Variant ID: 17-7577120-C-T

NM_000546.5(TP53):c.818G>A;(p.Arg273His)

This variant was identified in 1266 publications




Publications:


Olaparib and Pembrolizumab Treatment for BRCA1-Mutated and PD-L1-Positive Intrahepatic Cholangiocarcinoma Recurrence and Metastasis: A Case Report.

Oncotargets And Therapy
F Xiong, J Gong, Q Wang
Publication Date: 2020

Variant appearance in text: TP53: R273H
PMID: 32753881
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Molecular Biology of Osteosarcoma.

Cancers
AM Czarnecka, K Synoradzki, W Firlej, E Bartnik, P Sobczuk, M Fiedorowicz, P Grieb, P Rutkowski
Publication Date: 2020-07-31

Variant appearance in text: p53: R273H
PMID: 32751922
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TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.

Experimental And Therapeutic Medicine
H Yang, Y Chen, Y Jiang, D Wang, J Yan, Z Zhou
Publication Date: 2020-08

Variant appearance in text: TP53: R273H
PMID: 32742376
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TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection.

Ebiomedicine
A Klinakis, T Rampias
Publication Date: 2020-07-30

Variant appearance in text: TP53: R273H
PMID: 32739866
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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
J Li, W Jiang, J Wei, J Zhang, L Cai, M Luo, Z Wang, W Sun, S Wang, C Wang, C Dai, J Liu, G Wang, J Wang, Q Xu, Y Deng
Publication Date: 2020-08-01

Variant appearance in text: TP53: R273H
PMID: 32738923
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Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.

Cell Death & Disease
S Sun, H Chen, L Sun, M Wang, X Wu, ZJ Xiao
Publication Date: 2020-07-30

Variant appearance in text: p53: R273H
PMID: 32733026
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Limited Practical Utility of Liquid Biopsy in the Treated Patients with Advanced Breast Cancer.

Diagnostics (Basel, Switzerland)
A Niwinska, A Bałabas, M Kulecka, A Kluska, M Piątkowska, A Paziewska, K Pyśniak, W Olszewski, M Mikula, J Ostrowski
Publication Date: 2020-07-28

Variant appearance in text: TP53: Arg273His
PMID: 32731384
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Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Cancers
YC Wang, JL Huang, KW Lee, HH Lu, YJ Lin, LF Chen, CS Wang, YC Cheng, ZT Zeng, PY Chu, CS Lin
Publication Date: 2020-07-25

Variant appearance in text: p53: R273H
PMID: 32722430
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Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer.

Cancers
L Seeneevassen, J Giraud, S Molina-Castro, E Sifré, C Tiffon, C Beauvoit, C Staedel, F Mégraud, P Lehours, OCB Martin, H Boeuf, P Dubus, C Varon
Publication Date: 2020-07-22

Variant appearance in text: TP53: 818G>A; Arg273His
PMID: 32707998
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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery
L Shan, J Yu, Z He, S Chen, M Liu, H Ding, L Xu, J Zhao, A Yang, H Jiang
Publication Date: 2020

Variant appearance in text: p53: R273H
PMID: 32704382
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Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma.

Scientific Reports
GG Jinesh, M Napoli, HD Ackerman, PM Raulji, N Montey, ER Flores, AS Brohl
Publication Date: 2020-07-23

Variant appearance in text: p53: R273H
PMID: 32704163
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Gene expression profiling of glioblastoma cell lines depending on TP53 status after tumor-treating fields (TTFields) treatment.

Scientific Reports
YJ Lee, HW Seo, JH Baek, SH Lim, SG Hwang, EH Kim
Publication Date: 2020-07-23

Variant appearance in text: TP53: R273H; rs28934576
PMID: 32704022
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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports
Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura
Publication Date: 2020-07-23

Variant appearance in text: TP53: R273H
PMID: 32704002
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ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage.

Cell Death & Disease
H Patel, MS Sheikh, Y Huang
Publication Date: 2020-07-17

Variant appearance in text: p53: R273H
PMID: 32681017
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MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia.

Scientific Reports
CH Yu, TK Lin, ST Jou, CY Lin, KH Lin, MY Lu, SH Chen, CN Cheng, KH Wu, SC Wang, HH Chang, MJ Li, YL Ni, YN Su, DT Lin, HY Chen, CJ Harrison, CC Hung, SW Lin, YL Yang
Publication Date: 2020-07-13

Variant appearance in text: TP53: R273H
PMID: 32661308
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The Janus Face of p53-Targeting Ubiquitin Ligases.

