TP53 c.830G>C ;(p.C277S)

Variant ID: 17-7577108-C-G

NM_000546.5(TP53):c.830G>C;(p.C277S)

This variant was identified in 34 publications

View GRCh38 version.




Publications:


A small molecule reacts with the p53 somatic mutant Y220C to rescue wild-type thermal stability.

Cancer Discovery
Guiley, Keelan Z KZ; Shokat, Kevan M KM
Publication Date: 2022-10-05

Variant appearance in text: p53: C277S
PubMed Link: 36197521
Variant Present in the following documents:
  • Main text
  • 56.pdf
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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: C277S
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.

Nature Medicine
Sartore-Bianchi, Andrea A; Pietrantonio, Filippo F; Lonardi, Sara S; Mussolin, Benedetta B; Rua, Francesco F; Crisafulli, Giovanni G; Bartolini, Alice A; Fenocchio, Elisabetta E; Amatu, Alessio A; Manca, Paolo P; Bergamo, Francesca F; Tosi, Federica F; Mauri, Gianluca G; Ambrosini, Margherita M; Daniel, Francesca F; Torri, Valter V; Vanzulli, Angelo A; Regge, Daniele D; Cappello, Giovanni G; Marchiò, Caterina C; Berrino, Enrico E; Sapino, Anna A; Marsoni, Silvia S; Siena, Salvatore S; Bardelli, Alberto A
Publication Date: 2022-08

Variant appearance in text: TP53: C277S
PubMed Link: 35915157
Variant Present in the following documents:
  • 41591_2022_1886_MOESM1_ESM.pdf
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Landscape of somatic alterations in large-scale solid tumors from an Asian population.

Nature Communications
Wu, Liqun L; Yao, Herui H; Chen, Hui H; Wang, Aodi A; Guo, Kun K; Gou, Wenli W; Yu, Yanfei Y; Li, Xiang X; Yao, Ming M; Yuan, Shaohua S; Pang, Fei F; Hu, Jinwei J; Chen, Lijuan L; Liu, Wenjin W; Yao, Jicheng J; Zhang, Shuirong S; Dong, Xiaowei X; Wang, Weifeng W; Hu, Jing J; Ling, Qi Q; Ding, Songming S; Wei, Yan Y; Li, Qiang Q; Cao, Weichun W; Wang, Shuang S; Di, Yang Y; Feng, Feiling F; Zhao, Gang G; Zhang, Jian J; Huang, Ling L; Xu, Jia J; Yan, Wangjun W; Tong, Zhongsheng Z; Jiang, Da D; Ji, Tao T; Li, Qiao Q; Xu, Ling L; He, Huiying H; Shang, Liang L; Liu, Jin J; Wang, Kefeng K; Wu, Duoguang D; Shen, Jingnan J; Liu, Ye Y; Zhang, Ting T; Liang, Chaojie C; Wang, Yusheng Y; Shang, Yanhong Y; Guo, Jianji J; Liang, Guanbiao G; Xu, Shifeng S; Liu, Junfeng J; Wang, Kai K; Wang, Minghui M
Publication Date: 2022-07-23

Variant appearance in text: TP53: C277S
PubMed Link: 35871175
Variant Present in the following documents:
  • 41467_2022_31780_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Publication Date: 2022-07-13

Variant appearance in text: TP53: 830G>C
PubMed Link: 35831314
Variant Present in the following documents:
  • 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.

Science Advances
Lopez, Abraham A; Dahiya, Vinay V; Delhommel, Florent F; Freiburger, Lee L; Stehle, Ralf R; Asami, Sam S; Rutz, Daniel D; Blair, Laura L; Buchner, Johannes J; Sattler, Michael M
Publication Date: 2021-12-17

Variant appearance in text: p53: C277S
PubMed Link: 34919431
Variant Present in the following documents:
  • Main text
  • sciadv.abl7295.pdf
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Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.

Science Advances
Lopez, Abraham A; Dahiya, Vinay V; Delhommel, Florent F; Freiburger, Lee L; Stehle, Ralf R; Asami, Sam S; Rutz, Daniel D; Blair, Laura L; Buchner, Johannes J; Sattler, Michael M
Publication Date: 2021-12-17

Variant appearance in text: p53: C277S
PubMed Link: 34919431
Variant Present in the following documents:
  • Main text
  • sciadv.abl7295.pdf
View BVdb publication page



p53 Forms Redox-Dependent Protein-Protein Interactions through Cysteine 277.

