Publications:

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Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis.

Nature Communications

Wei, Hudie H; Qu, Lingzhi L; Dai, Shuyan S; Li, Yun Y; Wang, Haolan H; Feng, Yilu Y; Chen, Xiaojuan X; Jiang, Longying L; Guo, Ming M; Li, Jun J; Chen, Zhuchu Z; Chen, Lin L; Zhang, Ye Y; Chen, Yongheng Y

Publication Date: 2021-04-16

Variant appearance in text: p53: R248A

PubMed Link: 33863900

Variant Present in the following documents:

• Main text
• 41467_2021_22655_MOESM1_ESM.pdf
• 41467_2021_Article_22655.pdf

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Manumycin polyketides act as molecular glues between UBR7 and P53.

Nature Chemical Biology

Isobe, Yosuke Y; Okumura, Mikiko M; McGregor, Lynn M LM; Brittain, Scott M SM; Jones, Michael D MD; Liang, Xiaoyou X; White, Ross R; Forrester, William W; McKenna, Jeffrey M JM; Tallarico, John A JA; Schirle, Markus M; Maimone, Thomas J TJ; Nomura, Daniel K DK

Publication Date: 2020-11

Variant appearance in text: TP53: R248A

PubMed Link: 32572277

Variant Present in the following documents:

• NIHMS1589521-supplement-SuppInfo.pdf

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Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy.

Nucleic Acids Research

Krüger, Annika A; Stier, Anna A; Fischbach, Arthur A; Bürkle, Alexander A; Hauser, Karin K; Mangerich, Aswin A

Publication Date: 2019-05-21

Variant appearance in text: p53: R248A

PubMed Link: 30892621

Variant Present in the following documents:

• Main text
• gkz175.pdf

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An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53.

Excli Journal

Malami, Ibrahim I; Muhammad, Aliyu A; Etti, Imaobong C IC; Waziri, Peter M PM; Alhassan, Alhassan M AM

Publication Date: 2017

Variant appearance in text: p53: R248A

PubMed Link: 29333130

Variant Present in the following documents:

• Main text
• EXCLI-16-1276.pdf

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Vermont: a multi-perspective visual interactive platform for mutational analysis.

Bmc Bioinformatics

Fassio, Alexandre V AV; Martins, Pedro M PM; Guimarães, Samuel da S SDS; Junior, Sócrates S A SSA; Ribeiro, Vagner S VS; de Melo-Minardi, Raquel C RC; Silveira, Sabrina de A SA

Publication Date: 2017-09-13

Variant appearance in text: p53: Arg248Ala

PubMed Link: 28929973

Variant Present in the following documents:

• Main text
• 12859_2017_Article_1789.pdf
• 12859_2017_1789_MOESM1_ESM.pdf

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Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax.

Pharmaceutical Research

Matissek, Karina J KJ; Okal, Abood A; Mossalam, Mohanad M; Lim, Carol S CS

Publication Date: 2014-09

Variant appearance in text: p53: R248A

PubMed Link: 24633417

Variant Present in the following documents:

• Main text

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Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.

Plos One

Barakat, Khaled K; Issack, Bilkiss B BB; Stepanova, Maria M; Tuszynski, Jack J

Publication Date: 2011

Variant appearance in text: p53: R248A

PubMed Link: 22110706

Variant Present in the following documents:

• Main text
• pone.0027651.pdf

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Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms.

Plos Computational Biology

Cheng, Tammy M K TM; Lu, Yu-En YE; Vendruscolo, Michele M; Lio', Pietro P; Blundell, Tom L TL

Publication Date: 2008-07-25

Variant appearance in text: p53: R248A

PubMed Link: 18654622

Variant Present in the following documents:

• Main text
• pcbi.1000135.pdf

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