Publications:

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Olaparib and Pembrolizumab Treatment for BRCA1-Mutated and PD-L1-Positive Intrahepatic Cholangiocarcinoma Recurrence and Metastasis: A Case Report.

Oncotargets And Therapy

F Xiong, J Gong, Q Wang

Publication Date: 2020

Variant appearance in text: TP53: R273H

PMID: 32753881

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Molecular Biology of Osteosarcoma.

Cancers

AM Czarnecka, K Synoradzki, W Firlej, E Bartnik, P Sobczuk, M Fiedorowicz, P Grieb, P Rutkowski

Publication Date: 2020-07-31

Variant appearance in text: p53: R273H

PMID: 32751922

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TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.

Experimental And Therapeutic Medicine

H Yang, Y Chen, Y Jiang, D Wang, J Yan, Z Zhou

Publication Date: 2020-08

Variant appearance in text: TP53: R273H

PMID: 32742376

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TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection.

Ebiomedicine

A Klinakis, T Rampias

Publication Date: 2020-07-30

Variant appearance in text: TP53: R273H

PMID: 32739866

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

J Li, W Jiang, J Wei, J Zhang, L Cai, M Luo, Z Wang, W Sun, S Wang, C Wang, C Dai, J Liu, G Wang, J Wang, Q Xu, Y Deng

Publication Date: 2020-08-01

Variant appearance in text: TP53: R273H

PMID: 32738923

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Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.

Cell Death & Disease

S Sun, H Chen, L Sun, M Wang, X Wu, ZJ Xiao

Publication Date: 2020-07-30

Variant appearance in text: p53: R273H

PMID: 32733026

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Limited Practical Utility of Liquid Biopsy in the Treated Patients with Advanced Breast Cancer.

Diagnostics (Basel, Switzerland)

A Niwinska, A Bałabas, M Kulecka, A Kluska, M Piątkowska, A Paziewska, K Pyśniak, W Olszewski, M Mikula, J Ostrowski

Publication Date: 2020-07-28

Variant appearance in text: TP53: Arg273His

PMID: 32731384

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Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Cancers

YC Wang, JL Huang, KW Lee, HH Lu, YJ Lin, LF Chen, CS Wang, YC Cheng, ZT Zeng, PY Chu, CS Lin

Publication Date: 2020-07-25

Variant appearance in text: p53: R273H

PMID: 32722430

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Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer.

Cancers

L Seeneevassen, J Giraud, S Molina-Castro, E Sifré, C Tiffon, C Beauvoit, C Staedel, F Mégraud, P Lehours, OCB Martin, H Boeuf, P Dubus, C Varon

Publication Date: 2020-07-22

Variant appearance in text: TP53: 818G>A; Arg273His

PMID: 32707998

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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery

L Shan, J Yu, Z He, S Chen, M Liu, H Ding, L Xu, J Zhao, A Yang, H Jiang

Publication Date: 2020

Variant appearance in text: p53: R273H

PMID: 32704382

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Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma.

Scientific Reports

GG Jinesh, M Napoli, HD Ackerman, PM Raulji, N Montey, ER Flores, AS Brohl

Publication Date: 2020-07-23

Variant appearance in text: p53: R273H

PMID: 32704163

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Gene expression profiling of glioblastoma cell lines depending on TP53 status after tumor-treating fields (TTFields) treatment.

Scientific Reports

YJ Lee, HW Seo, JH Baek, SH Lim, SG Hwang, EH Kim

Publication Date: 2020-07-23

Variant appearance in text: TP53: R273H; rs28934576

PMID: 32704022

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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports

Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura

Publication Date: 2020-07-23

Variant appearance in text: TP53: R273H

PMID: 32704002

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ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage.

Cell Death & Disease

H Patel, MS Sheikh, Y Huang

Publication Date: 2020-07-17

Variant appearance in text: p53: R273H

PMID: 32681017

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MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia.

Scientific Reports

CH Yu, TK Lin, ST Jou, CY Lin, KH Lin, MY Lu, SH Chen, CN Cheng, KH Wu, SC Wang, HH Chang, MJ Li, YL Ni, YN Su, DT Lin, HY Chen, CJ Harrison, CC Hung, SW Lin, YL Yang

Publication Date: 2020-07-13

Variant appearance in text: TP53: R273H

PMID: 32661308

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The Janus Face of p53-Targeting Ubiquitin Ligases.

