Publications:

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Pan-cancer clinical impact of latent drivers from double mutations.

Communications Biology

Yavuz, Bengi Ruken BR; Tsai, Chung-Jung CJ; Nussinov, Ruth R; Tuncbag, Nurcan N

Publication Date: 2023-02-20

Variant appearance in text: TP53: A161S

PubMed Link: 36808143

Variant Present in the following documents:

• 42003_2023_4519_MOESM3_ESM.xlsx, sheet 3

View BVdb publication page

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Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications

Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI

Publication Date: 2023-02-08

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 36755027

Variant Present in the following documents:

• 41467_2023_36328_MOESM7_ESM.xlsx, sheet 1
• 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC).

Oncotarget

Alam, Md Maksudul MM; Fermin, Janmaris Marin JM; Knackstedt, Mark M; Noonan, Mackenzie J MJ; Powell, Taylor T; Goodreau, Landon L; Daniel, Emily K EK; Rong, Xiaohua X; Moore-Medlin, Tara T; Khandelwal, Alok R AR; Nathan, Cherie-Ann O CO

Publication Date: 2023-02-02

Variant appearance in text: TP53: A161S

PubMed Link: 36745547

Variant Present in the following documents:

• Main text
• oncotarget-14-28355.pdf

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: TP53: A161S

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms.

Frontiers In Immunology

Liu, Zhichao Z; Lin, Guo G; Yan, Zeping Z; Li, Linduo L; Wu, Xingchen X; Shi, Jingrong J; He, Jianxing J; Zhao, Lei L; Liang, Hengrui H; Wang, Wei W

Publication Date: 2022

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 36238300

Variant Present in the following documents:

• Table_1.xlsx, sheet 4

View BVdb publication page

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EPHA5 mutation was associated with adverse outcome of atezolizumab treatment in late-stage non-small cell lung cancers.

Bmc Pulmonary Medicine

Li, Zhenxiang Z; Zhou, Qing Q; Wang, Qi Q; Wang, Haiyong H; Yue, Weiming W

Publication Date: 2022-09-19

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 36123678

Variant Present in the following documents:

• 12890_2022_2161_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience

Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X

Publication Date: 2022-09-16

Variant appearance in text: p53: 481G>T

PubMed Link: 36117989

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

View BVdb publication page

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Integrated cohort of esophageal squamous cell cancer reveals genomic features underlying clinical characteristics.

Nature Communications

Li, Minghao M; Zhang, Zicheng Z; Wang, Qianrong Q; Yi, Yan Y; Li, Baosheng B

Publication Date: 2022-09-07

Variant appearance in text: TP53: A161S

PubMed Link: 36071046

Variant Present in the following documents:

• 41467_2022_32962_MOESM15_ESM.xlsx, sheet 22

View BVdb publication page

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Landscape of somatic alterations in large-scale solid tumors from an Asian population.

Nature Communications

Wu, Liqun L; Yao, Herui H; Chen, Hui H; Wang, Aodi A; Guo, Kun K; Gou, Wenli W; Yu, Yanfei Y; Li, Xiang X; Yao, Ming M; Yuan, Shaohua S; Pang, Fei F; Hu, Jinwei J; Chen, Lijuan L; Liu, Wenjin W; Yao, Jicheng J; Zhang, Shuirong S; Dong, Xiaowei X; Wang, Weifeng W; Hu, Jing J; Ling, Qi Q; Ding, Songming S; Wei, Yan Y; Li, Qiang Q; Cao, Weichun W; Wang, Shuang S; Di, Yang Y; Feng, Feiling F; Zhao, Gang G; Zhang, Jian J; Huang, Ling L; Xu, Jia J; Yan, Wangjun W; Tong, Zhongsheng Z; Jiang, Da D; Ji, Tao T; Li, Qiao Q; Xu, Ling L; He, Huiying H; Shang, Liang L; Liu, Jin J; Wang, Kefeng K; Wu, Duoguang D; Shen, Jingnan J; Liu, Ye Y; Zhang, Ting T; Liang, Chaojie C; Wang, Yusheng Y; Shang, Yanhong Y; Guo, Jianji J; Liang, Guanbiao G; Xu, Shifeng S; Liu, Junfeng J; Wang, Kai K; Wang, Minghui M

Publication Date: 2022-07-23

Variant appearance in text: TP53: A161S

PubMed Link: 35871175

Variant Present in the following documents:

• 41467_2022_31780_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology

Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J

Publication Date: 2022

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 35814426

Variant Present in the following documents:

• DataSheet_1.xlsx, sheet 2

View BVdb publication page

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Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition.

