Publications:

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Genomics-Driven Precision Medicine in Pediatric Solid Tumors.

Cancers

Suthapot, Praewa P; Chiangjong, Wararat W; Chaiyawat, Parunya P; Choochuen, Pongsakorn P; Pruksakorn, Dumnoensun D; Sangkhathat, Surasak S; Hongeng, Suradej S; Anurathapan, Usanarat U; Chutipongtanate, Somchai S

Publication Date: 2023-02-23

Variant appearance in text: TP53: N345K

PubMed Link: 36900212

Variant Present in the following documents:

• cancers-15-01418.pdf

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Genomic landscape of lung cancer in the young.

Frontiers In Oncology

Ruiz, Rossana R; Galvez-Nino, Marco M; Roque, Katia K; Montes, Jaime J; Nuñez, Maria M; Raez, Luis L; Sánchez-Gambetta, Sergio S; Jaúregui, Sandra S; Viale, Sandra S; Smith, Edward S ES; Pinto, Joseph A JA; Mas, Luis L

Publication Date: 2022

Variant appearance in text: TP53: N345K

PubMed Link: 36263208

Variant Present in the following documents:

• DataSheet_2.pdf

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Tinengotinib (TT-00420), a Novel Spectrum-Selective Small Molecule Kinase Inhibitor, Is Highly Active Against Triple Negative Breast Cancer.

Molecular Cancer Therapeutics

Peng, Peng P; Qiang, Xiaoyan X; Li, Guoyu G; Li, Lin L; Ni, Shumao S; Yu, Qi Q; Sourd, Laura L; Marangoni, Elisabetta E; Hu, Chao C; Wang, Dong D; Wu, Di D; Wu, Frank F

Publication Date: 2022-10-12

Variant appearance in text: TP53: N345K

PubMed Link: 36223547

Variant Present in the following documents:

• mct-22-0012_supplementary_tables_s1-7_supps1-s7.xlsx, sheet 7

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Improving prediction of response to neoadjuvant treatment in patients with breast cancer by combining liquid biopsies with multiparametric MRI: protocol of the LIMA study - a multicentre prospective observational cohort study.

Bmj Open

Janssen, Liselore M LM; Suelmann, Britt B M BBM; Elias, Sjoerd G SG; Janse, Markus H A MHA; van Diest, Paul J PJ; van der Wall, Elsken E; Gilhuijs, Kenneth G A KGA

Publication Date: 2022-09-20

Variant appearance in text: TP53: N345K

PubMed Link: 36127090

Variant Present in the following documents:

• bmjopen-2022-061334.reviewer_comments.pdf
• bmjopen-2022-061334supp001.pdf
• bmjopen-2022-061334.draft_revisions.pdf

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A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma.

International Journal Of Cancer

Jo, Jung Hyun JH; Jung, Dawoon E DE; Lee, Hee Seung HS; Park, Soo Been SB; Chung, Moon Jae MJ; Park, Jeong Youp JY; Bang, Seungmin S; Park, Seung Woo SW; Cho, Sangsook S; Song, Si Young SY

Publication Date: 2022-11-01

Variant appearance in text: TP53: N345K

PubMed Link: 35657348

Variant Present in the following documents:

• IJC-151-1565-s001.pdf

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Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.

Nature Communications

Zhang, Yiqun Y; Chen, Fengju F; Chandrashekar, Darshan S DS; Varambally, Sooryanarayana S; Creighton, Chad J CJ

Publication Date: 2022-05-13

Variant appearance in text: p53: N345K

PubMed Link: 35562349

Variant Present in the following documents:

• 41467_2022_30342_MOESM4_ESM.xlsx, sheet 1

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Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study.

Plos One

Aoyagi, Yasuko Y; Kano, Yoshihito Y; Tohyama, Kohki K; Matsudera, Shotaro S; Kumaki, Yuichi Y; Takahashi, Kenta K; Mitsumura, Takahiro T; Harada, Yohei Y; Sato, Akemi A; Nakamura, Hideaki H; Sueoka, Eisaburo E; Aragane, Naoko N; Kimura, Koichiro K; Onishi, Iichiro I; Takemoto, Akira A; Akahoshi, Keiichi K; Ono, Hiroaki H; Ishikawa, Toshiaki T; Tokunaga, Masanori M; Nakagawa, Tsuyoshi T; Oshima, Noriko N; Nakamura, Reiko R; Takagi, Masatoshi M; Asakage, Takahiro T; Uetake, Hiroyuki H; Tanabe, Minoru M; Miyake, Satoshi S; Kinugasa, Yusuke Y; Ikeda, Sadakatsu S

Publication Date: 2022

Variant appearance in text: TP53: N345K

PubMed Link: 35358259

Variant Present in the following documents:

• Main text

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Targeted next generation sequencing of circulating tumor DNA provides prognostic information for management in breast cancer patients.