Antioxidants (Basel, Switzerland)
Shi, Tao T; Polderman, Paulien E PE; Pagès-Gallego, Marc M; van Es, Robert M RM; Vos, Harmjan R HR; Burgering, Boudewijn M T BMT; Dansen, Tobias B TB
Publication Date: 2021-10-06

Variant appearance in text: p53: C277S
PubMed Link: 34679713
Variant Present in the following documents:
  • Main text
  • antioxidants-10-01578.pdf
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A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Sun, Xun X; Dyson, H Jane HJ; Wright, Peter E PE
Publication Date: 2021-01-05

Variant appearance in text: p53: C277S
PubMed Link: 33443163
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prevalence of germline TP53 variants among early-onset breast cancer patients from Polish population.

Breast Cancer (Tokyo, Japan)
Rogoża-Janiszewska, Emilia E; Malińska, Karolina K; Górski, Bohdan B; Scott, Rodney J RJ; Cybulski, Cezary C; Kluźniak, Wojciech W; Lener, Marcin M; Jakubowska, Anna A; Gronwald, Jacek J; Huzarski, Tomasz T; Lubiński, Jan J; Dębniak, Tadeusz T
Publication Date: 2021-01

Variant appearance in text: TP53: C277s
PubMed Link: 32888145
Variant Present in the following documents:
  • Main text
  • 12282_2020_Article_1151.pdf
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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: TP53: C277S
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target.

Molecular Carcinogenesis
Eckert, Richard L RL
Publication Date: 2019-06

Variant appearance in text: p53: C277S
PubMed Link: 30693974
Variant Present in the following documents:
  • Main text
View BVdb publication page



Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Krois, Alexander S AS; Dyson, H Jane HJ; Wright, Peter E PE
Publication Date: 2018-11-27

Variant appearance in text: p53: C277S
PubMed Link: 30420502
Variant Present in the following documents:
  • Main text
View BVdb publication page



Contribution of allelic imbalance to colorectal cancer.

Nature Communications
Palin, Kimmo K; Pitkänen, Esa E; Turunen, Mikko M; Sahu, Biswajyoti B; Pihlajamaa, Päivi P; Kivioja, Teemu T; Kaasinen, Eevi E; Välimäki, Niko N; Hänninen, Ulrika A UA; Cajuso, Tatiana T; Aavikko, Mervi M; Tuupanen, Sari S; Kilpivaara, Outi O; van den Berg, Linda L; Kondelin, Johanna J; Tanskanen, Tomas T; Katainen, Riku R; Grau, Marta M; Rauanheimo, Heli H; Plaketti, Roosa-Maria RM; Taira, Aurora A; Sulo, Päivi P; Hartonen, Tuomo T; Dave, Kashyap K; Schmierer, Bernhard B; Botla, Sandeep S; Sokolova, Maria M; Vähärautio, Anna A; Gladysz, Kornelia K; Ongen, Halit H; Dermitzakis, Emmanouil E; Bramsen, Jesper Bertram JB; Ørntoft, Torben Falck TF; Andersen, Claus Lindbjerg CL; Ristimäki, Ari A; Lepistö, Anna A; Renkonen-Sinisalo, Laura L; Mecklin, Jukka-Pekka JP; Taipale, Jussi J; Aaltonen, Lauri A LA
Publication Date: 2018-09-10

Variant appearance in text: TP53: C277S
PubMed Link: 30202008
Variant Present in the following documents:
  • 41467_2018_6132_MOESM11_ESM.xlsx, sheet 1
View BVdb publication page



Somatic mutations in early onset luminal breast cancer.

Oncotarget
Encinas, Giselly G; Sabelnykova, Veronica Y VY; de Lyra, Eduardo Carneiro EC; Hirata Katayama, Maria Lucia ML; Maistro, Simone S; de Vasconcellos Valle, Pedro Wilson Mompean PWM; de Lima Pereira, Gláucia Fernanda GF; Rodrigues, Lívia Munhoz LM; de Menezes Pacheco Serio, Pedro Adolpho PA; de Gouvêa, Ana Carolina Ribeiro Chaves ACRC; Geyer, Felipe Correa FC; Basso, Ricardo Alves RA; Pasini, Fátima Solange FS; Del Pilar Esteves Diz, Maria M; Brentani, Maria Mitzi MM; Guedes Sampaio Góes, João Carlos JC; Chammas, Roger R; Boutros, Paul C PC; Koike Folgueira, Maria Aparecida Azevedo MAA
Publication Date: 2018-04-27

Variant appearance in text: TP53: 830G>C
PubMed Link: 29854292
Variant Present in the following documents:
  • Main text
View BVdb publication page



The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.