Frontiers In Molecular Biosciences

Semenov, Oleg O; Daks, Alexandra A; Fedorova, Olga O; Shuvalov, Oleg O; Barlev, Nickolai A NA

Publication Date: 2022

Variant appearance in text: p53: A161S

PubMed Link: 35813818

Variant Present in the following documents:

• Main text
• fmolb-09-928399.pdf

View BVdb publication page

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Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.

Aging

Su, Xiaofan X; Jin, Haoxuan H; Wang, Jiaqian J; Lu, Huiping H; Gu, Tiantian T; Gao, Zhibo Z; Li, Manxiang M

Publication Date: 2022-05-25

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 35613927

Variant Present in the following documents:

• aging-14-204101-s004.xlsx, sheet 1

View BVdb publication page

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Targeting tumor innervation: premises, promises, and challenges.

Cell Death Discovery

Li, Xinyu X; Peng, Xueqiang X; Yang, Shuo S; Wei, Shibo S; Fan, Qing Q; Liu, Jingang J; Yang, Liang L; Li, Hangyu H

Publication Date: 2022-03-25

Variant appearance in text: p53: A161s

PubMed Link: 35338118

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: TP53: A161S

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer.

Journal For Immunotherapy Of Cancer

Stein, Alexander A; Simnica, Donjete D; Schultheiß, Christoph C; Scholz, Rebekka R; Tintelnot, Joseph J; Gökkurt, Eray E; von Wenserski, Lisa L; Willscher, Edith E; Paschold, Lisa L; Sauer, Markus M; Lorenzen, Sylvie S; Riera-Knorrenschild, Jorge J; Depenbusch, Reinhard R; Ettrich, Thomas J TJ; Dörfel, Steffen S; Al-Batran, Salah-Eddin SE; Karthaus, Meinolf M; Pelzer, Uwe U; Waberer, Lisa L; Hinke, Axel A; Bauer, Marcus M; Massa, Chiara C; Seliger, Barbara B; Wickenhauser, Claudia C; Bokemeyer, Carsten C; Hegewisch-Becker, Susanna S; Binder, Mascha M

Publication Date: 2021-07

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 34315821

Variant Present in the following documents:

• jitc-2021-002844supp002.xlsx, sheet 1

View BVdb publication page

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A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases.

Scientific Reports

Magraner-Pardo, Lorena L; Laskowski, Roman A RA; Pons, Tirso T; Thornton, Janet M JM

Publication Date: 2021-07-12

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 34253785

Variant Present in the following documents:

• 41598_2021_93715_MOESM2_ESM.xlsx, sheet 10
• 41598_2021_93715_MOESM2_ESM.xlsx, sheet 9

View BVdb publication page

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Profiling of 520 Candidate Genes in 50 Surgically Treated Chinese Small Cell Lung Cancer Patients.

Frontiers In Oncology

Yuan, Ting T; Wang, Xin X; Sun, Sijin S; Cao, Zheng Z; Feng, Xiaoli X; Gao, Yibo Y

Publication Date: 2021

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 34168983

Variant Present in the following documents:

• DataSheet_2.xlsx, sheet 3

View BVdb publication page

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Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology

Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN

Publication Date: 2021

Variant appearance in text: TP53: A161S

PubMed Link: 34113354

Variant Present in the following documents:

• Table_1.xlsx, sheet 18
• Table_1.xlsx, sheet 2

View BVdb publication page

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Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients.