Cells

Q Hao, Y Chen, X Zhou

Publication Date: 2020-07-09

Variant appearance in text: p53: R273H

PMID: 32660118

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Molecular Features of Metaplastic Breast Carcinoma: An Infrequent Subtype of Triple Negative Breast Carcinoma.

Cancers

S González-Martínez, B Pérez-Mies, I Carretero-Barrio, ML Palacios-Berraquero, J Perez-García, J Cortés, J Palacios

Publication Date: 2020-07-08

Variant appearance in text: TP53: R273H

PMID: 32650408

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Genetics of human malignant peripheral nerve sheath tumors.

Neuro-Oncology Advances

A Pemov, H Li, W Presley, MR Wallace, DT Miller

Publication Date: 2020-07

Variant appearance in text: TP53: 818G>A

PMID: 32642732

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Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy.

Breast Cancer Research And Treatment

K Li, N Liao, B Chen, G Zhang, Y Wang, L Guo, G Wei, M Jia, L Wen, C Ren, L Cao, H Mok, C Li, J Lin, X Chen, Z Zhang, T Hou, M Li, J Liu, CM Balch, N Liao

Publication Date: 2020-07-07

Variant appearance in text: TP53: R273H

PMID: 32638235

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Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis.

Cancers

A Ianevski, E Kulesskiy, K Krpina, G Lou, Y Aman, A Bugai, K Aasumets, Y Akimov, D Bulanova, K Gildemann, AF Arutyunyan, OY Susova, AL Zhuze, P Ji, W Wang, T Holien, M Bugge, E Zusinaite, V Oksenych, H Lysvand, JM Gerhold, M Bjørås, P Johansen, A Waage, CA Heckman, EF Fang, DE Kainov

Publication Date: 2020-06-25

Variant appearance in text: TP53: R273H

PMID: 32630560

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Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.

Bmc Cancer

J Ruhnau, J Parczyk, K Danker, B Eickholt, A Klein

Publication Date: 2020-07-02

Variant appearance in text: p53: R273H

PMID: 32615946

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Uterine fibroids may play a protecting role against endometrial carcinoma in Chinese women with gynecological diseases.

Bioscience Reports

Q Li, L Xia, Y Dong, Y Cheng, H Cao

Publication Date: 2020-07-01

Variant appearance in text: rs28934576

PMID: 32608475

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Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction.

Frontiers In Pharmacology

F Wang, F Mayca Pozo, D Tian, X Geng, X Yao, Y Zhang, J Tang

Publication Date: 2020

Variant appearance in text: TP53: 818G>A; R273H

PMID: 32581812

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Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.

Signal Transduction And Targeted Therapy

RD Cervantes-Villagrana, D Albores-García, AR Cervantes-Villagrana, SJ García-Acevez

Publication Date: 2020-06-18

Variant appearance in text: p53: R273H

PMID: 32555170

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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)

G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar

Publication Date: 2020-06-17

Variant appearance in text: TP53: R273H

PMID: 32552660

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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics

V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones

Publication Date: 2020

Variant appearance in text: p53: R273H

PMID: 32546937

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Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling.

Mbio

S Sharma, K Munger

Publication Date: 2020-06-16

Variant appearance in text: TP53: R273H

PMID: 32546626

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The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells.

Biomolecules

G Butera, J Brandi, C Cavallini, A Scarpa, RT Lawlor, MT Scupoli, E Marengo, D Cecconi, M Manfredi, M Donadelli

Publication Date: 2020-06-09

Variant appearance in text: p53: R273H

PMID: 32526853

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Mutant p53 as an Antigen in Cancer Immunotherapy.

International Journal Of Molecular Sciences

N Sobhani, A D'Angelo, X Wang, KH Young, D Generali, Y Li

Publication Date: 2020-06-08

Variant appearance in text: p53: 818G>A

PMID: 32521648

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Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer.

Cancers

A Sellitto, Y D'Agostino, E Alexandrova, J Lamberti, G Pecoraro, D Memoli, D Rocco, E Coviello, G Giurato, G Nassa, R Tarallo, A Weisz, F Rizzo

Publication Date: 2020-06-05

Variant appearance in text: p53: R273H

PMID: 32516978

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Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment.

Molecules (Basel, Switzerland)

M Zoetemelk, GM Ramzy, M Rausch, P Nowak-Sliwinska

Publication Date: 2020-06-04

Variant appearance in text: TP53: R273H

PMID: 32512790

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Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review.

