Variant ID: 17-7577538-C-T

NM_000546.5(TP53):c.743G>A;(p.Arg248Gln)

This variant was identified in 650 publications




Publications:


TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.

Experimental And Therapeutic Medicine
H Yang, Y Chen, Y Jiang, D Wang, J Yan, Z Zhou
Publication Date: 2020-08

Variant appearance in text: TP53: R248Q
PMID: 32742376
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Should immunohistochemical expression of mismatch repair (MMR) proteins and microsatellite instability (MSI) analysis be routinely performed for poorly differentiated colorectal neuroendocrine carcinomas?

Endocrinology, Diabetes & Metabolism Case Reports
TV Luong, Z Nisa, J Watkins, AR Hayes
Publication Date: 2020-07-29

Variant appearance in text: TP53: 743G>A
PMID: 32729847
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The identification of nuclear αvβ3 integrin in ovarian cancer: non-paradigmal localization with cancer promoting actions.

Oncogenesis
C Seraya-Bareket, A Weisz, E Shinderman-Maman, S Teper-Roth, D Stamler, N Arbib, Y Kadan, A Fishman, D Kidron, E Edelstein, M Ellis, O Ashur-Fabian
Publication Date: 2020-07-29

Variant appearance in text: p53: R248Q
PMID: 32728020
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Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.

Scientific Reports
Y Nanki, T Chiyoda, A Hirasawa, A Ookubo, M Itoh, M Ueno, T Akahane, K Kameyama, W Yamagami, F Kataoka, D Aoki
Publication Date: 2020-07-28

Variant appearance in text: p53: R248Q
PMID: 32724113
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EGFR, BRCA1, BRCA2 and TP53 genetic profile in Moroccan triple negative breast cancer cases.

International Journal Of Molecular Epidemiology And Genetics
F Jouali, FZ El Ansari, N Marchoudi, A Barakat, H Zmaimita, H Samlali, J Fekkak
Publication Date: 2020

Variant appearance in text: TP53: 743G>A; Arg248Gln
PMID: 32714499
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MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia.

Scientific Reports
CH Yu, TK Lin, ST Jou, CY Lin, KH Lin, MY Lu, SH Chen, CN Cheng, KH Wu, SC Wang, HH Chang, MJ Li, YL Ni, YN Su, DT Lin, HY Chen, CJ Harrison, CC Hung, SW Lin, YL Yang
Publication Date: 2020-07-13

Variant appearance in text: TP53: R248Q
PMID: 32661308
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The Janus Face of p53-Targeting Ubiquitin Ligases.

Cells
Q Hao, Y Chen, X Zhou
Publication Date: 2020-07-09

Variant appearance in text: p53: R248Q
PMID: 32660118
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Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype.

Cell Communication And Signaling : Ccs
A Yokoi, T Matsumoto, Y Oguri, Y Hasegawa, M Tochimoto, M Nakagawa, M Saegusa
Publication Date: 2020-07-07

Variant appearance in text: p53: R248Q
PMID: 32635925
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Optimization of a WGA-Free Molecular Tagging-Based NGS Protocol for CTCs Mutational Profiling.

International Journal Of Molecular Sciences
G De Luca, B Cardinali, L Del Mastro, S Lastraioli, F Carli, M Ferrarini, GA Calin, A Garuti, C Mazzitelli, S Zupo, M Dono
Publication Date: 2020-06-19

Variant appearance in text: TP53: Arg248Gln
PMID: 32575430
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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)
G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar
Publication Date: 2020-06-17

Variant appearance in text: TP53: R248Q
PMID: 32552660
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Double Agent: SPDEF Gene with Both Oncogenic and Tumor-Suppressor Functions in Breast Cancer.

Cancer Management And Research
T Ye, J Feng, X Wan, D Xie, J Liu
Publication Date: 2020

Variant appearance in text: p53: R248Q
PMID: 32547225
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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics
V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones
Publication Date: 2020

Variant appearance in text: TP53: R248Q
PMID: 32546937
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Mutant p53 as an Antigen in Cancer Immunotherapy.

