Variant ID: 17-7578406-C-T

NM_000546.5(TP53):c.524G>A;(p.Arg175His)

This variant was identified in 1362 publications




Publications:


Association of TP53 Mutations with Response to Anlotinib Treatment in Advanced Non-Small Cell Lung Cancer.

Oncotargets And Therapy
S Fang, W Cheng, M Zhang, R Yang
Publication Date: 2020

Variant appearance in text: TP53: R175H
PMID: 32753898
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Molecular Biology of Osteosarcoma.

Cancers
AM Czarnecka, K Synoradzki, W Firlej, E Bartnik, P Sobczuk, M Fiedorowicz, P Grieb, P Rutkowski
Publication Date: 2020-07-31

Variant appearance in text: p53: R175H
PMID: 32751922
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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
J Li, W Jiang, J Wei, J Zhang, L Cai, M Luo, Z Wang, W Sun, S Wang, C Wang, C Dai, J Liu, G Wang, J Wang, Q Xu, Y Deng
Publication Date: 2020-08-01

Variant appearance in text: TP53: R175H
PMID: 32738923
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Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.

Cell Death & Disease
S Sun, H Chen, L Sun, M Wang, X Wu, ZJ Xiao
Publication Date: 2020-07-30

Variant appearance in text: p53: R175H
PMID: 32733026
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Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Cancers
YC Wang, JL Huang, KW Lee, HH Lu, YJ Lin, LF Chen, CS Wang, YC Cheng, ZT Zeng, PY Chu, CS Lin
Publication Date: 2020-07-25

Variant appearance in text: p53: R175H
PMID: 32722430
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TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy.

Cancers
F Graziano, NW Fischer, I Bagaloni, M Di Bartolomeo, S Lonardi, B Vincenzi, G Perrone, L Fornaro, E Ongaro, G Aprile, R Bisonni, M Prisciandaro, D Malkin, J Gariépy, M Fassan, F Loupakis, D Sarti, M Del Prete, V Catalano, P Alessandroni, M Magnani, A Ruzzo
Publication Date: 2020-07-24

Variant appearance in text: TP53: R175H
PMID: 32722340
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EGFR, BRCA1, BRCA2 and TP53 genetic profile in Moroccan triple negative breast cancer cases.

International Journal Of Molecular Epidemiology And Genetics
F Jouali, FZ El Ansari, N Marchoudi, A Barakat, H Zmaimita, H Samlali, J Fekkak
Publication Date: 2020

Variant appearance in text: TP53: 524G>A; Arg175His
PMID: 32714499
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Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma.

Scientific Reports
GG Jinesh, M Napoli, HD Ackerman, PM Raulji, N Montey, ER Flores, AS Brohl
Publication Date: 2020-07-23

Variant appearance in text: p53: R175H
PMID: 32704163
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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports
Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura
Publication Date: 2020-07-23

Variant appearance in text: TP53: R175H
PMID: 32704002
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Applied precision medicine in metastatic pancreatic ductal adenocarcinoma.

Therapeutic Advances In Medical Oncology
H Taghizadeh, L Müllauer, RM Mader, M Schindl, GW Prager
Publication Date: 2020

Variant appearance in text: TP53: Arg175His
PMID: 32699558
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Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.

Nature Communications
Y Li, B Li, W Li, Y Wang, S Akgül, DM Treisman, KA Heist, BR Pierce, B Hoff, CY Ho, DO Ferguson, A Rehemtulla, S Zheng, BD Ross, JZ Li, Y Zhu
Publication Date: 2020-07-22

Variant appearance in text: TP53: R175H
PMID: 32699356
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Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma.

Endocrine Connections
A Jouinot, J Lippert, M Fassnacht, B De La Villeon, A Septier, M Neou, K Perlemoine, S Appenzeller, M Sibony, S Gaujoux, B Dousset, R Libe, L Groussin, CL Ronchi, G Assie, J Bertherat
Publication Date: 2020-07-01

Variant appearance in text: TP53: R175H
PMID: 32698135
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Immunohistochemical detection of p53 and pp53 Ser392 in canine hemangiomas and hemangiosarcomas located in the skin.

Bmc Veterinary Research
MJ García-Iglesias, JL Cuevas-Higuera, A Bastida-Sáenz, MG de Garnica-García, L Polledo, P Perero, J González-Fernández, B Fernández-Martínez, C Pérez-Martínez
Publication Date: 2020-07-13

Variant appearance in text: TP53: R175H
PMID: 32660487
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The Janus Face of p53-Targeting Ubiquitin Ligases.

Cells
Q Hao, Y Chen, X Zhou
Publication Date: 2020-07-09

Variant appearance in text: p53: R175H
PMID: 32660118
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XAF1 as a modifier of p53 function and cancer susceptibility.

Science Advances
EM Pinto, BC Figueiredo, W Chen, HCR Galvao, MN Formiga, MCBV Fragoso, P Ashton-Prolla, EMSF Ribeiro, G Felix, TEB Costa, SA Savage, M Yeager, EI Palmero, S Volc, H Salvador, JL Fuster-Soler, C Lavarino, G Chantada, D Vaur, V Odone-Filho, L Brugières, T Else, EM Stoffel, KN Maxwell, MI Achatz, L Kowalski, KC de Andrade, A Pappo, E Letouze, AC Latronico, BB Mendonca, MQ Almeida, VB Brondani, CM Bittar, EWS Soares, C Mathias, CRN Ramos, M Machado, W Zhou, K Jones, A Vogt, PP Klincha, KM Santiago, H Komechen, MM Paraizo, IZS Parise, KV Hamilton, J Wang, E Rampersaud, MR Clay, AJ Murphy, E Lalli, KE Nichols, RC Ribeiro, C Rodriguez-Galindo, M Korbonits, J Zhang, MG Thomas, JP Connelly, S Pruett-Miller, Y Diekmann, G Neale, G Wu, GP Zambetti
Publication Date: 2020-06

Variant appearance in text: TP53: R175H
PMID: 32637605
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A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status.

Journal Of Experimental & Clinical Cancer Research : Cr
A Garufi, S Baldari, R Pettinari, MS Gilardini Montani, V D'Orazi, G Pistritto, A Crispini, E Giorno, G Toietta, F Marchetti, M Cirone, G D'Orazi
Publication Date: 2020-06-30

Variant appearance in text: p53: R175H
PMID: 32605658
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Good Cop, Bad Cop: Defining the Roles of Δ40p53 in Cancer and Aging.

Cancers
L Steffens Reinhardt, X Zhang, A Wawruszak, K Groen, GN De Iuliis, KA Avery-Kiejda
Publication Date: 2020-06-23

Variant appearance in text: p53: R175H
PMID: 32585821
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Analysis of targeted somatic mutations in pleomorphic carcinoma of the lung using next-generation sequencing technique.

Thoracic Cancer
S Manabe, R Kasajima, S Murakami, Y Miyagi, T Yokose, T Kondo, H Saito, H Ito, T Kaneko, K Yamada
Publication Date: 2020-06-23

Variant appearance in text: TP53: R175H
PMID: 32578376
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Application of Genetically Engineered Pigs in Biomedical Research.

Genes
M Hryhorowicz, D Lipiński, S Hryhorowicz, A Nowak-Terpiłowska, N Ryczek, J Zeyland
Publication Date: 2020-06-19

Variant appearance in text: TP53: R175H
PMID: 32575461
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Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells.

Journal Of Immunology (Baltimore, Md. : 1950)
A Sachs, E Moore, Z Kosaloglu-Yalcin, B Peters, J Sidney, SA Rosenberg, PF Robbins, A Sette
Publication Date: 2020-06-22

Variant appearance in text: TP53: R175H
PMID: 32571843
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Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity.

