Publications:

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Real World Characteristics and Clinical Outcomes of HER2-Mutant Non-Small Cell Lung Cancer Patients Detected by Next-Generation Sequencing.

Cancer Research And Treatment

Ahn, Beung-Chul BC; Han, Ye-Jeong YJ; Kim, Hye Ryun HR; Hong, Min Hee MH; Cho, Byoung Chul BC; Lim, Sun Min SM

Publication Date: 2022-11-09

Variant appearance in text: HER2: L866M

PubMed Link: 36397236

Variant Present in the following documents:

• crt-2022-359.pdf

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Emerging Role of ERBB2 in Targeted Therapy for Metastatic Colorectal Cancer: Signaling Pathways to Therapeutic Strategies.

Cancers

Wang, Nannan N; Cao, Yuepeng Y; Si, Chengshuai C; Shao, Peng P; Su, Guoqing G; Wang, Ke K; Bao, Jun J; Yang, Liu L

Publication Date: 2022-10-21

Variant appearance in text: ERBB2: L866M

PubMed Link: 36291943

Variant Present in the following documents:

• Main text
• cancers-14-05160.pdf

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HER2 in Metastatic Colorectal Cancer: Pathology, Somatic Alterations, and Perspectives for Novel Therapeutic Schemes.

Life (Basel, Switzerland)

Ivanova, Mariia M; Venetis, Konstantinos K; Guerini-Rocco, Elena E; Bottiglieri, Luca L; Mastropasqua, Mauro Giuseppe MG; Garrone, Ornella O; Fusco, Nicola N; Ghidini, Michele M

Publication Date: 2022-09-09

Variant appearance in text: HER2: L866M

PubMed Link: 36143438

Variant Present in the following documents:

• Main text
• life-12-01403.pdf

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Precision Medicine in Metastatic Colorectal Cancer: Targeting ERBB2 (HER-2) Oncogene.

Cancers

Torres-Jiménez, Javier J; Esteban-Villarrubia, Jorge J; Ferreiro-Monteagudo, Reyes R

Publication Date: 2022-07-30

Variant appearance in text: ERBB2: L866M

PubMed Link: 35954382

Variant Present in the following documents:

• Main text
• cancers-14-03718.pdf

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: ERBB2: Leu866Met

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: ERBB2: L866M

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Beyond RAS and BRAF: HER2, a New Actionable Oncotarget in Advanced Colorectal Cancer.

International Journal Of Molecular Sciences

Guarini, Chiara C; Grassi, Teresa T; Pezzicoli, Gaetano G; Porta, Camillo C

Publication Date: 2021-06-24

Variant appearance in text: HER2: L866M

PubMed Link: 34202896

Variant Present in the following documents:

• Main text
• ijms-22-06813.pdf

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: ERBB2: L866M

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: ERBB2: L866M

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Lazzari, Luca L; Corti, Giorgio G; Picco, Gabriele G; Isella, Claudio C; Montone, Monica M; Arcella, Pamela P; Durinikova, Erika E; Zanella, Eugenia R ER; Novara, Luca L; Barbosa, Fabiane F; Cassingena, Andrea A; Cancelliere, Carlotta C; Medico, Enzo E; Sartore-Bianchi, Andrea A; Siena, Salvatore S; Garnett, Mathew J MJ; Bertotti, Andrea A; Trusolino, Livio L; Di Nicolantonio, Federica F; Linnebacher, Michael M; Bardelli, Alberto A; Arena, Sabrina S

Publication Date: 2019-10-15

Variant appearance in text: ERBB2: L866M

PubMed Link: 31375513

Variant Present in the following documents:

• Main text

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Dual HER2 inhibition strategies in the management of treatment-refractory metastatic colorectal cancer: History and status.

World Journal Of Clinical Cases

Kanat, Ozkan O; Ertas, Hulya H; Caner, Burcu B

Publication Date: 2018-10-06

Variant appearance in text: HER2: L866M

PubMed Link: 30294606

Variant Present in the following documents:

• Main text

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Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives.

Gastroenterology Research And Practice

Pellino, Gianluca G; Gallo, Gaetano G; Pallante, Pierlorenzo P; Capasso, Raffaella R; De Stefano, Alfonso A; Maretto, Isacco I; Malapelle, Umberto U; Qiu, Shengyang S; Nikolaou, Stella S; Barina, Andrea A; Clerico, Giuseppe G; Reginelli, Alfonso A; Giuliani, Antonio A; Sciaudone, Guido G; Kontovounisios, Christos C; Brunese, Luca L; Trompetto, Mario M; Selvaggi, Francesco F

Publication Date: 2018

Variant appearance in text: ERBB2: L866M

PubMed Link: 30008744

Variant Present in the following documents:

• Main text
• GRP2018-2397863.pdf

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Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Siena, S S; Sartore-Bianchi, A A; Marsoni, S S; Hurwitz, H I HI; McCall, S J SJ; Penault-Llorca, F F; Srock, S S; Bardelli, A A; Trusolino, L L

Publication Date: 2018-05-01

Variant appearance in text: HER2: L866M

PubMed Link: 29659677

Variant Present in the following documents:

• Main text
• mdy100.pdf

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Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.

