Publications:

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Genetic variants, pathophysiological pathways, and oral anticoagulation in patients with hypertrophic cardiomyopathy and atrial fibrillation.

Frontiers In Cardiovascular Medicine

Wang, Shengnan S; Chen, He H; Liu, Chunju C; Wu, Mengxian M; Sun, Wanlei W; Liu, Shenjian S; Zheng, Yan Y; He, Wenfeng W

Publication Date: 2023

Variant appearance in text: MYL4: E11K

PubMed Link: 37139132

Variant Present in the following documents:

• Main text
• fcvm-10-1023394.pdf

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: MYL4: 31G>A; Glu11Lys

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

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Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation.

Redox Biology

Zhong, Yuan Y; Tang, Kai K; Nattel, Stanley S; Zhai, Ming M; Gong, Shiyu S; Yu, Qing Q; Zeng, Yanxi Y; E, Guangxi G; Maimaitiaili, Nuerbiyemu N; Wang, Jun J; Xu, Yawei Y; Peng, Wenhui W; Li, Hailing H

Publication Date: 2023-01-11

Variant appearance in text: MYL4: E11k

PubMed Link: 36645977

Variant Present in the following documents:

• Main text
• main.pdf

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The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial Fibrotic Substrates.

Frontiers In Cardiovascular Medicine

Cunha, Pedro Silva PS; Laranjo, Sérgio S; Heijman, Jordi J; Oliveira, Mário Martins MM

Publication Date: 2022

Variant appearance in text: MYL4: E11K

PubMed Link: 35859594

Variant Present in the following documents:

• Main text
• fcvm-09-879984.pdf

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Cytoskeletal Protein Variants Driving Atrial Fibrillation: Potential Mechanisms of Action.

Cells

van Wijk, Stan W SW; Su, Wei W; Wijdeveld, Leonoor F J M LFJM; Ramos, Kennedy S KS; Brundel, Bianca J J M BJJM

Publication Date: 2022-01-25

Variant appearance in text: MYL4: E11K

PubMed Link: 35159226

Variant Present in the following documents:

• Main text
• cells-11-00416.pdf

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Cytoskeletal Protein Variants Driving Atrial Fibrillation: Potential Mechanisms of Action.

Cells

van Wijk, Stan W SW; Su, Wei W; Wijdeveld, Leonoor F J M LFJM; Ramos, Kennedy S KS; Brundel, Bianca J J M BJJM

Publication Date: 2022-01-25

Variant appearance in text: MYL4: E11K

PubMed Link: 35159226

Variant Present in the following documents:

• Main text
• cells-11-00416.pdf

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Modeling Human Cardiac Arrhythmias: Insights from Zebrafish.

Journal Of Cardiovascular Development And Disease

Gauvrit, Sébastien S; Bossaer, Jaclyn J; Lee, Joyce J; Collins, Michelle M MM

Publication Date: 2022-01-05

Variant appearance in text: MYL4: E11K

PubMed Link: 35050223

Variant Present in the following documents:

• Main text

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Atrial fibrillation-a complex polygenetic disease.

European Journal Of Human Genetics : Ejhg

Andersen, Julie H JH; Andreasen, Laura L; Olesen, Morten S MS

Publication Date: 2021-07

Variant appearance in text: MYL4: 31G>A; Glu11Lys

PubMed Link: 33279945

Variant Present in the following documents:

• 41431_2020_784_MOESM3_ESM.xlsx, sheet 1

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Atrial Cardiomyopathy: An Unexplored Limb of Virchow's Triad for AF Stroke Prophylaxis.

Frontiers In Cardiovascular Medicine

Darlington, Ashley A; McCauley, Mark D MD

Publication Date: 2020

Variant appearance in text: MYL4: E11K

PubMed Link: 32133372

Variant Present in the following documents:

• Main text
• fcvm-07-00011.pdf

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Insights into myosin regulatory and essential light chains: a focus on their roles in cardiac and skeletal muscle function, development and disease.

Journal Of Muscle Research And Cell Motility

Sitbon, Yoel H YH; Yadav, Sunil S; Kazmierczak, Katarzyna K; Szczesna-Cordary, Danuta D

Publication Date: 2020-12

Variant appearance in text: MYL4: E11K

PubMed Link: 31131433

Variant Present in the following documents:

• Main text

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Increased plasma microfibrillar-associated protein 4 is associated with atrial fibrillation and more advanced left atrial remodelling.

Archives Of Medical Science : Ams

Zhang, Xianlin X; Li, Hailing H; Kou, Wenxin W; Tang, Kai K; Zhao, Dongdong D; Zhang, Jingying J; Zhuang, Jianhui J; Zhao, Yifan Y; Ji, Shuya S; Peng, Wenhui W; Xu, Yawei Y

Publication Date: 2019-05

Variant appearance in text: MYL4: E11K

PubMed Link: 31110528

Variant Present in the following documents:

• AMS-15-32503.pdf

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Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats.

Journal Of The American Heart Association

Peng, Wenhui W; Li, Miaoxin M; Li, Hailing H; Tang, Kai K; Zhuang, Jianhui J; Zhang, Jianguo J; Xiao, Jingjing J; Jiang, Hui H; Li, Dali D; Yu, Yongchun Y; Sham, Pak C PC; Nattel, Stanley S; Xu, Yawei Y

Publication Date: 2017-10-28

Variant appearance in text: MYL4: E11K

PubMed Link: 29080865

Variant Present in the following documents:

• Main text
• JAH3-6-e007030.pdf
• JAH3-6-e007030-s001.pdf

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A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.

Nature Communications

Orr, Nathan N; Arnaout, Rima R; Gula, Lorne J LJ; Spears, Danna A DA; Leong-Sit, Peter P; Li, Qiuju Q; Tarhuni, Wadea W; Reischauer, Sven S; Chauhan, Vijay S VS; Borkovich, Matthew M; Uppal, Shaheen S; Adler, Arnon A; Coughlin, Shaun R SR; Stainier, Didier Y R DYR; Gollob, Michael H MH

Publication Date: 2016-04-12

Variant appearance in text: MYL4: Glu11Lys

PubMed Link: 27066836

Variant Present in the following documents:

• ncomms11303.pdf

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