American Journal Of Translational Research

R Li, P Li, W Xing, H Qiu

Publication Date: 2020

Variant appearance in text: TP53: R273H

PMID: 32509161

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Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells.

Oncogenesis

M Kang, KY Chong, TMP Hartwich, F Bi, AK Witham, D Patrick, MJ Morrisson, SL Cady, AP Cerchia, D Kelk, Y Liu, J Nucci, O Madarikan, D Ueno, BM Shuch, Y Yang-Hartwich

Publication Date: 2020-05-29

Variant appearance in text: p53: R273H

PMID: 32471985

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CDK12-Altered Prostate Cancer: Clinical Features and Therapeutic Outcomes to Standard Systemic Therapies, Poly (ADP-Ribose) Polymerase Inhibitors, and PD-1 Inhibitors.

Jco Precision Oncology

ES Antonarakis, P Isaacsson Velho, W Fu, H Wang, N Agarwal, V Sacristan Santos, BL Maughan, R Pili, N Adra, CN Sternberg, PJ Vlachostergios, ST Tagawa, AH Bryce, AL McNatty, ZR Reichert, R Dreicer, O Sartor, TL Lotan, M Hussain

Publication Date: 2020

Variant appearance in text: TP53: R273H

PMID: 32462107

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Astaxanthin Modulates Apoptotic Molecules to Induce Death of SKBR3 Breast Cancer Cells.

Marine Drugs

MS Kim, YT Ahn, CW Lee, H Kim, WG An

Publication Date: 2020-05-19

Variant appearance in text: p53: R273H

PMID: 32438569

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Clinical spectrum and prognostic value of TP53 mutations in circulating tumor DNA from breast cancer patients in China.

Cancer Communications (London, England)

Z Yi, F Ma, G Rong, Y Guan, C Li, B Xu

Publication Date: 2020-05-21

Variant appearance in text: TP53: R273H

PMID: 32436611

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Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer.

Journal Of Hematology & Oncology

Q Wang, W Geng, H Guo, Z Wang, K Xu, C Chen, S Wang

Publication Date: 2020-05-19

Variant appearance in text: p53: R273H

PMID: 32429972

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Proteomic Characterization of Colorectal Cancer Cells versus Normal-Derived Colon Mucosa Cells: Approaching Identification of Novel Diagnostic Protein Biomarkers in Colorectal Cancer.

International Journal Of Molecular Sciences

M Ludvigsen, L Thorlacius-Ussing, H Vorum, MP Moyer, MT Stender, O Thorlacius-Ussing, B Honoré

Publication Date: 2020-05-14

Variant appearance in text: TP53: R273H

PMID: 32422974

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P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

International Journal Of Molecular Sciences

AD Agupitan, P Neeson, S Williams, J Howitt, S Haupt, Y Haupt

Publication Date: 2020-05-13

Variant appearance in text: p53: R273H

PMID: 32414156

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Comparison of Circulating Cell-Free DNA Extraction Methods for Downstream Analysis in Cancer Patients.

Cancers

PV Leest, PA Boonstra, AT Elst, LCV Kempen, M Tibbesma, J Koopmans, A Miedema, M Tamminga, HJM Groen, AKL Reyners, E Schuuring

Publication Date: 2020-05-13

Variant appearance in text: TP53: R273H

PMID: 32414097

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TP53 in Myelodysplastic Syndromes: Recent Biological and Clinical Findings.

International Journal Of Molecular Sciences

C Cumbo, G Tota, L Anelli, A Zagaria, G Specchia, F Albano

Publication Date: 2020-05-13

Variant appearance in text: p53: R273H

PMID: 32414002

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Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA.

Thoracic Cancer

X Li, X Chen, L Wen, Y Wang, B Chen, Y Xue, L Guo, N Liao

Publication Date: 2020-05-15

Variant appearance in text: TP53: R273H

PMID: 32412177

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Pharmacogenomic Testing to Guide Personalized Cancer Medicine Decisions in Private Oncology Practice: A Case Study.

Frontiers In Oncology

G Astras, CI Papagiannopoulos, KA Kyritsis, C Markitani, IS Vizirianakis

Publication Date: 2020

Variant appearance in text: TP53: 818G>A

PMID: 32411592

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Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M.