Oncogene
Q Li, RM Karim, M Cheng, M Das, L Chen, C Zhang, HR Lawrence, GW Daughdrill, E Schonbrunn, H Ji, J Chen
Publication Date: 2020-06-17

Variant appearance in text: p53: R175H
PMID: 32555331
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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)
G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar
Publication Date: 2020-06-17

Variant appearance in text: TP53: R175H
PMID: 32552660
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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics
V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones
Publication Date: 2020

Variant appearance in text: p53: R175H
PMID: 32546937
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Comparative genomics of high grade neuroendocrine carcinoma of the cervix.

Plos One
RT Hillman, R Cardnell, J Fujimoto, WC Lee, J Zhang, LA Byers, P Ramalingam, M Leitao, E Swisher, PA Futreal, M Frumovitz
Publication Date: 2020

Variant appearance in text: TP53: 524G>A; R175H
PMID: 32544169
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Regulating tumor suppressor genes: post-translational modifications.

Signal Transduction And Targeted Therapy
L Chen, S Liu, Y Tao
Publication Date: 2020-06-10

Variant appearance in text: p53: R175H
PMID: 32532965
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The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells.

Biomolecules
G Butera, J Brandi, C Cavallini, A Scarpa, RT Lawlor, MT Scupoli, E Marengo, D Cecconi, M Manfredi, M Donadelli
Publication Date: 2020-06-09

Variant appearance in text: p53: R175H
PMID: 32526853
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Mutant p53 as an Antigen in Cancer Immunotherapy.

International Journal Of Molecular Sciences
N Sobhani, A D'Angelo, X Wang, KH Young, D Generali, Y Li
Publication Date: 2020-06-08

Variant appearance in text: p53: R175H
PMID: 32521648
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Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.

Nature Communications
D Wu, DT Gallagher, R Gowthaman, BG Pierce, RA Mariuzza
Publication Date: 2020-06-09

Variant appearance in text: p53: R175H
PMID: 32518267
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The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient.

Plos One
Y Li, T Li, Y Tang, Z Zhan, L Ding, L Song, T Yu, Y Yang, J Ma, Y Zhang, Y Zhou, S Gu, M Xu, Y Gao, Y Li
Publication Date: 2020

Variant appearance in text: p53: R175H
PMID: 32516327
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Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review.

American Journal Of Translational Research
R Li, P Li, W Xing, H Qiu
Publication Date: 2020

Variant appearance in text: TP53: R175H
PMID: 32509161
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In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

Plos Genetics
O Kim, EY Park, DL Klinkebiel, SD Pack, YH Shin, Z Abdullaev, RE Emerson, DM Coffey, SY Kwon, CJ Creighton, S Kwon, EC Chang, T Chiang, AN Yatsenko, J Chien, DJ Cheon, Y Yang-Hartwich, H Nakshatri, KP Nephew, RR Behringer, FM Fernández, CH Cho, B Vanderhyden, R Drapkin, RC Bast, KD Miller, AR Karpf, J Kim
Publication Date: 2020-06-04

Variant appearance in text: p53: R175H
PMID: 32497036
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Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells.

Oncogenesis
M Kang, KY Chong, TMP Hartwich, F Bi, AK Witham, D Patrick, MJ Morrisson, SL Cady, AP Cerchia, D Kelk, Y Liu, J Nucci, O Madarikan, D Ueno, BM Shuch, Y Yang-Hartwich
Publication Date: 2020-05-29

Variant appearance in text: p53: R175H
PMID: 32471985
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Astaxanthin Modulates Apoptotic Molecules to Induce Death of SKBR3 Breast Cancer Cells.

Marine Drugs
MS Kim, YT Ahn, CW Lee, H Kim, WG An
Publication Date: 2020-05-19

Variant appearance in text: p53: R175H
PMID: 32438569
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Clinical spectrum and prognostic value of TP53 mutations in circulating tumor DNA from breast cancer patients in China.

Cancer Communications (London, England)
Z Yi, F Ma, G Rong, Y Guan, C Li, B Xu
Publication Date: 2020-05-21

Variant appearance in text: TP53: R175H
PMID: 32436611
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Genetic Alterations Featuring Biological Models to Tailor Clinical Management of Pancreatic Cancer Patients.

Cancers
SR Nelson, N Walsh
Publication Date: 2020-05-14

Variant appearance in text: TP53: R175H
PMID: 32423157
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Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours.