Esmo Open

Martinelli, Erika E; Troiani, Teresa T; Sforza, Vincenzo V; Martini, Giulia G; Cardone, Claudia C; Vitiello, Pietro Paolo PP; Ciardiello, Davide D; Rachiglio, Anna Maria AM; Normanno, Nicola N; Sartore-Bianchi, Andrea A; Marsoni, Silvia S; Bardelli, Alberto A; Siena, Salvatore S; Ciardiello, Fortunato F

Publication Date: 2018

Variant appearance in text: HER2: L866M

PubMed Link: 29387480

Variant Present in the following documents:

• Main text

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Genomic alterations of ERBB receptors in cancer: clinical implications.

Oncotarget

Mishra, Rosalin R; Hanker, Ariella B AB; Garrett, Joan T JT

Publication Date: 2017-12-26

Variant appearance in text: HER2: L866M

PubMed Link: 29371993

Variant Present in the following documents:

• Main text

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Prolonged Response to HER2-Directed Therapy in a Patient With HER2-Amplified, Rapidly Progressive Metastatic Colorectal Cancer.

Journal Of The National Comprehensive Cancer Network : Jnccn

Parikh, Aparna A; Atreya, Chloe C; Korn, W Michael WM; Venook, Alan P AP

Publication Date: 2017-01

Variant appearance in text: HER2: L866M

PubMed Link: 28040715

Variant Present in the following documents:

• Main text

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Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer.

Cold Spring Harbor Molecular Case Studies

Aung, Kyaw L KL; Stockley, Tracy L TL; Serra, Stefano S; Kamel-Reid, Suzanne S; Bedard, Philippe L PL; Siu, Lillian L LL

Publication Date: 2016-09

Variant appearance in text: ERBB2: L866M

PubMed Link: 27626067

Variant Present in the following documents:

• Main text
• AungMCS001016.pdf

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The genomic landscape of response to EGFR blockade in colorectal cancer.

Nature

Bertotti, Andrea A; Papp, Eniko E; Jones, Siân S; Adleff, Vilmos V; Anagnostou, Valsamo V; Lupo, Barbara B; Sausen, Mark M; Phallen, Jillian J; Hruban, Carolyn A CA; Tokheim, Collin C; Niknafs, Noushin N; Nesselbush, Monica M; Lytle, Karli K; Sassi, Francesco F; Cottino, Francesca F; Migliardi, Giorgia G; Zanella, Eugenia R ER; Ribero, Dario D; Russolillo, Nadia N; Mellano, Alfredo A; Muratore, Andrea A; Paraluppi, Gianluca G; Salizzoni, Mauro M; Marsoni, Silvia S; Kragh, Michael M; Lantto, Johan J; Cassingena, Andrea A; Li, Qing Kay QK; Karchin, Rachel R; Scharpf, Robert R; Sartore-Bianchi, Andrea A; Siena, Salvatore S; Diaz, Luis A LA; Trusolino, Livio L; Velculescu, Victor E VE

Publication Date: 2015-10-08

Variant appearance in text: ERBB2: L866M

PubMed Link: 26416732

Variant Present in the following documents:

• Main text
• nihms710492.pdf

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HER2 activating mutations are targets for colorectal cancer treatment.

Cancer Discovery

Kavuri, Shyam M SM; Jain, Naveen N; Galimi, Francesco F; Cottino, Francesca F; Leto, Simonetta M SM; Migliardi, Giorgia G; Searleman, Adam C AC; Shen, Wei W; Monsey, John J; Trusolino, Livio L; Jacobs, Samuel A SA; Bertotti, Andrea A; Bose, Ron R

Publication Date: 2015-08

Variant appearance in text: HER2: L866M

PubMed Link: 26243863

Variant Present in the following documents:

• Main text

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ERBB2 emerges as a new target for colorectal cancer.

Cancer Discovery

Pectasides, Eirini E; Bass, Adam J AJ

Publication Date: 2015-08

Variant appearance in text: ERBB2: L866M

PubMed Link: 26243861

Variant Present in the following documents:

• Main text

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