Genome Medicine

Tsui, Dana W Y DWY; Cheng, Michael L ML; Shady, Maha M; Yang, Julie L JL; Stephens, Dennis D; Won, Helen H; Srinivasan, Preethi P; Huberman, Kety K; Meng, Fanli F; Jing, Xiaohong X; Patel, Juber J; Hasan, Maysun M; Johnson, Ian I; Gedvilaite, Erika E; Houck-Loomis, Brian B; Socci, Nicholas D ND; Selcuklu, S Duygu SD; Seshan, Venkatraman E VE; Zhang, Hongxin H; Chakravarty, Debyani D; Zehir, Ahmet A; Benayed, Ryma R; Arcila, Maria M; Ladanyi, Marc M; Funt, Samuel A SA; Feldman, Darren R DR; Li, Bob T BT; Razavi, Pedram P; Rosenberg, Jonathan J; Bajorin, Dean D; Iyer, Gopa G; Abida, Wassim W; Scher, Howard I HI; Rathkopf, Dana D; Viale, Agnes A; Berger, Michael F MF; Solit, David B DB

Publication Date: 2021-05-31

Variant appearance in text: TP53: A161S

PubMed Link: 34059130

Variant Present in the following documents:

• 13073_2021_898_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications

Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L

Publication Date: 2021-04-19

Variant appearance in text: TP53: A161S

PubMed Link: 33875650

Variant Present in the following documents:

• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Cancer-Associated Neurogenesis and Nerve-Cancer Cross-talk.

Cancer Research

Silverman, Deborah A DA; Martinez, Vena K VK; Dougherty, Patrick M PM; Myers, Jeffrey N JN; Calin, George A GA; Amit, Moran M

Publication Date: 2021-03-15

Variant appearance in text: p53: A161S

PubMed Link: 33334813

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: TP53: A161S

PubMed Link: 33133066

Variant Present in the following documents:

• Table_6.xlsx, sheet 7
• Table_1.xlsx, sheet 2
• Table_6.xlsx, sheet 2

View BVdb publication page

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Prospective Clinical Validation of the InVisionFirst-Lung Circulating Tumor DNA Assay for Molecular Profiling of Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer.

Jco Precision Oncology

Pritchett, Michael A MA; Camidge, D Ross DR; Patel, Manu M; Khatri, Jamil J; Boniol, Steven S; Friedman, Elke K EK; Khomani, Abderrahim A; Dalia, Samir S; Baker-Neblett, Katherine K; Plagnol, Vincent V; Howarth, Karen D KD; Jones, Gregory R GR; Rosenfeld, Nitzan N; Morris, Clive D CD; Govindan, Ramaswamy R

Publication Date: 2019

Variant appearance in text: TP53: A161S

PubMed Link: 32914040

Variant Present in the following documents:

• PO.18.00299.pdf

View BVdb publication page

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A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population.

Breast Cancer Research : Bcr

Kang, Taekyu T; Yau, Christina C; Wong, Christopher K CK; Sanborn, John Z JZ; Newton, Yulia Y; Vaske, Charlie C; Benz, Stephen C SC; Krings, Gregor G; Camarda, Roman R; Henry, Jill E JE; Stuart, Josh J; Powell, Mark M; Benz, Christopher C CC

Publication Date: 2020-07-31

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 32736587

Variant Present in the following documents:

• 13058_2020_1322_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of relevant genetic alterations in cancer using topological data analysis.

Nature Communications

Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG

Publication Date: 2020-07-30

Variant appearance in text: TP53: A161S

PubMed Link: 32732999

Variant Present in the following documents:

• 41467_2020_17659_MOESM3_ESM.xls, sheet 1

View BVdb publication page

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Inconsistent Intersample ALK FISH Results in Patients with Lung Cancer: Analysis of Potential Causes.

Cancers

Tang, Zhenya Z; Chen, Hui H; Hong, Lingzhi L; Tang, Guilin G; Toruner, Gokce A GA; Wang, Wei W; Roy Chowdhuri, Sinchita S; Yin, Wei W; Jung, Hai Suk HS; Gu, Jun J; Routbort, Mark J MJ; Zhang, Jianjun J; Khoury, Joseph D JD; Medeiros, L Jeffrey LJ

Publication Date: 2020-07-14

Variant appearance in text: TP53: 481G>T

PubMed Link: 32674491

Variant Present in the following documents:

• cancers-12-01903.pdf

View BVdb publication page

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports

Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM

Publication Date: 2020-06-23

Variant appearance in text: TP53: A161S

PubMed Link: 32579932

Variant Present in the following documents:

• mmc5.xlsx, sheet 3

View BVdb publication page

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Phase and context shape the function of composite oncogenic mutations.