International Journal Of Molecular Sciences
N Sobhani, A D'Angelo, X Wang, KH Young, D Generali, Y Li
Publication Date: 2020-06-08

Variant appearance in text: p53: R248Q
PMID: 32521648
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In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

Plos Genetics
O Kim, EY Park, DL Klinkebiel, SD Pack, YH Shin, Z Abdullaev, RE Emerson, DM Coffey, SY Kwon, CJ Creighton, S Kwon, EC Chang, T Chiang, AN Yatsenko, J Chien, DJ Cheon, Y Yang-Hartwich, H Nakshatri, KP Nephew, RR Behringer, FM Fernández, CH Cho, B Vanderhyden, R Drapkin, RC Bast, KD Miller, AR Karpf, J Kim
Publication Date: 2020-06-04

Variant appearance in text: p53: R248Q
PMID: 32497036
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The molecular pathogenesis of Trichilemmal carcinoma.

Bmc Cancer
JH Ha, C Lee, KS Lee, CS Pak, CH Sun, Y Koh, H Chang
Publication Date: 2020-06-03

Variant appearance in text: TP53: Arg248Gln
PMID: 32493317
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To target the untargetable: elucidation of synergy of APR-246 and azacitidine in TP53 mutant myelodysplastic syndromes and acute myeloid leukemia.

Haematologica
DA Sallman
Publication Date: 2020-06

Variant appearance in text: TP53: R248Q
PMID: 32482751
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Detection of ctDNA with Personalized Molecular Barcode NGS and Its Clinical Significance in Patients with Early Breast Cancer.

Translational Oncology
T Yoshinami, N Kagara, D Motooka, S Nakamura, T Miyake, T Tanei, Y Naoi, M Shimoda, K Shimazu, SJ Kim, S Noguchi
Publication Date: 2020-05-27

Variant appearance in text: TP53: R248Q
PMID: 32473569
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Early circulating tumour DNA kinetics measured by ultra-deep next-generation sequencing during radical radiotherapy for non-small cell lung cancer: a feasibility study.

Radiation Oncology (London, England)
GM Walls, L McConnell, J McAleese, P Murray, TB Lynch, K Savage, GG Hanna, DG de Castro
Publication Date: 2020-05-29

Variant appearance in text: TP53: Arg248Gln
PMID: 32471446
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The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Frontiers In Oncology
R Lombardo, F Tosi, A Nocerino, K Bencardino, V Gambi, R Ricotta, F Spina, S Siena, A Sartore-Bianchi
Publication Date: 2020

Variant appearance in text: TP53: R248Q
PMID: 32457826
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Tissue gene mutation profiles in patients with colorectal cancer and their clinical implications.

Biomedical Reports
J Ye, M Lin, C Zhang, X Zhu, S Li, H Liu, J Yin, H Yu, K Zhu
Publication Date: 2020-07

Variant appearance in text: TP53: R248Q
PMID: 32440349
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Clinical spectrum and prognostic value of TP53 mutations in circulating tumor DNA from breast cancer patients in China.

Cancer Communications (London, England)
Z Yi, F Ma, G Rong, Y Guan, C Li, B Xu
Publication Date: 2020-05-21

Variant appearance in text: TP53: R248Q
PMID: 32436611
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Azasteroid Alkylators as Dual Inhibitors of AKT and ERK Signaling for the Treatment of Ovarian Carcinoma.

Cancers
P Dalezis, E Geromichalou, A Polonifi, S Sagredou, N Nikoleousakos, M Nikolaou, V Sarli, MI Panayiotidis, DT Trafalis
Publication Date: 2020-05-16

Variant appearance in text: TP53: R248Q
PMID: 32429466
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Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours.

Nature Communications
PA Johansson, K Brooks, F Newell, JM Palmer, JS Wilmott, AL Pritchard, N Broit, S Wood, MS Carlino, C Leonard, LT Koufariotis, V Nathan, AB Beasley, M Howlie, R Dawson, H Rizos, CW Schmidt, GV Long, H Hamilton, JF Kiilgaard, T Isaacs, ES Gray, OJ Rolfe, JJ Park, A Stark, GJ Mann, RA Scolyer, JV Pearson, N van Baren, N Waddell, KW Wadt, LA McGrath, SK Warrier, W Glasson, NK Hayward
Publication Date: 2020-05-15

Variant appearance in text: p53: R248Q
PMID: 32415113
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P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

International Journal Of Molecular Sciences
AD Agupitan, P Neeson, S Williams, J Howitt, S Haupt, Y Haupt
Publication Date: 2020-05-13

Variant appearance in text: p53: R248Q
PMID: 32414156
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Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA.