Cells
Q Hao, Y Chen, X Zhou
Publication Date: 2020-07-09

Variant appearance in text: p53: R273H
PMID: 32660118
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Molecular Features of Metaplastic Breast Carcinoma: An Infrequent Subtype of Triple Negative Breast Carcinoma.

Cancers
S González-Martínez, B Pérez-Mies, I Carretero-Barrio, ML Palacios-Berraquero, J Perez-García, J Cortés, J Palacios
Publication Date: 2020-07-08

Variant appearance in text: TP53: R273H
PMID: 32650408
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Genetics of human malignant peripheral nerve sheath tumors.

Neuro-Oncology Advances
A Pemov, H Li, W Presley, MR Wallace, DT Miller
Publication Date: 2020-07

Variant appearance in text: TP53: 818G>A
PMID: 32642732
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Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy.

Breast Cancer Research And Treatment
K Li, N Liao, B Chen, G Zhang, Y Wang, L Guo, G Wei, M Jia, L Wen, C Ren, L Cao, H Mok, C Li, J Lin, X Chen, Z Zhang, T Hou, M Li, J Liu, CM Balch, N Liao
Publication Date: 2020-07-07

Variant appearance in text: TP53: R273H
PMID: 32638235
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Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis.

Cancers
A Ianevski, E Kulesskiy, K Krpina, G Lou, Y Aman, A Bugai, K Aasumets, Y Akimov, D Bulanova, K Gildemann, AF Arutyunyan, OY Susova, AL Zhuze, P Ji, W Wang, T Holien, M Bugge, E Zusinaite, V Oksenych, H Lysvand, JM Gerhold, M Bjørås, P Johansen, A Waage, CA Heckman, EF Fang, DE Kainov
Publication Date: 2020-06-25

Variant appearance in text: TP53: R273H
PMID: 32630560
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Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.

Bmc Cancer
J Ruhnau, J Parczyk, K Danker, B Eickholt, A Klein
Publication Date: 2020-07-02

Variant appearance in text: p53: R273H
PMID: 32615946
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Uterine fibroids may play a protecting role against endometrial carcinoma in Chinese women with gynecological diseases.

Bioscience Reports
Q Li, L Xia, Y Dong, Y Cheng, H Cao
Publication Date: 2020-07-01

Variant appearance in text: rs28934576
PMID: 32608475
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Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction.

Frontiers In Pharmacology
F Wang, F Mayca Pozo, D Tian, X Geng, X Yao, Y Zhang, J Tang
Publication Date: 2020

Variant appearance in text: TP53: 818G>A; R273H
PMID: 32581812
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Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.

Signal Transduction And Targeted Therapy
RD Cervantes-Villagrana, D Albores-García, AR Cervantes-Villagrana, SJ García-Acevez
Publication Date: 2020-06-18

Variant appearance in text: p53: R273H
PMID: 32555170
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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)
G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar
Publication Date: 2020-06-17

Variant appearance in text: TP53: R273H
PMID: 32552660
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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics
V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones
Publication Date: 2020

Variant appearance in text: p53: R273H
PMID: 32546937
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Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling.

Mbio
S Sharma, K Munger
Publication Date: 2020-06-16

Variant appearance in text: TP53: R273H
PMID: 32546626
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The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells.

Biomolecules
G Butera, J Brandi, C Cavallini, A Scarpa, RT Lawlor, MT Scupoli, E Marengo, D Cecconi, M Manfredi, M Donadelli
Publication Date: 2020-06-09

Variant appearance in text: p53: R273H
PMID: 32526853
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Mutant p53 as an Antigen in Cancer Immunotherapy.

International Journal Of Molecular Sciences
N Sobhani, A D'Angelo, X Wang, KH Young, D Generali, Y Li
Publication Date: 2020-06-08

Variant appearance in text: p53: 818G>A
PMID: 32521648
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Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer.

Cancers
A Sellitto, Y D'Agostino, E Alexandrova, J Lamberti, G Pecoraro, D Memoli, D Rocco, E Coviello, G Giurato, G Nassa, R Tarallo, A Weisz, F Rizzo
Publication Date: 2020-06-05

Variant appearance in text: p53: R273H
PMID: 32516978
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Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment.

