TP53 c.773A>T ;(p.E258V)

Variant ID: 17-7577508-T-A

NM_000546.5(TP53):c.773A>T;(p.E258V)

This variant was identified in 27 publications

View GRCh38 version.




Publications:


CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: 773A>T
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L.

International Journal Of Molecular Sciences
Lei, Jiangtao J; Li, Xuanyao X; Cai, Mengqiang M; Guo, Tianjing T; Lin, Dongdong D; Deng, Xiaohua X; Li, Yin Y
Publication Date: 2022-09-03

Variant appearance in text: p53: E258V
PubMed Link: 36077492
Variant Present in the following documents:
  • Main text
  • ijms-23-10100.pdf
View BVdb publication page



Integrated cohort of esophageal squamous cell cancer reveals genomic features underlying clinical characteristics.

Nature Communications
Li, Minghao M; Zhang, Zicheng Z; Wang, Qianrong Q; Yi, Yan Y; Li, Baosheng B
Publication Date: 2022-09-07

Variant appearance in text: TP53: E258V
PubMed Link: 36071046
Variant Present in the following documents:
  • 41467_2022_32962_MOESM15_ESM.xlsx, sheet 22
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: TP53: E258V
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Mutated p53 in HGSC-From a Common Mutation to a Target for Therapy.

Cancers
Saleh, Aya A; Perets, Ruth R
Publication Date: 2021-07-10

Variant appearance in text: TP53: E258V
PubMed Link: 34298679
Variant Present in the following documents:
  • Main text
  • cancers-13-03465.pdf
View BVdb publication page



The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine
Chang, Darwin D; Shain, A Hunter AH
Publication Date: 2021-07-16

Variant appearance in text: TP53: E258V
PubMed Link: 34272401
Variant Present in the following documents:
  • 41525_2021_226_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases.

Scientific Reports
Magraner-Pardo, Lorena L; Laskowski, Roman A RA; Pons, Tirso T; Thornton, Janet M JM
Publication Date: 2021-07-12

Variant appearance in text: TP53: 773A>T; E258V
PubMed Link: 34253785
Variant Present in the following documents:
  • 41598_2021_93715_MOESM2_ESM.xlsx, sheet 9
  • 41598_2021_93715_MOESM2_ESM.xlsx, sheet 10
View BVdb publication page



Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review.

Oncotargets And Therapy
Chen, Zhitao Z; Zhang, Lele L; Huang, Jiacheng J; Ding, Chenchen C; Zhang, Ting T; Wan, Dalong D; Xue, Liang L
Publication Date: 2021

Variant appearance in text: TP53: E258V
PubMed Link: 34113123
Variant Present in the following documents:
  • Main text
  • ott-14-3567.pdf
View BVdb publication page



The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction.

Cancers
Vodicka, Pavel P; Andera, Ladislav L; Opattova, Alena A; Vodickova, Ludmila L
Publication Date: 2021-01-27

Variant appearance in text: p53: E258V
PubMed Link: 33513745
Variant Present in the following documents:
  • Main text
  • cancers-13-00479.pdf
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: TP53: 773A>T; E258V
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: TP53: E258V
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit.

Leukemia
Cucco, Francesco F; Barrans, Sharon S; Sha, Chulin C; Clipson, Alexandra A; Crouch, Simon S; Dobson, Rachel R; Chen, Zi Z; Thompson, Joe Sneath JS; Care, Matthew A MA; Cummin, Thomas T; Caddy, Josh J; Liu, Hongxiang H; Robinson, Anne A; Schuh, Anna A; Fitzgibbon, Jude J; Painter, Daniel D; Smith, Alexandra A; Roman, Eve E; Tooze, Reuben R; Burton, Catherine C; Davies, Andrew J AJ; Westhead, David R DR; Johnson, Peter W M PWM; Du, Ming-Qing MQ
Publication Date: 2020-05

Variant appearance in text: TP53: E258V
PubMed Link: 31844144
Variant Present in the following documents:
  • 41375_2019_691_MOESM7_ESM.xlsx, sheet 2
View BVdb publication page



Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors.

International Journal Of Molecular Sciences
Li, Hui H; Zhang, Jinglin J; Tong, Joanna Hung Man JHM; Chan, Anthony Wing Hung AWH; Yu, Jun J; Kang, Wei W; To, Ka Fai KF
Publication Date: 2019-11-28

Variant appearance in text: p53: E258V
PubMed Link: 31795192
Variant Present in the following documents:
  • Main text
  • ijms-20-05999.pdf
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: TP53: E258V
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.

Nucleic Acids Research
Pradhan, Mohan R MR; Siau, Jia Wei JW; Kannan, Srinivasaraghavan S; Nguyen, Minh N MN; Ouaray, Zohra Z; Kwoh, Chee Keong CK; Lane, David P DP; Ghadessy, Farid F; Verma, Chandra S CS
Publication Date: 2019-02-28

Variant appearance in text: p53: E258V
PubMed Link: 30649466
Variant Present in the following documents:
  • Main text
  • gky1314.pdf
View BVdb publication page



The prognostic effects of somatic mutations in ER-positive breast cancer.

