Publications:

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Association of TP53 Mutations with Response to Anlotinib Treatment in Advanced Non-Small Cell Lung Cancer.

Oncotargets And Therapy

S Fang, W Cheng, M Zhang, R Yang

Publication Date: 2020

Variant appearance in text: TP53: R175H

PMID: 32753898

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Molecular Biology of Osteosarcoma.

Cancers

AM Czarnecka, K Synoradzki, W Firlej, E Bartnik, P Sobczuk, M Fiedorowicz, P Grieb, P Rutkowski

Publication Date: 2020-07-31

Variant appearance in text: p53: R175H

PMID: 32751922

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

J Li, W Jiang, J Wei, J Zhang, L Cai, M Luo, Z Wang, W Sun, S Wang, C Wang, C Dai, J Liu, G Wang, J Wang, Q Xu, Y Deng

Publication Date: 2020-08-01

Variant appearance in text: TP53: R175H

PMID: 32738923

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Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.

Cell Death & Disease

S Sun, H Chen, L Sun, M Wang, X Wu, ZJ Xiao

Publication Date: 2020-07-30

Variant appearance in text: p53: R175H

PMID: 32733026

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Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Cancers

YC Wang, JL Huang, KW Lee, HH Lu, YJ Lin, LF Chen, CS Wang, YC Cheng, ZT Zeng, PY Chu, CS Lin

Publication Date: 2020-07-25

Variant appearance in text: p53: R175H

PMID: 32722430

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TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy.

Cancers

F Graziano, NW Fischer, I Bagaloni, M Di Bartolomeo, S Lonardi, B Vincenzi, G Perrone, L Fornaro, E Ongaro, G Aprile, R Bisonni, M Prisciandaro, D Malkin, J Gariépy, M Fassan, F Loupakis, D Sarti, M Del Prete, V Catalano, P Alessandroni, M Magnani, A Ruzzo

Publication Date: 2020-07-24

Variant appearance in text: TP53: R175H

PMID: 32722340

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EGFR, BRCA1, BRCA2 and TP53 genetic profile in Moroccan triple negative breast cancer cases.

International Journal Of Molecular Epidemiology And Genetics

F Jouali, FZ El Ansari, N Marchoudi, A Barakat, H Zmaimita, H Samlali, J Fekkak

Publication Date: 2020

Variant appearance in text: TP53: 524G>A; Arg175His

PMID: 32714499

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Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma.

Scientific Reports

GG Jinesh, M Napoli, HD Ackerman, PM Raulji, N Montey, ER Flores, AS Brohl

Publication Date: 2020-07-23

Variant appearance in text: p53: R175H

PMID: 32704163

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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports

Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura

Publication Date: 2020-07-23

Variant appearance in text: TP53: R175H

PMID: 32704002

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Applied precision medicine in metastatic pancreatic ductal adenocarcinoma.

Therapeutic Advances In Medical Oncology

H Taghizadeh, L Müllauer, RM Mader, M Schindl, GW Prager

Publication Date: 2020

Variant appearance in text: TP53: Arg175His

PMID: 32699558

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Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.

Nature Communications

Y Li, B Li, W Li, Y Wang, S Akgül, DM Treisman, KA Heist, BR Pierce, B Hoff, CY Ho, DO Ferguson, A Rehemtulla, S Zheng, BD Ross, JZ Li, Y Zhu

Publication Date: 2020-07-22

Variant appearance in text: TP53: R175H

PMID: 32699356

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Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma.

Endocrine Connections

A Jouinot, J Lippert, M Fassnacht, B De La Villeon, A Septier, M Neou, K Perlemoine, S Appenzeller, M Sibony, S Gaujoux, B Dousset, R Libe, L Groussin, CL Ronchi, G Assie, J Bertherat

Publication Date: 2020-07-01

Variant appearance in text: TP53: R175H

PMID: 32698135

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Immunohistochemical detection of p53 and pp53 Ser392 in canine hemangiomas and hemangiosarcomas located in the skin.

