ERBB2 c.2686C>T ;(p.R896C)

Variant ID: 17-37881616-C-T

NM_004448.2(ERBB2):c.2686C>T;(p.R896C)

This variant was identified in 52 publications

View GRCh38 version.




Publications:


Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Publication Date: 2022-06-15

Variant appearance in text: ERBB2: R896C
PubMed Link: 35705558
Variant Present in the following documents:
  • 41467_2022_30496_MOESM2_ESM.xls, sheet 1
View BVdb publication page



Germline Variants in Cancer Genes from Young Breast Cancer Mexican Patients.

Cancers
Gómez-Flores-Ramos, Liliana L; Barraza-Arellano, Angélica Leticia AL; Mohar, Alejandro A; Trujillo-Martínez, Miguel M; Grimaldo, Lizbeth L; Ortiz-Lopez, Rocío R; Treviño, Víctor V
Publication Date: 2022-03-24

Variant appearance in text: HER2: R896C
PubMed Link: 35406420
Variant Present in the following documents:
  • Main text
  • cancers-14-01647.pdf
View BVdb publication page



Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling.

Nature Communications
Wu, Lucia Ruojia LR; Dai, Peng P; Wang, Michael Xiangjiang MX; Chen, Sherry Xi SX; Cohen, Evan N EN; Jayachandran, Gitanjali G; Zhang, Jinny Xuemeng JX; Serrano, Angela V AV; Xie, Nina Guanyi NG; Ueno, Naoto T NT; Reuben, James M JM; Barcenas, Carlos H CH; Zhang, David Yu DY
Publication Date: 2022-04-04

Variant appearance in text: ERBB2: R896C
PubMed Link: 35379811
Variant Present in the following documents:
  • 41467_2022_29487_MOESM4_ESM.xlsx, sheet 3
  • 41467_2022_29487_MOESM4_ESM.xlsx, sheet 2
View BVdb publication page



Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach.

Advances In Protein Chemistry And Structural Biology
Thirumal Kumar, D D; Shree Devi, M S MS; Udhaya Kumar, S S; Sherlin, Annie A; Mathew, Aishwarya A; Lakshmipriya, M M; Sathiyarajeswaran, P P; Gnanasambandan, R R; Siva, R R; Magesh, R R; George Priya Doss, C C
Publication Date: 2022

Variant appearance in text: ERBB2: R896C
PubMed Link: 35305722
Variant Present in the following documents:
  • mmc09-01-9780323992275.pdf
View BVdb publication page



Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research
Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL
Publication Date: 2022-05

Variant appearance in text: ERBB2: R896C
PubMed Link: 35229492
Variant Present in the following documents:
  • PCMR-35-369-s003.xlsx, sheet 12
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: ERBB2: Arg896Cys
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



KIT/PDGFRA/KDR amplification defines a novel molecular subtype of adenoid cystic carcinoma patients who may benefit from treatment with tyrosine kinase inhibitors.

Translational Cancer Research
Hou, Helei H; Jia, Dongmei D; Yan, Weihua W; Zhang, Xiaoping X; Wang, Chunbao C; Li, Yujun Y; Chen, Hua H; Huang, Weiqing W; Li, Zhuokun Z; Zhang, Xiaochun X
Publication Date: 2020-08

Variant appearance in text: HER2: R896C
PubMed Link: 35117834
Variant Present in the following documents:
  • Main text
  • tcr-09-08-4703.pdf
View BVdb publication page



Clinical Utility of Plasma-Based Comprehensive Molecular Profiling in Advanced Non-Small-Cell Lung Cancer.

Jco Precision Oncology
Schouten, Robert D RD; Vessies, Daan C L DCL; Bosch, Linda J W LJW; Barlo, Nicole P NP; van Lindert, Anne S R ASR; Cillessen, Saskia A G M SAGM; van den Broek, Daan D; van den Heuvel, Michel M MM; Monkhorst, Kim K
Publication Date: 2021-07

Variant appearance in text: ERBB2: R896C
PubMed Link: 34632253
Variant Present in the following documents:
  • po-5-1112.pdf
View BVdb publication page



Clinical Utility of Plasma-Based Comprehensive Molecular Profiling in Advanced Non-Small-Cell Lung Cancer.

