TP53 c.1053G>T ;(p.K351N)

Variant ID: 17-7573974-C-A

NM_000546.5(TP53):c.1053G>T;(p.K351N)

This variant was identified in 30 publications

View GRCh38 version.




Publications:


Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence.

Metabolites
Murali, Roopak R; Balasubramaniam, Vaishnavi V; Srinivas, Satish S; Sundaram, Sandhya S; Venkatraman, Ganesh G; Warrier, Sudha S; Dharmarajan, Arun A; Gandhirajan, Rajesh Kumar RK
Publication Date: 2023-04-15

Variant appearance in text: TP53: K351N
PubMed Link: 37110218
Variant Present in the following documents:
  • Main text
  • metabolites-13-00560.pdf
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Neoadjuvant Chemotherapy Versus Primary Debulking Surgery in FIGO Stage III and IV Epithelial Ovarian, Tubal or Peritoneal Cancer: A Systematic Review and Meta-Analysis.

Oncology Reviews
Tzanis, Alexander A AA; Iavazzo, Christos C; Hadjivasilis, Alexandros A; Tsouvali, Hara H; Antoniou, George Α GΑ; Antoniou, Stavros A SA
Publication Date: 2022

Variant appearance in text: TP53: K351N
PubMed Link: 36531160
Variant Present in the following documents:
  • or-16-10605.pdf
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Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry.

Diagnostic Pathology
Li, Meiping M; Bao, Lei L; Lu, Bo B; Ge, Wenshun W; Ren, Lifang L
Publication Date: 2022-10-13

Variant appearance in text: TP53: K351N
PubMed Link: 36229840
Variant Present in the following documents:
  • 13000_2022_Article_1262.pdf
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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: 1053G>T
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



THSD7B Mutation Induces Platinum Resistance in Small Cell Lung Cancer Patients.

Drug Design, Development And Therapy
Yao, Zifu Z; Lin, Anqi A; Yi, Yonglin Y; Shen, Weitao W; Zhang, Jian J; Luo, Peng P
Publication Date: 2022

Variant appearance in text: TP53: K351N
PubMed Link: 35685767
Variant Present in the following documents:
  • Main text
  • dddt-16-1679.pdf
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Relationship Between Neoadjuvant Chemotherapy and Log Odds of Positive Lymph Nodes and Their Prognostic Role in Advanced Ovarian Cancer Patients With Optimal Cytoreductive Surgery.

Frontiers In Oncology
Hou, Yue-Min YM; Xue, Yan Y; Yao, Jin-Meng JM; Feng, Fang F; An, Rui-Fang RF
Publication Date: 2022

Variant appearance in text: TP53: K351N
PubMed Link: 35651797
Variant Present in the following documents:
  • fonc-12-878275.pdf
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Impact of neoadjuvant chemotherapy on somatic mutation status in high-grade serous ovarian carcinoma.

Journal Of Ovarian Research
Marchocki, Zibi Z; Tone, Alicia A; Virtanen, Carl C; de Borja, Richard R; Clarke, Blaise B; Brown, Theodore T; May, Taymaa T
Publication Date: 2022-05-02

Variant appearance in text: TP53: K351N
PubMed Link: 35501919
Variant Present in the following documents:
  • Main text
  • 13048_2022_Article_983.pdf
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Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches.

Frontiers In Cell And Developmental Biology
Alvarado-Ortiz, Eduardo E; de la Cruz-López, Karen Griselda KG; Becerril-Rico, Jared J; Sarabia-Sánchez, Miguel Angel MA; Ortiz-Sánchez, Elizabeth E; García-Carrancá, Alejandro A
Publication Date: 2020

Variant appearance in text: p53: K351N
PubMed Link: 33644030
Variant Present in the following documents:
  • Main text
  • fcell-08-607670.pdf
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Identification of Ovarian Cancer Patients Most Likely to Achieve Chemotherapy Response Score 3 Following Neoadjuvant Chemotherapy: Development of a Predictive Nomogram.

Frontiers In Oncology
Liang, Wei-Feng WF; Li, Hui H; Wu, Jie-Ying JY; Liu, Chang-Hao CH; Wu, Miao-Fang MF; Li, Jing J
Publication Date: 2020

Variant appearance in text: TP53: K351N
PubMed Link: 33123471
Variant Present in the following documents:
  • fonc-10-560888.pdf
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Identification of the key genes associated with chemotherapy sensitivity in ovarian cancer patients.

