Publications:

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Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance.

Cell Reports

Emdal, Kristina B KB; Palacio-Escat, Nicolàs N; Wigerup, Caroline C; Eguchi, Akihiro A; Nilsson, Helén H; Bekker-Jensen, Dorte B DB; Rönnstrand, Lars L; Kazi, Julhash U JU; Puissant, Alexandre A; Itzykson, Raphaël R; Saez-Rodriguez, Julio J; Masson, Kristina K; Blume-Jensen, Peter P; Olsen, Jesper V JV

Publication Date: 2022-08-09

Variant appearance in text: p53: S315A

PubMed Link: 35947955

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• mmc8.pdf

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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.

Cell Reports

Waters, Andrew M AM; Khatib, Tala O TO; Papke, Bjoern B; Goodwin, Craig M CM; Hobbs, G Aaron GA; Diehl, J Nathaniel JN; Yang, Runying R; Edwards, A Cole AC; Walsh, Katherine H KH; Sulahian, Rita R; McFarland, James M JM; Kapner, Kevin S KS; Gilbert, Thomas S K TSK; Stalnecker, Clint A CA; Javaid, Sehrish S; Barkovskaya, Anna A; Grover, Kajal R KR; Hibshman, Priya S PS; Blake, Devon R DR; Schaefer, Antje A; Nowak, Katherine M KM; Klomp, Jennifer E JE; Hayes, Tikvah K TK; Kassner, Michelle M; Tang, Nanyun N; Tanaseichuk, Olga O; Chen, Kaisheng K; Zhou, Yingyao Y; Kalkat, Manpreet M; Herring, Laura E LE; Graves, Lee M LM; Penn, Linda Z LZ; Yin, Hongwei H HH; Aguirre, Andrew J AJ; Hahn, William C WC; Cox, Adrienne D AD; Der, Channing J CJ

Publication Date: 2021-06-29

Variant appearance in text: p53: S315A

PubMed Link: 34192548

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• Main text
• nihms-1720095.pdf

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Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.

Nucleic Acids Research

Biber, Stephanie S; Pospiech, Helmut H; Gottifredi, Vanesa V; Wiesmüller, Lisa L

Publication Date: 2020-12-02

Variant appearance in text: p53: S315A

PubMed Link: 33166398

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• Main text
• gkaa974.pdf

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Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Cancers

Wang, Yu-Chu YC; Huang, Jau-Ling JL; Lee, Ka-Wo KW; Lu, Hsing-Han HH; Lin, Yuan-Jen YJ; Chen, Long-Fong LF; Wang, Chung-Sheng CS; Cheng, Yun-Chiao YC; Zeng, Zih-Ting ZT; Chu, Pei-Yi PY; Lin, Chang-Shen CS

Publication Date: 2020-07-25

Variant appearance in text: p53: S315A

PubMed Link: 32722430

Variant Present in the following documents:

• Main text
• cancers-12-02053.pdf

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How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor.

International Journal Of Molecular Sciences

Ho, Teresa T; Tan, Ban Xiong BX; Lane, David D

Publication Date: 2019-12-18

Variant appearance in text: p53: S315A

PubMed Link: 31861395

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• Main text
• ijms-21-00013.pdf

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SDH5 Depletion Enhances Radiosensitivity by Regulating p53: A New Method for Noninvasive Prediction of Radiotherapy Response.

Theranostics

Zong, Yan Y; Li, Qianwen Q; Zhang, Furong F; Xian, Xunde X; Wang, Sihua S; Xia, Jiahong J; Li, Jie J; Tuo, Zhan Z; Xiao, Guangqin G; Liu, Li L; Li, Guiling G; Zhang, Sheng S; Wu, Gang G; Liu, Jun J

Publication Date: 2019

Variant appearance in text: p53: S315A

PubMed Link: 31588224

Variant Present in the following documents:

• Main text
• thnov09p6380.pdf

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: TP53: S315A

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Choi, Byung-Kwon BK; Dayaram, Tajhal T; Parikh, Neha N; Wilkins, Angela D AD; Nagarajan, Meena M; Novikov, Ilya B IB; Bachman, Benjamin J BJ; Jung, Sung Yun SY; Haas, Peter J PJ; Labrie, Jacques L JL; Pickering, Curtis R CR; Adikesavan, Anbu K AK; Regenbogen, Sam S; Kato, Linda L; Lelescu, Ana A; Buchovecky, Christie M CM; Zhang, Houyin H; Bao, Sheng Hua SH; Boyer, Stephen S; Weber, Griff G; Scott, Kenneth L KL; Chen, Ying Y; Spangler, Scott S; Donehower, Lawrence A LA; Lichtarge, Olivier O

Publication Date: 2018-10-16

Variant appearance in text: p53: S315A

PubMed Link: 30266789

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• Main text
• pnas.201806643.pdf

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Regulation of miR-34b/c-targeted gene expression program by SUMOylation.

Nucleic Acids Research

Li, Yi-Jia YJ; Du, Li L; Aldana-Masangkay, Grace G; Wang, Xiuli X; Urak, Ryan R; Forman, Stephen J SJ; Rosen, Steven T ST; Chen, Yuan Y

Publication Date: 2018-08-21

Variant appearance in text: p53: S315A

PubMed Link: 29893976

Variant Present in the following documents:

• Main text
• gky484.pdf

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Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases.

Cell Systems

Sampattavanich, Somponnat S; Steiert, Bernhard B; Kramer, Bernhard A BA; Gyori, Benjamin M BM; Albeck, John G JG; Sorger, Peter K PK

Publication Date: 2018-06-27

Variant appearance in text: p53: S315A

PubMed Link: 29886111

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CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer.

Theranostics

Xie, Jie J; Li, Yan Y; Jiang, Ke K; Hu, Kaishun K; Zhang, Sheng S; Dong, Xiaorong X; Dai, Xiaofang X; Liu, Li L; Zhang, Tao T; Yang, Kunyu K; Huang, Kai K; Chen, Junjie J; Shi, Shaojun S; Zhang, Yu Y; Wu, Gang G; Xu, Shuangbing S

Publication Date: 2018

Variant appearance in text: p53: S315A

PubMed Link: 29344296

Variant Present in the following documents:

• Main text
• thnov08p0650.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: S315A

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Down-regulation of LATS kinases alters p53 to promote cell migration.

Genes & Development

Furth, Noa N; Bossel Ben-Moshe, Noa N; Pozniak, Yair Y; Porat, Ziv Z; Geiger, Tamar T; Domany, Eytan E; Aylon, Yael Y; Oren, Moshe M

Publication Date: 2015-11-15

Variant appearance in text: p53: S315A

PubMed Link: 26588988

Variant Present in the following documents:

• Main text
• 2325.pdf
• supp_29.22.2325_Supplemental_Material.pdf

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Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.

The Journal Of Biological Chemistry

Ji, Lei L; Xu, Jinjin J; Liu, Jian J; Amjad, Ali A; Zhang, Kun K; Liu, Qingwu Q; Zhou, Lei L; Xiao, Jianru J; Li, Xiaotao X

Publication Date: 2015-05-01

Variant appearance in text: p53: S315A

PubMed Link: 25767119

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EBNA3C regulates p53 through induction of Aurora kinase B.

Oncotarget

Jha, Hem C HC; Yang, Karren K; El-Naccache, Darine W DW; Sun, Zhiguo Z; Robertson, Erle S ES

Publication Date: 2015-03-20

Variant appearance in text: p53: S315A

PubMed Link: 25691063

Variant Present in the following documents:

• Main text
• oncotarget-06-5788.pdf

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: S315A

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence.

Molecular & Cellular Proteomics : Mcp

de Graaf, Erik L EL; Kaplon, Joanna J; Zhou, Houjiang H; Heck, Albert J R AJ; Peeper, Daniel S DS; Altelaar, A F Maarten AF

Publication Date: 2014-08

Variant appearance in text: p53: S315A

PubMed Link: 24961811

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Mutant TP53 posttranslational modifications: challenges and opportunities.