The Korean Journal Of Physiology & Pharmacology : Official Journal Of The Korean Physiological Society And The Korean Society Of Pharmacology

J Lim, JH Choi, EM Park, YH Choi

Publication Date: 2020-05-01

Variant appearance in text: p53: R273H

PMID: 32395071

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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.

Nature Communications

LR Kong, RW Ong, TZ Tan, NAB Mohamed Salleh, M Thangavelu, JV Chan, LYJ Koh, G Periyasamy, JA Lau, TBU Le, L Wang, M Lee, S Kannan, CS Verma, CM Lim, WJ Chng, DP Lane, A Venkitaraman, HT Hung, CF Cheok, BC Goh

Publication Date: 2020-04-29

Variant appearance in text: p53: R273H

PMID: 32350249

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CAR T-cell therapy for a relapsed/refractory acute B-cell lymphoblastic lymphoma patient in the context of Li-Fraumeni syndrome.

Journal For Immunotherapy Of Cancer

L Chen, B Xu, X Long, J Gu, Y Lou, D Wang, Y Cao, N Wang, C Li, G Wang, Y Wang, L Zhu, J Wang, H An, M Xiao, Y Xiao, J Zhou

Publication Date: 2020-04

Variant appearance in text: TP53: 818G>A; R273H

PMID: 32345625

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Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins.

Cell Death & Disease

K Tutuska, L Parrilla-Monge, E Di Cesare, A Nemajerova, UM Moll

Publication Date: 2020-04-24

Variant appearance in text: p53: R273H

PMID: 32332697

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Recent Synthetic Approaches towards Small Molecule Reactivators of p53.

Biomolecules

JL Silva, CGS Lima, LP Rangel, GDS Ferretti, FP Pauli, RCB Ribeiro, TB da Silva, FC da Silva, VF Ferreira

Publication Date: 2020-04-20

Variant appearance in text: p53: R273H

PMID: 32326087

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Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer.

Geburtshilfe Und Frauenheilkunde

B Wappenschmidt, J Hauke, U Faust, D Niederacher, L Wiesmüller, G Schmidt, E Groß, A Gehrig, C Sutter, J Ramser, A Rump, N Arnold, A Meindl

Publication Date: 2020-04

Variant appearance in text: p53: Arg273His

PMID: 32322110

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The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.

Plos Genetics

BA Setty, GG Jinesh, M Arnold, F Pettersson, CH Cheng, L Cen, SJ Yoder, JK Teer, ER Flores, DR Reed, AS Brohl

Publication Date: 2020-04-20

Variant appearance in text: TP53: R273H

PMID: 32310940

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Establishment and characterization of patient-derived xenografts as paraclinical models for head and neck cancer.

Bmc Cancer

HN Kang, JH Kim, AY Park, JW Choi, SM Lim, J Kim, EJ Shin, MH Hong, KH Pyo, MR Yun, DH Kim, H Lee, SO Yoon, DH Kim, YM Park, HK Byeon, I Jung, S Paik, YW Koh, BC Cho, HR Kim

Publication Date: 2020-04-15

Variant appearance in text: TP53: R273H

PMID: 32293356

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Secondary Metabolites from the Culture of the Marine-derived Fungus Paradendryphiella salina PC 362H and Evaluation of the Anticancer Activity of Its Metabolite Hyalodendrin.

Marine Drugs

A Dezaire, CH Marchand, M Vallet, N Ferrand, S Chaouch, E Mouray, AK Larsen, M Sabbah, SD Lemaire, S Prado, AE Escargueil

Publication Date: 2020-04-03

Variant appearance in text: TP53: R273H

PMID: 32260204

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Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells

G Laetitia, S Sven, J Fabrice

Publication Date: 2020-03-30

Variant appearance in text: TP53: 818G>A

PMID: 32235612

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Context is everything: extrinsic signalling and gain-of-function p53 mutants.

Cell Death Discovery

I Amelio, G Melino

Publication Date: 2020

Variant appearance in text: p53: R273H

PMID: 32218993

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Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma.

Plos One

G Wang, M Wu, AC Durham, E Radaelli, NJ Mason, X Xu, DB Roth

Publication Date: 2020

Variant appearance in text: TP53: R273H

PMID: 32210430

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YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.

Science Advances

H Omori, M Nishio, M Masuda, Y Miyachi, F Ueda, T Nakano, K Sato, K Mimori, K Taguchi, H Hikasa, H Nishina, H Tashiro, T Kiyono, TW Mak, K Nakao, T Nakagawa, T Maehama, A Suzuki

Publication Date: 2020-03

Variant appearance in text: TP53: R273H

PMID: 32206709

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Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets.

