Contributions of candidate-gene associations studies and genome-wide association studies (GWAS) to identification of genetic variations associated with asthma.
Annals Of Translational Medicine
Friedrich, Frederico F; de Castro, Miguel Ângelo Uflacker Lutz MÂUL; da Costa Herter, Eduardo E; Prestes, Laura Menestrino LM; Pinto, Leonardo Araújo LA
Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.
American Journal Of Respiratory And Critical Care Medicine
Haider, Sadia S; Granell, Raquel R; Curtin, John J; Fontanella, Sara S; Cucco, Alex A; Turner, Stephen S; Simpson, Angela A; Roberts, Graham G; Murray, Clare S CS; Holloway, John W JW; Devereux, Graham G; Cullinan, Paul P; Arshad, Syed Hasan SH; Custovic, Adnan A
Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.
Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.
Nature Genetics
Võsa, Urmo U; Claringbould, Annique A; Westra, Harm-Jan HJ; Bonder, Marc Jan MJ; Deelen, Patrick P; Zeng, Biao B; Kirsten, Holger H; Saha, Ashis A; Kreuzhuber, Roman R; Yazar, Seyhan S; Brugge, Harm H; Oelen, Roy R; de Vries, Dylan H DH; van der Wijst, Monique G P MGP; Kasela, Silva S; Pervjakova, Natalia N; Alves, Isabel I; Favé, Marie-Julie MJ; Agbessi, Mawussé M; Christiansen, Mark W MW; Jansen, Rick R; Seppälä, Ilkka I; Tong, Lin L; Teumer, Alexander A; Schramm, Katharina K; Hemani, Gibran G; Verlouw, Joost J; Yaghootkar, Hanieh H; Sönmez Flitman, Reyhan R; Brown, Andrew A; Kukushkina, Viktorija V; Kalnapenkis, Anette A; Rüeger, Sina S; Porcu, Eleonora E; Kronberg, Jaanika J; Kettunen, Johannes J; Lee, Bernett B; Zhang, Futao F; Qi, Ting T; Hernandez, Jose Alquicira JA; Arindrarto, Wibowo W; Beutner, Frank F; , ; , ; Dmitrieva, Julia J; Elansary, Mahmoud M; Fairfax, Benjamin P BP; Georges, Michel M; Heijmans, Bastiaan T BT; Hewitt, Alex W AW; Kähönen, Mika M; Kim, Yungil Y; Knight, Julian C JC; Kovacs, Peter P; Krohn, Knut K; Li, Shuang S; Loeffler, Markus M; Marigorta, Urko M UM; Mei, Hailang H; Momozawa, Yukihide Y; Müller-Nurasyid, Martina M; Nauck, Matthias M; Nivard, Michel G MG; Penninx, Brenda W J H BWJH; Pritchard, Jonathan K JK; Raitakari, Olli T OT; Rotzschke, Olaf O; Slagboom, Eline P EP; Stehouwer, Coen D A CDA; Stumvoll, Michael M; Sullivan, Patrick P; 't Hoen, Peter A C PAC; Thiery, Joachim J; Tönjes, Anke A; van Dongen, Jenny J; van Iterson, Maarten M; Veldink, Jan H JH; Völker, Uwe U; Warmerdam, Robert R; Wijmenga, Cisca C; Swertz, Morris M; Andiappan, Anand A; Montgomery, Grant W GW; Ripatti, Samuli S; Perola, Markus M; Kutalik, Zoltan Z; Dermitzakis, Emmanouil E; Bergmann, Sven S; Frayling, Timothy T; van Meurs, Joyce J; Prokisch, Holger H; Ahsan, Habibul H; Pierce, Brandon L BL; Lehtimäki, Terho T; Boomsma, Dorret I DI; Psaty, Bruce M BM; Gharib, Sina A SA; Awadalla, Philip P; Milani, Lili L; Ouwehand, Willem H WH; Downes, Kate K; Stegle, Oliver O; Battle, Alexis A; Visscher, Peter M PM; Yang, Jian J; Scholz, Markus M; Powell, Joseph J; Gibson, Greg G; Esko, Tõnu T; Franke, Lude L
Macrophage Receptor With Collagenous Structure Polymorphism and Recurrent Respiratory Infections and Wheezing During Infancy: A 5-Years Follow-Up Study.
Frontiers In Pediatrics
Savino, Francesco F; Pellegrino, Francesco F; Daprà, Valentina V; Calvi, Cristina C; Alliaudi, Carla C; Montanari, Paola P; Galliano, Ilaria I; Bergallo, Massimiliano M
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts.