Jco Precision Oncology
Schouten, Robert D RD; Vessies, Daan C L DCL; Bosch, Linda J W LJW; Barlo, Nicole P NP; van Lindert, Anne S R ASR; Cillessen, Saskia A G M SAGM; van den Broek, Daan D; van den Heuvel, Michel M MM; Monkhorst, Kim K
Publication Date: 2021-07

Variant appearance in text: ERBB2: R896C
PubMed Link: 34632253
Variant Present in the following documents:
  • po-5-1112.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: ERBB2: R896C
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Dissecting the biological heterogeneity of HER2-positive breast cancer.

Breast (Edinburgh, Scotland)
Schettini, Francesco F; Prat, Aleix A
Publication Date: 2021-10

Variant appearance in text: HER2: R896C
PubMed Link: 34392185
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Molecular Biomarkers for Contemporary Therapies in Hormone Receptor-Positive Breast Cancer.

Genes
Freelander, Allegra A; Brown, Lauren J LJ; Parker, Andrew A; Segara, Davendra D; Portman, Neil N; Lau, Brandon B; Lim, Elgene E
Publication Date: 2021-02-17

Variant appearance in text: HER2: Arg896Cys
PubMed Link: 33671468
Variant Present in the following documents:
  • Main text
  • genes-12-00285.pdf
View BVdb publication page



Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.

Nature Communications
Bakouny, Ziad Z; Braun, David A DA; Shukla, Sachet A SA; Pan, Wenting W; Gao, Xin X; Hou, Yue Y; Flaifel, Abdallah A; Tang, Stephen S; Bosma-Moody, Alice A; He, Meng Xiao MX; Vokes, Natalie N; Nyman, Jackson J; Xie, Wanling W; Nassar, Amin H AH; Abou Alaiwi, Sarah S; Flippot, Ronan R; Bouchard, Gabrielle G; Steinharter, John A JA; Nuzzo, Pier Vitale PV; Ficial, Miriam M; Sant'Angelo, Miriam M; Forman, Juliet J; Berchuck, Jacob E JE; Dudani, Shaan S; Bi, Kevin K; Park, Jihye J; Camp, Sabrina S; Sticco-Ivins, Maura M; Hirsch, Laure L; Baca, Sylvan C SC; Wind-Rotolo, Megan M; Ross-Macdonald, Petra P; Sun, Maxine M; Lee, Gwo-Shu Mary GM; Chang, Steven L SL; Wei, Xiao X XX; McGregor, Bradley A BA; Harshman, Lauren C LC; Genovese, Giannicola G; Ellis, Leigh L; Pomerantz, Mark M; Hirsch, Michelle S MS; Freedman, Matthew L ML; Atkins, Michael B MB; Wu, Catherine J CJ; Ho, Thai H TH; Linehan, W Marston WM; McDermott, David F DF; Heng, Daniel Y C DYC; Viswanathan, Srinivas R SR; Signoretti, Sabina S; Van Allen, Eliezer M EM; Choueiri, Toni K TK
Publication Date: 2021-02-05

Variant appearance in text: ERBB2: 2686C>T; R896C
PubMed Link: 33547292
Variant Present in the following documents:
  • 41467_2021_21068_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Evaluation of the Oncomine Pan-Cancer Cell-Free Assay for Analyzing Circulating Tumor DNA in the Cerebrospinal Fluid in Patients with Central Nervous System Malignancies.

