Publications:

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Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hao, Suisui S; Tong, Jingshan J; Jha, Anupma A; Risnik, Denise D; Lizardo, Darleny D; Lu, Xinyan X; Goel, Ajay A; Opresko, Patricia L PL; Yu, Jian J; Zhang, Lin L

Publication Date: 2022-12-20

Variant appearance in text: p53: K164R

PubMed Link: 36508676

Variant Present in the following documents:

• pnas.202211775.pdf
• pnas.2211775119.sapp.pdf

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Mutant p53K120R expression enables a partial capacity to modulate metabolism.

Frontiers In Genetics

Monti, Paola P; Ravera, Silvia S; Speciale, Andrea A; Velkova, Irena I; Foggetti, Giorgia G; Degan, Paolo P; Fronza, Gilberto G; Menichini, Paola P

Publication Date: 2022

Variant appearance in text: p53: K164R

PubMed Link: 36226181

Variant Present in the following documents:

• Main text
• fgene-13-974662.pdf

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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience

Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X

Publication Date: 2022-09-16

Variant appearance in text: p53: 491A>G

PubMed Link: 36117989

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

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An unexpected role for Dicer as a reader of the unacetylated DNA binding domain of p53 in transcriptional regulation.

Science Advances

Yang, Xin X; Wang, Xingwu X; Li, Zhiming Z; Duan, Shoufu S; Li, Huan H; Jin, Jian J; Zhang, Zhiguo Z; Gu, Wei W

Publication Date: 2021-10-29

Variant appearance in text: p53: K164R

PubMed Link: 34705508

Variant Present in the following documents:

• Main text
• sciadv.abi6684_sm.pdf
• sciadv.abi6684.pdf

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Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage.

Plos One

Inomata, Yuriko Y; Abe, Takuya T; Tsuda, Masataka M; Takeda, Shunichi S; Hirota, Kouji K

Publication Date: 2021

Variant appearance in text: p53: K164R

PubMed Link: 34061890

Variant Present in the following documents:

• Main text
• pone.0252587.pdf

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An unexpected role for p53 in regulating cancer cell-intrinsic PD-1 by acetylation.

Science Advances

Cao, Zhijie Z; Kon, Ning N; Liu, Yajing Y; Xu, Wenbin W; Wen, Jia J; Yao, Han H; Zhang, Mi M; Wu, Zhen Z; Yan, Xiaojun X; Zhu, Wei-Guo WG; Gu, Wei W; Wang, Donglai D

Publication Date: 2021-03

Variant appearance in text: p53: K164R

PubMed Link: 33789902

Variant Present in the following documents:

• Main text
• abf4148.pdf

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An unexpected role for p53 in regulating cancer cell-intrinsic PD-1 by acetylation.

Science Advances

Cao, Zhijie Z; Kon, Ning N; Liu, Yajing Y; Xu, Wenbin W; Wen, Jia J; Yao, Han H; Zhang, Mi M; Wu, Zhen Z; Yan, Xiaojun X; Zhu, Wei-Guo WG; Gu, Wei W; Wang, Donglai D

Publication Date: 2021-03

Variant appearance in text: p53: K164R

PubMed Link: 33789902

Variant Present in the following documents:

• Main text
• abf4148.pdf

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The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.

Frontiers In Pharmacology

Will Castro, Luiza S E P LSEP; Pieters, Wietske W; Alemdehy, Mir Farshid MF; Aslam, Muhammad A MA; Buoninfante, Olimpia Alessandra OA; Raaijmakers, Jonne A JA; Pilzecker, Bas B; van den Berk, Paul C M PCM; Te Riele, Hein H; Medema, René H RH; Pedrosa, Rozangela C RC; Jacobs, Heinz H

Publication Date: 2021

Variant appearance in text: p53: K164R

PubMed Link: 33679394

Variant Present in the following documents:

• Main text

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TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma.

Frontiers In Pharmacology

Wan, Jingwei J; Guo, Alyssa Aihui AA; King, Pendelton P; Guo, Shanchun S; Saafir, Talib T; Jiang, Yugang Y; Liu, Mingli M

Publication Date: 2020

Variant appearance in text: TP53: K164R

PubMed Link: 33381038

Variant Present in the following documents:

• Main text

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mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.

Genes & Development

Kon, Ning N; Ou, Yang Y; Wang, Shang-Jui SJ; Li, Huan H; Rustgi, Anil K AK; Gu, Wei W

Publication Date: 2021-01-01

Variant appearance in text: p53: K164R

PubMed Link: 33303641

Variant Present in the following documents:

• Main text
• 59.pdf

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Phase and context shape the function of composite oncogenic mutations.

Nature

Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS

Publication Date: 2020-06

Variant appearance in text: TP53: K164R

PubMed Link: 32461694

Variant Present in the following documents:

• NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2

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Abrogation of FBW7α-dependent p53 degradation enhances p53's function as a tumor suppressor.

The Journal Of Biological Chemistry

Tripathi, Vivek V; Kaur, Ekjot E; Kharat, Suhas Sampat SS; Hussain, Mansoor M; Damodaran, Arun Prasath AP; Kulshrestha, Swati S; Sengupta, Sagar S

Publication Date: 2019-09-06

Variant appearance in text: p53: K164R

PubMed Link: 31346036

Variant Present in the following documents:

• Main text

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: TP53: K164R

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Germ-line and somatic EPHA2 coding variants in lens aging and cataract.

