; Nouruzi, Shaghayegh S; Bishop, Jennifer L JL; Johansson, Martin M; Zoubeidi, Amina A