Molecules (Basel, Switzerland)
M Zoetemelk, GM Ramzy, M Rausch, P Nowak-Sliwinska
Publication Date: 2020-06-04

Variant appearance in text: TP53: R273H
PMID: 32512790
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Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review.

American Journal Of Translational Research
R Li, P Li, W Xing, H Qiu
Publication Date: 2020

Variant appearance in text: TP53: R273H
PMID: 32509161
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Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells.

Oncogenesis
M Kang, KY Chong, TMP Hartwich, F Bi, AK Witham, D Patrick, MJ Morrisson, SL Cady, AP Cerchia, D Kelk, Y Liu, J Nucci, O Madarikan, D Ueno, BM Shuch, Y Yang-Hartwich
Publication Date: 2020-05-29

Variant appearance in text: p53: R273H
PMID: 32471985
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CDK12-Altered Prostate Cancer: Clinical Features and Therapeutic Outcomes to Standard Systemic Therapies, Poly (ADP-Ribose) Polymerase Inhibitors, and PD-1 Inhibitors.

Jco Precision Oncology
ES Antonarakis, P Isaacsson Velho, W Fu, H Wang, N Agarwal, V Sacristan Santos, BL Maughan, R Pili, N Adra, CN Sternberg, PJ Vlachostergios, ST Tagawa, AH Bryce, AL McNatty, ZR Reichert, R Dreicer, O Sartor, TL Lotan, M Hussain
Publication Date: 2020

Variant appearance in text: TP53: R273H
PMID: 32462107
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Astaxanthin Modulates Apoptotic Molecules to Induce Death of SKBR3 Breast Cancer Cells.

Marine Drugs
MS Kim, YT Ahn, CW Lee, H Kim, WG An
Publication Date: 2020-05-19

Variant appearance in text: p53: R273H
PMID: 32438569
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Clinical spectrum and prognostic value of TP53 mutations in circulating tumor DNA from breast cancer patients in China.

Cancer Communications (London, England)
Z Yi, F Ma, G Rong, Y Guan, C Li, B Xu
Publication Date: 2020-05-21

Variant appearance in text: TP53: R273H
PMID: 32436611
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Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer.

Journal Of Hematology & Oncology
Q Wang, W Geng, H Guo, Z Wang, K Xu, C Chen, S Wang
Publication Date: 2020-05-19

Variant appearance in text: p53: R273H
PMID: 32429972
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Proteomic Characterization of Colorectal Cancer Cells versus Normal-Derived Colon Mucosa Cells: Approaching Identification of Novel Diagnostic Protein Biomarkers in Colorectal Cancer.

International Journal Of Molecular Sciences
M Ludvigsen, L Thorlacius-Ussing, H Vorum, MP Moyer, MT Stender, O Thorlacius-Ussing, B Honoré
Publication Date: 2020-05-14

Variant appearance in text: TP53: R273H
PMID: 32422974
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P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

International Journal Of Molecular Sciences
AD Agupitan, P Neeson, S Williams, J Howitt, S Haupt, Y Haupt
Publication Date: 2020-05-13

Variant appearance in text: p53: R273H
PMID: 32414156
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Comparison of Circulating Cell-Free DNA Extraction Methods for Downstream Analysis in Cancer Patients.

Cancers
PV Leest, PA Boonstra, AT Elst, LCV Kempen, M Tibbesma, J Koopmans, A Miedema, M Tamminga, HJM Groen, AKL Reyners, E Schuuring
Publication Date: 2020-05-13

Variant appearance in text: TP53: R273H
PMID: 32414097
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TP53 in Myelodysplastic Syndromes: Recent Biological and Clinical Findings.

International Journal Of Molecular Sciences
C Cumbo, G Tota, L Anelli, A Zagaria, G Specchia, F Albano
Publication Date: 2020-05-13

Variant appearance in text: p53: R273H
PMID: 32414002
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Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA.

Thoracic Cancer
X Li, X Chen, L Wen, Y Wang, B Chen, Y Xue, L Guo, N Liao
Publication Date: 2020-05-15

Variant appearance in text: TP53: R273H
PMID: 32412177
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Pharmacogenomic Testing to Guide Personalized Cancer Medicine Decisions in Private Oncology Practice: A Case Study.

Frontiers In Oncology
G Astras, CI Papagiannopoulos, KA Kyritsis, C Markitani, IS Vizirianakis
Publication Date: 2020

Variant appearance in text: TP53: 818G>A
PMID: 32411592
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Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M.