Bmc Veterinary Research

MJ García-Iglesias, JL Cuevas-Higuera, A Bastida-Sáenz, MG de Garnica-García, L Polledo, P Perero, J González-Fernández, B Fernández-Martínez, C Pérez-Martínez

Publication Date: 2020-07-13

Variant appearance in text: TP53: R175H

PMID: 32660487

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The Janus Face of p53-Targeting Ubiquitin Ligases.

Cells

Q Hao, Y Chen, X Zhou

Publication Date: 2020-07-09

Variant appearance in text: p53: R175H

PMID: 32660118

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XAF1 as a modifier of p53 function and cancer susceptibility.

Science Advances

EM Pinto, BC Figueiredo, W Chen, HCR Galvao, MN Formiga, MCBV Fragoso, P Ashton-Prolla, EMSF Ribeiro, G Felix, TEB Costa, SA Savage, M Yeager, EI Palmero, S Volc, H Salvador, JL Fuster-Soler, C Lavarino, G Chantada, D Vaur, V Odone-Filho, L Brugières, T Else, EM Stoffel, KN Maxwell, MI Achatz, L Kowalski, KC de Andrade, A Pappo, E Letouze, AC Latronico, BB Mendonca, MQ Almeida, VB Brondani, CM Bittar, EWS Soares, C Mathias, CRN Ramos, M Machado, W Zhou, K Jones, A Vogt, PP Klincha, KM Santiago, H Komechen, MM Paraizo, IZS Parise, KV Hamilton, J Wang, E Rampersaud, MR Clay, AJ Murphy, E Lalli, KE Nichols, RC Ribeiro, C Rodriguez-Galindo, M Korbonits, J Zhang, MG Thomas, JP Connelly, S Pruett-Miller, Y Diekmann, G Neale, G Wu, GP Zambetti

Publication Date: 2020-06

Variant appearance in text: TP53: R175H

PMID: 32637605

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A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status.

Journal Of Experimental & Clinical Cancer Research : Cr

A Garufi, S Baldari, R Pettinari, MS Gilardini Montani, V D'Orazi, G Pistritto, A Crispini, E Giorno, G Toietta, F Marchetti, M Cirone, G D'Orazi

Publication Date: 2020-06-30

Variant appearance in text: p53: R175H

PMID: 32605658

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Good Cop, Bad Cop: Defining the Roles of Δ40p53 in Cancer and Aging.

Cancers

L Steffens Reinhardt, X Zhang, A Wawruszak, K Groen, GN De Iuliis, KA Avery-Kiejda

Publication Date: 2020-06-23

Variant appearance in text: p53: R175H

PMID: 32585821

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Analysis of targeted somatic mutations in pleomorphic carcinoma of the lung using next-generation sequencing technique.

Thoracic Cancer

S Manabe, R Kasajima, S Murakami, Y Miyagi, T Yokose, T Kondo, H Saito, H Ito, T Kaneko, K Yamada

Publication Date: 2020-06-23

Variant appearance in text: TP53: R175H

PMID: 32578376

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Application of Genetically Engineered Pigs in Biomedical Research.

Genes

M Hryhorowicz, D Lipiński, S Hryhorowicz, A Nowak-Terpiłowska, N Ryczek, J Zeyland

Publication Date: 2020-06-19

Variant appearance in text: TP53: R175H

PMID: 32575461

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Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells.

Journal Of Immunology (Baltimore, Md. : 1950)

A Sachs, E Moore, Z Kosaloglu-Yalcin, B Peters, J Sidney, SA Rosenberg, PF Robbins, A Sette

Publication Date: 2020-06-22

Variant appearance in text: TP53: R175H

PMID: 32571843

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Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity.

Oncogene

Q Li, RM Karim, M Cheng, M Das, L Chen, C Zhang, HR Lawrence, GW Daughdrill, E Schonbrunn, H Ji, J Chen

Publication Date: 2020-06-17

Variant appearance in text: p53: R175H

PMID: 32555331

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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)

G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar

Publication Date: 2020-06-17

Variant appearance in text: TP53: R175H

PMID: 32552660

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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics

V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones

Publication Date: 2020

Variant appearance in text: p53: R175H

PMID: 32546937

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Comparative genomics of high grade neuroendocrine carcinoma of the cervix.

