Publications:

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Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart.

Journal Of Molecular Cell Biology

Huang, Shibo S; Cao, Bo B; Wang, Jieqiong J; Zhang, Yiwei Y; Ledet, Elisa E; Sartor, Oliver O; Xiong, Yuqin Y; Zeng, Shelya X SX; Lu, Hua H

Publication Date: 2022-03-29

Variant appearance in text: p53: K381R

PubMed Link: 34918105

Variant Present in the following documents:

• Main text
• mjab078.pdf

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Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.

Clinical And Translational Gastroenterology

Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD

Publication Date: 2021-11-18

Variant appearance in text: TP53: 1142A>G

PubMed Link: 34797250

Variant Present in the following documents:

• ct9-12-e00431-s005.xlsx, sheet 1

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Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells.

Science Advances

Shi, Xiangguo X; Jiang, Yajian Y; Kitano, Ayumi A; Hu, Tianyuan T; Murdaugh, Rebecca L RL; Li, Yuan Y; Hoegenauer, Kevin A KA; Chen, Rui R; Takahashi, Koichi K; Nakada, Daisuke D

Publication Date: 2021-07

Variant appearance in text: p53: K381R

PubMed Link: 34290089

Variant Present in the following documents:

• Main text
• abf3895.pdf

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Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells.

Science Advances

Shi, Xiangguo X; Jiang, Yajian Y; Kitano, Ayumi A; Hu, Tianyuan T; Murdaugh, Rebecca L RL; Li, Yuan Y; Hoegenauer, Kevin A KA; Chen, Rui R; Takahashi, Koichi K; Nakada, Daisuke D

Publication Date: 2021-07

Variant appearance in text: p53: K381R

PubMed Link: 34290089

Variant Present in the following documents:

• Main text
• abf3895.pdf

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mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.

Genes & Development

Kon, Ning N; Ou, Yang Y; Wang, Shang-Jui SJ; Li, Huan H; Rustgi, Anil K AK; Gu, Wei W

Publication Date: 2021-01-01

Variant appearance in text: p53: K381R

PubMed Link: 33303641

Variant Present in the following documents:

• Main text
• 59.pdf

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Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.

The Journal Of Biological Chemistry

Choi, Seo-Hyun SH; Koh, Dong-In DI; Cho, Su-Yeon SY; Kim, Min-Kyeong MK; Kim, Kyung-Sup KS; Hur, Man-Wook MW

Publication Date: 2019-08-30

Variant appearance in text: p53: K381R

PubMed Link: 31296660

Variant Present in the following documents:

• Main text

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G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1.

Theranostics

Zhang, Jie J; Wang, Yafang Y; Shen, Yanyan Y; He, Pengxing P; Ding, Jian J; Chen, Yi Y

Publication Date: 2018

Variant appearance in text: p53: K381R

PubMed Link: 29774081

Variant Present in the following documents:

• Main text
• thnov08p2884.pdf

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USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.

Nature Communications

Padmanabhan, Achuth A; Candelaria, Nicholes N; Wong, Kwong-Kwok KK; Nikolai, Bryan C BC; Lonard, David M DM; O'Malley, Bert W BW; Richards, JoAnne S JS

Publication Date: 2018-03-28

Variant appearance in text: p53: K381R

PubMed Link: 29593334

Variant Present in the following documents:

• 41467_2018_3599_MOESM1_ESM.pdf
• 41467_2018_3599_MOESM2_ESM.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: K381R

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer.

Oncotarget

Alzoubi, Samer S; Brody, Leigh L; Rahman, Sunniyat S; Mahul-Mellier, Anne-Laure AL; Mercado, Nicolas N; Ito, Kazuhiro K; El-Bahrawy, Mona M; Silver, Andrew A; Boobis, Alan A; Bell, Jimmy D JD; Hajji, Nabil N

Publication Date: 2016-07-12

Variant appearance in text: p53: K381R

PubMed Link: 27283986

Variant Present in the following documents:

• Main text
• oncotarget-07-44505.pdf

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Koh, Dong-In DI; Han, Dohyun D; Ryu, Hoon H; Choi, Won-Il WI; Jeon, Bu-Nam BN; Kim, Min-Kyeong MK; Kim, Youngsoo Y; Kim, Jin Young JY; Parry, Lee L; Clarke, Alan R AR; Reynolds, Albert B AB; Hur, Man-Wook MW

Publication Date: 2014-10-21

Variant appearance in text: p53: K381R

PubMed Link: 25288747

Variant Present in the following documents:

• Main text

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Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Brochier, Camille C; Dennis, Gretel G; Rivieccio, Mark A MA; McLaughlin, Kathryn K; Coppola, Giovanni G; Ratan, Rajiv R RR; Langley, Brett B

Publication Date: 2013-05-15

Variant appearance in text: p53: K381R

PubMed Link: 23678107

Variant Present in the following documents:

• Main text

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p53 requires an intact C-terminal domain for DNA binding and transactivation.

Journal Of Molecular Biology

Kim, Hyunjung H; Kim, Kyunghwan K; Choi, Jongkyu J; Heo, Kyu K; Baek, Hwa Jin HJ; Roeder, Robert G RG; An, Woojin W

Publication Date: 2012-02-03

Variant appearance in text: p53: K381R

PubMed Link: 22178617

Variant Present in the following documents:

• Main text

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RNA content in the nucleolus alters p53 acetylation via MYBBP1A.

The Embo Journal

Kuroda, Takao T; Murayama, Akiko A; Katagiri, Naohiro N; Ohta, Yu-mi YM; Fujita, Etsuko E; Masumoto, Hiroshi H; Ema, Masatsugu M; Takahashi, Satoru S; Kimura, Keiji K; Yanagisawa, Junn J

Publication Date: 2011-03-16

Variant appearance in text: p53: K381R

PubMed Link: 21297583

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• Main text

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Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.

Journal Of Virology

Pennella, Mario A MA; Liu, Yue Y; Woo, Jennifer L JL; Kim, Chongwoo A CA; Berk, Arnold J AJ

Publication Date: 2010-12

Variant appearance in text: p53: K381R

PubMed Link: 20861261

Variant Present in the following documents:

• Main text

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