Thoracic Cancer
X Li, X Chen, L Wen, Y Wang, B Chen, Y Xue, L Guo, N Liao
Publication Date: 2020-05-15

Variant appearance in text: TP53: R248Q
PMID: 32412177
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Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties.

Nature Communications
M Nakayama, CP Hong, H Oshima, E Sakai, SJ Kim, M Oshima
Publication Date: 2020-05-11

Variant appearance in text: p53: R248Q
PMID: 32393735
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DNA methylation of chronic lymphocytic leukemia with differential response to chemotherapy.

Scientific Data
DY Yosifov, J Bloehdorn, H Döhner, P Lichter, S Stilgenbauer, D Mertens
Publication Date: 2020-05-01

Variant appearance in text: TP53: 743G>A
PMID: 32358561
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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.

Nature Communications
LR Kong, RW Ong, TZ Tan, NAB Mohamed Salleh, M Thangavelu, JV Chan, LYJ Koh, G Periyasamy, JA Lau, TBU Le, L Wang, M Lee, S Kannan, CS Verma, CM Lim, WJ Chng, DP Lane, A Venkitaraman, HT Hung, CF Cheok, BC Goh
Publication Date: 2020-04-29

Variant appearance in text: p53: R248Q
PMID: 32350249
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Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins.

Cell Death & Disease
K Tutuska, L Parrilla-Monge, E Di Cesare, A Nemajerova, UM Moll
Publication Date: 2020-04-24

Variant appearance in text: p53: R248Q
PMID: 32332697
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The Status of p53 Oligomeric and Aggregation States in Cancer.

Biomolecules
GAP de Oliveira, EC Petronilho, MM Pedrote, MA Marques, TCRG Vieira, EA Cino, JL Silva
Publication Date: 2020-04-04

Variant appearance in text: p53: R248Q
PMID: 32260447
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Comprehensive genomic profile of cholangiocarcinomas in China.

Oncology Letters
W Tian, W Hu, X Shi, P Liu, X Ma, W Zhao, L Qu, S Zhang, W Shi, A Liu, J Cao
Publication Date: 2020-04

Variant appearance in text: TP53: R248Q
PMID: 32256810
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Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells
G Laetitia, S Sven, J Fabrice
Publication Date: 2020-03-30

Variant appearance in text: TP53: 743G>A
PMID: 32235612
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Integrated Informatics Analysis of Cancer-Related Variants.

Jco Clinical Cancer Informatics
KA Pagel, R Kim, K Moad, B Busby, L Zheng, C Tokheim, M Ryan, R Karchin
Publication Date: 2020-03

Variant appearance in text: TP53: R248Q
PMID: 32228266
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Comparison of Somatic Mutation Profiles Between Formalin-Fixed Paraffin Embedded Tissues and Plasma Cell-Free DNA from Ovarian Cancer Patients Before and After Surgery.

Bioresearch Open Access
M Jagelkova, K Zelinova, Z Laucekova, M Bobrovska, Z Dankova, M Grendar, K Dokus
Publication Date: 2020

Variant appearance in text: TP53: 743G>A
PMID: 32219013
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Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets.

Journal Of Cancer
A De, A De, R Sharma, W Suo, M Sharma
Publication Date: 2020

Variant appearance in text: TP53: R248Q
PMID: 32194804
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A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes.

Cancers
K Larson, R Kannaiyan, R Pandey, Y Chen, HM Babiker, D Mahadevan
Publication Date: 2020-03-16

Variant appearance in text: TP53: R248Q
PMID: 32188081
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Concordance between TP53 alterations in blood and tissue: impact of time interval, biopsy site, cancer type and circulating tumor DNA burden.

Molecular Oncology
CC Bieg-Bourne, R Okamura, R Kurzrock
Publication Date: 2020-03-18

Variant appearance in text: TP53: R248Q
PMID: 32187847
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Minimal barriers to invasion during human colorectal tumor growth.