Plos One

RT Hillman, R Cardnell, J Fujimoto, WC Lee, J Zhang, LA Byers, P Ramalingam, M Leitao, E Swisher, PA Futreal, M Frumovitz

Publication Date: 2020

Variant appearance in text: TP53: 524G>A; R175H

PMID: 32544169

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Regulating tumor suppressor genes: post-translational modifications.

Signal Transduction And Targeted Therapy

L Chen, S Liu, Y Tao

Publication Date: 2020-06-10

Variant appearance in text: p53: R175H

PMID: 32532965

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The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells.

Biomolecules

G Butera, J Brandi, C Cavallini, A Scarpa, RT Lawlor, MT Scupoli, E Marengo, D Cecconi, M Manfredi, M Donadelli

Publication Date: 2020-06-09

Variant appearance in text: p53: R175H

PMID: 32526853

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Mutant p53 as an Antigen in Cancer Immunotherapy.

International Journal Of Molecular Sciences

N Sobhani, A D'Angelo, X Wang, KH Young, D Generali, Y Li

Publication Date: 2020-06-08

Variant appearance in text: p53: R175H

PMID: 32521648

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Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.

Nature Communications

D Wu, DT Gallagher, R Gowthaman, BG Pierce, RA Mariuzza

Publication Date: 2020-06-09

Variant appearance in text: p53: R175H

PMID: 32518267

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The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient.

Plos One

Y Li, T Li, Y Tang, Z Zhan, L Ding, L Song, T Yu, Y Yang, J Ma, Y Zhang, Y Zhou, S Gu, M Xu, Y Gao, Y Li

Publication Date: 2020

Variant appearance in text: p53: R175H

PMID: 32516327

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Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review.

American Journal Of Translational Research

R Li, P Li, W Xing, H Qiu

Publication Date: 2020

Variant appearance in text: TP53: R175H

PMID: 32509161

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In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

Plos Genetics

O Kim, EY Park, DL Klinkebiel, SD Pack, YH Shin, Z Abdullaev, RE Emerson, DM Coffey, SY Kwon, CJ Creighton, S Kwon, EC Chang, T Chiang, AN Yatsenko, J Chien, DJ Cheon, Y Yang-Hartwich, H Nakshatri, KP Nephew, RR Behringer, FM Fernández, CH Cho, B Vanderhyden, R Drapkin, RC Bast, KD Miller, AR Karpf, J Kim

Publication Date: 2020-06-04

Variant appearance in text: p53: R175H

PMID: 32497036

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Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells.

Oncogenesis

M Kang, KY Chong, TMP Hartwich, F Bi, AK Witham, D Patrick, MJ Morrisson, SL Cady, AP Cerchia, D Kelk, Y Liu, J Nucci, O Madarikan, D Ueno, BM Shuch, Y Yang-Hartwich

Publication Date: 2020-05-29

Variant appearance in text: p53: R175H

PMID: 32471985

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Astaxanthin Modulates Apoptotic Molecules to Induce Death of SKBR3 Breast Cancer Cells.

Marine Drugs

MS Kim, YT Ahn, CW Lee, H Kim, WG An

Publication Date: 2020-05-19

Variant appearance in text: p53: R175H

PMID: 32438569

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Clinical spectrum and prognostic value of TP53 mutations in circulating tumor DNA from breast cancer patients in China.

Cancer Communications (London, England)

Z Yi, F Ma, G Rong, Y Guan, C Li, B Xu

Publication Date: 2020-05-21

Variant appearance in text: TP53: R175H

PMID: 32436611

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Genetic Alterations Featuring Biological Models to Tailor Clinical Management of Pancreatic Cancer Patients.

Cancers

SR Nelson, N Walsh

Publication Date: 2020-05-14

Variant appearance in text: TP53: R175H

PMID: 32423157

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Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours.