Nature Communications
PA Johansson, K Brooks, F Newell, JM Palmer, JS Wilmott, AL Pritchard, N Broit, S Wood, MS Carlino, C Leonard, LT Koufariotis, V Nathan, AB Beasley, M Howlie, R Dawson, H Rizos, CW Schmidt, GV Long, H Hamilton, JF Kiilgaard, T Isaacs, ES Gray, OJ Rolfe, JJ Park, A Stark, GJ Mann, RA Scolyer, JV Pearson, N van Baren, N Waddell, KW Wadt, LA McGrath, SK Warrier, W Glasson, NK Hayward
Publication Date: 2020-05-15

Variant appearance in text: TP53: R175H
PMID: 32415113
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P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

International Journal Of Molecular Sciences
AD Agupitan, P Neeson, S Williams, J Howitt, S Haupt, Y Haupt
Publication Date: 2020-05-13

Variant appearance in text: p53: R175H
PMID: 32414156
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TP53 in Myelodysplastic Syndromes: Recent Biological and Clinical Findings.

International Journal Of Molecular Sciences
C Cumbo, G Tota, L Anelli, A Zagaria, G Specchia, F Albano
Publication Date: 2020-05-13

Variant appearance in text: p53: R175H
PMID: 32414002
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Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA.

Thoracic Cancer
X Li, X Chen, L Wen, Y Wang, B Chen, Y Xue, L Guo, N Liao
Publication Date: 2020-05-15

Variant appearance in text: TP53: R175H
PMID: 32412177
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Non-disruptive mutation in TP53 DNA-binding domain is a beneficial factor of esophageal squamous cell carcinoma.

Annals Of Translational Medicine
M Huang, J Jin, F Zhang, Y Wu, C Xu, L Ying, D Su
Publication Date: 2020-03

Variant appearance in text: TP53: R175H
PMID: 32355760
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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.

Nature Communications
LR Kong, RW Ong, TZ Tan, NAB Mohamed Salleh, M Thangavelu, JV Chan, LYJ Koh, G Periyasamy, JA Lau, TBU Le, L Wang, M Lee, S Kannan, CS Verma, CM Lim, WJ Chng, DP Lane, A Venkitaraman, HT Hung, CF Cheok, BC Goh
Publication Date: 2020-04-29

Variant appearance in text: p53: R175H
PMID: 32350249
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Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel.

Diagnostics (Basel, Switzerland)
D de Biase, G Acquaviva, M Visani, V Sanza, CM Argento, A De Leo, T Maloberti, A Pession, G Tallini
Publication Date: 2020-04-23

Variant appearance in text: TP53: R175H
PMID: 32340363
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Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins.

Cell Death & Disease
K Tutuska, L Parrilla-Monge, E Di Cesare, A Nemajerova, UM Moll
Publication Date: 2020-04-24

Variant appearance in text: p53: R175H
PMID: 32332697
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Recent Synthetic Approaches towards Small Molecule Reactivators of p53.

Biomolecules
JL Silva, CGS Lima, LP Rangel, GDS Ferretti, FP Pauli, RCB Ribeiro, TB da Silva, FC da Silva, VF Ferreira
Publication Date: 2020-04-20

Variant appearance in text: p53: R175H
PMID: 32326087
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Molecular Profiles of Brain and Pulmonary Metastatic Disease in Cancer of Unknown Primary.

The Oncologist
BR Bakow, CP Elco, M LeGolvan, D Dizon, TA Ollila
Publication Date: 2020-04-20

Variant appearance in text: TP53: R175H
PMID: 32310333
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Epithelial-mesenchymal transition status of circulating tumor cells in breast cancer and its clinical relevance.

Cancer Biology & Medicine
J Zhou, X Zhu, S Wu, J Guo, K Zhang, C Xu, H Chen, Y Jin, Y Sun, S Zheng, Y Chen
Publication Date: 2020-02-15

Variant appearance in text: TP53: 524G>A
PMID: 32296584
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The Status of p53 Oligomeric and Aggregation States in Cancer.