Human Mutation

Nguyen, Thuy-Ai TA; Menendez, Daniel D; Resnick, Michael A MA; Anderson, Carl W CW

Publication Date: 2014-06

Variant appearance in text: p53: S315A

PubMed Link: 24395704

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Methylation by Set9 modulates FoxO3 stability and transcriptional activity.

Aging

Calnan, Daniel R DR; Webb, Ashley E AE; White, Jamie L JL; Stowe, Timothy R TR; Goswami, Tapasree T; Shi, Xiaobing X; Espejo, Alexsandra A; Bedford, Mark T MT; Gozani, Or O; Gygi, Steven P SP; Brunet, Anne A

Publication Date: 2012-07

Variant appearance in text: p53: S315A

PubMed Link: 22820736

Variant Present in the following documents:

• Main text
• aging-04-462.pdf

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Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation.

Plos Pathogens

Cai, Qiliang Q; Xiao, Bingyi B; Si, Huaxin H; Cervini, Amanda A; Gao, Jianming J; Lu, Jie J; Upadhyay, Santosh K SK; Verma, Suhbash C SC; Robertson, Erle S ES

Publication Date: 2012

Variant appearance in text: p53: S315A

PubMed Link: 22396649

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• Main text
• ppat.1002566.pdf

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Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.

Plos One

Nantajit, Danupon D; Fan, Ming M; Duru, Nadire N; Wen, Yunfei Y; Reed, John C JC; Li, Jian Jian JJ

Publication Date: 2010-08-23

Variant appearance in text: p53: S315A

PubMed Link: 20808790

Variant Present in the following documents:

• Main text
• pone.0012341.pdf

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Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo.

Cell Death And Differentiation

Lee, M K MK; Tong, W M WM; Wang, Z Q ZQ; Sabapathy, K K

Publication Date: 2011-02

Variant appearance in text: p53: S315A

PubMed Link: 20671749

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The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.

Plos One

Valbuena, Alberto A; Blanco, Sandra S; Vega, Francisco M FM; Lazo, Pedro A PA

Publication Date: 2008-07-09

Variant appearance in text: p53: S315A

PubMed Link: 18612383

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FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.

The Journal Of Experimental Medicine

You, Han H; Pellegrini, Marc M; Tsuchihara, Katsuya K; Yamamoto, Kazuo K; Hacker, Georg G; Erlacher, Miriam M; Villunger, Andreas A; Mak, Tak W TW

Publication Date: 2006-07-10

Variant appearance in text: p53: S315A

PubMed Link: 16801400

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• Main text
• jem2031657.pdf

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Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a.

Proceedings Of The National Academy Of Sciences Of The United States Of America

You, Han H; Yamamoto, Kazuo K; Mak, Tak Wah TW

Publication Date: 2006-06-13

Variant appearance in text: p53: S315A

PubMed Link: 16757565

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Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.

The Biochemical Journal

Shimizu, Harumi H; Saliba, David D; Wallace, Maura M; Finlan, Lee L; Langridge-Smith, Patrick R R PR; Hupp, Ted R TR

Publication Date: 2006-07-15

Variant appearance in text: p53: S315A

PubMed Link: 16579792

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Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.

Molecular And Cellular Biology

Pluquet, Olivier O; Qu, Li-Ke LK; Baltzis, Dionissios D; Koromilas, Antonis E AE

Publication Date: 2005-11

Variant appearance in text: p53: S315A

PubMed Link: 16227590

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Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.

Molecular And Cellular Biology

Berger, Michael M; Stahl, Nathalie N; Del Sal, Giannino G; Haupt, Ygal Y

Publication Date: 2005-07

Variant appearance in text: p53: S315A

PubMed Link: 15964795

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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.

Genes & Development

Qu, LiKe L; Huang, Shirley S; Baltzis, Dionissios D; Rivas-Estilla, Ana-Maria AM; Pluquet, Olivier O; Hatzoglou, Maria M; Koumenis, Costas C; Taya, Yoichi Y; Yoshimura, Akihiko A; Koromilas, Antonis E AE

Publication Date: 2004-02-01

Variant appearance in text: p53: S315A

PubMed Link: 14744935

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