Nature Communications

PA Johansson, K Brooks, F Newell, JM Palmer, JS Wilmott, AL Pritchard, N Broit, S Wood, MS Carlino, C Leonard, LT Koufariotis, V Nathan, AB Beasley, M Howlie, R Dawson, H Rizos, CW Schmidt, GV Long, H Hamilton, JF Kiilgaard, T Isaacs, ES Gray, OJ Rolfe, JJ Park, A Stark, GJ Mann, RA Scolyer, JV Pearson, N van Baren, N Waddell, KW Wadt, LA McGrath, SK Warrier, W Glasson, NK Hayward

Publication Date: 2020-05-15

Variant appearance in text: TP53: R175H

PMID: 32415113

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P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

International Journal Of Molecular Sciences

AD Agupitan, P Neeson, S Williams, J Howitt, S Haupt, Y Haupt

Publication Date: 2020-05-13

Variant appearance in text: p53: R175H

PMID: 32414156

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TP53 in Myelodysplastic Syndromes: Recent Biological and Clinical Findings.

International Journal Of Molecular Sciences

C Cumbo, G Tota, L Anelli, A Zagaria, G Specchia, F Albano

Publication Date: 2020-05-13

Variant appearance in text: p53: R175H

PMID: 32414002

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Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA.

Thoracic Cancer

X Li, X Chen, L Wen, Y Wang, B Chen, Y Xue, L Guo, N Liao

Publication Date: 2020-05-15

Variant appearance in text: TP53: R175H

PMID: 32412177

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Non-disruptive mutation in TP53 DNA-binding domain is a beneficial factor of esophageal squamous cell carcinoma.

Annals Of Translational Medicine

M Huang, J Jin, F Zhang, Y Wu, C Xu, L Ying, D Su

Publication Date: 2020-03

Variant appearance in text: TP53: R175H

PMID: 32355760

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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.

Nature Communications

LR Kong, RW Ong, TZ Tan, NAB Mohamed Salleh, M Thangavelu, JV Chan, LYJ Koh, G Periyasamy, JA Lau, TBU Le, L Wang, M Lee, S Kannan, CS Verma, CM Lim, WJ Chng, DP Lane, A Venkitaraman, HT Hung, CF Cheok, BC Goh

Publication Date: 2020-04-29

Variant appearance in text: p53: R175H

PMID: 32350249

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Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel.

Diagnostics (Basel, Switzerland)

D de Biase, G Acquaviva, M Visani, V Sanza, CM Argento, A De Leo, T Maloberti, A Pession, G Tallini

Publication Date: 2020-04-23

Variant appearance in text: TP53: R175H

PMID: 32340363

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Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins.

Cell Death & Disease

K Tutuska, L Parrilla-Monge, E Di Cesare, A Nemajerova, UM Moll

Publication Date: 2020-04-24

Variant appearance in text: p53: R175H

PMID: 32332697

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Recent Synthetic Approaches towards Small Molecule Reactivators of p53.

Biomolecules

JL Silva, CGS Lima, LP Rangel, GDS Ferretti, FP Pauli, RCB Ribeiro, TB da Silva, FC da Silva, VF Ferreira

Publication Date: 2020-04-20

Variant appearance in text: p53: R175H

PMID: 32326087

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Molecular Profiles of Brain and Pulmonary Metastatic Disease in Cancer of Unknown Primary.

The Oncologist

BR Bakow, CP Elco, M LeGolvan, D Dizon, TA Ollila

Publication Date: 2020-04-20

Variant appearance in text: TP53: R175H

PMID: 32310333

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Epithelial-mesenchymal transition status of circulating tumor cells in breast cancer and its clinical relevance.

Cancer Biology & Medicine

J Zhou, X Zhu, S Wu, J Guo, K Zhang, C Xu, H Chen, Y Jin, Y Sun, S Zheng, Y Chen

Publication Date: 2020-02-15

Variant appearance in text: TP53: 524G>A

PMID: 32296584

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The Status of p53 Oligomeric and Aggregation States in Cancer.