Biomolecules
GAP de Oliveira, EC Petronilho, MM Pedrote, MA Marques, TCRG Vieira, EA Cino, JL Silva
Publication Date: 2020-04-04

Variant appearance in text: p53: R175H
PMID: 32260447
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Comprehensive genomic profile of cholangiocarcinomas in China.

Oncology Letters
W Tian, W Hu, X Shi, P Liu, X Ma, W Zhao, L Qu, S Zhang, W Shi, A Liu, J Cao
Publication Date: 2020-04

Variant appearance in text: TP53: R175H
PMID: 32256810
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Context is everything: extrinsic signalling and gain-of-function p53 mutants.

Cell Death Discovery
I Amelio, G Melino
Publication Date: 2020

Variant appearance in text: p53: R175H
PMID: 32218993
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Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.

Medical Sciences (Basel, Switzerland)
U Testa, G Castelli, E Pelosi
Publication Date: 2020-03-23

Variant appearance in text: TP53: R175H
PMID: 32210163
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YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.

Science Advances
H Omori, M Nishio, M Masuda, Y Miyachi, F Ueda, T Nakano, K Sato, K Mimori, K Taguchi, H Hikasa, H Nishina, H Tashiro, T Kiyono, TW Mak, K Nakao, T Nakagawa, T Maehama, A Suzuki
Publication Date: 2020-03

Variant appearance in text: TP53: R175H
PMID: 32206709
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The Impact of Mutant p53 in the Non-Coding RNA World.

Biomolecules
S Di Agostino
Publication Date: 2020-03-19

Variant appearance in text: p53: R175H
PMID: 32204575
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BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Q Chen, JH Lei, J Bao, H Wang, W Hao, L Li, C Peng, T Masuda, K Miao, J Xu, X Xu, CX Deng
Publication Date: 2020-03

Variant appearance in text: TP53: R175H
PMID: 32195105
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A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes.

Cancers
K Larson, R Kannaiyan, R Pandey, Y Chen, HM Babiker, D Mahadevan
Publication Date: 2020-03-16

Variant appearance in text: TP53: R175H
PMID: 32188081
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Concordance between TP53 alterations in blood and tissue: impact of time interval, biopsy site, cancer type and circulating tumor DNA burden.

Molecular Oncology
CC Bieg-Bourne, R Okamura, R Kurzrock
Publication Date: 2020-03-18

Variant appearance in text: TP53: R175H
PMID: 32187847
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Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV.

Diagnostic Pathology
X Catteau, N D'haene, JC Noël
Publication Date: 2020-03-14

Variant appearance in text: p53: R175H
PMID: 32169099
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Primary malignant pericardial tumour in Lynch syndrome.

Bmc Cancer
P Paolisso, G Saturi, A Foà, M Saponara, M Nannini, MA Pantaleo, O Leone, D Turchetti, D Calistri, C Savini, D Pacini, C Pizzi, N Galiè
Publication Date: 2020-03-06

Variant appearance in text: TP53: R175H
PMID: 32143595
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Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation.

Biomolecules
A Garufi, G Federici, MS Gilardini Montani, A Crispini, M Cirone, G D'Orazi
Publication Date: 2020-03-03

Variant appearance in text: p53: R175H
PMID: 32138264
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Neoantigens in Hematologic Malignancies.

Frontiers In Immunology
MA Biernacki, M Bleakley
Publication Date: 2020

Variant appearance in text: TP53: R175H
PMID: 32117272
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TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies.

Cancer Letters
MD Wilkie, EA Anaam, AS Lau, CP Rubbi, TM Jones, MT Boyd, N Vlatković
Publication Date: 2020-02-27

Variant appearance in text: p53: R175H
PMID: 32113989
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Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.

Journal For Immunotherapy Of Cancer
SH Tseng, ST Park, B Lam, YC Tsai, MA Cheng, E Farmer, D Xing, CF Hung
Publication Date: 2020-02

Variant appearance in text: p53: R175H
PMID: 32111730
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Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells.