Nature Communications
MD Ryser, D Mallo, A Hall, T Hardman, LM King, S Tatishchev, IC Sorribes, CC Maley, JR Marks, ES Hwang, D Shibata
Publication Date: 2020-03-09

Variant appearance in text: TP53: R248Q
PMID: 32152322
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Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation.

Biomolecules
A Garufi, G Federici, MS Gilardini Montani, A Crispini, M Cirone, G D'Orazi
Publication Date: 2020-03-03

Variant appearance in text: p53: R248Q
PMID: 32138264
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Neoantigens in Hematologic Malignancies.

Frontiers In Immunology
MA Biernacki, M Bleakley
Publication Date: 2020

Variant appearance in text: TP53: R248Q
PMID: 32117272
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Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells.

Biomolecules
M Cordani, G Butera, R Pacchiana, F Masetto, N Mullappilly, C Riganti, M Donadelli
Publication Date: 2020-02-26

Variant appearance in text: p53: R248Q
PMID: 32111081
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Phase I studies of vorinostat with ixazomib or pazopanib imply a role of antiangiogenesis-based therapy for TP53 mutant malignancies.

Scientific Reports
Y Wang, F Janku, S Piha-Paul, K Hess, R Broaddus, L Liu, N Shi, M Overman, S Kopetz, V Subbiah, A Naing, D Hong, AM Tsimberidou, D Karp, J Yao, S Fu
Publication Date: 2020-02-20

Variant appearance in text: TP53: R248Q
PMID: 32080210
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Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis.

International Journal Of Molecular Sciences
KA Roszkowska, S Gizinski, M Sady, Z Gajewski, MB Olszewski
Publication Date: 2020-02-17

Variant appearance in text: p53: R248Q
PMID: 32079237
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p53's Extended Reach: The Mutant p53 Secretome.

Biomolecules
E Pavlakis, T Stiewe
Publication Date: 2020-02-15

Variant appearance in text: p53: R248Q
PMID: 32075247
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Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53.

Biomolecules
SN Loh
Publication Date: 2020-02-14

Variant appearance in text: p53: R248Q
PMID: 32075132
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Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer.

Therapeutic Advances In Medical Oncology
A Canonici, AL Browne, MFK Ibrahim, KP Fanning, S Roche, NT Conlon, F O'Neill, J Meiller, M Cremona, C Morgan, BT Hennessy, AJ Eustace, F Solca, N O'Donovan, J Crown
Publication Date: 2020

Variant appearance in text: TP53: R248Q
PMID: 32064003
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Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status.

Applied Surface Science
A Padmanabhan, M Kaushik, R Niranjan, JS Richards, B Ebright, GD Venkatasubbu
Publication Date: 2019-09

Variant appearance in text: p53: R248Q
PMID: 32042215
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Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication.

Nature Structural & Molecular Biology
D Ardeljan, JP Steranka, C Liu, Z Li, MS Taylor, LM Payer, M Gorbounov, JS Sarnecki, V Deshpande, RH Hruban, JD Boeke, D Fenyö, PH Wu, A Smogorzewska, AJ Holland, KH Burns
Publication Date: 2020-02

Variant appearance in text: TP53: R248Q
PMID: 32042151
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Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes.

Blood Advances
G Montalban-Bravo, R Kanagal-Shamanna, CB Benton, CA Class, KS Chien, K Sasaki, K Naqvi, Y Alvarado, TM Kadia, F Ravandi, N Daver, K Takahashi, E Jabbour, G Borthakur, N Pemmaraju, M Konopleva, KA Soltysiak, SR Pierce, CE Bueso-Ramos, KP Patel, H Kantarjian, G Garcia-Manero
Publication Date: 2020-02-11

Variant appearance in text: TP53: R248Q
PMID: 32027746
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NVP-BEZ235 inhibits thyroid cancer growth by p53- dependent/independent p21 upregulation.

International Journal Of Biological Sciences
B Ruan, W Liu, P Chen, R Cui, Y Li, M Ji, P Hou, Q Yang
Publication Date: 2020

Variant appearance in text: TP53: R248Q
PMID: 32025215
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Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma.

Cancer Research And Treatment : Official Journal Of Korean Cancer Association
MC Choi, S Hwang, S Kim, SG Jung, H Park, WD Joo, SH Song, C Lee, TH Kim, H Kang, HJ An
Publication Date: 2020-01-06

Variant appearance in text: TP53: R248Q
PMID: 32019284
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Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test.