Biomolecules

GAP de Oliveira, EC Petronilho, MM Pedrote, MA Marques, TCRG Vieira, EA Cino, JL Silva

Publication Date: 2020-04-04

Variant appearance in text: p53: R175H

PMID: 32260447

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Comprehensive genomic profile of cholangiocarcinomas in China.

Oncology Letters

W Tian, W Hu, X Shi, P Liu, X Ma, W Zhao, L Qu, S Zhang, W Shi, A Liu, J Cao

Publication Date: 2020-04

Variant appearance in text: TP53: R175H

PMID: 32256810

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Context is everything: extrinsic signalling and gain-of-function p53 mutants.

Cell Death Discovery

I Amelio, G Melino

Publication Date: 2020

Variant appearance in text: p53: R175H

PMID: 32218993

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Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.

Medical Sciences (Basel, Switzerland)

U Testa, G Castelli, E Pelosi

Publication Date: 2020-03-23

Variant appearance in text: TP53: R175H

PMID: 32210163

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YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.

Science Advances

H Omori, M Nishio, M Masuda, Y Miyachi, F Ueda, T Nakano, K Sato, K Mimori, K Taguchi, H Hikasa, H Nishina, H Tashiro, T Kiyono, TW Mak, K Nakao, T Nakagawa, T Maehama, A Suzuki

Publication Date: 2020-03

Variant appearance in text: TP53: R175H

PMID: 32206709

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The Impact of Mutant p53 in the Non-Coding RNA World.

Biomolecules

S Di Agostino

Publication Date: 2020-03-19

Variant appearance in text: p53: R175H

PMID: 32204575

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BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

Q Chen, JH Lei, J Bao, H Wang, W Hao, L Li, C Peng, T Masuda, K Miao, J Xu, X Xu, CX Deng

Publication Date: 2020-03

Variant appearance in text: TP53: R175H

PMID: 32195105

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A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes.

Cancers

K Larson, R Kannaiyan, R Pandey, Y Chen, HM Babiker, D Mahadevan

Publication Date: 2020-03-16

Variant appearance in text: TP53: R175H

PMID: 32188081

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Concordance between TP53 alterations in blood and tissue: impact of time interval, biopsy site, cancer type and circulating tumor DNA burden.

Molecular Oncology

CC Bieg-Bourne, R Okamura, R Kurzrock

Publication Date: 2020-03-18

Variant appearance in text: TP53: R175H

PMID: 32187847

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Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV.

Diagnostic Pathology

X Catteau, N D'haene, JC Noël

Publication Date: 2020-03-14

Variant appearance in text: p53: R175H

PMID: 32169099

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Primary malignant pericardial tumour in Lynch syndrome.

Bmc Cancer

P Paolisso, G Saturi, A Foà, M Saponara, M Nannini, MA Pantaleo, O Leone, D Turchetti, D Calistri, C Savini, D Pacini, C Pizzi, N Galiè

Publication Date: 2020-03-06

Variant appearance in text: TP53: R175H

PMID: 32143595

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Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation.

Biomolecules

A Garufi, G Federici, MS Gilardini Montani, A Crispini, M Cirone, G D'Orazi

Publication Date: 2020-03-03

Variant appearance in text: p53: R175H

PMID: 32138264

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Neoantigens in Hematologic Malignancies.

Frontiers In Immunology

MA Biernacki, M Bleakley

Publication Date: 2020

Variant appearance in text: TP53: R175H

PMID: 32117272

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TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies.

Cancer Letters

MD Wilkie, EA Anaam, AS Lau, CP Rubbi, TM Jones, MT Boyd, N Vlatković

Publication Date: 2020-02-27

Variant appearance in text: p53: R175H

PMID: 32113989

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Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.

Journal For Immunotherapy Of Cancer

SH Tseng, ST Park, B Lam, YC Tsai, MA Cheng, E Farmer, D Xing, CF Hung

Publication Date: 2020-02

Variant appearance in text: p53: R175H

PMID: 32111730

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Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells.

