TP53 c.705C>A ;(p.N235K)

Variant ID: 17-7577576-G-T

NM_000546.5(TP53):c.705C>A;(p.N235K)

This variant was identified in 24 publications

View GRCh38 version.




Publications:


Rational design of phase separating peptides based on phase separating protein sequence of p53.

Scientific Reports
Kamagata, Kiyoto K; Hando, Atsumi A; Ariefai, Maulana M; Iwaki, Nanako N; Kanbayashi, Saori S; Koike, Ryotaro R; Ikeda, Keisuke K
Publication Date: 2023-04-06

Variant appearance in text: p53: N235K
PubMed Link: 37024567
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_32632.pdf
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Bioinformatics and Network Pharmacology of the First Crystal Structured Clerodin: Anticancer and Antioxidant Potential against Human Breast Carcinoma Cell.

Acs Omega
Pakrashy, Sourav S; Mandal, Prakash K PK; Nanda Goswami, Juli J; Dey, Surya Kanta SK; Maiti Choudhury, Sujata S; Bhattacharya, Biswajit B; Emmerling, Franziska F; Alasmary, Fatmah Ali FA; Dolai, Malay M
Publication Date: 2022-12-27

Variant appearance in text: p53: N235K
PubMed Link: 36591129
Variant Present in the following documents:
  • Main text
  • ao2c07173.pdf
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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: 705C>A
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
  • mmc5.xlsx, sheet 1
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Rational peptide design for regulating liquid-liquid phase separation on the basis of residue-residue contact energy.

Scientific Reports
Kamagata, Kiyoto K; Ariefai, Maulana M; Takahashi, Hiroto H; Hando, Atsumi A; Subekti, Dwiky Rendra Graha DRG; Ikeda, Keisuke K; Hirano, Atsushi A; Kameda, Tomoshi T
Publication Date: 2022-08-12

Variant appearance in text: p53: N235K
PubMed Link: 35962177
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_17829.pdf
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Landscape of somatic alterations in large-scale solid tumors from an Asian population.

Nature Communications
Wu, Liqun L; Yao, Herui H; Chen, Hui H; Wang, Aodi A; Guo, Kun K; Gou, Wenli W; Yu, Yanfei Y; Li, Xiang X; Yao, Ming M; Yuan, Shaohua S; Pang, Fei F; Hu, Jinwei J; Chen, Lijuan L; Liu, Wenjin W; Yao, Jicheng J; Zhang, Shuirong S; Dong, Xiaowei X; Wang, Weifeng W; Hu, Jing J; Ling, Qi Q; Ding, Songming S; Wei, Yan Y; Li, Qiang Q; Cao, Weichun W; Wang, Shuang S; Di, Yang Y; Feng, Feiling F; Zhao, Gang G; Zhang, Jian J; Huang, Ling L; Xu, Jia J; Yan, Wangjun W; Tong, Zhongsheng Z; Jiang, Da D; Ji, Tao T; Li, Qiao Q; Xu, Ling L; He, Huiying H; Shang, Liang L; Liu, Jin J; Wang, Kefeng K; Wu, Duoguang D; Shen, Jingnan J; Liu, Ye Y; Zhang, Ting T; Liang, Chaojie C; Wang, Yusheng Y; Shang, Yanhong Y; Guo, Jianji J; Liang, Guanbiao G; Xu, Shifeng S; Liu, Junfeng J; Wang, Kai K; Wang, Minghui M
Publication Date: 2022-07-23

Variant appearance in text: TP53: N235K
PubMed Link: 35871175
Variant Present in the following documents:
  • 41467_2022_31780_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Structure-dependent recruitment and diffusion of guest proteins in liquid droplets of FUS.

Scientific Reports
Kamagata, Kiyoto K; Iwaki, Nanako N; Kanbayashi, Saori S; Banerjee, Trishit T; Chiba, Rika R; Gaudon, Virginie V; Castaing, Bertrand B; Sakomoto, Seiji S
Publication Date: 2022-05-02

Variant appearance in text: p53: N235K
PubMed Link: 35501371
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_11177.pdf
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Molecular principles of recruitment and dynamics of guest proteins in liquid droplets.