Cancer Research And Treatment : Official Journal Of Korean Cancer Association
HC Shin, HB Lee, TK Yoo, ES Lee, RN Kim, B Park, KA Yoon, C Park, ES Lee, HG Moon, DY Noh, SY Kong, W Han
Publication Date: 2020-02-04

Variant appearance in text: TP53: 743G>A; Arg248Gln
PMID: 32019277
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Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Bmc Cancer
V Manoharan, EH Karunanayake, KH Tennekoon, S De Silva, AIA Imthikab, K De Silva, P Angunawela, S Vishwakula, J Lunec
Publication Date: 2020-01-30

Variant appearance in text: TP53: Arg248Gln; rs11540652
PMID: 32000721
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Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
P Malekzadeh, R Yossef, G Cafri, BC Paria, FJ Lowery, M Jafferji, ML Good, A Sachs, AR Copeland, SP Kim, S Kivitz, MR Parkhurst, PF Robbins, S Ray, L Xi, M Raffeld, Z Yu, NP Restifo, RPT Somerville, SA Rosenberg, DC Deniger
Publication Date: 2020-01-29

Variant appearance in text: p53: R248Q
PMID: 31996390
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MLH1 promoter hypermethylation in uterine carcinosarcoma rarely coexists with TP53 mutation.

Contemporary Oncology (Poznan, Poland)
M Kunc, A Gabrych, B Rekawiecki, A Gorczynski, S Franke, J Haybaeck, W Biernat, P Czapiewski
Publication Date: 2019

Variant appearance in text: p53: 743G>A
PMID: 31992951
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Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma.

Cells
E Flynt, K Bisht, V Sridharan, M Ortiz, F Towfic, A Thakurta
Publication Date: 2020-01-24

Variant appearance in text: TP53: R248Q
PMID: 31991614
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Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers.

Iscience
MM Pedrote, MF Motta, GDS Ferretti, DR Norberto, TCLS Spohr, FRS Lima, E Gratton, JL Silva, GAP de Oliveira
Publication Date: 2020-01-08

Variant appearance in text: p53: R248Q
PMID: 31981923
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Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression.

Biomed Research International
Y Yang, J He, J Chen, L Lin, Y Liu, C Zhou, Y Su, H Wei
Publication Date: 2019

Variant appearance in text: p53: R248Q
PMID: 31976328
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Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes.

Scientific Reports
J Zhu, M Singh, G Selivanova, S Peuget
Publication Date: 2020-01-23

Variant appearance in text: p53: R248Q
PMID: 31974452
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Patient-Derived Orthotopic Xenograft Models of Pediatric Brain Tumors: In a Mature Phase or Still in Its Infancy?

Frontiers In Oncology
E Hermans, E Hulleman
Publication Date: 2019

Variant appearance in text: TP53: R248Q
PMID: 31970083
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Genetic mutations in lung enteric adenocarcinoma identified using next-generation sequencing.

International Journal Of Clinical And Experimental Pathology
L Lin, W Zhuang, W Wang, C Xu, R Chen, Y Guan, X Yi, Y Shao, Y Tai, Y Chen, M Wu, J Wei, G Chen
Publication Date: 2017

Variant appearance in text: TP53: R248Q
PMID: 31966835
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Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing.

Scientific Reports
MV Nemtsova, AI Kalinkin, EB Kuznetsova, IV Bure, EA Alekseeva, II Bykov, TV Khorobrykh, DS Mikhaylenko, AS Tanas, SI Kutsev, DV Zaletaev, VV Strelnikov
Publication Date: 2020-01-16

Variant appearance in text: TP53: R248Q; rs11540652
PMID: 31949278
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Eccrine porocarcinoma: A rare case of an in situ tumor with lymph node metastases.

Jaad Case Reports
AC van den Brand, J Damman, FH Groenendijk, R Waalboer-Spuij
Publication Date: 2020-01

Variant appearance in text: TP53: 743G>A
PMID: 31909137
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Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease.