Biomolecules

M Cordani, G Butera, R Pacchiana, F Masetto, N Mullappilly, C Riganti, M Donadelli

Publication Date: 2020-02-26

Variant appearance in text: p53: R175H

PMID: 32111081

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Phase I studies of vorinostat with ixazomib or pazopanib imply a role of antiangiogenesis-based therapy for TP53 mutant malignancies.

Scientific Reports

Y Wang, F Janku, S Piha-Paul, K Hess, R Broaddus, L Liu, N Shi, M Overman, S Kopetz, V Subbiah, A Naing, D Hong, AM Tsimberidou, D Karp, J Yao, S Fu

Publication Date: 2020-02-20

Variant appearance in text: TP53: R175H

PMID: 32080210

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Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis.

International Journal Of Molecular Sciences

KA Roszkowska, S Gizinski, M Sady, Z Gajewski, MB Olszewski

Publication Date: 2020-02-17

Variant appearance in text: p53: R175H

PMID: 32079237

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p53's Extended Reach: The Mutant p53 Secretome.

Biomolecules

E Pavlakis, T Stiewe

Publication Date: 2020-02-15

Variant appearance in text: p53: R175H

PMID: 32075247

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Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53.

Biomolecules

SN Loh

Publication Date: 2020-02-14

Variant appearance in text: p53: R175H

PMID: 32075132

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Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery.

Oncotarget

LF Ye, E Reznik, JM Korn, F Lin, G Yang, K Malesky, H Gao, A Loo, R Pagliarini, T Mikkelsen, DC Lo, AC deCarvalho, BR Stockwell

Publication Date: 2020-01-28

Variant appearance in text: p53: R175H

PMID: 32064048

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Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status.

Applied Surface Science

A Padmanabhan, M Kaushik, R Niranjan, JS Richards, B Ebright, GD Venkatasubbu

Publication Date: 2019-09

Variant appearance in text: p53: R175H

PMID: 32042215

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Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78.

Frontiers In Oncology

B Borjan, J Kern, N Steiner, E Gunsilius, D Wolf, G Untergasser

Publication Date: 2019

Variant appearance in text: p53: R175H

PMID: 32039016

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Identifying multi-hit carcinogenic gene combinations: Scaling up a weighted set cover algorithm using compressed binary matrix representation on a GPU.

Scientific Reports

Q Al Hajri, S Dash, WC Feng, HR Garner, R Anandakrishnan

Publication Date: 2020-02-06

Variant appearance in text: TP53: R175H

PMID: 32029803

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Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes.

Blood Advances

G Montalban-Bravo, R Kanagal-Shamanna, CB Benton, CA Class, KS Chien, K Sasaki, K Naqvi, Y Alvarado, TM Kadia, F Ravandi, N Daver, K Takahashi, E Jabbour, G Borthakur, N Pemmaraju, M Konopleva, KA Soltysiak, SR Pierce, CE Bueso-Ramos, KP Patel, H Kantarjian, G Garcia-Manero

Publication Date: 2020-02-11

Variant appearance in text: TP53: R175H

PMID: 32027746

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The PI3K/mTOR dual inhibitor NVP-BEZ235 stimulates mutant p53 degradation to exhibit anti-tumor effect on triple-negative breast cancer cells.

Febs Open Bio

J Cai, J Xia, J Zou, Q Wang, Q Ma, R Sun, H Liao, L Xu, D Wang, X Guo

Publication Date: 2020-02-06

Variant appearance in text: p53: R175H

PMID: 32027103

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Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.

Nature Genetics

NS Sethi, O Kikuchi, GN Duronio, MD Stachler, JM McFarland, R Ferrer-Luna, Y Zhang, C Bao, R Bronson, D Patil, F Sanchez-Vega, JB Liu, E Sicinska, JB Lazaro, KL Ligon, R Beroukhim, AJ Bass

Publication Date: 2020-02-05

Variant appearance in text: TP53: R175H

PMID: 32025000

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Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma.

Cancer Research And Treatment : Official Journal Of Korean Cancer Association

MC Choi, S Hwang, S Kim, SG Jung, H Park, WD Joo, SH Song, C Lee, TH Kim, H Kang, HJ An

Publication Date: 2020-01-06

Variant appearance in text: TP53: R175H

PMID: 32019284

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Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.