The Journal Of Molecular Diagnostics : Jmd
Shah, Mauli M; Takayasu, Takeshi T; Zorofchian Moghadamtousi, Soheil S; Arevalo, Octavio O; Chen, Melissa M; Lan, Chieh C; Duose, Dzifa D; Hu, Peter P; Zhu, Jay-Jiguang JJ; Roy-Chowdhuri, Sinchita S; Riascos, Roy F RF; Chen, Hui H; Luthra, Rajyalakshmi R; Esquenazi, Yoshua Y; Ballester, Leomar Y LY
Publication Date: 2021-02

Variant appearance in text: ERBB2: R896C
PubMed Link: 33531134
Variant Present in the following documents:
  • Main text
View BVdb publication page



Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine
Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS
Publication Date: 2021-01

Variant appearance in text: ERBB2: R896C
PubMed Link: 33314633
Variant Present in the following documents:
  • CAM4-10-53-s003.xlsx, sheet 1
View BVdb publication page



Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction.

Nature Communications
Lin, Yuan Y; Luo, Yingying Y; Sun, Yanxia Y; Guo, Wenjia W; Zhao, Xuan X; Xi, Yiyi Y; Ma, Yuling Y; Shao, Mingming M; Tan, Wen W; Gao, Ge G; Wu, Chen C; Lin, Dongxin D
Publication Date: 2020-11-30

Variant appearance in text: ERBB2: R896C
PubMed Link: 33257699
Variant Present in the following documents:
  • 41467_2020_19949_MOESM8_ESM.xlsx, sheet 1
View BVdb publication page



Tyrosine Kinase Receptors in Oncology.

International Journal Of Molecular Sciences
Esteban-Villarrubia, Jorge J; Soto-Castillo, Juan José JJ; Pozas, Javier J; San Román-Gil, María M; Orejana-Martín, Inmaculada I; Torres-Jiménez, Javier J; Carrato, Alfredo A; Alonso-Gordoa, Teresa T; Molina-Cerrillo, Javier J
Publication Date: 2020-11-12

Variant appearance in text: HER2: R896C
PubMed Link: 33198314
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer
Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F
Publication Date: 2020

Variant appearance in text: HER2: R896C
PubMed Link: 33145402
Variant Present in the following documents:
  • Main text
  • 41523_2020_Article_201.pdf
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs758222990
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.

Breast Cancer Research : Bcr
Kurozumi, Sasagu S; Alsaleem, Mansour M; Monteiro, Cíntia J CJ; Bhardwaj, Kartikeya K; Joosten, Stacey E P SEP; Fujii, Takaaki T; Shirabe, Ken K; Green, Andrew R AR; Ellis, Ian O IO; Rakha, Emad A EA; Mongan, Nigel P NP; Heery, David M DM; Zwart, Wilbert W; Oesterreich, Steffi S; Johnston, Simon J SJ
Publication Date: 2020-08-11

Variant appearance in text: HER2: R896C
PubMed Link: 32782013
Variant Present in the following documents:
  • Main text
  • 13058_2020_Article_1324.pdf
View BVdb publication page



Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y
Publication Date: 2020-08-01

Variant appearance in text: ERBB2: R896C
PubMed Link: 32738923
Variant Present in the following documents:
  • 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine.

Scientific Reports
López-Cortés, Andrés A; Paz-Y-Miño, César C; Guerrero, Santiago S; Cabrera-Andrade, Alejandro A; Barigye, Stephen J SJ; Munteanu, Cristian R CR; González-Díaz, Humberto H; Pazos, Alejandro A; Pérez-Castillo, Yunierkis Y; Tejera, Eduardo E
Publication Date: 2020-03-24

Variant appearance in text: ERBB2: R896C
PubMed Link: 32210335
Variant Present in the following documents:
  • 41598_2020_62279_MOESM2_ESM.xlsx, sheet 33
  • 41598_2020_62279_MOESM2_ESM.xlsx, sheet 40
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: ERBB2: R896C
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
View BVdb publication page



Response to Afatinib in a Patient with Non-Small Cell Lung Cancer Harboring HER2 R896G Mutation: A Case Report.