Journal Of Cancer

A De, A De, R Sharma, W Suo, M Sharma

Publication Date: 2020

Variant appearance in text: TP53: R273H

PMID: 32194804

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A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes.

Cancers

K Larson, R Kannaiyan, R Pandey, Y Chen, HM Babiker, D Mahadevan

Publication Date: 2020-03-16

Variant appearance in text: TP53: R273H

PMID: 32188081

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Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV.

Diagnostic Pathology

X Catteau, N D'haene, JC Noël

Publication Date: 2020-03-14

Variant appearance in text: p53: R273H

PMID: 32169099

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Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing.

Bmc Cancer

H Zhang, H Wang, X Qian, S Gao, J Xia, J Liu, Y Cheng, J Man, X Zhai

Publication Date: 2020-03-12

Variant appearance in text: TP53: R273H

PMID: 32164600

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Ras pathway mutation feature in the same individuals at diagnosis and relapse of childhood acute lymphoblastic leukemia.

Translational Pediatrics

HH Zhang, HS Wang, XW Qian, XH Zhu, H Miao, Y Yu, JH Meng, J Le, JY Jiang, P Cao, WJ Jiang, P Wang, Y Fu, J Li, MX Qian, XW Zhai

Publication Date: 2020-02

Variant appearance in text: TP53: R273H

PMID: 32154130

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Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation.

Biomolecules

A Garufi, G Federici, MS Gilardini Montani, A Crispini, M Cirone, G D'Orazi

Publication Date: 2020-03-03

Variant appearance in text: p53: R273H

PMID: 32138264

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Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells.

Biomolecules

M Cordani, G Butera, R Pacchiana, F Masetto, N Mullappilly, C Riganti, M Donadelli

Publication Date: 2020-02-26

Variant appearance in text: p53: R273H

PMID: 32111081

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Phase I studies of vorinostat with ixazomib or pazopanib imply a role of antiangiogenesis-based therapy for TP53 mutant malignancies.

Scientific Reports

Y Wang, F Janku, S Piha-Paul, K Hess, R Broaddus, L Liu, N Shi, M Overman, S Kopetz, V Subbiah, A Naing, D Hong, AM Tsimberidou, D Karp, J Yao, S Fu

Publication Date: 2020-02-20

Variant appearance in text: TP53: R273H

PMID: 32080210

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Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis.

International Journal Of Molecular Sciences

KA Roszkowska, S Gizinski, M Sady, Z Gajewski, MB Olszewski

Publication Date: 2020-02-17

Variant appearance in text: p53: R273H

PMID: 32079237

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p53's Extended Reach: The Mutant p53 Secretome.

Biomolecules

E Pavlakis, T Stiewe

Publication Date: 2020-02-15

Variant appearance in text: p53: R273H

PMID: 32075247

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Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53.

Biomolecules

SN Loh

Publication Date: 2020-02-14

Variant appearance in text: p53: R273H

PMID: 32075132

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Genetic Variants Detected Using Cell-Free DNA from Blood and Tumor Samples in Patients with Inflammatory Breast Cancer.

International Journal Of Molecular Sciences

JS Winn, Z Hasse, M Slifker, J Pei, SM Arisi-Fernandez, JN Talarchek, E Obeid, DA Baldwin, Y Gong, E Ross, M Cristofanilli, RK Alpaugh, SV Fernandez

Publication Date: 2020-02-14

Variant appearance in text: TP53: 818G>A; R273H

PMID: 32075053

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BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors.

Bmc Cancer

E Miele, L Abballe, GP Spinelli, ZM Besharat, G Catanzaro, M Chiacchiarini, A Vacca, A Po, C Capalbo, E Ferretti

Publication Date: 2020-02-17

Variant appearance in text: TP53: R273H

PMID: 32066410

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Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status.

Applied Surface Science

A Padmanabhan, M Kaushik, R Niranjan, JS Richards, B Ebright, GD Venkatasubbu

Publication Date: 2019-09

Variant appearance in text: p53: R273H

PMID: 32042215

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Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population.