The Korean Journal Of Physiology & Pharmacology : Official Journal Of The Korean Physiological Society And The Korean Society Of Pharmacology
J Lim, JH Choi, EM Park, YH Choi
Publication Date: 2020-05-01

Variant appearance in text: p53: R273H
PMID: 32395071
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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.

Nature Communications
LR Kong, RW Ong, TZ Tan, NAB Mohamed Salleh, M Thangavelu, JV Chan, LYJ Koh, G Periyasamy, JA Lau, TBU Le, L Wang, M Lee, S Kannan, CS Verma, CM Lim, WJ Chng, DP Lane, A Venkitaraman, HT Hung, CF Cheok, BC Goh
Publication Date: 2020-04-29

Variant appearance in text: p53: R273H
PMID: 32350249
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CAR T-cell therapy for a relapsed/refractory acute B-cell lymphoblastic lymphoma patient in the context of Li-Fraumeni syndrome.

Journal For Immunotherapy Of Cancer
L Chen, B Xu, X Long, J Gu, Y Lou, D Wang, Y Cao, N Wang, C Li, G Wang, Y Wang, L Zhu, J Wang, H An, M Xiao, Y Xiao, J Zhou
Publication Date: 2020-04

Variant appearance in text: TP53: 818G>A; R273H
PMID: 32345625
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Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins.

Cell Death & Disease
K Tutuska, L Parrilla-Monge, E Di Cesare, A Nemajerova, UM Moll
Publication Date: 2020-04-24

Variant appearance in text: p53: R273H
PMID: 32332697
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Recent Synthetic Approaches towards Small Molecule Reactivators of p53.

Biomolecules
JL Silva, CGS Lima, LP Rangel, GDS Ferretti, FP Pauli, RCB Ribeiro, TB da Silva, FC da Silva, VF Ferreira
Publication Date: 2020-04-20

Variant appearance in text: p53: R273H
PMID: 32326087
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Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer.

Geburtshilfe Und Frauenheilkunde
B Wappenschmidt, J Hauke, U Faust, D Niederacher, L Wiesmüller, G Schmidt, E Groß, A Gehrig, C Sutter, J Ramser, A Rump, N Arnold, A Meindl
Publication Date: 2020-04

Variant appearance in text: p53: Arg273His
PMID: 32322110
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The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.

Plos Genetics
BA Setty, GG Jinesh, M Arnold, F Pettersson, CH Cheng, L Cen, SJ Yoder, JK Teer, ER Flores, DR Reed, AS Brohl
Publication Date: 2020-04-20

Variant appearance in text: TP53: R273H
PMID: 32310940
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Establishment and characterization of patient-derived xenografts as paraclinical models for head and neck cancer.

Bmc Cancer
HN Kang, JH Kim, AY Park, JW Choi, SM Lim, J Kim, EJ Shin, MH Hong, KH Pyo, MR Yun, DH Kim, H Lee, SO Yoon, DH Kim, YM Park, HK Byeon, I Jung, S Paik, YW Koh, BC Cho, HR Kim
Publication Date: 2020-04-15

Variant appearance in text: TP53: R273H
PMID: 32293356
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Secondary Metabolites from the Culture of the Marine-derived Fungus Paradendryphiella salina PC 362H and Evaluation of the Anticancer Activity of Its Metabolite Hyalodendrin.

Marine Drugs
A Dezaire, CH Marchand, M Vallet, N Ferrand, S Chaouch, E Mouray, AK Larsen, M Sabbah, SD Lemaire, S Prado, AE Escargueil
Publication Date: 2020-04-03

Variant appearance in text: TP53: R273H
PMID: 32260204
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Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells
G Laetitia, S Sven, J Fabrice
Publication Date: 2020-03-30

Variant appearance in text: TP53: 818G>A
PMID: 32235612
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Context is everything: extrinsic signalling and gain-of-function p53 mutants.

Cell Death Discovery
I Amelio, G Melino
Publication Date: 2020

Variant appearance in text: p53: R273H
PMID: 32218993
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Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma.

Plos One
G Wang, M Wu, AC Durham, E Radaelli, NJ Mason, X Xu, DB Roth
Publication Date: 2020

Variant appearance in text: TP53: R273H
PMID: 32210430
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YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.