Annals Of Translational Medicine

Shim, Hyoeun H; Kwon, Min Jeong MJ; Park, In Hae IH; Kim, Min Kyeong MK; Cho, Eun-Hae EH; Lee, Junnam J; Lee, Seung-Tae ST; Sim, Sung Hoon SH; Lee, Keun Seok KS; Kim, Yun-Hee YH; Kim, Seok-Ki SK; Lee, Eun Sook ES; Kong, Sun-Young SY

Publication Date: 2022-01

Variant appearance in text: TP53: N345K

PubMed Link: 35282050

Variant Present in the following documents:

• atm-10-02-28.pdf

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Evaluation and diagnostic value of next-generation sequencing analysis of residual liquid-based cytology specimens of pancreatic masses.

Cancer Cytopathology

Sekita-Hatakeyama, Yoko Y; Fujii, Tomomi T; Nishikawa, Takeshi T; Mitoro, Akira A; Sawai, Masayoshi M; Itami, Hiroe H; Morita, Kouhei K; Uchiyama, Tomoko T; Takeda, Maiko M; Sho, Masayuki M; Yoshiji, Hitoshi H; Hatakeyama, Kinta K; Ohbayashi, Chiho C

Publication Date: 2022-03

Variant appearance in text: TP53: N345K

PubMed Link: 34665935

Variant Present in the following documents:

• CNCY-130-202.pdf

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Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications

Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A

Publication Date: 2021-04-14

Variant appearance in text: TP53: N345K

PubMed Link: 33854067

Variant Present in the following documents:

• 41467_2021_22478_MOESM8_ESM.xlsx, sheet 11

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Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.

Cell Death And Differentiation

Doffe, Flora F; Carbonnier, Vincent V; Tissier, Manon M; Leroy, Bernard B; Martins, Isabelle I; Mattsson, Johanna S M JSM; Micke, Patrick P; Pavlova, Sarka S; Pospisilova, Sarka S; Smardova, Jana J; Joerger, Andreas C AC; Wiman, Klas G KG; Kroemer, Guido G; Soussi, Thierry T

Publication Date: 2021-05

Variant appearance in text: TP53: N345K

PubMed Link: 33257846

Variant Present in the following documents:

• 41418_2020_672_MOESM1_ESM.pdf

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Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.

Cell Death And Differentiation

Doffe, Flora F; Carbonnier, Vincent V; Tissier, Manon M; Leroy, Bernard B; Martins, Isabelle I; Mattsson, Johanna S M JSM; Micke, Patrick P; Pavlova, Sarka S; Pospisilova, Sarka S; Smardova, Jana J; Joerger, Andreas C AC; Wiman, Klas G KG; Kroemer, Guido G; Soussi, Thierry T

Publication Date: 2021-05

Variant appearance in text: TP53: N345K

PubMed Link: 33257846

Variant Present in the following documents:

• 41418_2020_672_MOESM1_ESM.pdf

View BVdb publication page

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Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.

Nature Communications

Desbois, Mélanie M; Udyavar, Akshata R AR; Ryner, Lisa L; Kozlowski, Cleopatra C; Guan, Yinghui Y; Dürrbaum, Milena M; Lu, Shan S; Fortin, Jean-Philippe JP; Koeppen, Hartmut H; Ziai, James J; Chang, Ching-Wei CW; Keerthivasan, Shilpa S; Plante, Marie M; Bourgon, Richard R; Bais, Carlos C; Hegde, Priti P; Daemen, Anneleen A; Turley, Shannon S; Wang, Yulei Y

Publication Date: 2020-11-04

Variant appearance in text: TP53: Asn345Lys

PubMed Link: 33149148

Variant Present in the following documents:

• 41467_2020_19408_MOESM8_ESM.xlsx, sheet 10

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Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants.

Communications Biology

Inagaki-Kawata, Yukiko Y; Yoshida, Kenichi K; Kawaguchi-Sakita, Nobuko N; Kawashima, Masahiro M; Nishimura, Tomomi T; Senda, Noriko N; Shiozawa, Yusuke Y; Takeuchi, Yasuhide Y; Inoue, Yoshikage Y; Sato-Otsubo, Aiko A; Fujii, Yoichi Y; Nannya, Yasuhito Y; Suzuki, Eiji E; Takada, Masahiro M; Tanaka, Hiroko H; Shiraishi, Yuichi Y; Chiba, Kenichi K; Kataoka, Yuki Y; Torii, Masae M; Yoshibayashi, Hiroshi H; Yamagami, Kazuhiko K; Okamura, Ryuji R; Moriguchi, Yoshio Y; Kato, Hironori H; Tsuyuki, Shigeru S; Yamauchi, Akira A; Suwa, Hirofumi H; Inamoto, Takashi T; Miyano, Satoru S; Ogawa, Seishi S; Toi, Masakazu M