Oncotargets And Therapy
Lin, Ling L; Ge, Hongfei H; Yan, Zhengqing Z; Wang, Guoqiang G; Wu, Xiaomai X; Lv, Dongqing D
Publication Date: 2019

Variant appearance in text: HER2: R896C
PubMed Link: 31849493
Variant Present in the following documents:
  • Main text
  • ott-12-10897.pdf
View BVdb publication page



Identification of Genetic Mutations in Cancer: Challenge and Opportunity in the New Era of Targeted Therapy.

Frontiers In Oncology
Jin, Jing J; Wu, Xu X; Yin, Jianhua J; Li, Mingxing M; Shen, Jing J; Li, Jing J; Zhao, Yueshui Y; Zhao, Qijie Q; Wu, Jingbo J; Wen, Qinglian Q; Cho, Chi Hin CH; Yi, Tao T; Xiao, Zhangang Z; Qu, Liping L
Publication Date: 2019

Variant appearance in text: HER2: R896C
PubMed Link: 31058077
Variant Present in the following documents:
  • Main text
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: ERBB2: R896C
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Computational algorithms for in silico profiling of activating mutations in cancer.

Cellular And Molecular Life Sciences : Cmls
Jordan, E Joseph EJ; Patil, Keshav K; Suresh, Krishna K; Park, Jin H JH; Mosse, Yael P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R
Publication Date: 2019-07

Variant appearance in text: HER2: R896C
PubMed Link: 30982079
Variant Present in the following documents:
  • Main text
View BVdb publication page



Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms.

Journal Of Hematology & Oncology
Lima, Zeinab Safarpour ZS; Ghadamzadeh, Mostafa M; Arashloo, Farzad Tahmasebi FT; Amjad, Ghazaleh G; Ebadi, Mohammad Reza MR; Younesi, Ladan L
Publication Date: 2019-04-11

Variant appearance in text: HER2: R896C
PubMed Link: 30975222
Variant Present in the following documents:
  • Main text
  • 13045_2019_Article_725.pdf
View BVdb publication page



Targeted mutation detection in breast cancer using MammaSeq™.

Breast Cancer Research : Bcr
Smith, Nicholas G NG; Gyanchandani, Rekha R; Shah, Osama S OS; Gurda, Grzegorz T GT; Lucas, Peter C PC; Hartmaier, Ryan J RJ; Brufsky, Adam M AM; Puhalla, Shannon S; Bahreini, Amir A; Kota, Karthik K; Wald, Abigail I AI; Nikiforov, Yuri E YE; Nikiforova, Marina N MN; Oesterreich, Steffi S; Lee, Adrian V AV
Publication Date: 2019-02-08

Variant appearance in text: ERBB2: R896C
PubMed Link: 30736836
Variant Present in the following documents:
  • 13058_2019_1102_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.

Bmc Cancer
Koyama, Takahiko T; Rhrissorrakrai, Kahn K; Parida, Laxmi L
Publication Date: 2019-02-01

Variant appearance in text: ERBB2: 2686C>T; R896C
PubMed Link: 30709382
Variant Present in the following documents:
  • 12885_2019_5313_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: ERBB2: R896C
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 3
View BVdb publication page



Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Chen, Yinnan Y; Zhang, Yanmin Y
Publication Date: 2018-06

Variant appearance in text: HER2: R896C
PubMed Link: 29938175
Variant Present in the following documents:
  • Main text
  • ADVS-5-1700964.pdf
View BVdb publication page



Simultaneous identification of clinically relevant single nucleotide variants, copy number alterations and gene fusions in solid tumors by targeted next-generation sequencing.