Nature

Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS

Publication Date: 2020-06

Variant appearance in text: TP53: A161S

PubMed Link: 32461694

Variant Present in the following documents:

• NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2

View BVdb publication page

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Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material.

Bmc Cancer

Steeghs, Elisabeth M P EMP; Kroeze, Leonie I LI; Tops, Bastiaan B J BBJ; van Kempen, Leon C LC; Ter Elst, Arja A; Kastner-van Raaij, Annemiek W M AWM; Hendriks-Cornelissen, Sandra J B SJB; Hermsen, Mandy J W MJW; Jansen, Erik A M EAM; Nederlof, Petra M PM; Schuuring, Ed E; Ligtenberg, Marjolijn J L MJL; Eijkelenboom, Astrid A

Publication Date: 2020-04-07

Variant appearance in text: TP53: 481G>T; Ala161Ser

PubMed Link: 32264863

Variant Present in the following documents:

• 12885_2020_6785_MOESM2_ESM.xlsx, sheet 7

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: TP53: A161S

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Oncogene

Luiken, Sarah S; Fraas, Angelika A; Bieg, Matthias M; Sugiyanto, Raisatun R; Goeppert, Benjamin B; Singer, Stephan S; Ploeger, Carolin C; Warsow, Gregor G; Marquardt, Jens U JU; Sticht, Carsten C; De La Torre, Carolina C; Pusch, Stefan S; Mehrabi, Arianeb A; Gretz, Norbert N; Schlesner, Matthias M; Eils, Roland R; Schirmacher, Peter P; Longerich, Thomas T; Roessler, Stephanie S

Publication Date: 2020-04

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 32055024

Variant Present in the following documents:

• 41388_2020_1198_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Metabolic Pathways Enhancement Confers Poor Prognosis in p53 Exon Mutant Hepatocellular Carcinoma.

Cancer Informatics

Chen, Po-Ming PM; Li, Jian-Rong JR; Liu, Chun-Chi CC; Tang, Feng-Yao FY; Chiang, En-Pei Isabel EI

Publication Date: 2020

Variant appearance in text: p53: A161S

PubMed Link: 31933519

Variant Present in the following documents:

• Main text
• 10.1177_1176935119899913.pdf

View BVdb publication page

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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology

Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M

Publication Date: 2020-01-07

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 31925297

Variant Present in the following documents:

• 42003_2019_736_MOESM13_ESM.xlsx, sheet 1
• 42003_2019_736_MOESM4_ESM.xlsx, sheet 1
• 42003_2019_736_MOESM10_ESM.xlsx, sheet 1
• 42003_2019_736_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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BRAF Mutation in Colorectal Rhabdoid and Poorly Differentiated Medullary Carcinomas.

Cancers

Bolzacchini, Elena E; Digiacomo, Nunzio N; Marrazzo, Cristina C; Sahnane, Nora N; Maragliano, Roberta R; Gill, Anthony A; Albarello, Luca L; Sessa, Fausto F; Furlan, Daniela D; Capella, Carlo C

Publication Date: 2019-08-26

Variant appearance in text: TP53: A161S

PubMed Link: 31455041

Variant Present in the following documents:

• Main text

View BVdb publication page

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Impact of KRAS and TP53 Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients With STK11-Mutated Advanced Non-Small-Cell Lung Cancer.

Jco Precision Oncology

Bange, Erin E; Marmarelis, Melina E ME; Hwang, Wei-Ting WT; Yang, Yu-Xiao YX; Thompson, Jeffrey C JC; Rosenbaum, Jason J; Bauml, Joshua M JM; Ciunci, Christine C; Alley, Evan W EW; Cohen, Roger B RB; Langer, Corey J CJ; Carpenter, Erica E; Aggarwal, Charu C

Publication Date: 2019

Variant appearance in text: TP53: A161S

PubMed Link: 31428721

Variant Present in the following documents:

• Main text

View BVdb publication page

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RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling.