Bmc Medical Genomics

S da Costa E Silva Carvalho, NM Cury, DB Brotto, LF de Araujo, RCA Rosa, LA Texeira, JR Plaça, AA Marques, KC Peronni, PC Ruy, GA Molfetta, JC Moriguti, DM Carraro, EI Palmero, P Ashton-Prolla, VE de Faria Ferraz, WA Silva

Publication Date: 2020-02-10

Variant appearance in text: TP53: Arg273His; rs28934576

PMID: 32039725

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SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.

Nucleic Acids Research

CL Xu, B Sang, GZ Liu, JM Li, XD Zhang, LX Liu, RF Thorne, M Wu

Publication Date: 2020-02-07

Variant appearance in text: p53: R273H

PMID: 32030426

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Identifying multi-hit carcinogenic gene combinations: Scaling up a weighted set cover algorithm using compressed binary matrix representation on a GPU.

Scientific Reports

Q Al Hajri, S Dash, WC Feng, HR Garner, R Anandakrishnan

Publication Date: 2020-02-06

Variant appearance in text: TP53: R273H

PMID: 32029803

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Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes.

Blood Advances

G Montalban-Bravo, R Kanagal-Shamanna, CB Benton, CA Class, KS Chien, K Sasaki, K Naqvi, Y Alvarado, TM Kadia, F Ravandi, N Daver, K Takahashi, E Jabbour, G Borthakur, N Pemmaraju, M Konopleva, KA Soltysiak, SR Pierce, CE Bueso-Ramos, KP Patel, H Kantarjian, G Garcia-Manero

Publication Date: 2020-02-11

Variant appearance in text: TP53: R273H

PMID: 32027746

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The PI3K/mTOR dual inhibitor NVP-BEZ235 stimulates mutant p53 degradation to exhibit anti-tumor effect on triple-negative breast cancer cells.

Febs Open Bio

J Cai, J Xia, J Zou, Q Wang, Q Ma, R Sun, H Liao, L Xu, D Wang, X Guo

Publication Date: 2020-02-06

Variant appearance in text: p53: R273H

PMID: 32027103

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Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.

The Embo Journal

K Hoffmann, H Berger, H Kulbe, S Thillainadarasan, HJ Mollenkopf, T Zemojtel, E Taube, S Darb-Esfahani, M Mangler, J Sehouli, R Chekerov, EI Braicu, TF Meyer, M Kessler

Publication Date: 2020-02-03

Variant appearance in text: p53: R273H

PMID: 32009247

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Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

P Malekzadeh, R Yossef, G Cafri, BC Paria, FJ Lowery, M Jafferji, ML Good, A Sachs, AR Copeland, SP Kim, S Kivitz, MR Parkhurst, PF Robbins, S Ray, L Xi, M Raffeld, Z Yu, NP Restifo, RPT Somerville, SA Rosenberg, DC Deniger

Publication Date: 2020-01-29

Variant appearance in text: p53: R273H

PMID: 31996390

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Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma.

Cells

E Flynt, K Bisht, V Sridharan, M Ortiz, F Towfic, A Thakurta

Publication Date: 2020-01-24

Variant appearance in text: TP53: R273H

PMID: 31991614

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Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers.

Iscience

MM Pedrote, MF Motta, GDS Ferretti, DR Norberto, TCLS Spohr, FRS Lima, E Gratton, JL Silva, GAP de Oliveira

Publication Date: 2020-01-08

Variant appearance in text: p53: R273H

PMID: 31981923

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Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression.

Biomed Research International

Y Yang, J He, J Chen, L Lin, Y Liu, C Zhou, Y Su, H Wei

Publication Date: 2019

Variant appearance in text: TP53: R273H

PMID: 31976328

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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53.

Cell Reports

JG Kang, CU Lago, JE Lee, JH Park, MP Donnelly, MF Starost, C Liu, J Kwon, AC Noguchi, K Ge, PY Wang, PM Hwang

Publication Date: 2020-01-21

Variant appearance in text: TP53: R273H

PMID: 31968253

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N6-Methyladenosine: A Potential Breakthrough for Human Cancer.

Molecular Therapy. Nucleic Acids

L Liu, Y Wang, J Wu, J Liu, Z Qin, H Fan

Publication Date: 2019-12-20

Variant appearance in text: p53: R273H

PMID: 31958696

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The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas.

Cancers

B Segura-Collar, R Gargini, E Tovar-Ambel, E Hernández-SanMiguel, C Epifano, I Pérez de Castro, A Hernández-Laín, S Casas-Tintó, P Sánchez-Gómez

Publication Date: 2020-01-14

Variant appearance in text: p53: R273H

PMID: 31947645

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Molecular Classification of Gastric Cancer among Alaska Native People.