Publication Date: 2020-10-16

Variant appearance in text: TP53: N345K

PubMed Link: 33067557

Variant Present in the following documents:

• 42003_2020_1301_MOESM1_ESM.pdf

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Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Cancer Research And Treatment

Lee, Youngwoo Y; Lee, Soohyeon S; Sung, Jae Sook JS; Chung, Hee-Joon HJ; Lim, Ah-Reum AR; Kim, Ju Won JW; Choi, Yoon Ji YJ; Park, Kyong Hwa KH; Kim, Yeul Hong YH

Publication Date: 2021-01

Variant appearance in text: TP53: N345K

PubMed Link: 32810930

Variant Present in the following documents:

• crt-2020-559-suppl3.pdf

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Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy.

Breast Cancer Research And Treatment

Li, Kai K; Liao, Ning N; Chen, Bo B; Zhang, Guochun G; Wang, Yulei Y; Guo, Liping L; Wei, Guangnan G; Jia, Minghan M; Wen, Lingzhu L; Ren, Chongyang C; Cao, Li L; Mok, Hsiaopei H; Li, Cheukfai C; Lin, Jiali J; Chen, Xiaoqing X; Zhang, Zhou Z; Hou, Ting T; Li, Min M; Liu, Jing J; Balch, Charles M CM; Liao, Ning N

Publication Date: 2020-09

Variant appearance in text: TP53: N345K

PubMed Link: 32638235

Variant Present in the following documents:

• 10549_2020_Article_5778.pdf

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Using somatic variant richness to mine signals from rare variants in the cancer genome.

Nature Communications

Chakraborty, Saptarshi S; Arora, Arshi A; Begg, Colin B CB; Shen, Ronglai R

Publication Date: 2019-12-03

Variant appearance in text: TP53: N345K

PubMed Link: 31796730

Variant Present in the following documents:

• 41467_2019_Article_13402.pdf

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Liquid Biopsy Detects Relapse Five Months Earlier than Regular Clinical Follow-Up and Guides Targeted Treatment in Breast Cancer.

Case Reports In Oncological Medicine

Cheng, Fiona Tsui-Fen FT; Lapke, Nina N; Wu, Chin-Chu CC; Lu, Yen-Jung YJ; Chen, Shu-Jen SJ; Yu, Pei-Ning PN; Liu, Yen-Ting YT; Tan, Kien Thiam KT

Publication Date: 2019

Variant appearance in text: TP53: N345K

PubMed Link: 31583146

Variant Present in the following documents:

• CRIONM2019-6545298.pdf

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: TP53: N345K

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Monitoring colorectal cancer following surgery using plasma circulating tumor DNA.

Oncology Letters

Sun, Xiao X; Huang, Tanxiao T; Cheng, Fangsheng F; Huang, Kaibing K; Liu, Ming M; He, Wan W; Li, Mingwei M; Zhang, Xiaoni X; Xu, Mingyan M; Chen, Shifu S; Xia, Ligang L

Publication Date: 2018-04

Variant appearance in text: TP53: N345K

PubMed Link: 29541205

Variant Present in the following documents:

• ol-15-04-4365.pdf

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Integrated genomic analyses of de novo pathways underlying atypical meningiomas.

Nature Communications

Harmancı, Akdes Serin AS; Youngblood, Mark W MW; Clark, Victoria E VE; Coşkun, Süleyman S; Henegariu, Octavian O; Duran, Daniel D; Erson-Omay, E Zeynep EZ; Kaulen, Leon D LD; Lee, Tong Ihn TI; Abraham, Brian J BJ; Simon, Matthias M; Krischek, Boris B; Timmer, Marco M; Goldbrunner, Roland R; Omay, S Bülent SB; Baranoski, Jacob J; Baran, Burçin B; Carrión-Grant, Geneive G; Bai, Hanwen H; Mishra-Gorur, Ketu K; Schramm, Johannes J; Moliterno, Jennifer J; Vortmeyer, Alexander O AO; Bilgüvar, Kaya K; Yasuno, Katsuhito K; Young, Richard A RA; Günel, Murat M

Publication Date: 2017-02-14

Variant appearance in text: TP53: N345K

PubMed Link: 28195122

Variant Present in the following documents:

• ncomms14433-s3.xlsx, sheet 3

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In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.