The Embo Journal

K Hoffmann, H Berger, H Kulbe, S Thillainadarasan, HJ Mollenkopf, T Zemojtel, E Taube, S Darb-Esfahani, M Mangler, J Sehouli, R Chekerov, EI Braicu, TF Meyer, M Kessler

Publication Date: 2020-02-03

Variant appearance in text: p53: R175H

PMID: 32009247

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Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Bmc Cancer

V Manoharan, EH Karunanayake, KH Tennekoon, S De Silva, AIA Imthikab, K De Silva, P Angunawela, S Vishwakula, J Lunec

Publication Date: 2020-01-30

Variant appearance in text: TP53: Arg175His; rs28934578

PMID: 32000721

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Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

P Malekzadeh, R Yossef, G Cafri, BC Paria, FJ Lowery, M Jafferji, ML Good, A Sachs, AR Copeland, SP Kim, S Kivitz, MR Parkhurst, PF Robbins, S Ray, L Xi, M Raffeld, Z Yu, NP Restifo, RPT Somerville, SA Rosenberg, DC Deniger

Publication Date: 2020-01-29

Variant appearance in text: p53: R175H

PMID: 31996390

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Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma.

Cells

E Flynt, K Bisht, V Sridharan, M Ortiz, F Towfic, A Thakurta

Publication Date: 2020-01-24

Variant appearance in text: TP53: R175H

PMID: 31991614

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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.

Molecules And Cells

Y Date, K Ito

Publication Date: 2020-01-23

Variant appearance in text: p53: R175H

PMID: 31991537

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Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm.

Acs Chemical Biology

MR Bauer, A Krämer, G Settanni, RN Jones, X Ni, R Khan Tareque, AR Fersht, J Spencer, AC Joerger

Publication Date: 2020-01-28

Variant appearance in text: p53: R175H

PMID: 31990523

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White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer.

Nature Communications

A Leal, NCT van Grieken, DN Palsgrove, J Phallen, JE Medina, C Hruban, MAM Broeckaert, V Anagnostou, V Adleff, DC Bruhm, JV Canzoniero, J Fiksel, M Nordsmark, FARM Warmerdam, HMW Verheul, DJ van Spronsen, LV Beerepoot, MM Geenen, JEA Portielje, EPM Jansen, J van Sandick, E Meershoek-Klein Kranenbarg, HWM van Laarhoven, DL van der Peet, CJH van de Velde, M Verheij, R Fijneman, RB Scharpf, GA Meijer, A Cats, VE Velculescu

Publication Date: 2020-01-27

Variant appearance in text: TP53: R175H

PMID: 31988276

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Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers.

Iscience

MM Pedrote, MF Motta, GDS Ferretti, DR Norberto, TCLS Spohr, FRS Lima, E Gratton, JL Silva, GAP de Oliveira

Publication Date: 2020-01-08

Variant appearance in text: p53: R175H

PMID: 31981923

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Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression.

Biomed Research International

Y Yang, J He, J Chen, L Lin, Y Liu, C Zhou, Y Su, H Wei

Publication Date: 2019

Variant appearance in text: TP53: R175H

PMID: 31976328

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Patient-Derived Orthotopic Xenograft Models of Pediatric Brain Tumors: In a Mature Phase or Still in Its Infancy?

Frontiers In Oncology

E Hermans, E Hulleman

Publication Date: 2019

Variant appearance in text: TP53: R175H

PMID: 31970083

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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53.

Cell Reports

JG Kang, CU Lago, JE Lee, JH Park, MP Donnelly, MF Starost, C Liu, J Kwon, AC Noguchi, K Ge, PY Wang, PM Hwang

Publication Date: 2020-01-21

Variant appearance in text: p53: R175H

PMID: 31968253

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Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing.