Biomolecules
M Cordani, G Butera, R Pacchiana, F Masetto, N Mullappilly, C Riganti, M Donadelli
Publication Date: 2020-02-26

Variant appearance in text: p53: R175H
PMID: 32111081
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Phase I studies of vorinostat with ixazomib or pazopanib imply a role of antiangiogenesis-based therapy for TP53 mutant malignancies.

Scientific Reports
Y Wang, F Janku, S Piha-Paul, K Hess, R Broaddus, L Liu, N Shi, M Overman, S Kopetz, V Subbiah, A Naing, D Hong, AM Tsimberidou, D Karp, J Yao, S Fu
Publication Date: 2020-02-20

Variant appearance in text: TP53: R175H
PMID: 32080210
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Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis.

International Journal Of Molecular Sciences
KA Roszkowska, S Gizinski, M Sady, Z Gajewski, MB Olszewski
Publication Date: 2020-02-17

Variant appearance in text: p53: R175H
PMID: 32079237
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p53's Extended Reach: The Mutant p53 Secretome.

Biomolecules
E Pavlakis, T Stiewe
Publication Date: 2020-02-15

Variant appearance in text: p53: R175H
PMID: 32075247
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Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53.

Biomolecules
SN Loh
Publication Date: 2020-02-14

Variant appearance in text: p53: R175H
PMID: 32075132
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Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery.

Oncotarget
LF Ye, E Reznik, JM Korn, F Lin, G Yang, K Malesky, H Gao, A Loo, R Pagliarini, T Mikkelsen, DC Lo, AC deCarvalho, BR Stockwell
Publication Date: 2020-01-28

Variant appearance in text: p53: R175H
PMID: 32064048
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Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status.

Applied Surface Science
A Padmanabhan, M Kaushik, R Niranjan, JS Richards, B Ebright, GD Venkatasubbu
Publication Date: 2019-09

Variant appearance in text: p53: R175H
PMID: 32042215
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Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78.

Frontiers In Oncology
B Borjan, J Kern, N Steiner, E Gunsilius, D Wolf, G Untergasser
Publication Date: 2019

Variant appearance in text: p53: R175H
PMID: 32039016
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Identifying multi-hit carcinogenic gene combinations: Scaling up a weighted set cover algorithm using compressed binary matrix representation on a GPU.

Scientific Reports
Q Al Hajri, S Dash, WC Feng, HR Garner, R Anandakrishnan
Publication Date: 2020-02-06

Variant appearance in text: TP53: R175H
PMID: 32029803
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Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes.

Blood Advances
G Montalban-Bravo, R Kanagal-Shamanna, CB Benton, CA Class, KS Chien, K Sasaki, K Naqvi, Y Alvarado, TM Kadia, F Ravandi, N Daver, K Takahashi, E Jabbour, G Borthakur, N Pemmaraju, M Konopleva, KA Soltysiak, SR Pierce, CE Bueso-Ramos, KP Patel, H Kantarjian, G Garcia-Manero
Publication Date: 2020-02-11

Variant appearance in text: TP53: R175H
PMID: 32027746
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The PI3K/mTOR dual inhibitor NVP-BEZ235 stimulates mutant p53 degradation to exhibit anti-tumor effect on triple-negative breast cancer cells.

Febs Open Bio
J Cai, J Xia, J Zou, Q Wang, Q Ma, R Sun, H Liao, L Xu, D Wang, X Guo
Publication Date: 2020-02-06

Variant appearance in text: p53: R175H
PMID: 32027103
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Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.

Nature Genetics
NS Sethi, O Kikuchi, GN Duronio, MD Stachler, JM McFarland, R Ferrer-Luna, Y Zhang, C Bao, R Bronson, D Patil, F Sanchez-Vega, JB Liu, E Sicinska, JB Lazaro, KL Ligon, R Beroukhim, AJ Bass
Publication Date: 2020-02-05

Variant appearance in text: TP53: R175H
PMID: 32025000
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Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma.