Plos One

Bennett, Thomas M TM; M'Hamdi, Oussama O; Hejtmancik, J Fielding JF; Shiels, Alan A

Publication Date: 2017

Variant appearance in text: TP53: K164R

PubMed Link: 29267365

Variant Present in the following documents:

• pone.0189881.s007.xlsx, sheet 1

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Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.

Genome Medicine

Alfaro, Javier A JA; Ignatchenko, Alexandr A; Ignatchenko, Vladimir V; Sinha, Ankit A; Boutros, Paul C PC; Kislinger, Thomas T

Publication Date: 2017-07-18

Variant appearance in text: TP53: K164R

PubMed Link: 28716134

Variant Present in the following documents:

• 13073_2017_454_MOESM7_ESM.xlsx, sheet 1

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Regulation of transcriptional activators by DNA-binding domain ubiquitination.

Cell Death And Differentiation

Landré, Vivien V; Revi, Bhindu B; Mir, Maria Gil MG; Verma, Chandra C; Hupp, Ted R TR; Gilbert, Nick N; Ball, Kathryn L KL

Publication Date: 2017-05

Variant appearance in text: p53: K164R

PubMed Link: 28362432

Variant Present in the following documents:

• Main text

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: K164R

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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NEDDylation promotes stress granule assembly.

Nature Communications

Jayabalan, Aravinth Kumar AK; Sanchez, Anthony A; Park, Ra Young RY; Yoon, Sang Pil SP; Kang, Gum-Yong GY; Baek, Je-Hyun JH; Anderson, Paul P; Kee, Younghoon Y; Ohn, Takbum T

Publication Date: 2016-07-06

Variant appearance in text: p53: K164R

PubMed Link: 27381497

Variant Present in the following documents:

• Main text

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: TP53: K164R

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT.

The Journal Of Clinical Investigation

Leszczynska, Katarzyna B KB; Foskolou, Iosifina P IP; Abraham, Aswin G AG; Anbalagan, Selvakumar S; Tellier, Céline C; Haider, Syed S; Span, Paul N PN; O'Neill, Eric E EE; Buffa, Francesca M FM; Hammond, Ester M EM

Publication Date: 2015-06

Variant appearance in text: p53: K164R

PubMed Link: 25961455

Variant Present in the following documents:

• Main text

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Tumor suppressor p53 stole the AKT in hypoxia.

The Journal Of Clinical Investigation

Yun, Zhong Z; Glazer, Peter M PM

Publication Date: 2015-06

Variant appearance in text: p53: K164R

PubMed Link: 25961449

Variant Present in the following documents:

• Main text

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: K164R

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Drosten, Matthias M; Sum, Eleanor Y M EY; Lechuga, Carmen G CG; Simón-Carrasco, Lucía L; Jacob, Harrys K C HK; García-Medina, Raquel R; Huang, Sidong S; Beijersbergen, Roderick L RL; Bernards, Rene R; Barbacid, Mariano M

Publication Date: 2014-10-21

Variant appearance in text: p53: K164R

PubMed Link: 25288756

Variant Present in the following documents:

• Main text

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Functional analysis of the acetylation of human p53 in DNA damage responses.

Protein & Cell

Chung, Sun-Ku SK; Zhu, Shengyun S; Xu, Yang Y; Fu, Xuemei X

Publication Date: 2014-07

Variant appearance in text: p53: K164R

PubMed Link: 24691905

Variant Present in the following documents:

• Main text
• 13238_2014_Article_48.pdf

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Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.

The Embo Journal

Chang, Jonathan J; Davis-Dusenbery, Brandi N BN; Kashima, Risa R; Jiang, Xuan X; Marathe, Nisha N; Sessa, Roberto R; Louie, Justin J; Gu, Wei W; Lagna, Giorgio G; Hata, Akiko A

Publication Date: 2013-12-11

Variant appearance in text: p53: K164R

PubMed Link: 24219989

Variant Present in the following documents:

• Main text

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MOZ increases p53 acetylation and premature senescence through its complex formation with PML.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Rokudai, Susumu S; Laptenko, Oleg O; Arnal, Suzzette M SM; Taya, Yoichi Y; Kitabayashi, Issay I; Prives, Carol C

Publication Date: 2013-03-05

Variant appearance in text: p53: K164R

PubMed Link: 23431171

Variant Present in the following documents:

• Main text

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: TP53: K164R

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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RNA content in the nucleolus alters p53 acetylation via MYBBP1A.

The Embo Journal

Kuroda, Takao T; Murayama, Akiko A; Katagiri, Naohiro N; Ohta, Yu-mi YM; Fujita, Etsuko E; Masumoto, Hiroshi H; Ema, Masatsugu M; Takahashi, Satoru S; Kimura, Keiji K; Yanagisawa, Junn J

Publication Date: 2011-03-16

Variant appearance in text: p53: K164R

PubMed Link: 21297583

Variant Present in the following documents:

• Main text

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Modes of p53 regulation.

Cell

Kruse, Jan-Philipp JP; Gu, Wei W

Publication Date: 2009-05-15

Variant appearance in text: p53: K164R

PubMed Link: 19450511

Variant Present in the following documents:

• Main text

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Acetylation is indispensable for p53 activation.

Cell

Tang, Yi Y; Zhao, Wenhui W; Chen, Yue Y; Zhao, Yingming Y; Gu, Wei W

Publication Date: 2008-05-16

Variant appearance in text: p53: K164R

PubMed Link: 18485870

Variant Present in the following documents:

• Main text

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