Cancer Medicine
Z Gatalica, S Vranic, B Krušlin, K Poorman, P Stafford, D Kacerovska, W Senarathne, E Florento, E Contreras, A Leary, A Choi, GK In
Publication Date: 2020-01-03

Variant appearance in text: TP53: R248Q
PMID: 31899853
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Detection of KRAS mutations in plasma cell-free DNA of colorectal cancer patients and comparison with cancer panel data for tissue samples of the same cancers.

Genomics & Informatics
S Min, S Shin, YJ Chung
Publication Date: 2019-12

Variant appearance in text: TP53: R248Q
PMID: 31896242
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Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis.

Scientific Reports
CW Chou, CH Lin, TH Hsiao, CC Lo, CY Hsieh, CC Huang, YP Sher
Publication Date: 2019-12-31

Variant appearance in text: p53: R248Q
PMID: 31892709
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Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression.

The Journal Of Experimental Medicine
MR Girotti, M Salatino, T Dalotto-Moreno, GA Rabinovich
Publication Date: 2020-02-03

Variant appearance in text: p53: R248Q
PMID: 31873723
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High-throughput prediction of MHC class I and class II neoantigens with MHCnuggets.

Cancer Immunology Research
XM Shao, R Bhattacharya, J Huang, IKA Sivakumar, C Tokheim, L Zheng, D Hirsch, B Kaminow, A Omdahl, M Bonsack, AB Riemer, VE Velculescu, V Anagnostou, KA Pagel, R Karchin
Publication Date: 2019-12-23

Variant appearance in text: TP53: R248Q
PMID: 31871119
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Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.

Nature Communications
MS Esfahani, LJ Lee, YJ Jeon, RA Flynn, H Stehr, AB Hui, N Ishisoko, E Kildebeck, AM Newman, SV Bratman, MH Porteus, HY Chang, AA Alizadeh, M Diehn
Publication Date: 2019-12-13

Variant appearance in text: TP53: R248Q
PMID: 31836708
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Do Mutations Turn p53 into an Oncogene?

International Journal Of Molecular Sciences
C Pitolli, Y Wang, M Mancini, Y Shi, G Melino, I Amelio
Publication Date: 2019-12-11

Variant appearance in text: p53: R248Q
PMID: 31835684
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Nanopore Targeted Sequencing for Rapid Gene Mutations Detection in Acute Myeloid Leukemia.

Genes
C Cumbo, CF Minervini, P Orsini, L Anelli, A Zagaria, A Minervini, N Coccaro, L Impera, G Tota, E Parciante, MR Conserva, O Spinelli, A Rambaldi, G Specchia, F Albano
Publication Date: 2019-12-09

Variant appearance in text: TP53: 743G>A
PMID: 31835432
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Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway.

Nature Communications
S Chen, Q Wang, H Yu, ML Capitano, S Vemula, SC Nabinger, R Gao, C Yao, M Kobayashi, Z Geng, A Fahey, D Henley, SZ Liu, S Barajas, W Cai, ER Wolf, B Ramdas, Z Cai, H Gao, N Luo, Y Sun, TN Wong, DC Link, Y Liu, HS Boswell, LD Mayo, G Huang, R Kapur, MC Yoder, HE Broxmeyer, Z Gao, Y Liu
Publication Date: 2019-12-11

Variant appearance in text: p53: R248Q
PMID: 31827082
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Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis.

International Journal Of Molecular Sciences
Y Stein, V Rotter, R Aloni-Grinstein
Publication Date: 2019-12-08

Variant appearance in text: p53: R248Q
PMID: 31817996
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Irradiation induces p53 loss of heterozygosity in breast cancer expressing mutant p53.

Communications Biology
A Ghaleb, A Yallowitz, N Marchenko
Publication Date: 2019

Variant appearance in text: p53: R248Q
PMID: 31799437
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Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors.

International Journal Of Molecular Sciences
H Li, J Zhang, JHM Tong, AWH Chan, J Yu, W Kang, KF To
Publication Date: 2019-11-28

Variant appearance in text: p53: R248Q
PMID: 31795192
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Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance.

World Journal Of Surgical Oncology
N Batta, M Pandey
Publication Date: 2019-11-27

Variant appearance in text: TP53: 743G>A
PMID: 31775759
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Childhood adrenocortical tumor: A clinical and immunohistochemical study of 13 cases.