Oncotarget
Oliveira, Duarte Mendes DM; Mirante, Teresa T; Mignogna, Chiara C; Scrima, Marianna M; Migliozzi, Simona S; Rocco, Gaetano G; Franco, Renato R; Corcione, Francesco F; Viglietto, Giuseppe G; Malanga, Donatella D; Rizzuto, Antonia A
Publication Date: 2018-04-27

Variant appearance in text: ERBB2: R896C
PubMed Link: 29854313
Variant Present in the following documents:
  • Main text
  • oncotarget-09-22749.pdf
View BVdb publication page



iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Cell Death & Disease
Melguizo-Sanchis, Dario D; Xu, Yaobo Y; Taheem, Dheraj D; Yu, Min M; Tilgner, Katarzyna K; Barta, Tomas T; Gassner, Katja K; Anyfantis, George G; Wan, Tengfei T; Elango, Ramu R; Alharthi, Sameer S; El-Harouni, Ashraf A AA; Przyborski, Stefan S; Adam, Soheir S; Saretzki, Gabriele G; Samarasinghe, Sujith S; Armstrong, Lyle L; Lako, Majlinda M
Publication Date: 2018-01-26

Variant appearance in text: ERBB2: R896C
PubMed Link: 29374141
Variant Present in the following documents:
  • 41419_2017_141_MOESM8_ESM.xlsx, sheet 2
View BVdb publication page



Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.

Cancer
Ross, Jeffrey S JS; Fakih, Marwan M; Ali, Siraj M SM; Elvin, Julia A JA; Schrock, Alexa B AB; Suh, James J; Vergilio, Jo-Anne JA; Ramkissoon, Shakti S; Severson, Eric E; Daniel, Sugganth S; Fabrizio, David D; Frampton, Garrett G; Sun, James J; Miller, Vincent A VA; Stephens, Philip J PJ; Gay, Laurie M LM
Publication Date: 2018-04-01

Variant appearance in text: ERBB2: R896C
PubMed Link: 29338072
Variant Present in the following documents:
  • Main text
  • CNCR-124-1358.pdf
View BVdb publication page



Prevalence and detection of low-allele-fraction variants in clinical cancer samples.

Nature Communications
Shin, Hyun-Tae HT; Choi, Yoon-La YL; Yun, Jae Won JW; Kim, Nayoung K D NKD; Kim, Sook-Young SY; Jeon, Hyo Jeong HJ; Nam, Jae-Yong JY; Lee, Chung C; Ryu, Daeun D; Kim, Sang Cheol SC; Park, Kyunghee K; Lee, Eunjin E; Bae, Joon Seol JS; Son, Dae Soon DS; Joung, Je-Gun JG; Lee, Jeeyun J; Kim, Seung Tae ST; Ahn, Myung-Ju MJ; Lee, Se-Hoon SH; Ahn, Jin Seok JS; Lee, Woo Yong WY; Oh, Bo Young BY; Park, Yeon Hee YH; Lee, Jeong Eon JE; Lee, Kwang Hyuk KH; Kim, Hee Cheol HC; Kim, Kyoung-Mee KM; Im, Young-Hyuck YH; Park, Keunchil K; Park, Peter J PJ; Park, Woong-Yang WY
Publication Date: 2017-11-09

Variant appearance in text: ERBB2: R896C
PubMed Link: 29123093
Variant Present in the following documents:
  • 41467_2017_1470_MOESM11_ESM.xlsx, sheet 1
View BVdb publication page



Molecular characterization of circulating colorectal tumor cells defines genetic signatures for individualized cancer care.

Oncotarget
Kong, Say Li SL; Liu, Xingliang X; Suhaimi, Nur-Afidah Mohamed NM; Koh, Kenneth Jia Hao KJH; Hu, Min M; Lee, Daniel Yoke San DYS; Cima, Igor I; Phyo, Wai Min WM; Lee, Esther Xing Wei EXW; Tai, Joyce A JA; Foong, Yu Miin YM; Vo, Jess Honganh JH; Koh, Poh Koon PK; Zhang, Tong T; Ying, Jackie Y JY; Lim, Bing B; Tan, Min-Han MH; Hillmer, Axel M AM
Publication Date: 2017-09-15

Variant appearance in text: ERBB2: R896C
PubMed Link: 28978093
Variant Present in the following documents:
  • oncotarget-08-68026-s002.xlsx, sheet 5
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: ERBB2: 2686C>T; R896C
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
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Longitudinal analysis of treatment-induced genomic alterations in gliomas.

