TP53 c.1145A>G ;(p.K382R)

Variant ID: 17-7572964-T-C

NM_000546.5(TP53):c.1145A>G;(p.K382R)

This variant was identified in 38 publications

View GRCh38 version.




Publications:


Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart.

Journal Of Molecular Cell Biology
Huang, Shibo S; Cao, Bo B; Wang, Jieqiong J; Zhang, Yiwei Y; Ledet, Elisa E; Sartor, Oliver O; Xiong, Yuqin Y; Zeng, Shelya X SX; Lu, Hua H
Publication Date: 2022-03-29

Variant appearance in text: p53: K382R
PubMed Link: 34918105
Variant Present in the following documents:
  • Main text
  • mjab078.pdf
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p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy.

Frontiers In Immunology
Sun, Maomao M; Li, Jiaxin J; Mao, Liangfeng L; Wu, Jie J; Deng, Zhiya Z; He, Man M; An, Sheng S; Zeng, Zhenhua Z; Huang, Qiaobing Q; Chen, Zhongqing Z
Publication Date: 2021

Variant appearance in text: p53: K382R
PubMed Link: 34335587
Variant Present in the following documents:
  • Main text
  • fimmu-12-685523.pdf
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mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.

Genes & Development
Kon, Ning N; Ou, Yang Y; Wang, Shang-Jui SJ; Li, Huan H; Rustgi, Anil K AK; Gu, Wei W
Publication Date: 2021-01-01

Variant appearance in text: p53: K382R
PubMed Link: 33303641
Variant Present in the following documents:
  • Main text
  • 59.pdf
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STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma.

Leukemia
Lobello, Cosimo C; Tichy, Boris B; Bystry, Vojtech V; Radova, Lenka L; Filip, Daniel D; Mraz, Marek M; Montes-Mojarro, Ivonne-Aidee IA; Prokoph, Nina N; Larose, Hugo H; Liang, Huan-Chang HC; Sharma, Geeta G GG; Mologni, Luca L; Belada, David D; Kamaradova, Katerina K; Fend, Falko F; Gambacorti-Passerini, Carlo C; Merkel, Olaf O; Turner, Suzanne D SD; Janikova, Andrea A; Pospisilova, Sarka S
Publication Date: 2021-05

Variant appearance in text: TP53: 1145A>G; K382R
PubMed Link: 33247178
Variant Present in the following documents:
  • 41375_2020_1093_MOESM4_ESM.xlsx, sheet 1
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PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.

Nature Communications
Cai, Weijia W; Su, Liya L; Liao, Lili L; Liu, Zongzhi Z ZZ; Langbein, Lauren L; Dulaimi, Essel E; Testa, Joseph R JR; Uzzo, Robert G RG; Zhong, Zhijiu Z; Jiang, Wei W; Yan, Qin Q; Zhang, Qing Q; Yang, Haifeng H
Publication Date: 2019-12-20

Variant appearance in text: p53: K382R
PubMed Link: 31863007
Variant Present in the following documents:
  • Main text
  • 41467_2019_Article_13608.pdf
  • 41467_2019_13608_MOESM2_ESM.pdf
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Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.

The Journal Of Biological Chemistry
Choi, Seo-Hyun SH; Koh, Dong-In DI; Cho, Su-Yeon SY; Kim, Min-Kyeong MK; Kim, Kyung-Sup KS; Hur, Man-Wook MW
Publication Date: 2019-08-30

Variant appearance in text: p53: K382R
PubMed Link: 31296660
Variant Present in the following documents:
  • Main text
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L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control.

Nature Neuroscience
Lu, Jiayin J; Periz, Goran G; Lu, Yu-Ning YN; Tang, Qing Q; Liu, Yang Y; Zhang, Tao T; Shah, Yajas Y; Thombre, Ravi R; Aljumaah, Reham R; Li, Weixin W; Mojsilovic-Petrovic, Jelena J; Ji, Yon Y; Johnson, Kenji K; Kalb, Robert R; Wang, Jiou J
Publication Date: 2019-06

Variant appearance in text: p53: K382R
PubMed Link: 31061493
Variant Present in the following documents:
  • Main text
  • nihms-1523941.pdf
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Decoding Somatic Driver Gene Mutations and Affected Signaling Pathways in Human Medulloblastoma Subgroups.