Cancer Medicine
Zheng, Hui H; Zhang, Meiqin M; Ma, Shuang S; Yang, Wenting W; Xie, Suhong S; Wang, Yanchun Y; Liu, Yixuan Y; Kai, Jinyan J; Ma, Qian Q; Lu, Renquan R; Guo, Lin L
Publication Date: 2020-07

Variant appearance in text: TP53: K351N
PubMed Link: 32441484
Variant Present in the following documents:
  • CAM4-9-5200.pdf
View BVdb publication page



The Discordance of Gene Mutations between Circulating Tumor Cells and Primary/Metastatic Tumor.

Molecular Therapy Oncolytics
Wang, Qi Q; Zhao, Lanbo L; Han, Lu L; Tuo, Xiaoqian X; Ma, Sijia S; Wang, Yiran Y; Feng, Xue X; Liang, Dongxin D; Sun, Chao C; Wang, Qing Q; Song, Qing Q; Li, Qiling Q
Publication Date: 2019-12-20

Variant appearance in text: TP53: K351N
PubMed Link: 31650022
Variant Present in the following documents:
  • mmc3.xls, sheet 1
View BVdb publication page



Evaluating the benefits of neoadjuvant chemotherapy for advanced epithelial ovarian cancer: a retrospective study.

Journal Of Ovarian Research
Gao, Yan Y; Li, Yuan Y; Zhang, Chunyu C; Han, Jinsong J; Liang, Huamao H; Zhang, Kun K; Guo, Hongyan H
Publication Date: 2019-09-13

Variant appearance in text: TP53: K351N
PubMed Link: 31519183
Variant Present in the following documents:
  • 13048_2019_Article_562.pdf
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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: TP53: K351N
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



TP53 mutations in epithelial ovarian cancer.

Translational Cancer Research
Zhang, Yu Y; Cao, Lan L; Nguyen, Daniel D; Lu, Hua H
Publication Date: 2016-12

Variant appearance in text: TP53: K351N
PubMed Link: 30613473
Variant Present in the following documents:
  • Main text
View BVdb publication page



Functional role of the Tau protein in epithelial ovarian cancer cells.

Reproductive Medicine And Biology
Yamauchi, Aisa A; Kobayashi, Asami A; Oikiri, Hiroe H; Yokoyama, Yoshihito Y
Publication Date: 2017-04

Variant appearance in text: TP53: K351N
PubMed Link: 29259462
Variant Present in the following documents:
  • RMB2-16-143.pdf
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Inhibition of coiled coil domain containing protein 69 enhances platinum-induced apoptosis in ovarian cancer cells.

Oncotarget
Cui, Long L; Liang, Bo B; Yang, Yihua Y; Zhu, Minhui M; Kwong, Joseph J; Zheng, Hongliang H; Wang, Chi Chiu CC
Publication Date: 2017-11-24

Variant appearance in text: p53: K351N
PubMed Link: 29254192
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of neoadjuvant chemotherapy on platinum resistance in stage IIIC and IV epithelial ovarian cancer.

Medicine
Luo, Yanlin Y; Lee, Maria M; Kim, Hee Seung HS; Chung, Hyun Hoon HH; Song, Yong Sang YS
Publication Date: 2016-09

Variant appearance in text: TP53: K351N
PubMed Link: 27603388
Variant Present in the following documents:
  • Main text
  • medi-95-e4797.pdf
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: TP53: 1053G>T; K351N
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 2
View BVdb publication page



The 15th Chinese Society of Gynecologic Oncology National Conference and the 6th Southern China Ovarian Cancer Summit, March 10-13, 2016, Guangzhou.

Journal Of Gynecologic Oncology
Soochit, Ashvin A; Zhang, Chuyao C; Liu, Jihong J
Publication Date: 2016-09

Variant appearance in text: TP53: K351N
PubMed Link: 27329198
Variant Present in the following documents:
  • jgo-27-e50.pdf
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Lysines in the tetramerization domain of p53 selectively modulate G1 arrest.