Science Advances
H Omori, M Nishio, M Masuda, Y Miyachi, F Ueda, T Nakano, K Sato, K Mimori, K Taguchi, H Hikasa, H Nishina, H Tashiro, T Kiyono, TW Mak, K Nakao, T Nakagawa, T Maehama, A Suzuki
Publication Date: 2020-03

Variant appearance in text: TP53: R273H
PMID: 32206709
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Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets.

Journal Of Cancer
A De, A De, R Sharma, W Suo, M Sharma
Publication Date: 2020

Variant appearance in text: TP53: R273H
PMID: 32194804
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A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes.

Cancers
K Larson, R Kannaiyan, R Pandey, Y Chen, HM Babiker, D Mahadevan
Publication Date: 2020-03-16

Variant appearance in text: TP53: R273H
PMID: 32188081
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Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV.

Diagnostic Pathology
X Catteau, N D'haene, JC Noël
Publication Date: 2020-03-14

Variant appearance in text: p53: R273H
PMID: 32169099
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Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing.

Bmc Cancer
H Zhang, H Wang, X Qian, S Gao, J Xia, J Liu, Y Cheng, J Man, X Zhai
Publication Date: 2020-03-12

Variant appearance in text: TP53: R273H
PMID: 32164600
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Ras pathway mutation feature in the same individuals at diagnosis and relapse of childhood acute lymphoblastic leukemia.

Translational Pediatrics
HH Zhang, HS Wang, XW Qian, XH Zhu, H Miao, Y Yu, JH Meng, J Le, JY Jiang, P Cao, WJ Jiang, P Wang, Y Fu, J Li, MX Qian, XW Zhai
Publication Date: 2020-02

Variant appearance in text: TP53: R273H
PMID: 32154130
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Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation.

Biomolecules
A Garufi, G Federici, MS Gilardini Montani, A Crispini, M Cirone, G D'Orazi
Publication Date: 2020-03-03

Variant appearance in text: p53: R273H
PMID: 32138264
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Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells.

Biomolecules
M Cordani, G Butera, R Pacchiana, F Masetto, N Mullappilly, C Riganti, M Donadelli
Publication Date: 2020-02-26

Variant appearance in text: p53: R273H
PMID: 32111081
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Phase I studies of vorinostat with ixazomib or pazopanib imply a role of antiangiogenesis-based therapy for TP53 mutant malignancies.

Scientific Reports
Y Wang, F Janku, S Piha-Paul, K Hess, R Broaddus, L Liu, N Shi, M Overman, S Kopetz, V Subbiah, A Naing, D Hong, AM Tsimberidou, D Karp, J Yao, S Fu
Publication Date: 2020-02-20

Variant appearance in text: TP53: R273H
PMID: 32080210
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Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis.

International Journal Of Molecular Sciences
KA Roszkowska, S Gizinski, M Sady, Z Gajewski, MB Olszewski
Publication Date: 2020-02-17

Variant appearance in text: p53: R273H
PMID: 32079237
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p53's Extended Reach: The Mutant p53 Secretome.

Biomolecules
E Pavlakis, T Stiewe
Publication Date: 2020-02-15

Variant appearance in text: p53: R273H
PMID: 32075247
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Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53.

Biomolecules
SN Loh
Publication Date: 2020-02-14

Variant appearance in text: p53: R273H
PMID: 32075132
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Genetic Variants Detected Using Cell-Free DNA from Blood and Tumor Samples in Patients with Inflammatory Breast Cancer.

International Journal Of Molecular Sciences
JS Winn, Z Hasse, M Slifker, J Pei, SM Arisi-Fernandez, JN Talarchek, E Obeid, DA Baldwin, Y Gong, E Ross, M Cristofanilli, RK Alpaugh, SV Fernandez
Publication Date: 2020-02-14

Variant appearance in text: TP53: 818G>A; R273H
PMID: 32075053
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BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors.

Bmc Cancer
E Miele, L Abballe, GP Spinelli, ZM Besharat, G Catanzaro, M Chiacchiarini, A Vacca, A Po, C Capalbo, E Ferretti
Publication Date: 2020-02-17

Variant appearance in text: TP53: R273H
PMID: 32066410
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Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status.

Applied Surface Science
A Padmanabhan, M Kaushik, R Niranjan, JS Richards, B Ebright, GD Venkatasubbu
Publication Date: 2019-09

Variant appearance in text: p53: R273H
PMID: 32042215
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Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population.