Journal Of Cancer
Robbins, Charles J CJ; Bou-Dargham, Mayassa J MJ; Sanchez, Kevin K; Rosen, Matthew C MC; Sang, Qing-Xiang Amy QA
Publication Date: 2018

Variant appearance in text: TP53: 1145A>G
PubMed Link: 30588243
Variant Present in the following documents:
  • jcav09p4596s2.xlsx, sheet 1
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USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.

Nature Communications
Padmanabhan, Achuth A; Candelaria, Nicholes N; Wong, Kwong-Kwok KK; Nikolai, Bryan C BC; Lonard, David M DM; O'Malley, Bert W BW; Richards, JoAnne S JS
Publication Date: 2018-03-28

Variant appearance in text: p53: K382R
PubMed Link: 29593334
Variant Present in the following documents:
  • 41467_2018_3599_MOESM1_ESM.pdf
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Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.

Nature Communications
Loffreda, Alessia A; Jacchetti, Emanuela E; Antunes, Sofia S; Rainone, Paolo P; Daniele, Tiziana T; Morisaki, Tatsuya T; Bianchi, Marco E ME; Tacchetti, Carlo C; Mazza, Davide D
Publication Date: 2017-08-22

Variant appearance in text: p53: K382R
PubMed Link: 28827596
Variant Present in the following documents:
  • Main text
View BVdb publication page



The interplay between epigenetic changes and the p53 protein in stem cells.

Genes & Development
Levine, Arnold J AJ; Berger, Shelley L SL
Publication Date: 2017-06-15

Variant appearance in text: p53: K382R
PubMed Link: 28765161
Variant Present in the following documents:
  • Main text
  • 1195.pdf
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Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.

Cancer Cell
Veschi, Veronica V; Liu, Zhihui Z; Voss, Ty C TC; Ozbun, Laurent L; Gryder, Berkley B; Yan, Chunhua C; Hu, Ying Y; Ma, Anqi A; Jin, Jian J; Mazur, Sharlyn J SJ; Lam, Norris N; Souza, Barbara K BK; Giannini, Giuseppe G; Hager, Gordon L GL; Arrowsmith, Cheryl H CH; Khan, Javed J; Appella, Ettore E; Thiele, Carol J CJ
Publication Date: 2017-01-09

Variant appearance in text: p53: K382R
PubMed Link: 28073004
Variant Present in the following documents:
  • Main text
View BVdb publication page



PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.

Cell Reports
Missiroli, Sonia S; Bonora, Massimo M; Patergnani, Simone S; Poletti, Federica F; Perrone, Mariasole M; Gafà, Roberta R; Magri, Eros E; Raimondi, Andrea A; Lanza, Giovanni G; Tacchetti, Carlo C; Kroemer, Guido G; Pandolfi, Pier Paolo PP; Pinton, Paolo P; Giorgi, Carlotta C
Publication Date: 2016-08-30

Variant appearance in text: p53: K382R
PubMed Link: 27545895
Variant Present in the following documents:
  • Main text
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Lysine methylation represses p53 activity in teratocarcinoma cancer cells.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Zhu, Jiajun J; Dou, Zhixun Z; Sammons, Morgan A MA; Levine, Arnold J AJ; Berger, Shelley L SL
Publication Date: 2016-08-30

Variant appearance in text: p53: K382R
PubMed Link: 27535933
Variant Present in the following documents:
  • Main text
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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: TP53: K382R
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s5.xls, sheet 1
View BVdb publication page



Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer.

Oncotarget
Alzoubi, Samer S; Brody, Leigh L; Rahman, Sunniyat S; Mahul-Mellier, Anne-Laure AL; Mercado, Nicolas N; Ito, Kazuhiro K; El-Bahrawy, Mona M; Silver, Andrew A; Boobis, Alan A; Bell, Jimmy D JD; Hajji, Nabil N
Publication Date: 2016-07-12

Variant appearance in text: TP53: K382R
PubMed Link: 27283986
Variant Present in the following documents:
  • Main text
  • oncotarget-07-44505.pdf
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Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Phang, Beng Hooi BH; Othman, Rashidah R; Bougeard, Gaelle G; Chia, Ren Hui RH; Frebourg, Thierry T; Tang, Choong Leong CL; Cheah, Peh Yean PY; Sabapathy, Kanaga K
Publication Date: 2015-11-17

Variant appearance in text: p53: K382R
PubMed Link: 26578795
Variant Present in the following documents:
  • Main text
View BVdb publication page



The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

Molecular Cell
Laptenko, Oleg O; Shiff, Idit I; Freed-Pastor, Will W; Zupnick, Andrew A; Mattia, Melissa M; Freulich, Ella E; Shamir, Inbal I; Kadouri, Noam N; Kahan, Tamar T; Manfredi, James J; Simon, Itamar I; Prives, Carol C
Publication Date: 2015-03-19

Variant appearance in text: p53: K382R
PubMed Link: 25794615
Variant Present in the following documents:
  • Main text
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p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling.