Nature Communications
Griffith, Obi L OL; Spies, Nicholas C NC; Anurag, Meenakshi M; Griffith, Malachi M; Luo, Jingqin J; Tu, Dongsheng D; Yeo, Belinda B; Kunisaki, Jason J; Miller, Christopher A CA; Krysiak, Kilannin K; Hundal, Jasreet J; Ainscough, Benjamin J BJ; Skidmore, Zachary L ZL; Campbell, Katie K; Kumar, Runjun R; Fronick, Catrina C; Cook, Lisa L; Snider, Jacqueline E JE; Davies, Sherri S; Kavuri, Shyam M SM; Chang, Eric C EC; Magrini, Vincent V; Larson, David E DE; Fulton, Robert S RS; Liu, Shuzhen S; Leung, Samuel S; Voduc, David D; Bose, Ron R; Dowsett, Mitch M; Wilson, Richard K RK; Nielsen, Torsten O TO; Mardis, Elaine R ER; Ellis, Matthew J MJ
Publication Date: 2018-09-04

Variant appearance in text: TP53: E258V
PubMed Link: 30181556
Variant Present in the following documents:
  • 41467_2018_5914_MOESM6_ESM.xlsx, sheet 10
  • 41467_2018_5914_MOESM6_ESM.xlsx, sheet 5
  • 41467_2018_5914_MOESM6_ESM.xlsx, sheet 9
  • 41467_2018_5914_MOESM6_ESM.xlsx, sheet 6
View BVdb publication page



Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS).

International Journal Of Molecular Sciences
Garziera, Marica M; Cecchin, Erika E; Canzonieri, Vincenzo V; Sorio, Roberto R; Giorda, Giorgio G; Scalone, Simona S; De Mattia, Elena E; Roncato, Rossana R; Gagno, Sara S; Poletto, Elena E; Romanato, Loredana L; Sartor, Franca F; Polesel, Jerry J; Toffoli, Giuseppe G
Publication Date: 2018-05-18

Variant appearance in text: p53: E258V
PubMed Link: 29783665
Variant Present in the following documents:
  • Main text
  • ijms-19-01510.pdf
View BVdb publication page



Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma.

Jci Insight
Lee, Hyun-Sung HS; Jang, Hee-Jin HJ; Choi, Jong Min JM; Zhang, Jun J; de Rosen, Veronica Lenge VL; Wheeler, Thomas M TM; Lee, Ju-Seog JS; Tu, Thuydung T; Jindra, Peter T PT; Kerman, Ronald H RH; Jung, Sung Yun SY; Kheradmand, Farrah F; Sugarbaker, David J DJ; Burt, Bryan M BM
Publication Date: 2018-04-05

Variant appearance in text: TP53: E258V
PubMed Link: 29618661
Variant Present in the following documents:
  • jciinsight-3-98575-s002.xlsx, sheet 1
View BVdb publication page



Mutant p53 partners in crime.

Cell Death And Differentiation
Kim, Michael P MP; Lozano, Guillermina G
Publication Date: 2018-01

Variant appearance in text: p53: E258V
PubMed Link: 29099488
Variant Present in the following documents:
  • Main text
  • cdd2017185a.pdf
View BVdb publication page



Hspb1 and Tp53 Mutation and Expression Analysis in Cat Mammary Tumors.

Iranian Journal Of Biotechnology
Saif, Rashid R; Awan, Ali Raza AR; Lyons, Leslie L; Gandolfi, Barbara B; Tayyab, Muhammad M; Ellahi Babar, Masroor M; Khalid Mehmood, Asim A; Ullah, Zia Z; Wasim, Muhammad M
Publication Date: 2016-09

Variant appearance in text: p53: 773A>T
PubMed Link: 28959337
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: TP53: 773A>T; E258V
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



INDELseek: detection of complex insertions and deletions from next-generation sequencing data.

Bmc Genomics
Au, Chun Hang CH; Leung, Anskar Y H AY; Kwong, Ava A; Chan, Tsun Leung TL; Ma, Edmond S K ES
Publication Date: 2017-01-05

Variant appearance in text: TP53: Glu258Val
PubMed Link: 28056804
Variant Present in the following documents:
  • Main text
  • 12864_2016_Article_3449.pdf
View BVdb publication page



iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: TP53: E258V
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s5.xls, sheet 1
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: TP53: E258V
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 1
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: TP53: E258V
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients.

Biomed Research International
Stancheva, Gergana G; Goranova, Teodora T; Laleva, Maria M; Kamenova, Margarita M; Mitkova, Atanaska A; Velinov, Nikolay N; Poptodorov, George G; Mitev, Vanio V; Kaneva, Radka R; Gabrovsky, Nikolay N
Publication Date: 2014

Variant appearance in text: TP53: 773A>T
PubMed Link: 24868540
Variant Present in the following documents:
  • Main text
  • BMRI2014-654727.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: TP53: E258V
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page