African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Genome Medicine
Washington, Charles C; Dapas, Matthew M; Biddanda, Arjun A; Magnaye, Kevin M KM; Aneas, Ivy I; Helling, Britney A BA; Szczesny, Brooke B; Boorgula, Meher Preethi MP; Taub, Margaret A MA; Kenny, Eimear E; Mathias, Rasika A RA; Barnes, Kathleen C KC; , ; Khurana Hershey, Gurjit K GK; Kercsmar, Carolyn M CM; Gereige, Jessica D JD; Makhija, Melanie M; Gruchalla, Rebecca S RS; Gill, Michelle A MA; Liu, Andrew H AH; Rastogi, Deepa D; Busse, William W; Gergen, Peter J PJ; Visness, Cynthia M CM; Gold, Diane R DR; Hartert, Tina T; Johnson, Christine C CC; Lemanske, Robert F RF; Martinez, Fernando D FD; Miller, Rachel L RL; Ownby, Dennis D; Seroogy, Christine M CM; Wright, Anne L AL; Zoratti, Edward M EM; Bacharier, Leonard B LB; Kattan, Meyer M; O'Connor, George T GT; Wood, Robert A RA; Nobrega, Marcelo A MA; Altman, Matthew C MC; Jackson, Daniel J DJ; Gern, James E JE; McKennan, Christopher G CG; Ober, Carole C
Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.
Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.
Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts.
Frontiers In Immunology
Hose, Alexander J AJ; Pagani, Giulia G; Karvonen, Anne M AM; Kirjavainen, Pirkka V PV; Roduit, Caroline C; Genuneit, Jon J; Schmaußer-Hechfellner, Elisabeth E; Depner, Martin M; Frei, Remo R; Lauener, Roger R; Riedler, Josef J; Schaub, Bianca B; Fuchs, Oliver O; von Mutius, Erika E; Divaret-Chauveau, Amandine A; Pekkanen, Juha J; Ege, Markus J MJ
Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.
American Journal Of Respiratory And Critical Care Medicine
Gui, Hongsheng H; Levin, Albert M AM; Hu, Donglei D; Sleiman, Patrick P; Xiao, Shujie S; Mak, Angel C Y ACY; Yang, Mao M; Barczak, Andrea J AJ; Huntsman, Scott S; Eng, Celeste C; Hochstadt, Samantha S; Zhang, Ellen E; Whitehouse, Kyle K; Simons, Samantha S; Cabral, Whitney W; Takriti, Sami S; Abecasis, Gonçalo G; Blackwell, Thomas W TW; Kang, Hyun Min HM; Nickerson, Deborah A DA; Germer, Soren S; Lanfear, David E DE; Gilliland, Frank F; Gauderman, W James WJ; Kumar, Rajesh R; Erle, David J DJ; Martinez, Fernando D FD; Hakonarson, Hakon H; Burchard, Esteban G EG; Williams, L Keoki LK
Chromosome 17q21 SNP rs8076131 risk allele associates with airway smooth muscle hypertrophy in fatal asthma.
Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology
Miller, Marina M; Rosenthal, Peter P; Weng, Ning N; Pham, Alex A; Hur, Gyu-Young GY; Elliot, John J; Green, Francis H Y FHY; James, Alan A; Broide, David H DH
Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.
International Journal Of Environmental Research And Public Health
Braun, Markus M; Klingelhöfer, Doris D; Oremek, Gerhard M GM; Quarcoo, David D; Groneberg, David A DA
Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
The Lancet. Respiratory Medicine
Ober, Carole C; McKennan, Chris G CG; Magnaye, Kevin M KM; Altman, Matthew C MC; Washington, Charles C; Stanhope, Catherine C; Naughton, Katherine A KA; Rosasco, Mario G MG; Bacharier, Leonard B LB; Billheimer, Dean D; Gold, Diane R DR; Gress, Lisa L; Hartert, Tina T; Havstad, Suzanne S; Khurana Hershey, Gurjit K GK; Hallmark, Brian B; Hogarth, D Kyle DK; Jackson, Daniel J DJ; Johnson, Christine C CC; Kattan, Meyer M; Lemanske, Robert F RF; Lynch, Susan V SV; Mendonca, Eneida A EA; Miller, Rachel L RL; Naureckas, Edward T ET; O'Connor, George T GT; Seroogy, Christine M CM; Wegienka, Ganesa G; White, Steven R SR; Wood, Robert A RA; Wright, Anne L AL; Zoratti, Edward M EM; Martinez, Fernando D FD; Ownby, Dennis D; Nicolae, Dan L DL; Levin, Albert M AM; Gern, James E JE; ,
The Asthma-associated PER1-like domain-containing protein 1 (PERLD1) Haplotype Influences Soluble Glycosylphosphatidylinositol Anchor Protein (sGPI-AP) Levels in Serum and Immune Cell Proliferation.