Cancer Research And Treatment : Official Journal Of Korean Cancer Association
MC Choi, S Hwang, S Kim, SG Jung, H Park, WD Joo, SH Song, C Lee, TH Kim, H Kang, HJ An
Publication Date: 2020-01-06

Variant appearance in text: TP53: R175H
PMID: 32019284
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Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.

The Embo Journal
K Hoffmann, H Berger, H Kulbe, S Thillainadarasan, HJ Mollenkopf, T Zemojtel, E Taube, S Darb-Esfahani, M Mangler, J Sehouli, R Chekerov, EI Braicu, TF Meyer, M Kessler
Publication Date: 2020-02-03

Variant appearance in text: p53: R175H
PMID: 32009247
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Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Bmc Cancer
V Manoharan, EH Karunanayake, KH Tennekoon, S De Silva, AIA Imthikab, K De Silva, P Angunawela, S Vishwakula, J Lunec
Publication Date: 2020-01-30

Variant appearance in text: TP53: Arg175His; rs28934578
PMID: 32000721
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Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
P Malekzadeh, R Yossef, G Cafri, BC Paria, FJ Lowery, M Jafferji, ML Good, A Sachs, AR Copeland, SP Kim, S Kivitz, MR Parkhurst, PF Robbins, S Ray, L Xi, M Raffeld, Z Yu, NP Restifo, RPT Somerville, SA Rosenberg, DC Deniger
Publication Date: 2020-01-29

Variant appearance in text: p53: R175H
PMID: 31996390
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Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma.

Cells
E Flynt, K Bisht, V Sridharan, M Ortiz, F Towfic, A Thakurta
Publication Date: 2020-01-24

Variant appearance in text: TP53: R175H
PMID: 31991614
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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.

Molecules And Cells
Y Date, K Ito
Publication Date: 2020-01-23

Variant appearance in text: p53: R175H
PMID: 31991537
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Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm.

Acs Chemical Biology
MR Bauer, A Krämer, G Settanni, RN Jones, X Ni, R Khan Tareque, AR Fersht, J Spencer, AC Joerger
Publication Date: 2020-01-28

Variant appearance in text: p53: R175H
PMID: 31990523
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White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer.

Nature Communications
A Leal, NCT van Grieken, DN Palsgrove, J Phallen, JE Medina, C Hruban, MAM Broeckaert, V Anagnostou, V Adleff, DC Bruhm, JV Canzoniero, J Fiksel, M Nordsmark, FARM Warmerdam, HMW Verheul, DJ van Spronsen, LV Beerepoot, MM Geenen, JEA Portielje, EPM Jansen, J van Sandick, E Meershoek-Klein Kranenbarg, HWM van Laarhoven, DL van der Peet, CJH van de Velde, M Verheij, R Fijneman, RB Scharpf, GA Meijer, A Cats, VE Velculescu
Publication Date: 2020-01-27

Variant appearance in text: TP53: R175H
PMID: 31988276
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Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers.

Iscience
MM Pedrote, MF Motta, GDS Ferretti, DR Norberto, TCLS Spohr, FRS Lima, E Gratton, JL Silva, GAP de Oliveira
Publication Date: 2020-01-08

Variant appearance in text: p53: R175H
PMID: 31981923
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Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression.

Biomed Research International
Y Yang, J He, J Chen, L Lin, Y Liu, C Zhou, Y Su, H Wei
Publication Date: 2019

Variant appearance in text: TP53: R175H
PMID: 31976328
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Patient-Derived Orthotopic Xenograft Models of Pediatric Brain Tumors: In a Mature Phase or Still in Its Infancy?

Frontiers In Oncology
E Hermans, E Hulleman
Publication Date: 2019

Variant appearance in text: TP53: R175H
PMID: 31970083
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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53.

Cell Reports
JG Kang, CU Lago, JE Lee, JH Park, MP Donnelly, MF Starost, C Liu, J Kwon, AC Noguchi, K Ge, PY Wang, PM Hwang
Publication Date: 2020-01-21

Variant appearance in text: p53: R175H
PMID: 31968253
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Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing.