Bmc Medical Genomics
S da Costa E Silva Carvalho, NM Cury, DB Brotto, LF de Araujo, RCA Rosa, LA Texeira, JR Plaça, AA Marques, KC Peronni, PC Ruy, GA Molfetta, JC Moriguti, DM Carraro, EI Palmero, P Ashton-Prolla, VE de Faria Ferraz, WA Silva
Publication Date: 2020-02-10

Variant appearance in text: TP53: Arg273His; rs28934576
PMID: 32039725
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SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.

Nucleic Acids Research
CL Xu, B Sang, GZ Liu, JM Li, XD Zhang, LX Liu, RF Thorne, M Wu
Publication Date: 2020-02-07

Variant appearance in text: p53: R273H
PMID: 32030426
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Identifying multi-hit carcinogenic gene combinations: Scaling up a weighted set cover algorithm using compressed binary matrix representation on a GPU.

Scientific Reports
Q Al Hajri, S Dash, WC Feng, HR Garner, R Anandakrishnan
Publication Date: 2020-02-06

Variant appearance in text: TP53: R273H
PMID: 32029803
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Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes.

Blood Advances
G Montalban-Bravo, R Kanagal-Shamanna, CB Benton, CA Class, KS Chien, K Sasaki, K Naqvi, Y Alvarado, TM Kadia, F Ravandi, N Daver, K Takahashi, E Jabbour, G Borthakur, N Pemmaraju, M Konopleva, KA Soltysiak, SR Pierce, CE Bueso-Ramos, KP Patel, H Kantarjian, G Garcia-Manero
Publication Date: 2020-02-11

Variant appearance in text: TP53: R273H
PMID: 32027746
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The PI3K/mTOR dual inhibitor NVP-BEZ235 stimulates mutant p53 degradation to exhibit anti-tumor effect on triple-negative breast cancer cells.

Febs Open Bio
J Cai, J Xia, J Zou, Q Wang, Q Ma, R Sun, H Liao, L Xu, D Wang, X Guo
Publication Date: 2020-02-06

Variant appearance in text: p53: R273H
PMID: 32027103
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Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.

The Embo Journal
K Hoffmann, H Berger, H Kulbe, S Thillainadarasan, HJ Mollenkopf, T Zemojtel, E Taube, S Darb-Esfahani, M Mangler, J Sehouli, R Chekerov, EI Braicu, TF Meyer, M Kessler
Publication Date: 2020-02-03

Variant appearance in text: p53: R273H
PMID: 32009247
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Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
P Malekzadeh, R Yossef, G Cafri, BC Paria, FJ Lowery, M Jafferji, ML Good, A Sachs, AR Copeland, SP Kim, S Kivitz, MR Parkhurst, PF Robbins, S Ray, L Xi, M Raffeld, Z Yu, NP Restifo, RPT Somerville, SA Rosenberg, DC Deniger
Publication Date: 2020-01-29

Variant appearance in text: p53: R273H
PMID: 31996390
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Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma.

Cells
E Flynt, K Bisht, V Sridharan, M Ortiz, F Towfic, A Thakurta
Publication Date: 2020-01-24

Variant appearance in text: TP53: R273H
PMID: 31991614
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Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers.

Iscience
MM Pedrote, MF Motta, GDS Ferretti, DR Norberto, TCLS Spohr, FRS Lima, E Gratton, JL Silva, GAP de Oliveira
Publication Date: 2020-01-08

Variant appearance in text: p53: R273H
PMID: 31981923
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Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression.

Biomed Research International
Y Yang, J He, J Chen, L Lin, Y Liu, C Zhou, Y Su, H Wei
Publication Date: 2019

Variant appearance in text: TP53: R273H
PMID: 31976328
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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53.

Cell Reports
JG Kang, CU Lago, JE Lee, JH Park, MP Donnelly, MF Starost, C Liu, J Kwon, AC Noguchi, K Ge, PY Wang, PM Hwang
Publication Date: 2020-01-21

Variant appearance in text: TP53: R273H
PMID: 31968253
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N6-Methyladenosine: A Potential Breakthrough for Human Cancer.

Molecular Therapy. Nucleic Acids
L Liu, Y Wang, J Wu, J Liu, Z Qin, H Fan
Publication Date: 2019-12-20

Variant appearance in text: p53: R273H
PMID: 31958696
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The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas.