Frontiers In Immunology
Hose, Alexander J AJ; Pagani, Giulia G; Karvonen, Anne M AM; Kirjavainen, Pirkka V PV; Roduit, Caroline C; Genuneit, Jon J; Schmaußer-Hechfellner, Elisabeth E; Depner, Martin M; Frei, Remo R; Lauener, Roger R; Riedler, Josef J; Schaub, Bianca B; Fuchs, Oliver O; von Mutius, Erika E; Divaret-Chauveau, Amandine A; Pekkanen, Juha J; Ege, Markus J MJ
ERS International Congress 2020: highlights from the Paediatric Assembly.
Erj Open Research
Ardura-Garcia, Cristina C; Cuevas-Ocaña, Sara S; Freitag, Nadine N; Kampouras, Asterios A; King, John A JA; Kouis, Panayiotis P; Mensink-Bout, Sara M SM; Whitehouse, Abigail L AL; Williams, Emma E; Dassios, Theodore T; Duijts, Liesbeth L; Ersu, Refika H RH; Gaillard, Erol A EA; Horsley, Alex R AR; Proesmans, Marijke M; Rottier, Robbert R; Schramm, Dirk D; Moeller, Alexander A; Pijnenburg, Marielle W MW
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa.
Clinical And Translational Allergy
Laulajainen-Hongisto, Anu A; Lyly, Annina A; Hanif, Tanzeela T; Dhaygude, Kishor K; Kankainen, Matti M; Renkonen, Risto R; Donner, Kati K; Mattila, Pirkko P; Jartti, Tuomas T; Bousquet, Jean J; Kauppi, Paula P; Toppila-Salmi, Sanna S
Increased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease.
Plos One
Ban, Ga-Young GY; Youn, Dong-Ye DY; Ye, Young-Min YM; Park, Hae-Sim HS
Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.
American Journal Of Respiratory And Critical Care Medicine
Gui, Hongsheng H; Levin, Albert M AM; Hu, Donglei D; Sleiman, Patrick P; Xiao, Shujie S; Mak, Angel C Y ACY; Yang, Mao M; Barczak, Andrea J AJ; Huntsman, Scott S; Eng, Celeste C; Hochstadt, Samantha S; Zhang, Ellen E; Whitehouse, Kyle K; Simons, Samantha S; Cabral, Whitney W; Takriti, Sami S; Abecasis, Gonçalo G; Blackwell, Thomas W TW; Kang, Hyun Min HM; Nickerson, Deborah A DA; Germer, Soren S; Lanfear, David E DE; Gilliland, Frank F; Gauderman, W James WJ; Kumar, Rajesh R; Erle, David J DJ; Martinez, Fernando D FD; Hakonarson, Hakon H; Burchard, Esteban G EG; Williams, L Keoki LK
Age-of-onset information helps identify 76 genetic variants associated with allergic disease.
Plos Genetics
Ferreira, Manuel A R MAR; Vonk, Judith M JM; Baurecht, Hansjörg H; Marenholz, Ingo I; Tian, Chao C; Hoffman, Joshua D JD; Helmer, Quinta Q; Tillander, Annika A; Ullemar, Vilhelmina V; Lu, Yi Y; Grosche, Sarah S; Rüschendorf, Franz F; Granell, Raquel R; Brumpton, Ben M BM; Fritsche, Lars G LG; Bhatta, Laxmi L; Gabrielsen, Maiken E ME; Nielsen, Jonas B JB; Zhou, Wei W; Hveem, Kristian K; Langhammer, Arnulf A; Holmen, Oddgeir L OL; Løset, Mari M; Abecasis, Gonçalo R GR; Willer, Cristen J CJ; Emami, Nima C NC; Cavazos, Taylor B TB; Witte, John S JS; Szwajda, Agnieszka A; , ; , ; Hinds, David A DA; Hübner, Norbert N; Weidinger, Stephan S; Magnusson, Patrik Ke PK; Jorgenson, Eric E; Karlsson, Robert R; Paternoster, Lavinia L; Boomsma, Dorret I DI; Almqvist, Catarina C; Lee, Young-Ae YA; Koppelman, Gerard H GH
CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions.
Nar Genomics And Bioinformatics
Stuart, William D WD; Guo, Minzhe M; Fink-Baldauf, Iris M IM; Coleman, Alan M AM; Clancy, John P JP; Mall, Marcus A MA; Lim, Foong-Yen FY; Brewington, John J JJ; Maeda, Yutaka Y
Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.