The Journal Of Biological Chemistry
Yuan, Lin L; Chen, Zhongbin Z; Song, Shanshan S; Wang, Shan S; Tian, Chunyan C; Xing, Guichun G; Chen, Xiaojuan X; Xiao, Zhi-Xiong ZX; He, Fuchu F; Zhang, Lingqiang L
Publication Date: 2015-01-30

Variant appearance in text: p53: K382R
PubMed Link: 25505178
Variant Present in the following documents:
  • Main text
  • zbc3172.pdf
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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Drosten, Matthias M; Sum, Eleanor Y M EY; Lechuga, Carmen G CG; Simón-Carrasco, Lucía L; Jacob, Harrys K C HK; García-Medina, Raquel R; Huang, Sidong S; Beijersbergen, Roderick L RL; Bernards, Rene R; Barbacid, Mariano M
Publication Date: 2014-10-21

Variant appearance in text: p53: K382R
PubMed Link: 25288756
Variant Present in the following documents:
  • Main text
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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Koh, Dong-In DI; Han, Dohyun D; Ryu, Hoon H; Choi, Won-Il WI; Jeon, Bu-Nam BN; Kim, Min-Kyeong MK; Kim, Youngsoo Y; Kim, Jin Young JY; Parry, Lee L; Clarke, Alan R AR; Reynolds, Albert B AB; Hur, Man-Wook MW
Publication Date: 2014-10-21

Variant appearance in text: p53: K382R
PubMed Link: 25288747
Variant Present in the following documents:
  • Main text
View BVdb publication page



JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation.

Plos Biology
Wang, Feng F; He, Lin L; Huangyang, Peiwei P; Liang, Jing J; Si, Wenzhe W; Yan, Ruorong R; Han, Xiao X; Liu, Shumeng S; Gui, Bin B; Li, Wanjin W; Miao, Di D; Jing, Chao C; Liu, Zhihua Z; Pei, Fei F; Sun, Luyang L; Shang, Yongfeng Y
Publication Date: 2014-03

Variant appearance in text: p53: K382R
PubMed Link: 24667498
Variant Present in the following documents:
  • Main text
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Modulation of homology-directed repair in T98G glioblastoma cells due to interactions between wildtype p53, Rad51 and HCMV IE1-72.

Viruses
Kulkarni, Amit S AS; Fortunato, Elizabeth A EA
Publication Date: 2014-02-26

Variant appearance in text: p53: K382R
PubMed Link: 24576846
Variant Present in the following documents:
  • Main text
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Dual role of SIRT1 in UVB-induced skin tumorigenesis.

Oncogene
Ming, M M; Soltani, K K; Shea, C R CR; Li, X X; He, Y Y YY
Publication Date: 2015-01-15

Variant appearance in text: p53: K382R
PubMed Link: 24441046
Variant Present in the following documents:
  • Main text
  • nihms550291.pdf
  • NIHMS550291-supplement-1.pdf
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The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.

The Journal Of Biological Chemistry
Ono, Wakana W; Hayashi, Yuki Y; Yokoyama, Wataru W; Kuroda, Takao T; Kishimoto, Hiroyuki H; Ito, Ichiaki I; Kimura, Keiji K; Akaogi, Kensuke K; Waku, Tsuyoshi T; Yanagisawa, Junn J
Publication Date: 2014-02-21

Variant appearance in text: p53: K382R
PubMed Link: 24375404
Variant Present in the following documents:
  • Main text
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Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability through its deubiquitinating activity.

The Journal Of Biological Chemistry
Lee, Kyeong Won KW; Cho, Jin Gu JG; Kim, Chul Min CM; Kang, A Young AY; Kim, Min M; Ahn, Byung Yong BY; Chung, Sung Soo SS; Lim, Key-Hwan KH; Baek, Kwang-Hyun KH; Sung, Jong-Hyuk JH; Park, Kyong Soo KS; Park, Sang Gyu SG
Publication Date: 2013-11-15

Variant appearance in text: p53: K382R
PubMed Link: 24072712
Variant Present in the following documents:
  • Main text
View BVdb publication page



A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation.

