Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Nature Communications
Hussong, Stacy A SA; Banh, Andy Q AQ; Van Skike, Candice E CE; Dorigatti, Angela O AO; Hernandez, Stephen F SF; Hart, Matthew J MJ; Ferran, Beatriz B; Makhlouf, Haneen H; Gaczynska, Maria M; Osmulski, Pawel A PA; McAllen, Salome A SA; Dineley, Kelly T KT; Ungvari, Zoltan Z; Perez, Viviana I VI; Kayed, Rakez R; Galvan, Veronica V
The oDGal Mouse: A Novel, Physiologically Relevant Rodent Model of Sporadic Alzheimer's Disease.
International Journal Of Molecular Sciences
Chadwick, Wayne W; Maudsley, Stuart S; Hull, William W; Havolli, Enes E; Boshoff, Eugene E; Hill, Mark D W MDW; Goetghebeur, Pascal J D PJD; Harrison, David C DC; Nizami, Sohaib S; Bedford, David C DC; Coope, Gareth G; Real, Katia K; Thiemermann, Christoph C; Maycox, Peter P; Carlton, Mark M; Cole, Sarah L SL
24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer's Disease.
Antioxidants (Basel, Switzerland)
Testa, Gabriella G; Giannelli, Serena S; Sottero, Barbara B; Staurenghi, Erica E; Giaccone, Giorgio G; Caroppo, Paola P; Gamba, Paola P; Leonarduzzi, Gabriella G
Modeling Alzheimer's disease in primary neurons reveals DNA damage response coupled with MAPK-DLK signaling in wild-type tau-induced neurodegeneration.
Research Square
Li, Sanming S; Roy, Ethan R ER; Wang, Yanyu Y; Watkins, Trent T; Cao, Wei W
Slingshot homolog-1 mediates the secretion of small extracellular vesicles containing misfolded proteins by regulating autophagy cargo receptors and actin dynamics.
Frontiers In Aging Neuroscience
Cazzaro, Sara S; Fang, Cenxiao C; Khan, Hirah H; Witas, Richard R; Kee, Teresa R TR; Woo, Jung-A A JA; Kang, David E DE
The interplay between oxidative stress and autophagy: focus on the development of neurological diseases.
Behavioral And Brain Functions : Bbf
Talebi, Marjan M; Mohammadi Vadoud, Seyyed Ali SA; Haratian, Alireza A; Talebi, Mohsen M; Farkhondeh, Tahereh T; Pourbagher-Shahri, Ali Mohammad AM; Samarghandian, Saeed S
Ginsenoside Rd Attenuates Tau Phosphorylation in Olfactory Bulb, Spinal Cord, and Telencephalon by Regulating Glycogen Synthase Kinase 3β and Cyclin-Dependent Kinase 5.
Evidence-Based Complementary And Alternative Medicine : Ecam
The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy.
Cells
Aragonès, Gemma G; Rowan, Sheldon S; Francisco, Sarah G SG; Whitcomb, Elizabeth A EA; Yang, Wenxin W; Perini-Villanueva, Giuliana G; Schalkwijk, Casper G CG; Taylor, Allen A; Bejarano, Eloy E
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
Nature Communications
Caballero, Benjamin B; Bourdenx, Mathieu M; Luengo, Enrique E; Diaz, Antonio A; Sohn, Peter Dongmin PD; Chen, Xu X; Wang, Chao C; Juste, Yves R YR; Wegmann, Susanne S; Patel, Bindi B; Young, Zapporah T ZT; Kuo, Szu Yu SY; Rodriguez-Navarro, Jose Antonio JA; Shao, Hao H; Lopez, Manuela G MG; Karch, Celeste M CM; Goate, Alison M AM; Gestwicki, Jason E JE; Hyman, Bradley T BT; Gan, Li L; Cuervo, Ana Maria AM
The Synaptic Dysregulation in Adolescent Rats Exposed to Maternal Immune Activation.
Frontiers In Molecular Neuroscience
Cieślik, Magdalena M; Gassowska-Dobrowolska, Magdalena M; Zawadzka, Aleksandra A; Frontczak-Baniewicz, Małgorzata M; Gewartowska, Magdalena M; Dominiak, Agnieszka A; Czapski, Grzegorz A GA; Adamczyk, Agata A
Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer's disease: a pre-clinical study.
Aging
Cecarini, Valentina V; Bonfili, Laura L; Gogoi, Olee O; Lawrence, Solomon S; Venanzi, Franco M FM; Azevedo, Vasco V; Mancha-Agresti, Pamela P; Drumond, Mariana Martins MM; Rossi, Giacomo G; Berardi, Sara S; Galosi, Livio L; Cuccioloni, Massimiliano M; Angeletti, Mauro M; Suchodolski, Jan S JS; Pilla, Rachel R; Lidbury, Jonathan A JA; Eleuteri, Anna Maria AM
Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer's disease: a meta-analytic review on potential mechanisms.
Translational Neurodegeneration
Qin, Chuan C; Lu, Yalan Y; Wang, Kewei K; Bai, Lin L; Shi, Guiying G; Huang, Yiying Y; Li, Yongning Y
Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings.