TP53 c.1117A>C ;(p.K373Q)

Variant ID: 17-7572992-T-G

NM_000546.5(TP53):c.1117A>C;(p.K373Q)

This variant was identified in 7 publications

View GRCh38 version.




Publications:


ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation.

Oncotarget
Morton, Derrick J DJ; Patel, Divya D; Joshi, Jugal J; Hunt, Aisha A; Knowell, Ashley E AE; Chaudhary, Jaideep J
Publication Date: 2017-01-10

Variant appearance in text: p53: K373Q
PubMed Link: 27911860
Variant Present in the following documents:
  • Main text
  • oncotarget-08-2536.pdf
View BVdb publication page



iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: TP53: K373Q
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s5.xls, sheet 1
View BVdb publication page



SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.

Nature Communications
Johmura, Yoshikazu Y; Sun, Jia J; Kitagawa, Kyoko K; Nakanishi, Keiko K; Kuno, Toshiya T; Naiki-Ito, Aya A; Sawada, Yumi Y; Miyamoto, Tomomi T; Okabe, Atsushi A; Aburatani, Hiroyuki H; Li, ShengFan S; Miyoshi, Ichiro I; Takahashi, Satoru S; Kitagawa, Masatoshi M; Nakanishi, Makoto M
Publication Date: 2016-02-12

Variant appearance in text: p53: K373Q
PubMed Link: 26868148
Variant Present in the following documents:
  • ncomms10574.pdf
View BVdb publication page



The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

Molecular Cell
Laptenko, Oleg O; Shiff, Idit I; Freed-Pastor, Will W; Zupnick, Andrew A; Mattia, Melissa M; Freulich, Ella E; Shamir, Inbal I; Kadouri, Noam N; Kahan, Tamar T; Manfredi, James J; Simon, Itamar I; Prives, Carol C
Publication Date: 2015-03-19

Variant appearance in text: p53: K373Q
PubMed Link: 25794615
Variant Present in the following documents:
  • Main text
View BVdb publication page



The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.

The Journal Of Biological Chemistry
Ono, Wakana W; Hayashi, Yuki Y; Yokoyama, Wataru W; Kuroda, Takao T; Kishimoto, Hiroyuki H; Ito, Ichiaki I; Kimura, Keiji K; Akaogi, Kensuke K; Waku, Tsuyoshi T; Yanagisawa, Junn J
Publication Date: 2014-02-21

Variant appearance in text: p53: K373Q
PubMed Link: 24375404
Variant Present in the following documents:
  • Main text
View BVdb publication page



Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Brochier, Camille C; Dennis, Gretel G; Rivieccio, Mark A MA; McLaughlin, Kathryn K; Coppola, Giovanni G; Ratan, Rajiv R RR; Langley, Brett B
Publication Date: 2013-05-15

Variant appearance in text: p53: K373Q
PubMed Link: 23678107
Variant Present in the following documents:
  • Main text
View BVdb publication page



Transcriptional regulation by p53.

Cold Spring Harbor Perspectives In Biology
Beckerman, Rachel R; Prives, Carol C
Publication Date: 2010-08

Variant appearance in text: p53: K373Q
PubMed Link: 20679336
Variant Present in the following documents:
  • Main text
View BVdb publication page