The Journal Of Biological Chemistry
Madan, Esha E; Parker, Taylor M TM; Bauer, Matthias R MR; Dhiman, Alisha A; Pelham, Christopher J CJ; Nagane, Masaki M; Kuppusamy, M Lakshmi ML; Holmes, Matti M; Holmes, Thomas R TR; Shaik, Kranti K; Shee, Kevin K; Kiparoidze, Salome S; Smith, Sean D SD; Park, Yu-Soon A YA; Gomm, Jennifer J JJ; Jones, Louise J LJ; Tomás, Ana R AR; Cunha, Ana C AC; Selvendiran, Karuppaiyah K; Hansen, Laura A LA; Fersht, Alan R AR; Hideg, Kálmán K; Gogna, Rajan R; Kuppusamy, Periannan P
Publication Date: 2018-03-23

Variant appearance in text: p53: C277S
PubMed Link: 29382728
Variant Present in the following documents:
  • Main text
View BVdb publication page



New insight into transglutaminase 2 and link to neurodegenerative diseases.

Bmb Reports
Min, Boram B; Chung, Kwang Chul KC
Publication Date: 2018-01

Variant appearance in text: p53: C277S
PubMed Link: 29187283
Variant Present in the following documents:
  • Main text
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Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging.

Aging
Baldelli, Sara S; Ciriolo, Maria Rosa MR
Publication Date: 2016-12-20

Variant appearance in text: p53: C277S
PubMed Link: 28025407
Variant Present in the following documents:
  • Main text
  • aging-08-3450-s001.pdf
  • aging-08-3450.pdf
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2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Bauer, Matthias R MR; Joerger, Andreas C AC; Fersht, Alan R AR
Publication Date: 2016-09-06

Variant appearance in text: p53: C277S
PubMed Link: 27551077
Variant Present in the following documents:
  • Main text
View BVdb publication page



Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy.

Cell Death & Disease
Kang, J H JH; Lee, J-S JS; Hong, D D; Lee, S-H SH; Kim, N N; Lee, W-K WK; Sung, T-W TW; Gong, Y-D YD; Kim, S-Y SY
Publication Date: 2016-03-31

Variant appearance in text: p53: C277S
PubMed Link: 27031960
Variant Present in the following documents:
  • Main text
View BVdb publication page



DNA Charge Transport: from Chemical Principles to the Cell.

Cell Chemical Biology
Arnold, Anna R AR; Grodick, Michael A MA; Barton, Jacqueline K JK
Publication Date: 2016-01-21

Variant appearance in text: p53: C277S
PubMed Link: 26933744
Variant Present in the following documents:
  • Main text
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: TP53: C277S
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 1
View BVdb publication page



Oxidation of p53 through DNA charge transport involves a network of disulfides within the DNA-binding domain.

Biochemistry
Schaefer, Kathryn N KN; Geil, Wendy M WM; Sweredoski, Michael J MJ; Moradian, Annie A; Hess, Sonja S; Barton, Jacqueline K JK
Publication Date: 2015-01-27

Variant appearance in text: p53: C277S
PubMed Link: 25584637
Variant Present in the following documents:
  • Main text
  • bi501424v.pdf
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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: TP53: C277S
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Transglutaminase regulation of cell function.

Physiological Reviews
Eckert, Richard L RL; Kaartinen, Mari T MT; Nurminskaya, Maria M; Belkin, Alexey M AM; Colak, Gozde G; Johnson, Gail V W GV; Mehta, Kapil K
Publication Date: 2014-04

Variant appearance in text: p53: C277S
PubMed Link: 24692352
Variant Present in the following documents:
  • Main text
View BVdb publication page



Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1.

Plos One
Hsieh, Yu-Fan YF; Liu, Guang-Yaw GY; Lee, Yi-Ju YJ; Yang, Jiann-Jou JJ; Sándor, Katalin K; Sarang, Zsolt Z; Bononi, Angela A; Pinton, Paolo P; Tretter, László L; Szondy, Zsuzsa Z; Tsay, Gregory J GJ
Publication Date: 2013

Variant appearance in text: p53: C277S
PubMed Link: 24349085
Variant Present in the following documents:
  • pone.0081516.pdf
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Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation.