Medicine
X Wu, J Xu, J Wang, W Gu, C Zou
Publication Date: 2019-11

Variant appearance in text: TP53: Arg248Gln
PMID: 31725643
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The Association and Significance of p53 in Gynecologic Cancers: The Potential of Targeted Therapy.

International Journal Of Molecular Sciences
M Nakamura, T Obata, T Daikoku, H Fujiwara
Publication Date: 2019-11-04

Variant appearance in text: TP53: 743G>A
PMID: 31689961
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Models for Understanding Resistance to Chemotherapy in Liver Cancer.

Cancers
JJG Marin, E Herraez, E Lozano, RIR Macias, O Briz
Publication Date: 2019-10-29

Variant appearance in text: p53: R248Q
PMID: 31671735
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Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy.

Genes
LK Urbina-Jara, A Rojas-Martinez, E Martinez-Ledesma, D Aguilar, C Villarreal-Garza, R Ortiz-Lopez
Publication Date: 2019-10-10

Variant appearance in text: TP53: 743G>A; R248Q; rs11540652
PMID: 31658756
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PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors.

Oncotarget
AM Smith, CRC Zhang, AS Cristino, JP Grady, JL Fink, AS Moore
Publication Date: 2019-10-08

Variant appearance in text: TP53: R248Q
PMID: 31645898
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Ceramide-Rubusoside Nanomicelles, a Potential Therapeutic Approach to Target Cancers Carrying p53 Missense Mutations.

Molecular Cancer Therapeutics
SK Khiste, Z Liu, KR Roy, MB Uddin, SB Hosain, X Gu, S Nazzal, RA Hill, YY Liu
Publication Date: 2019-10-23

Variant appearance in text: p53: R248Q
PMID: 31645443
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Gain of function in somatic TP53 mutations is associated with immune-rich breast tumors and changes in tumor-associated macrophages.

Molecular Genetics & Genomic Medicine
M Behring, AI Vazquez, X Cui, MR Irvin, AI Ojesina, S Agarwal, U Manne, S Shrestha
Publication Date: 2019-12

Variant appearance in text: TP53: R248Q
PMID: 31637877
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Chaperone-Mediated Autophagy and Its Emerging Role in Hematological Malignancies.

Cells
G Robert, A Jacquel, P Auberger
Publication Date: 2019-10-16

Variant appearance in text: TP53: R248Q
PMID: 31623164
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Transcriptional Regulation of Energy Metabolism in Cancer Cells.

Cells
S Rodríguez-Enríquez, Á Marín-Hernández, JC Gallardo-Pérez, SC Pacheco-Velázquez, JA Belmont-Díaz, DX Robledo-Cadena, JL Vargas-Navarro, NA Corona de la Peña, E Saavedra, R Moreno-Sánchez
Publication Date: 2019-10-09

Variant appearance in text: p53: R248Q
PMID: 31600993
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Exploratory findings from a prematurely closed international, multicentre, academic trial: RAVELLO, a phase III study of regorafenib versus placebo as maintenance therapy after first-line treatment in RAS wild-type metastatic colorectal cancer.

Esmo Open
C Cardone, E Martinelli, T Troiani, V Sforza, A Avallone, A Nappi, V Montesarchio, F Andreozzi, M Biglietto, F Calabrese, R Bordonaro, S Cordio, G Bregni, A Febbraro, R Garcia-Carbonero, J Feliu, A Cervantes, F Ciardiello
Publication Date: 2019

Variant appearance in text: TP53: R248Q
PMID: 31555481
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Distinct TP53 Mutation Subtypes Differentially Influence Cellular Iron Metabolism.

Nutrients
SL Clarke, LR Thompson, E Dandekar, A Srinivasan, MR Montgomery
Publication Date: 2019-09-07

Variant appearance in text: TP53: R248Q
PMID: 31500291
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Synergistic effects of PRIMA-1Met (APR-246) and Azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia.

Haematologica
N Maslah, N Salomao, L Drevon, E Verger, N Partouche, P Ly, P Aubin, N Naoui, MH Schlageter, C Bally, E Miekoutima, R Rahmé, J Lehmann-Che, L Ades, P Fenaux, B Cassinat, S Giraudier
Publication Date: 2019-09-05

Variant appearance in text: TP53: 743G>A
PMID: 31488557
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High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study.