Genome Medicine
Erson-Omay, E Zeynep EZ; Henegariu, Octavian O; Omay, S Bülent SB; Harmancı, Akdes Serin AS; Youngblood, Mark W MW; Mishra-Gorur, Ketu K; Li, Jie J; Özduman, Koray K; Carrión-Grant, Geneive G; Clark, Victoria E VE; Çağlar, Caner C; Bakırcıoğlu, Mehmet M; Pamir, M Necmettin MN; Tabar, Viviane V; Vortmeyer, Alexander O AO; Bilguvar, Kaya K; Yasuno, Katsuhito K; DeAngelis, Lisa M LM; Baehring, Joachim M JM; Moliterno, Jennifer J; Günel, Murat M
Publication Date: 2017-02-02

Variant appearance in text: ERBB2: R896C
PubMed Link: 28153049
Variant Present in the following documents:
  • 13073_2017_401_MOESM3_ESM.xlsx, sheet 2
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TumorNext: A comprehensive tumor profiling assay that incorporates high resolution copy number analysis and germline status to improve testing accuracy.

Oncotarget
Gray, Phillip N PN; Vuong, Huy H; Tsai, Pei P; Lu, Hsaio-Mei HM; Mu, Wenbo W; Hsuan, Vickie V; Hoo, Jayne J; Shah, Swati S; Uyeda, Lisa L; Fox, Susanne S; Patel, Harshil H; Janicek, Mike M; Brown, Sandra S; Dobrea, Lavinia L; Wagman, Lawrence L; Plimack, Elizabeth E; Mehra, Ranee R; Golemis, Erica A EA; Bilusic, Marijo M; Zibelman, Matthew M; Elliott, Aaron A
Publication Date: 2016-10-18

Variant appearance in text: ERBB2: R896C
PubMed Link: 27626691
Variant Present in the following documents:
  • Main text
  • oncotarget-07-68206.pdf
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CRISPR/Cas9 therapeutics: a cure for cancer and other genetic diseases.

Oncotarget
Khan, Faheem Ahmed FA; Pandupuspitasari, Nuruliarizki Shinta NS; Chun-Jie, Huang H; Ao, Zhou Z; Jamal, Muhammad M; Zohaib, Ali A; Khan, Farhan Ahmed FA; Hakim, Muthia Raihana MR; ShuJun, Zhang Z
Publication Date: 2016-08-09

Variant appearance in text: HER2: R896C
PubMed Link: 27250031
Variant Present in the following documents:
  • oncotarget-07-52541.pdf
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PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.

Plos Computational Biology
Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J
Publication Date: 2016-05

Variant appearance in text: ERBB2: R896C
PubMed Link: 27224906
Variant Present in the following documents:
  • pcbi.1004962.s005.xlsx, sheet 1
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HER2 missense mutations have distinct effects on oncogenic signaling and migration.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Zabransky, Daniel J DJ; Yankaskas, Christopher L CL; Cochran, Rory L RL; Wong, Hong Yuen HY; Croessmann, Sarah S; Chu, David D; Kavuri, Shyam M SM; Red Brewer, Monica M; Rosen, D Marc DM; Dalton, W Brian WB; Cimino-Mathews, Ashley A; Cravero, Karen K; Button, Berry B; Kyker-Snowman, Kelly K; Cidado, Justin J; Erlanger, Bracha B; Parsons, Heather A HA; Manto, Kristen M KM; Bose, Ron R; Lauring, Josh J; Arteaga, Carlos L CL; Konstantopoulos, Konstantinos K; Park, Ben Ho BH
Publication Date: 2015-11-10

Variant appearance in text: HER2: R896C
PubMed Link: 26508629
Variant Present in the following documents:
  • Main text
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Analysis of different HER-2 mutations in breast cancer progression and drug resistance.