Scientific Reports
Sio, Yang Yie YY; Anantharaman, Ramani R; Lee, Sean Qiu En SQE; Matta, Sri Anusha SA; Ng, Yu Ting YT; Chew, Fook Tim FT
Genome-wide association study of medication-use and associated disease in the UK Biobank.
Nature Communications
Wu, Yeda Y; Byrne, Enda M EM; Zheng, Zhili Z; Kemper, Kathryn E KE; Yengo, Loic L; Mallett, Andrew J AJ; Yang, Jian J; Visscher, Peter M PM; Wray, Naomi R NR
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS.
Nature Communications
Pan, David Z DZ; Garske, Kristina M KM; Alvarez, Marcus M; Bhagat, Yash V YV; Boocock, James J; Nikkola, Elina E; Miao, Zong Z; Raulerson, Chelsea K CK; Cantor, Rita M RM; Civelek, Mete M; Glastonbury, Craig A CA; Small, Kerrin S KS; Boehnke, Michael M; Lusis, Aldons J AJ; Sinsheimer, Janet S JS; Mohlke, Karen L KL; Laakso, Markku M; Pajukanta, Päivi P; Ko, Arthur A
Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus.
The Journal Of Allergy And Clinical Immunology
Kothari, Parul H PH; Qiu, Weiliang W; Croteau-Chonka, Damien C DC; Martinez, Fernando D FD; Liu, Andrew H AH; Lemanske, Robert F RF; Ober, Carole C; Krishnan, Jerry A JA; Nicolae, Dan L DL; Barnes, Kathleen C KC; London, Stephanie J SJ; Barraza-Villarreal, Albino A; White, Steven R SR; Naureckas, Edward T ET; Millstein, Joshua J; Gauderman, W James WJ; Gilliland, Frank D FD; Carey, Vincent J VJ; Weiss, Scott T ST; Raby, Benjamin A BA; ,
A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
The Journal Of Allergy And Clinical Immunology
Stein, Michelle M MM; Thompson, Emma E EE; Schoettler, Nathan N; Helling, Britney A BA; Magnaye, Kevin M KM; Stanhope, Catherine C; Igartua, Catherine C; Morin, Andréanne A; Washington, Charles C; Nicolae, Dan D; Bønnelykke, Klaus K; Ober, Carole C
Genetic variants and risk of asthma in an American Indian population.
Annals Of Allergy, Asthma & Immunology : Official Publication Of The American College Of Allergy, Asthma, & Immunology
Best, Lyle G LG; Azure, Crystal C; Segarra, Alexandre A; Enright, Kendra J KJ; Hamley, Shawn S; Jerome, Dara D; O'Leary, Marcia A MA; O'Leary, Rae A RA; Parisien, Ashley A; Trottier, Kayana K; Yracheta, Joseph M JM; Torgerson, Dara G DG
Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers.
The Journal Of Allergy And Clinical Immunology
DeVries, Avery A; Wlasiuk, Gabriela G; Miller, Susan J SJ; Bosco, Anthony A; Stern, Debra A DA; Lohman, I Carla IC; Rothers, Janet J; Jones, Anya C AC; Nicodemus-Johnson, Jessie J; Vasquez, Monica M MM; Curtin, John A JA; Simpson, Angela A; Custovic, Adnan A; Jackson, Daniel J DJ; Gern, James E JE; Lemanske, Robert F RF; Guerra, Stefano S; Wright, Anne L AL; Ober, Carole C; Halonen, Marilyn M; Vercelli, Donata D
Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression.
Human Genetics
Cavalli, Marco M; Pan, Gang G; Nord, Helena H; Wallerman, Ola O; Wallén Arzt, Emelie E; Berggren, Olof O; Elvers, Ingegerd I; Eloranta, Maija-Leena ML; Rönnblom, Lars L; Lindblad Toh, Kerstin K; Wadelius, Claes C
Rule-based models of the interplay between genetic and environmental factors in childhood allergy.
Plos One
Bornelöv, Susanne S; Sääf, Annika A; Melén, Erik E; Bergström, Anna A; Torabi Moghadam, Behrooz B; Pulkkinen, Ville V; Acevedo, Nathalie N; Orsmark Pietras, Christina C; Ege, Markus M; Braun-Fahrländer, Charlotte C; Riedler, Josef J; Doekes, Gert G; Kabesch, Michael M; van Hage, Marianne M; Kere, Juha J; Scheynius, Annika A; Söderhäll, Cilla C; Pershagen, Göran G; Komorowski, Jan J
Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma.
Journal Of Neuro-Oncology
Backes, Danielle M DM; Siddiq, Afshan A; Cox, David G DG; Calboli, Federico C F FC; Gaziano, J Michael JM; Ma, Jing J; Stampfer, Meir M; Hunter, David J DJ; Camargo, Carlos A CA; Michaud, Dominique S DS
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.
The Journal Of Allergy And Clinical Immunology
Granell, Raquel R; Henderson, A John AJ; Timpson, Nicholas N; St Pourcain, Beate B; Kemp, John P JP; Ring, Susan M SM; Ho, Karen K; Montgomery, Stephen B SB; Dermitzakis, Emmanouil T ET; Evans, David M DM; Sterne, Jonathan A C JA
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Nature Genetics
Torgerson, Dara G DG; Ampleford, Elizabeth J EJ; Chiu, Grace Y GY; Gauderman, W James WJ; Gignoux, Christopher R CR; Graves, Penelope E PE; Himes, Blanca E BE; Levin, Albert M AM; Mathias, Rasika A RA; Hancock, Dana B DB; Baurley, James W JW; Eng, Celeste C; Stern, Debra A DA; Celedón, Juan C JC; Rafaels, Nicholas N; Capurso, Daniel D; Conti, David V DV; Roth, Lindsey A LA; Soto-Quiros, Manuel M; Togias, Alkis A; Li, Xingnan X; Myers, Rachel A RA; Romieu, Isabelle I; Van Den Berg, David J DJ; Hu, Donglei D; Hansel, Nadia N NN; Hernandez, Ryan D RD; Israel, Elliott E; Salam, Muhammad T MT; Galanter, Joshua J; Avila, Pedro C PC; Avila, Lydiana L; Rodriquez-Santana, Jose R JR; Chapela, Rocio R; Rodriguez-Cintron, William W; Diette, Gregory B GB; Adkinson, N Franklin NF; Abel, Rebekah A RA; Ross, Kevin D KD; Shi, Min M; Faruque, Mezbah U MU; Dunston, Georgia M GM; Watson, Harold R HR; Mantese, Vito J VJ; Ezurum, Serpil C SC; Liang, Liming L; Ruczinski, Ingo I; Ford, Jean G JG; Huntsman, Scott S; Chung, Kian Fan KF; Vora, Hita H; Li, Xia X; Calhoun, William J WJ; Castro, Mario M; Sienra-Monge, Juan J JJ; del Rio-Navarro, Blanca B; Deichmann, Klaus A KA; Heinzmann, Andrea A; Wenzel, Sally E SE; Busse, William W WW; Gern, James E JE; Lemanske, Robert F RF; Beaty, Terri H TH; Bleecker, Eugene R ER; Raby, Benjamin A BA; Meyers, Deborah A DA; London, Stephanie J SJ; , ; Gilliland, Frank D FD; , ; Burchard, Esteban G EG; , ; Martinez, Fernando D FD; , ; Weiss, Scott T ST; , ; Williams, L Keoki LK; , ; Barnes, Kathleen C KC; , ; Ober, Carole C; Nicolae, Dan L DL
Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations.
The Journal Of Allergy And Clinical Immunology
Galanter, Joshua M JM; Torgerson, Dara D; Gignoux, Christopher R CR; Sen, Saunak S; Roth, Lindsey A LA; Via, Marc M; Aldrich, Melinda C MC; Eng, Celeste C; Huntsman, Scott S; Rodriguez-Santana, Jose J; Rodriguez-Cintrón, William W; Chapela, Rocio R; Ford, Jean G JG; Burchard, Esteban G EG
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
American Journal Of Human Genetics
Verlaan, Dominique J DJ; Berlivet, Soizik S; Hunninghake, Gary M GM; Madore, Anne-Marie AM; Larivière, Mathieu M; Moussette, Sanny S; Grundberg, Elin E; Kwan, Tony T; Ouimet, Manon M; Ge, Bing B; Hoberman, Rose R; Swiatek, Marcin M; Dias, Joana J; Lam, Kevin C L KC; Koka, Vonda V; Harmsen, Eef E; Soto-Quiros, Manuel M; Avila, Lydiana L; Celedón, Juan C JC; Weiss, Scott T ST; Dewar, Ken K; Sinnett, Daniel D; Laprise, Catherine C; Raby, Benjamin A BA; Pastinen, Tomi T; Naumova, Anna K AK
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
American Journal Of Respiratory And Critical Care Medicine
Rogers, Angela J AJ; Raby, Benjamin A BA; Lasky-Su, Jessica A JA; Murphy, Amy A; Lazarus, Ross R; Klanderman, Barbara J BJ; Sylvia, Jody S JS; Ziniti, John P JP; Lange, Christoph C; Celedón, Juan C JC; Silverman, Edwin K EK; Weiss, Scott T ST
ORMDL3 gene is associated with asthma in three ethnically diverse populations.
American Journal Of Respiratory And Critical Care Medicine
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