Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase.
Biochemistry
Daubner, S Colette SC; Avila, Audrey A; Bailey, Johnathan O JO; Barrera, Dimitrios D; Bermudez, Jaclyn Y JY; Giles, David H DH; Khan, Crystal A CA; Shaheen, Noel N; Thompson, Janie Womac JW; Vasquez, Jessica J; Oxley, Susan P SP; Fitzpatrick, Paul F PF