Neoplasia (New York, N.Y.)
Lee, Su-Jin SJ; Lee, Sun-Hye SH; Yoon, Min-Ho MH; Park, Bum-Joon BJ
Publication Date: 2013-07

Variant appearance in text: p53: K382R
PubMed Link: 23814485
Variant Present in the following documents:
  • Main text
View BVdb publication page



Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Brochier, Camille C; Dennis, Gretel G; Rivieccio, Mark A MA; McLaughlin, Kathryn K; Coppola, Giovanni G; Ratan, Rajiv R RR; Langley, Brett B
Publication Date: 2013-05-15

Variant appearance in text: p53: K382R
PubMed Link: 23678107
Variant Present in the following documents:
  • Main text
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A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.

Molecular Cell
Moore, Kaitlyn E KE; Carlson, Scott M SM; Camp, Nathan D ND; Cheung, Peggie P; James, Richard G RG; Chua, Katrin F KF; Wolf-Yadlin, Alejandro A; Gozani, Or O
Publication Date: 2013-05-09

Variant appearance in text: p53: K382R
PubMed Link: 23583077
Variant Present in the following documents:
  • Main text
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A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.

Cell Death And Differentiation
Kracikova, M M; Akiri, G G; George, A A; Sachidanandam, R R; Aaronson, S A SA
Publication Date: 2013-04

Variant appearance in text: p53: K382R
PubMed Link: 23306555
Variant Present in the following documents:
  • Main text
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The incredible ULKs.

Cell Communication And Signaling : Ccs
Alers, Sebastian S; Löffler, Antje S AS; Wesselborg, Sebastian S; Stork, Björn B
Publication Date: 2012-03-13

Variant appearance in text: p53: K382R
PubMed Link: 22413737
Variant Present in the following documents:
  • Main text
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p53 requires an intact C-terminal domain for DNA binding and transactivation.

Journal Of Molecular Biology
Kim, Hyunjung H; Kim, Kyunghwan K; Choi, Jongkyu J; Heo, Kyu K; Baek, Hwa Jin HJ; Roeder, Robert G RG; An, Woojin W
Publication Date: 2012-02-03

Variant appearance in text: p53: K382R
PubMed Link: 22178617
Variant Present in the following documents:
  • Main text
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RNA content in the nucleolus alters p53 acetylation via MYBBP1A.

The Embo Journal
Kuroda, Takao T; Murayama, Akiko A; Katagiri, Naohiro N; Ohta, Yu-mi YM; Fujita, Etsuko E; Masumoto, Hiroshi H; Ema, Masatsugu M; Takahashi, Satoru S; Kimura, Keiji K; Yanagisawa, Junn J
Publication Date: 2011-03-16

Variant appearance in text: p53: K382R
PubMed Link: 21297583
Variant Present in the following documents:
  • Main text
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Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.

Journal Of Virology
Pennella, Mario A MA; Liu, Yue Y; Woo, Jennifer L JL; Kim, Chongwoo A CA; Berk, Arnold J AJ
Publication Date: 2010-12

Variant appearance in text: p53: K382R
PubMed Link: 20861261
Variant Present in the following documents:
  • Main text
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HIPK2 modulates p53 activity towards pro-apoptotic transcription.

Molecular Cancer
Puca, Rosa R; Nardinocchi, Lavinia L; Sacchi, Ada A; Rechavi, Gideon G; Givol, David D; D'Orazi, Gabriella G
Publication Date: 2009-10-14

Variant appearance in text: p53: K382R
PubMed Link: 19828042
Variant Present in the following documents:
  • Main text
  • 1476-4598-8-85.pdf
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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.

The Embo Journal
Insinga, Alessandra A; Monestiroli, Silvia S; Ronzoni, Simona S; Carbone, Roberta R; Pearson, Mark M; Pruneri, Giancarlo G; Viale, Giuseppe G; Appella, Ettore E; Pelicci, PierGiuseppe P; Minucci, Saverio S
Publication Date: 2004-03-10

Variant appearance in text: p53: K382R
PubMed Link: 14976551
Variant Present in the following documents:
  • Main text
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Conjugation of Smt3 to dorsal may potentiate the Drosophila immune response.

Molecular And Cellular Biology
Bhaskar, Vinay V; Smith, Matthew M; Courey, Albert J AJ
Publication Date: 2002-01

Variant appearance in text: p53: K382R
PubMed Link: 11756545
Variant Present in the following documents:
  • Main text
View BVdb publication page