The Journal Of Biological Chemistry
Seong, Hyun-A HA; Ha, Hyunjung H
Publication Date: 2012-06-15

Variant appearance in text: p53: C277S
PubMed Link: 22532570
Variant Present in the following documents:
  • Main text
View BVdb publication page



Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins.

Cell Death And Differentiation
D'Eletto, M M; Farrace, M G MG; Rossin, F F; Strappazzon, F F; Giacomo, G Di GD; Cecconi, F F; Melino, G G; Sepe, S S; Moreno, S S; Fimia, G M GM; Falasca, L L; Nardacci, R R; Piacentini, M M
Publication Date: 2012-07

Variant appearance in text: p53: C277S
PubMed Link: 22322858
Variant Present in the following documents:
  • Main text
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Transglutaminase 2: a molecular Swiss army knife.

Biochimica Et Biophysica Acta
Gundemir, Soner S; Colak, Gozde G; Tucholski, Janusz J; Johnson, Gail V W GV
Publication Date: 2012-02

Variant appearance in text: p53: C277S
PubMed Link: 22015769
Variant Present in the following documents:
  • Main text
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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: TP53: C277S
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

Embo Molecular Medicine
McConoughey, Stephen J SJ; Basso, Manuela M; Niatsetskaya, Zoya V ZV; Sleiman, Sama F SF; Smirnova, Natalia A NA; Langley, Brett C BC; Mahishi, Lata L; Cooper, Arthur J L AJ; Antonyak, Marc A MA; Cerione, Rick A RA; Li, Bo B; Starkov, Anatoly A; Chaturvedi, Rajnish Kumar RK; Beal, M Flint MF; Coppola, Giovanni G; Geschwind, Daniel H DH; Ryu, Hoon H; Xia, Li L; Iismaa, Siiri E SE; Pallos, Judit J; Pasternack, Ralf R; Hils, Martin M; Fan, Jing J; Raymond, Lynn A LA; Marsh, J Lawrence JL; Thompson, Leslie M LM; Ratan, Rajiv R RR
Publication Date: 2010-09

Variant appearance in text: p53: C277S
PubMed Link: 20665636
Variant Present in the following documents:
  • Main text
  • emmm0002-0349.pdf
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Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast.

Biochemistry
Stoner, Christopher S CS; Pearson, George D GD; Koç, Ahmet A; Merwin, Jason R JR; Lopez, Nathan I NI; Merrill, Gary F GF
Publication Date: 2009-09-29

Variant appearance in text: p53: C277S
PubMed Link: 19681600
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical and biological significance of tissue transglutaminase in ovarian carcinoma.

Cancer Research
Hwang, Jee Young JY; Mangala, Lingegowda S LS; Fok, Jansina Y JY; Lin, Yvonne G YG; Merritt, William M WM; Spannuth, Whitney A WA; Nick, Alpa M AM; Fiterman, Derek J DJ; Vivas-Mejia, Pablo E PE; Deavers, Michael T MT; Coleman, Robert L RL; Lopez-Berestein, Gabriel G; Mehta, Kapil K; Sood, Anil K AK
Publication Date: 2008-07-15

Variant appearance in text: p53: C277S
PubMed Link: 18632639
Variant Present in the following documents:
  • Main text
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Transglutaminase 2 inhibits Rb binding of human papillomavirus E7 by incorporating polyamine.

The Embo Journal
Jeon, Ju-Hong JH; Choi, Kyung-Ho KH; Cho, Sung-Yup SY; Kim, Chai-Wan CW; Shin, Dong-Myung DM; Kwon, Joon-Cheol JC; Song, Kye-Yong KY; Park, Sang-Chul SC; Kim, In-Gyu IG
Publication Date: 2003-10-01

Variant appearance in text: p53: C277S
PubMed Link: 14517264
Variant Present in the following documents:
  • Main text
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Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277.

Nucleic Acids Research
Buzek, Jiri J; Latonen, Leena L; Kurki, Sari S; Peltonen, Karita K; Laiho, Marikki M
Publication Date: 2002-06-01

Variant appearance in text: p53: C277S
PubMed Link: 12034820
Variant Present in the following documents:
  • Main text
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