International Journal Of Environmental Research And Public Health
Braun, Markus M; Klingelhöfer, Doris D; Oremek, Gerhard M GM; Quarcoo, David D; Groneberg, David A DA
Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
The Lancet. Respiratory Medicine
Ober, Carole C; McKennan, Chris G CG; Magnaye, Kevin M KM; Altman, Matthew C MC; Washington, Charles C; Stanhope, Catherine C; Naughton, Katherine A KA; Rosasco, Mario G MG; Bacharier, Leonard B LB; Billheimer, Dean D; Gold, Diane R DR; Gress, Lisa L; Hartert, Tina T; Havstad, Suzanne S; Khurana Hershey, Gurjit K GK; Hallmark, Brian B; Hogarth, D Kyle DK; Jackson, Daniel J DJ; Johnson, Christine C CC; Kattan, Meyer M; Lemanske, Robert F RF; Lynch, Susan V SV; Mendonca, Eneida A EA; Miller, Rachel L RL; Naureckas, Edward T ET; O'Connor, George T GT; Seroogy, Christine M CM; Wegienka, Ganesa G; White, Steven R SR; Wood, Robert A RA; Wright, Anne L AL; Zoratti, Edward M EM; Martinez, Fernando D FD; Ownby, Dennis D; Nicolae, Dan L DL; Levin, Albert M AM; Gern, James E JE; ,
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.
Science Advances
Klarić, Lucija L; Tsepilov, Yakov A YA; Stanton, Chloe M CM; Mangino, Massimo M; Sikka, Timo Tõnis TT; Esko, Tõnu T; Pakhomov, Eugene E; Salo, Perttu P; Deelen, Joris J; McGurnaghan, Stuart J SJ; Keser, Toma T; Vučković, Frano F; Ugrina, Ivo I; Krištić, Jasminka J; Gudelj, Ivan I; Štambuk, Jerko J; Plomp, Rosina R; Pučić-Baković, Maja M; Pavić, Tamara T; Vilaj, Marija M; Trbojević-Akmačić, Irena I; Drake, Camilla C; Dobrinić, Paula P; Mlinarec, Jelena J; Jelušić, Barbara B; Richmond, Anne A; Timofeeva, Maria M; Grishchenko, Alexander K AK; Dmitrieva, Julia J; Bermingham, Mairead L ML; Sharapov, Sodbo Zh SZ; Farrington, Susan M SM; Theodoratou, Evropi E; Uh, Hae-Won HW; Beekman, Marian M; Slagboom, Eline P EP; Louis, Edouard E; Georges, Michel M; Wuhrer, Manfred M; Colhoun, Helen M HM; Dunlop, Malcolm G MG; Perola, Markus M; Fischer, Krista K; Polasek, Ozren O; Campbell, Harry H; Rudan, Igor I; Wilson, James F JF; Zoldoš, Vlatka V; Vitart, Veronique V; Spector, Tim T; Aulchenko, Yurii S YS; Lauc, Gordan G; Hayward, Caroline C
Transcript specific regulation of expression influences susceptibility to multiple sclerosis.
European Journal Of Human Genetics : Ejhg
Ban, Maria M; Liao, Wenjia W; Baker, Amie A; Compston, Alastair A; Thorpe, John J; Molyneux, Paul P; Fraser, Mary M; Khadake, Jyoti J; Jones, Joanne J; Coles, Alasdair A; Sawcer, Stephen S
Characterization of longitudinal wheeze phenotypes from infancy to adolescence in Project Viva, a prebirth cohort study.
The Journal Of Allergy And Clinical Immunology
Sordillo, Joanne E JE; Coull, Brent A BA; Rifas-Shiman, Sheryl L SL; Wu, Ann Chen AC; Lutz, Sharon M SM; Hivert, Marie-France MF; Oken, Emily E; Gold, Diane R DR
Airway obstruction and bronchial reactivity from age 1 month until 13 years in children with asthma: A prospective birth cohort study.
Plos Medicine
Hallas, Henrik Wegener HW; Chawes, Bo Lund BL; Rasmussen, Morten Arendt MA; Arianto, Lambang L; Stokholm, Jakob J; Bønnelykke, Klaus K; Bisgaard, Hans H
An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma.
Chest
Kelly, Rachel S RS; Chawes, Bo L BL; Blighe, Kevin K; Virkud, Yamini V YV; Croteau-Chonka, Damien C DC; McGeachie, Michael J MJ; Clish, Clary B CB; Bullock, Kevin K; Celedón, Juan C JC; Weiss, Scott T ST; Lasky-Su, Jessica A JA
17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.
Allergy
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