Scientific Reports
Kamagata, Kiyoto K; Iwaki, Nanako N; Hazra, Milan Kumar MK; Kanbayashi, Saori S; Banerjee, Trishit T; Chiba, Rika R; Sakomoto, Seiji S; Gaudon, Virginie V; Castaing, Bertrand B; Takahashi, Hiroto H; Kimura, Michiko M; Oikawa, Hiroyuki H; Takahashi, Satoshi S; Levy, Yaakov Y
Publication Date: 2021-09-29

Variant appearance in text: p53: N235K
PubMed Link: 34588591
Variant Present in the following documents:
  • Main text
  • 41598_2021_Article_98955.pdf
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Transient binding and jumping dynamics of p53 along DNA revealed by sub-millisecond resolved single-molecule fluorescence tracking.

Scientific Reports
Subekti, Dwiky Rendra Graha DRG; Murata, Agato A; Itoh, Yuji Y; Takahashi, Satoshi S; Kamagata, Kiyoto K
Publication Date: 2020-08-13

Variant appearance in text: p53: N235K
PubMed Link: 32792545
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_70763.pdf
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Phase and context shape the function of composite oncogenic mutations.

Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Publication Date: 2020-06

Variant appearance in text: TP53: N235K
PubMed Link: 32461694
Variant Present in the following documents:
  • NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2
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Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.

Scientific Reports
Kamagata, Kiyoto K; Kanbayashi, Saori S; Honda, Masaya M; Itoh, Yuji Y; Takahashi, Hiroto H; Kameda, Tomoshi T; Nagatsugi, Fumi F; Takahashi, Satoshi S
Publication Date: 2020-01-17

Variant appearance in text: p53: N235K
PubMed Link: 31953488
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_57521.pdf
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Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53.

Scientific Reports
Kamagata, Kiyoto K; Mano, Eriko E; Itoh, Yuji Y; Wakamoto, Takuro T; Kitahara, Ryo R; Kanbayashi, Saori S; Takahashi, Hiroto H; Murata, Agato A; Kameda, Tomoshi T
Publication Date: 2019-06-28

Variant appearance in text: p53: N235K
PubMed Link: 31253862
Variant Present in the following documents:
  • Main text
  • 41598_2019_Article_44688.pdf
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Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting.

Journal Of Molecular Cell Biology
Tan, Yaw Sing YS; Mhoumadi, Yasmina Y; Verma, Chandra S CS
Publication Date: 2019-04-01

Variant appearance in text: p53: N235K
PubMed Link: 30726928
Variant Present in the following documents:
  • Main text
  • mjz009.pdf
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Selective identification of somatic mutations in pancreatic cancer cells through a combination of next-generation sequencing of plasma DNA using molecular barcodes and a bioinformatic variant filter.

Plos One
Kukita, Yoji Y; Ohkawa, Kazuyoshi K; Takada, Ryoji R; Uehara, Hiroyuki H; Katayama, Kazuhiro K; Kato, Kikuya K
Publication Date: 2018

Variant appearance in text: TP53: N235K
PubMed Link: 29451897
Variant Present in the following documents:
  • pone.0192611.s007.xlsx, sheet 1
View BVdb publication page



One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain.

Biophysical Journal
Murata, Agato A; Itoh, Yuji Y; Mano, Eriko E; Kanbayashi, Saori S; Igarashi, Chihiro C; Takahashi, Hiroto H; Takahashi, Satoshi S; Kamagata, Kiyoto K
Publication Date: 2017-06-06

Variant appearance in text: p53: N235K
PubMed Link: 28591603
Variant Present in the following documents:
  • Main text
View BVdb publication page



p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept.