The Journal Of Pathology. Clinical Research

McConechy, Melissa K MK; Hoang, Lien N LN; Chui, Michael Herman MH; Senz, Janine J; Yang, Winnie W; Rozenberg, Nirit N; Mackenzie, Robertson R; McAlpine, Jessica N JN; Huntsman, David G DG; Clarke, Blaise A BA; Gilks, Cyril Blake CB; Lee, Cheng-Han CH

Publication Date: 2015-07

Variant appearance in text: TP53: N345K

PubMed Link: 27499902

Variant Present in the following documents:

• CJP2-1-173-s002.xlsx, sheet 1

View BVdb publication page

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Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response.

Breast Cancer Research : Bcr

Lips, Esther H EH; Michaut, Magali M; Hoogstraat, Marlous M; Mulder, Lennart L; Besselink, Nicolle J M NJ; Koudijs, Marco J MJ; Cuppen, Edwin E; Voest, Emile E EE; Bernards, Rene R; Nederlof, Petra M PM; Wesseling, Jelle J; Rodenhuis, Sjoerd S; Wessels, Lodewyk F A LF; ,

Publication Date: 2015-10-03

Variant appearance in text: TP53: N345K

PubMed Link: 26433948

Variant Present in the following documents:

• 13058_2015_642_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer.

Genome Biology

Tan, Iain Beehuat IB; Malik, Simeen S; Ramnarayanan, Kalpana K; McPherson, John R JR; Ho, Dan Liang DL; Suzuki, Yuka Y; Ng, Sarah Boonhsui SB; Yan, Su S; Lim, Kiat Hon KH; Koh, Dennis D; Hoe, Chew Min CM; Chan, Chung Yip CY; Ten, Rachel R; Goh, Brian Kp BK; Chung, Alexander Yf AY; Tan, Joanna J; Chan, Cheryl Xueli CX; Tay, Su Ting ST; Alexander, Lezhava L; Nagarajan, Niranjan N; Hillmer, Axel M AM; Tang, Choon Leong CL; Chua, Clarinda C; Teh, Bin Tean BT; Rozen, Steve S; Tan, Patrick P

Publication Date: 2015-02-12

Variant appearance in text: TP53: N345K

PubMed Link: 25808843

Variant Present in the following documents:

• 13059_2015_589_MOESM4_ESM.pdf

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: N345K

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Targeting oxidative stress in embryonal rhabdomyosarcoma.

Cancer Cell

Chen, Xiang X; Stewart, Elizabeth E; Shelat, Anang A AA; Qu, Chunxu C; Bahrami, Armita A; Hatley, Mark M; Wu, Gang G; Bradley, Cori C; McEvoy, Justina J; Pappo, Alberto A; Spunt, Sheri S; Valentine, Marcus B MB; Valentine, Virginia V; Krafcik, Fred F; Lang, Walter H WH; Wierdl, Monika M; Tsurkan, Lyudmila L; Tolleman, Viktor V; Federico, Sara M SM; Morton, Chris C; Lu, Charles C; Ding, Li L; Easton, John J; Rusch, Michael M; Nagahawatte, Panduka P; Wang, Jianmin J; Parker, Matthew M; Wei, Lei L; Hedlund, Erin E; Finkelstein, David D; Edmonson, Michael M; Shurtleff, Sheila S; Boggs, Kristy K; Mulder, Heather H; Yergeau, Donald D; Skapek, Steve S; Hawkins, Douglas S DS; Ramirez, Nilsa N; Potter, Philip M PM; Sandoval, John A JA; Davidoff, Andrew M AM; Mardis, Elaine R ER; Wilson, Richard K RK; Zhang, Jinghui J; Downing, James R JR; Dyer, Michael A MA; ,

Publication Date: 2013-12-09

Variant appearance in text: TP53: N345K

PubMed Link: 24332040

Variant Present in the following documents:

• Main text

View BVdb publication page

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mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.

Science Translational Medicine

Elkabets, Moshe M; Vora, Sadhna S; Juric, Dejan D; Morse, Natasha N; Mino-Kenudson, Mari M; Muranen, Taru T; Tao, Jessica J; Campos, Ana Bosch AB; Rodon, Jordi J; Ibrahim, Yasir H YH; Serra, Violeta V; Rodrik-Outmezguine, Vanessa V; Hazra, Saswati S; Singh, Sharat S; Kim, Phillip P; Quadt, Cornelia C; Liu, Manway M; Huang, Alan A; Rosen, Neal N; Engelman, Jeffrey A JA; Scaltriti, Maurizio M; Baselga, José J

Publication Date: 2013-07-31

Variant appearance in text: TP53: N345K

PubMed Link: 23903756

Variant Present in the following documents:

• Main text

View BVdb publication page

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Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy.

Translational Oncogenomics

Sun, Daochun D; Tainsky, Michael A MA; Haddad, Ramsi R

Publication Date: 2012

Variant appearance in text: TP53: N345K

PubMed Link: 22346343

Variant Present in the following documents:

• tog-5-2012-001.pdf

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