Journal Of Cellular And Molecular Medicine
Sun, Zijia Z; Shi, Yaqin Y; Shen, Yan Y; Cao, Lulu L; Zhang, Wenwen W; Guan, Xiaoxiang X
Publication Date: 2015-12

Variant appearance in text: HER-2: R896C
PubMed Link: 26305917
Variant Present in the following documents:
  • Main text
  • JCMM-19-2691.pdf
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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: ERBB2: R896C
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
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Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

British Journal Of Haematology
Mansour, Marc R MR; Reed, Casie C; Eisenberg, Amy R AR; Tseng, Jen-Chieh JC; Twizere, Jean-Claude JC; Daakour, Sarah S; Yoda, Akinori A; Rodig, Scott J SJ; Tal, Noa N; Shochat, Chen C; Berezovskaya, Alla A; DeAngelo, Daniel J DJ; Sallan, Stephen E SE; Weinstock, David M DM; Izraeli, Shai S; Kung, Andrew L AL; Kentsis, Alex A; Look, A Thomas AT
Publication Date: 2015-01

Variant appearance in text: HER2: R896C
PubMed Link: 25256574
Variant Present in the following documents:
  • Main text
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Structure-functional prediction and analysis of cancer mutation effects in protein kinases.

Computational And Mathematical Methods In Medicine
Dixit, Anshuman A; Verkhivker, Gennady M GM
Publication Date: 2014

Variant appearance in text: ERBB2: R896C
PubMed Link: 24817905
Variant Present in the following documents:
  • CMMM2014-653487.pdf
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Response of an ERBB2-mutated inflammatory breast carcinoma to human epidermal growth factor receptor 2-targeted therapy.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Ali, Siraj M SM; Alpaugh, R Katherine RK; Downing, Sean R SR; Stephens, Philip J PJ; Yu, Jian Q JQ; Wu, Hong H; Buell, Jamie K JK; Miller, Vincent A VA; Lipson, Doron D; Palmer, Gary A GA; Ross, Jeffrey S JS; Cristofanilli, Massimo M
Publication Date: 2014-09-01

Variant appearance in text: ERBB2: R896C
PubMed Link: 24516025
Variant Present in the following documents:
  • Main text
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Activating mutations and senescence secretome: new insights into HER2 activation, drug sensitivity and metastatic progression.

Breast Cancer Research : Bcr
Acharyya, Swarnali S
Publication Date: 2013-04-23

Variant appearance in text: HER2: R896C
PubMed Link: 23634980
Variant Present in the following documents:
  • Main text
  • bcr3406.pdf
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Activating HER2 mutations in HER2 gene amplification negative breast cancer.

Cancer Discovery
Bose, Ron R; Kavuri, Shyam M SM; Searleman, Adam C AC; Shen, Wei W; Shen, Dong D; Koboldt, Daniel C DC; Monsey, John J; Goel, Nicholas N; Aronson, Adam B AB; Li, Shunqiang S; Ma, Cynthia X CX; Ding, Li L; Mardis, Elaine R ER; Ellis, Matthew J MJ
Publication Date: 2013-02

Variant appearance in text: HER2: R896C
PubMed Link: 23220880
Variant Present in the following documents:
  • Main text
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Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Chandarlapaty, Sarat S; Sakr, Rita A RA; Giri, Dilip D; Patil, Sujata S; Heguy, Adriana A; Morrow, Monica M; Modi, Shanu S; Norton, Larry L; Rosen, Neal N; Hudis, Clifford C; King, Tari A TA
Publication Date: 2012-12-15

Variant appearance in text: HER2: R896C
PubMed Link: 23092874
Variant Present in the following documents:
  • Main text
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A growing family: adding mutated Erbb4 as a novel cancer target.

Cell Cycle (Georgetown, Tex.)
Rudloff, Udo U; Samuels, Yardena Y
Publication Date: 2010-04-15

Variant appearance in text: ERBB2: R896C
PubMed Link: 20404484
Variant Present in the following documents:
  • Main text
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