International Journal Of Molecular Sciences
Uversky, Vladimir N VN
Publication Date: 2016-11-10

Variant appearance in text: p53: N235K
PubMed Link: 27834926
Variant Present in the following documents:
  • ijms-17-01874-s001.pdf
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Altered expression of estrogen receptor β2 is associated with different biological markers and clinicopathological factors in papillary thyroid cancer.

International Journal Of Clinical And Experimental Pathology
Dong, Wenwu W; Li, Jing J; Zhang, Hao H; Huang, Yanhong Y; He, Liang L; Wang, Zhihong Z; Shan, Zhongyan Z; Teng, Weiping W
Publication Date: 2015

Variant appearance in text: p53: N235K
PubMed Link: 26261608
Variant Present in the following documents:
  • Main text
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Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

British Journal Of Cancer
Wong, S Q SQ; Fellowes, A A; Doig, K K; Ellul, J J; Bosma, T J TJ; Irwin, D D; Vedururu, R R; Tan, A Y-C AY; Weiss, J J; Chan, K S KS; Lucas, M M; Thomas, D M DM; Dobrovic, A A; Parisot, J P JP; Fox, S B SB
Publication Date: 2015-04-14

Variant appearance in text: p53: 705C>A
PubMed Link: 25742471
Variant Present in the following documents:
  • bjc201580x7.xls, sheet 1
View BVdb publication page



Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue.

Acta Crystallographica. Section D, Biological Crystallography
Wallentine, Brad D BD; Wang, Ying Y; Tretyachenko-Ladokhina, Vira V; Tan, Martha M; Senear, Donald F DF; Luecke, Hartmut H
Publication Date: 2013-10

Variant appearance in text: p53: N235K
PubMed Link: 24100332
Variant Present in the following documents:
  • Main text
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Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain.

Biochemistry
Calhoun, Sara S; Daggett, Valerie V
Publication Date: 2011-06-14

Variant appearance in text: p53: N235K
PubMed Link: 21561095
Variant Present in the following documents:
  • Main text
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All-codon scanning identifies p53 cancer rescue mutations.

Nucleic Acids Research
Baronio, Roberta R; Danziger, Samuel A SA; Hall, Linda V LV; Salmon, Kirsty K; Hatfield, G Wesley GW; Lathrop, Richard H RH; Kaiser, Peter P
Publication Date: 2010-11

Variant appearance in text: p53: N235K
PubMed Link: 20581117
Variant Present in the following documents:
  • Main text
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Molecular mechanisms of functional rescue mediated by P53 tumor suppressor mutations.

Biophysical Chemistry
Tan, Yu-Hong YH; Chen, Y Morris YM; Ye, Xiang X; Lu, Qiang Q; Tretyachenko-Ladokhina, Vira V; Yang, Wei W; Senear, Donald F DF; Luo, Ray R
Publication Date: 2009-11

Variant appearance in text: p53: N235K
PubMed Link: 19748724
Variant Present in the following documents:
  • Main text
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Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants.

Bioinformatics (Oxford, England)
Danziger, Samuel A SA; Zeng, Jue J; Wang, Ying Y; Brachmann, Rainer K RK; Lathrop, Richard H RH
Publication Date: 2007-07-01

Variant appearance in text: p53: N235K
PubMed Link: 17646286
Variant Present in the following documents:
  • Main text
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Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.

Ieee/Acm Transactions On Computational Biology And Bioinformatics
Danziger, Samuel A SA; Swamidass, S Joshua SJ; Zeng, Jue J; Dearth, Lawrence R LR; Lu, Qiang Q; Chen, Jonathan H JH; Cheng, Jianlin J; Hoang, Vinh P VP; Saigo, Hiroto H; Luo, Ray R; Baldi, Pierre P; Brachmann, Rainer K RK; Lathrop, Richard H RH
Publication Date: 2006

Variant appearance in text: p53: N235K
PubMed Link: 17048398
Variant Present in the following documents:
  • Main text
View BVdb publication page