Scientific Reports
MV Nemtsova, AI Kalinkin, EB Kuznetsova, IV Bure, EA Alekseeva, II Bykov, TV Khorobrykh, DS Mikhaylenko, AS Tanas, SI Kutsev, DV Zaletaev, VV Strelnikov
Publication Date: 2020-01-16

Variant appearance in text: TP53: R175H; rs28934578
PMID: 31949278
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MiR-3196, a p53-responsive microRNA, functions as a tumor suppressor in hepatocellular carcinoma by targeting FOXP4.

American Journal Of Cancer Research
W Qi, C Gao, L Zhang, Z Gao, J Sui, C Han, D Sun
Publication Date: 2019

Variant appearance in text: p53: R175H
PMID: 31911853
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Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.

Npj Breast Cancer
LR Bollu, J Shepherd, D Zhao, Y Ma, W Tahaney, C Speers, A Mazumdar, GB Mills, PH Brown
Publication Date: 2020

Variant appearance in text: p53: R175H
PMID: 31909186
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Tumoral and immune heterogeneity in an anti-PD-1 responsive glioblastoma: a case study.

Cold Spring Harbor Molecular Case Studies
P Restrepo, R Yong, I Laface, N Tsankova, K Nael, G Akturk, R Sebra, S Gnjatic, A Hormigo, B Losic
Publication Date: 2020-01-06

Variant appearance in text: rs28934578
PMID: 31907277
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Detection of KRAS mutations in plasma cell-free DNA of colorectal cancer patients and comparison with cancer panel data for tissue samples of the same cancers.

Genomics & Informatics
S Min, S Shin, YJ Chung
Publication Date: 2019-12

Variant appearance in text: TP53: R175H
PMID: 31896242
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000269305.4 c.524G>A p.Arg175His missense_variant 5/11 -
ENST00000359597.4 c.524G>A p.Arg175His missense_variant 4/9 -
ENST00000413465.2 c.524G>A p.Arg175His missense_variant 4/7 -
ENST00000420246.2 c.524G>A p.Arg175His missense_variant 5/12 -
ENST00000445888.2 c.524G>A p.Arg175His missense_variant 5/11 -
ENST00000455263.2 c.524G>A p.Arg175His missense_variant 5/12 -
ENST00000504290.1 n.406G>A - non_coding_transcript_exon_variant 1/8 -
ENST00000504937.1 n.406G>A - non_coding_transcript_exon_variant 1/7 -
ENST00000505014.1 n.780G>A - non_coding_transcript_exon_variant 4/5 -
ENST00000509690.1 c.128G>A p.Arg43His missense_variant 2/6 -
ENST00000510385.1 n.406G>A - non_coding_transcript_exon_variant 1/8 -
ENST00000514944.1 c.245G>A p.Arg82His missense_variant 4/6 -
ENST00000574684.1 n.32G>A - non_coding_transcript_exon_variant 1/2 -
NM_000546.5 c.524G>A p.Arg175His missense_variant 5/11 -
NM_001126112.2 c.524G>A p.Arg175His missense_variant 5/11 -
NM_001126113.2 c.524G>A p.Arg175His missense_variant 5/12 -
NM_001126114.2 c.524G>A p.Arg175His missense_variant 5/12 -
NM_001126115.1 c.128G>A p.Arg43His missense_variant 1/7 -
NM_001126116.1 c.128G>A p.Arg43His missense_variant 1/8 -
NM_001126117.1 c.128G>A p.Arg43His missense_variant 1/8 -
NM_001126118.1 c.407G>A p.Arg136His missense_variant 4/10 -
NM_001276695.2 c.407G>A p.Arg136His missense_variant 5/12 -
NM_001276696.2 c.407G>A p.Arg136His missense_variant 5/12 -
NM_001276697.2 c.47G>A p.Arg16His missense_variant 1/7 -
NM_001276698.2 c.47G>A p.Arg16His missense_variant 1/8 -
NM_001276699.2 c.47G>A p.Arg16His missense_variant 1/8 -
NM_001276760.2 c.407G>A p.Arg136His missense_variant 5/11 -
NM_001276761.2 c.407G>A p.Arg136His missense_variant 5/11 -