Scientific Reports

MV Nemtsova, AI Kalinkin, EB Kuznetsova, IV Bure, EA Alekseeva, II Bykov, TV Khorobrykh, DS Mikhaylenko, AS Tanas, SI Kutsev, DV Zaletaev, VV Strelnikov

Publication Date: 2020-01-16

Variant appearance in text: TP53: R175H; rs28934578

PMID: 31949278

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MiR-3196, a p53-responsive microRNA, functions as a tumor suppressor in hepatocellular carcinoma by targeting FOXP4.

American Journal Of Cancer Research

W Qi, C Gao, L Zhang, Z Gao, J Sui, C Han, D Sun

Publication Date: 2019

Variant appearance in text: p53: R175H

PMID: 31911853

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Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.

Npj Breast Cancer

LR Bollu, J Shepherd, D Zhao, Y Ma, W Tahaney, C Speers, A Mazumdar, GB Mills, PH Brown

Publication Date: 2020

Variant appearance in text: p53: R175H

PMID: 31909186

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Tumoral and immune heterogeneity in an anti-PD-1 responsive glioblastoma: a case study.

Cold Spring Harbor Molecular Case Studies

P Restrepo, R Yong, I Laface, N Tsankova, K Nael, G Akturk, R Sebra, S Gnjatic, A Hormigo, B Losic

Publication Date: 2020-01-06

Variant appearance in text: rs28934578

PMID: 31907277

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Detection of KRAS mutations in plasma cell-free DNA of colorectal cancer patients and comparison with cancer panel data for tissue samples of the same cancers.

Genomics & Informatics

S Min, S Shin, YJ Chung

Publication Date: 2019-12

Variant appearance in text: TP53: R175H

PMID: 31896242

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000269305.4	c.524G>A	p.Arg175His	missense_variant	5/11	-
ENST00000359597.4	c.524G>A	p.Arg175His	missense_variant	4/9	-
ENST00000413465.2	c.524G>A	p.Arg175His	missense_variant	4/7	-
ENST00000420246.2	c.524G>A	p.Arg175His	missense_variant	5/12	-
ENST00000445888.2	c.524G>A	p.Arg175His	missense_variant	5/11	-
ENST00000455263.2	c.524G>A	p.Arg175His	missense_variant	5/12	-
ENST00000504290.1	n.406G>A	-	non_coding_transcript_exon_variant	1/8	-
ENST00000504937.1	n.406G>A	-	non_coding_transcript_exon_variant	1/7	-
ENST00000505014.1	n.780G>A	-	non_coding_transcript_exon_variant	4/5	-
ENST00000509690.1	c.128G>A	p.Arg43His	missense_variant	2/6	-
ENST00000510385.1	n.406G>A	-	non_coding_transcript_exon_variant	1/8	-
ENST00000514944.1	c.245G>A	p.Arg82His	missense_variant	4/6	-
ENST00000574684.1	n.32G>A	-	non_coding_transcript_exon_variant	1/2	-
NM_000546.5	c.524G>A	p.Arg175His	missense_variant	5/11	-
NM_001126112.2	c.524G>A	p.Arg175His	missense_variant	5/11	-
NM_001126113.2	c.524G>A	p.Arg175His	missense_variant	5/12	-
NM_001126114.2	c.524G>A	p.Arg175His	missense_variant	5/12	-
NM_001126115.1	c.128G>A	p.Arg43His	missense_variant	1/7	-
NM_001126116.1	c.128G>A	p.Arg43His	missense_variant	1/8	-
NM_001126117.1	c.128G>A	p.Arg43His	missense_variant	1/8	-
NM_001126118.1	c.407G>A	p.Arg136His	missense_variant	4/10	-
NM_001276695.2	c.407G>A	p.Arg136His	missense_variant	5/12	-
NM_001276696.2	c.407G>A	p.Arg136His	missense_variant	5/12	-
NM_001276697.2	c.47G>A	p.Arg16His	missense_variant	1/7	-
NM_001276698.2	c.47G>A	p.Arg16His	missense_variant	1/8	-
NM_001276699.2	c.47G>A	p.Arg16His	missense_variant	1/8	-
NM_001276760.2	c.407G>A	p.Arg136His	missense_variant	5/11	-
NM_001276761.2	c.407G>A	p.Arg136His	missense_variant	5/11	-