Cancers
M Cordova-Delgado, MP Pinto, IN Retamal, M Muñoz-Medel, ML Bravo, MF Fernández, B Cisternas, S Mondaca, C Sanchez, H Galindo, B Nervi, C Ibáñez, F Acevedo, J Madrid, J Peña, E Koch, MJ Maturana, D Romero, N de la Jara, J Torres, M Espinoza, C Balmaceda, Y Liao, Z Li, M Freire, V Gárate-Calderón, J Cáceres, G Sepúlveda-Hermosilla, R Lizana, L Ramos, R Artigas, E Norero, F Crovari, R Armisén, AH Corvalán, GI Owen, M Garrido
Publication Date: 2019-08-30

Variant appearance in text: TP53: R248Q
PMID: 31480291
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Phenylhexyl isothiocyanate suppresses cell proliferation and promotes apoptosis via repairing mutant P53 in human myeloid leukemia M2 cells.

Oncology Letters
Y Zou, Y Huang, X Ma
Publication Date: 2019-09

Variant appearance in text: p53: R248Q
PMID: 31452815
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Abstracts : 31 st European Congress of Pathology.

Virchows Archiv : An International Journal Of Pathology
.
Publication Date: 2019-09

Variant appearance in text: TP53: R248Q
PMID: 31440833
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Treatment of cancer cells with chemotherapeutic drugs results in profound changes in expression of genes encoding aldehyde-metabolizing enzymes.

Journal Of Cancer
OL Zinovieva, EN Grineva, GS Krasnov, DS Karpov, AO Zheltukhin, AV Snezhkina, AV Kudryavtseva, TD Mashkova, NA Lisitsyn
Publication Date: 2019

Variant appearance in text: p53: R248Q
PMID: 31413744
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000269305.4 c.743G>A p.Arg248Gln missense_variant 7/11 -
ENST00000359597.4 c.743G>A p.Arg248Gln missense_variant 6/9 -
ENST00000413465.2 c.743G>A p.Arg248Gln missense_variant 6/7 -
ENST00000420246.2 c.743G>A p.Arg248Gln missense_variant 7/12 -
ENST00000445888.2 c.743G>A p.Arg248Gln missense_variant 7/11 -
ENST00000455263.2 c.743G>A p.Arg248Gln missense_variant 7/12 -
ENST00000504290.1 n.625G>A - non_coding_transcript_exon_variant 3/8 -
ENST00000504937.1 n.625G>A - non_coding_transcript_exon_variant 3/7 -
ENST00000509690.1 c.347G>A p.Arg116Gln missense_variant 4/6 -
ENST00000510385.1 n.625G>A - non_coding_transcript_exon_variant 3/8 -
ENST00000514944.1 c.464G>A p.Arg155Gln missense_variant 6/6 -
NM_000546.5 c.743G>A p.Arg248Gln missense_variant 7/11 -
NM_001126112.2 c.743G>A p.Arg248Gln missense_variant 7/11 -
NM_001126113.2 c.743G>A p.Arg248Gln missense_variant 7/12 -
NM_001126114.2 c.743G>A p.Arg248Gln missense_variant 7/12 -
NM_001126115.1 c.347G>A p.Arg116Gln missense_variant 3/7 -
NM_001126116.1 c.347G>A p.Arg116Gln missense_variant 3/8 -
NM_001126117.1 c.347G>A p.Arg116Gln missense_variant 3/8 -
NM_001126118.1 c.626G>A p.Arg209Gln missense_variant 6/10 -
NM_001276695.2 c.626G>A p.Arg209Gln missense_variant 7/12 -
NM_001276696.2 c.626G>A p.Arg209Gln missense_variant 7/12 -
NM_001276697.2 c.266G>A p.Arg89Gln missense_variant 3/7 -
NM_001276698.2 c.266G>A p.Arg89Gln missense_variant 3/8 -
NM_001276699.2 c.266G>A p.Arg89Gln missense_variant 3/8 -
NM_001276760.2 c.626G>A p.Arg209Gln missense_variant 7/11 -
NM_001276761.2 c.626G>A p.Arg209Gln missense_variant 7/11 -