Cancers
B Segura-Collar, R Gargini, E Tovar-Ambel, E Hernández-SanMiguel, C Epifano, I Pérez de Castro, A Hernández-Laín, S Casas-Tintó, P Sánchez-Gómez
Publication Date: 2020-01-14

Variant appearance in text: p53: R273H
PMID: 31947645
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Molecular Classification of Gastric Cancer among Alaska Native People.

Cancers
HA Martinson, D Mallari, C Richter, TT Wu, J Tiesinga, SR Alberts, MJ Olnes
Publication Date: 2020-01-13

Variant appearance in text: TP53: R273H
PMID: 31941061
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Exosomes for Diagnosis and Therapy in Gastrointestinal Cancers.

International Journal Of Molecular Sciences
MP Scavo, N Depalo, V Tutino, V De Nunzio, C Ingrosso, F Rizzi, M Notarnicola, ML Curri, G Giannelli
Publication Date: 2020-01-06

Variant appearance in text: p53: R273H
PMID: 31935918
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MiR-3196, a p53-responsive microRNA, functions as a tumor suppressor in hepatocellular carcinoma by targeting FOXP4.

American Journal Of Cancer Research
W Qi, C Gao, L Zhang, Z Gao, J Sui, C Han, D Sun
Publication Date: 2019

Variant appearance in text: p53: R273H
PMID: 31911853
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Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.

Npj Breast Cancer
LR Bollu, J Shepherd, D Zhao, Y Ma, W Tahaney, C Speers, A Mazumdar, GB Mills, PH Brown
Publication Date: 2020

Variant appearance in text: p53: R273H
PMID: 31909186
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MicroRNA-769-3p inhibits tumor progression in glioma by suppressing ZEB2 and inhibiting the Wnt/β-catenin signaling pathway.

Oncology Letters
K Wang, S Yang, Y Gao, C Zhang, Q Sui
Publication Date: 2020-01

Variant appearance in text: p53: R273H
PMID: 31897212
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Inter-laboratory proficiency testing scheme for tumour next-generation sequencing in Ontario: a pilot study.

Current Oncology (Toronto, Ont.)
T Spence, N Stickle, C Yu, H Chow, H Feilotter, B Lo, E McCready, B Sadikovic, LL Siu, PL Bedard, TL Stockley
Publication Date: 2019-12

Variant appearance in text: TP53: 818G>A; R273H
PMID: 31896942
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000269305.4 c.818G>A p.Arg273His missense_variant 8/11 -
ENST00000359597.4 c.818G>A p.Arg273His missense_variant 7/9 -
ENST00000413465.2 c.782+379G>A - intron_variant - 6/6
ENST00000420246.2 c.818G>A p.Arg273His missense_variant 8/12 -
ENST00000445888.2 c.818G>A p.Arg273His missense_variant 8/11 -
ENST00000455263.2 c.818G>A p.Arg273His missense_variant 8/12 -
ENST00000504290.1 n.700G>A - non_coding_transcript_exon_variant 4/8 -
ENST00000504937.1 n.700G>A - non_coding_transcript_exon_variant 4/7 -
ENST00000509690.1 c.422G>A p.Arg141His missense_variant 5/6 -
ENST00000510385.1 n.700G>A - non_coding_transcript_exon_variant 4/8 -
NM_000546.5 c.818G>A p.Arg273His missense_variant 8/11 -
NM_001126112.2 c.818G>A p.Arg273His missense_variant 8/11 -
NM_001126113.2 c.818G>A p.Arg273His missense_variant 8/12 -
NM_001126114.2 c.818G>A p.Arg273His missense_variant 8/12 -
NM_001126115.1 c.422G>A p.Arg141His missense_variant 4/7 -
NM_001126116.1 c.422G>A p.Arg141His missense_variant 4/8 -
NM_001126117.1 c.422G>A p.Arg141His missense_variant 4/8 -
NM_001126118.1 c.701G>A p.Arg234His missense_variant 7/10 -
NM_001276695.2 c.701G>A p.Arg234His missense_variant 8/12 -
NM_001276696.2 c.701G>A p.Arg234His missense_variant 8/12 -
NM_001276697.2 c.341G>A p.Arg114His missense_variant 4/7 -
NM_001276698.2 c.341G>A p.Arg114His missense_variant 4/8 -
NM_001276699.2 c.341G>A p.Arg114His missense_variant 4/8 -
NM_001276760.2 c.701G>A p.Arg234His missense_variant 8/11 -
NM_001276761.2 c.701G>A p.Arg234His missense_variant 8/11 -