Cell Cycle (Georgetown, Tex.)
Beckerman, Rachel R; Yoh, Kathryn K; Mattia-Sansobrino, Melissa M; Zupnick, Andrew A; Laptenko, Oleg O; Karni-Schmidt, Orit O; Ahn, Jinwoo J; Byeon, In-Ja IJ; Keezer, Susan S; Prives, Carol C
Publication Date: 2016-06-02

Variant appearance in text: p53: K351N
PubMed Link: 27210019
Variant Present in the following documents:
  • Main text
View BVdb publication page



REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer.

Scientific Reports
Zhao, Min M; Rotgans, Bronwyn B; Wang, Tianfang T; Cummins, S F SF
Publication Date: 2016-03-15

Variant appearance in text: TP53: K351N
PubMed Link: 26975833
Variant Present in the following documents:
  • srep23167-s9.xls, sheet 1
View BVdb publication page



Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC).

Plos One
Ricketts, Christopher J CJ; Linehan, W Marston WM
Publication Date: 2015

Variant appearance in text: TP53: K351N
PubMed Link: 26484545
Variant Present in the following documents:
  • pone.0140257.s003.xlsx, sheet 1
View BVdb publication page



Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells.

Journal Of Ovarian Research
Zhong, Li-Xia LX; Li, Hong H; Wu, Mo-Li ML; Liu, Xiao-Yu XY; Zhong, Ming-Jun MJ; Chen, Xiao-Yan XY; Liu, Jia J; Zhang, Yang Y
Publication Date: 2015-04-22

Variant appearance in text: TP53: K351N
PubMed Link: 25896424
Variant Present in the following documents:
  • 13048_2015_Article_152.pdf
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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: TP53: K351N
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nature Medicine
Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L
Publication Date: 2014-12

Variant appearance in text: TP53: K351N
PubMed Link: 25326804
Variant Present in the following documents:
  • NIHMS630249-supplement-6.xlsx, sheet 1
View BVdb publication page



Tumor suppressor p53 and estrogen receptors in nuclear-mitochondrial communication.

Mitochondrion
Wickramasekera, Nadi T NT; Das, Gokul M GM
Publication Date: 2014-05

Variant appearance in text: p53: K351N
PubMed Link: 24177747
Variant Present in the following documents:
  • Main text
View BVdb publication page



p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1.

Molecular Biology Of The Cell
Santiago, Aleixo A; Li, Dawei D; Zhao, Lisa Y LY; Godsey, Adam A; Liao, Daiqing D
Publication Date: 2013-09

Variant appearance in text: p53: K351N
PubMed Link: 23825024
Variant Present in the following documents:
  • Main text
View BVdb publication page



Anticancer and antimicrobial activities of some antioxidant-rich cameroonian medicinal plants.

Plos One
Tamokou, Jean de Dieu Jde D; Chouna, Jean Rodolphe JR; Fischer-Fodor, Eva E; Chereches, Gabriela G; Barbos, Otilia O; Damian, Grigore G; Benedec, Daniela D; Duma, Mihaela M; Efouet, Alango Pépin Nkeng AP; Wabo, Hippolyte Kamdem HK; Kuiate, Jules Roger JR; Mot, Augustin A; Silaghi-Dumitrescu, Radu R
Publication Date: 2013

Variant appearance in text: p53: K351N
PubMed Link: 23409075
Variant Present in the following documents:
  • pone.0055880.pdf
View BVdb publication page



The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein.

The Journal Of Biological Chemistry
Muscolini, Michela M; Montagni, Elisa E; Palermo, Vanessa V; Di Agostino, Silvia S; Gu, Wei W; Abdelmoula-Souissi, Salma S; Mazzoni, Cristina C; Blandino, Giovanni G; Tuosto, Loretta L
Publication Date: 2011-11-18

Variant appearance in text: p53: K351N
PubMed Link: 21953469
Variant Present in the following documents:
  • Main text
View BVdb publication page



Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary.

The Journal Of Pathology
Ahmed, Ahmed Ashour AA; Etemadmoghadam, Dariush D; Temple, Jillian J; Lynch, Andy G AG; Riad, Mohamed M; Sharma, Raghwa R; Stewart, Colin C; Fereday, Sian S; Caldas, Carlos C; Defazio, Anna A; Bowtell, David D; Brenton, James D JD
Publication Date: 2010-05

Variant appearance in text: p53: K351N
PubMed Link: 20229506
Variant Present in the following documents:
  • Main text
  • path0221-0049.pdf
View BVdb publication page