Cancers

HA Martinson, D Mallari, C Richter, TT Wu, J Tiesinga, SR Alberts, MJ Olnes

Publication Date: 2020-01-13

Variant appearance in text: TP53: R273H

PMID: 31941061

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Exosomes for Diagnosis and Therapy in Gastrointestinal Cancers.

International Journal Of Molecular Sciences

MP Scavo, N Depalo, V Tutino, V De Nunzio, C Ingrosso, F Rizzi, M Notarnicola, ML Curri, G Giannelli

Publication Date: 2020-01-06

Variant appearance in text: p53: R273H

PMID: 31935918

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MiR-3196, a p53-responsive microRNA, functions as a tumor suppressor in hepatocellular carcinoma by targeting FOXP4.

American Journal Of Cancer Research

W Qi, C Gao, L Zhang, Z Gao, J Sui, C Han, D Sun

Publication Date: 2019

Variant appearance in text: p53: R273H

PMID: 31911853

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Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.

Npj Breast Cancer

LR Bollu, J Shepherd, D Zhao, Y Ma, W Tahaney, C Speers, A Mazumdar, GB Mills, PH Brown

Publication Date: 2020

Variant appearance in text: p53: R273H

PMID: 31909186

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MicroRNA-769-3p inhibits tumor progression in glioma by suppressing ZEB2 and inhibiting the Wnt/β-catenin signaling pathway.

Oncology Letters

K Wang, S Yang, Y Gao, C Zhang, Q Sui

Publication Date: 2020-01

Variant appearance in text: p53: R273H

PMID: 31897212

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Inter-laboratory proficiency testing scheme for tumour next-generation sequencing in Ontario: a pilot study.

Current Oncology (Toronto, Ont.)

T Spence, N Stickle, C Yu, H Chow, H Feilotter, B Lo, E McCready, B Sadikovic, LL Siu, PL Bedard, TL Stockley

Publication Date: 2019-12

Variant appearance in text: TP53: 818G>A; R273H

PMID: 31896942

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000269305.4	c.818G>A	p.Arg273His	missense_variant	8/11	-
ENST00000359597.4	c.818G>A	p.Arg273His	missense_variant	7/9	-
ENST00000413465.2	c.782+379G>A	-	intron_variant	-	6/6
ENST00000420246.2	c.818G>A	p.Arg273His	missense_variant	8/12	-
ENST00000445888.2	c.818G>A	p.Arg273His	missense_variant	8/11	-
ENST00000455263.2	c.818G>A	p.Arg273His	missense_variant	8/12	-
ENST00000504290.1	n.700G>A	-	non_coding_transcript_exon_variant	4/8	-
ENST00000504937.1	n.700G>A	-	non_coding_transcript_exon_variant	4/7	-
ENST00000509690.1	c.422G>A	p.Arg141His	missense_variant	5/6	-
ENST00000510385.1	n.700G>A	-	non_coding_transcript_exon_variant	4/8	-
NM_000546.5	c.818G>A	p.Arg273His	missense_variant	8/11	-
NM_001126112.2	c.818G>A	p.Arg273His	missense_variant	8/11	-
NM_001126113.2	c.818G>A	p.Arg273His	missense_variant	8/12	-
NM_001126114.2	c.818G>A	p.Arg273His	missense_variant	8/12	-
NM_001126115.1	c.422G>A	p.Arg141His	missense_variant	4/7	-
NM_001126116.1	c.422G>A	p.Arg141His	missense_variant	4/8	-
NM_001126117.1	c.422G>A	p.Arg141His	missense_variant	4/8	-
NM_001126118.1	c.701G>A	p.Arg234His	missense_variant	7/10	-
NM_001276695.2	c.701G>A	p.Arg234His	missense_variant	8/12	-
NM_001276696.2	c.701G>A	p.Arg234His	missense_variant	8/12	-
NM_001276697.2	c.341G>A	p.Arg114His	missense_variant	4/7	-
NM_001276698.2	c.341G>A	p.Arg114His	missense_variant	4/8	-
NM_001276699.2	c.341G>A	p.Arg114His	missense_variant	4/8	-
NM_001276760.2	c.701G>A	p.Arg234His	missense_variant	8/11	-
NM_001276761.2	c.701G>A	p.Arg234His	missense_variant	8/11	-