Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.
The Journal Of Biological Chemistry
Choi, Seo-Hyun SH; Koh, Dong-In DI; Cho, Su-Yeon SY; Kim, Min-Kyeong MK; Kim, Kyung-Sup KS; Hur, Man-Wook MW
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.
Nature Communications
Padmanabhan, Achuth A; Candelaria, Nicholes N; Wong, Kwong-Kwok KK; Nikolai, Bryan C BC; Lonard, David M DM; O'Malley, Bert W BW; Richards, JoAnne S JS
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.
Nature Communications
Loffreda, Alessia A; Jacchetti, Emanuela E; Antunes, Sofia S; Rainone, Paolo P; Daniele, Tiziana T; Morisaki, Tatsuya T; Bianchi, Marco E ME; Tacchetti, Carlo C; Mazza, Davide D
PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.
Cell Reports
Missiroli, Sonia S; Bonora, Massimo M; Patergnani, Simone S; Poletti, Federica F; Perrone, Mariasole M; Gafà, Roberta R; Magri, Eros E; Raimondi, Andrea A; Lanza, Giovanni G; Tacchetti, Carlo C; Kroemer, Guido G; Pandolfi, Pier Paolo PP; Pinton, Paolo P; Giorgi, Carlotta C
Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer.
Oncotarget
Alzoubi, Samer S; Brody, Leigh L; Rahman, Sunniyat S; Mahul-Mellier, Anne-Laure AL; Mercado, Nicolas N; Ito, Kazuhiro K; El-Bahrawy, Mona M; Silver, Andrew A; Boobis, Alan A; Bell, Jimmy D JD; Hajji, Nabil N
Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Drosten, Matthias M; Sum, Eleanor Y M EY; Lechuga, Carmen G CG; Simón-Carrasco, Lucía L; Jacob, Harrys K C HK; García-Medina, Raquel R; Huang, Sidong S; Beijersbergen, Roderick L RL; Bernards, Rene R; Barbacid, Mariano M
KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Koh, Dong-In DI; Han, Dohyun D; Ryu, Hoon H; Choi, Won-Il WI; Jeon, Bu-Nam BN; Kim, Min-Kyeong MK; Kim, Youngsoo Y; Kim, Jin Young JY; Parry, Lee L; Clarke, Alan R AR; Reynolds, Albert B AB; Hur, Man-Wook MW
Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability through its deubiquitinating activity.
The Journal Of Biological Chemistry
Lee, Kyeong Won KW; Cho, Jin Gu JG; Kim, Chul Min CM; Kang, A Young AY; Kim, Min M; Ahn, Byung Yong BY; Chung, Sung Soo SS; Lim, Key-Hwan KH; Baek, Kwang-Hyun KH; Sung, Jong-Hyuk JH; Park, Kyong Soo KS; Park, Sang Gyu SG
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.
Molecular Cell
Moore, Kaitlyn E KE; Carlson, Scott M SM; Camp, Nathan D ND; Cheung, Peggie P; James, Richard G RG; Chua, Katrin F KF; Wolf-Yadlin, Alejandro A; Gozani, Or O
Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.
Journal Of Virology
Pennella, Mario A MA; Liu, Yue Y; Woo, Jennifer L JL; Kim, Chongwoo A CA; Berk, Arnold J AJ