Nature Medicine

Yao, Zhan Z; Gao, Yijun Y; Su, Wenjing W; Yaeger, Rona R; Tao, Jessica J; Na, Na N; Zhang, Ying Y; Zhang, Chao C; Rymar, Andrey A; Tao, Anthony A; Timaul, Neilawattie M NM; Mcgriskin, Rory R; Outmezguine, Nathaniel A NA; Zhao, HuiYong H; Chang, Qing Q; Qeriqi, Besnik B; Barbacid, Mariano M; de Stanchina, Elisa E; Hyman, David M DM; Bollag, Gideon G; Rosen, Neal N

Publication Date: 2019-02

Variant appearance in text: TP53: A161S

PubMed Link: 30559419

Variant Present in the following documents:

• NIHMS1509287-supplement-2.pdf

View BVdb publication page

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Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.

Oncogene

Leong, Tracy L TL; Gayevskiy, Velimir V; Steinfort, Daniel P DP; De Massy, Marc R MR; Gonzalez-Rajal, Alvaro A; Marini, Kieren D KD; Stone, Emily E; Chin, Venessa V; Havryk, Adrian A; Plit, Marshall M; Irving, Louis B LB; Jennings, Barton R BR; McCloy, Rachael A RA; Jayasekara, W Samantha N WSN; Alamgeer, Muhammad M; Boolell, Vishal V; Field, Andrew A; Russell, Prudence A PA; Kumar, Beena B; Gough, Daniel J DJ; Szczepny, Anette A; Ganju, Vinod V; Rossello, Fernando J FJ; Cain, Jason E JE; Papenfuss, Anthony T AT; Asselin-Labat, Marie-Liesse ML; Cowley, Mark J MJ; Watkins, D Neil DN

Publication Date: 2019-03

Variant appearance in text: TP53: 481G>T; Ala161Ser

PubMed Link: 30348992

Variant Present in the following documents:

• 41388_2018_536_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.

Plos One

Pritchard, Antonia L AL; Johansson, Peter A PA; Nathan, Vaishnavi V; Howlie, Madeleine M; Symmons, Judith J; Palmer, Jane M JM; Hayward, Nicholas K NK

Publication Date: 2018

Variant appearance in text: TP53: 481G>T

PubMed Link: 29641532

Variant Present in the following documents:

• pone.0194098.s003.xlsx, sheet 2

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Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma.

Bmc Cancer

Lu, Hongyang H; Yang, Shifeng S; Zhu, Huineng H; Tong, Xiaoling X; Xie, Fajun F; Qin, Jing J; Han, Na N; Wu, Xue X; Fan, Yun Y; Shao, Yang W YW; Mao, Weimin W

Publication Date: 2018-03-05

Variant appearance in text: TP53: A161S

PubMed Link: 29506494

Variant Present in the following documents:

• 12885_2018_4159_MOESM2_ESM.xlsx, sheet 1

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Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma.

Frontiers In Genetics

Kancherla, Venkatesh V; Abdullazade, Samir S; Matter, Matthias S MS; Lanzafame, Manuela M; Quagliata, Luca L; Roma, Guglielmo G; Hoshida, Yujin Y; Terracciano, Luigi M LM; Ng, Charlotte K Y CKY; Piscuoglio, Salvatore S

Publication Date: 2018

Variant appearance in text: TP53: A161S

PubMed Link: 29456550

Variant Present in the following documents:

• Main text

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Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment.

Plos One

Ihle, Michaela Angelika MA; Huss, Sebastian S; Jeske, Wiebke W; Hartmann, Wolfgang W; Merkelbach-Bruse, Sabine S; Schildhaus, Hans-Ulrich HU; Büttner, Reinhard R; Sihto, Harri H; Sundby Hall, Kirsten K; Eriksson, Mikael M; Reichardt, Peter P; Joensuu, Heikki H; Wardelmann, Eva E

Publication Date: 2018

Variant appearance in text: p53: A161S

PubMed Link: 29451912

Variant Present in the following documents:

• Main text
• pone.0193048.pdf

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Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

Nature

Yao, Zhan Z; Yaeger, Rona R; Rodrik-Outmezguine, Vanessa S VS; Tao, Anthony A; Torres, Neilawattie M NM; Chang, Matthew T MT; Drosten, Matthias M; Zhao, Huiyong H; Cecchi, Fabiola F; Hembrough, Todd T; Michels, Judith J; Baumert, Hervé H; Miles, Linde L; Campbell, Naomi M NM; de Stanchina, Elisa E; Solit, David B DB; Barbacid, Mariano M; Taylor, Barry S BS; Rosen, Neal N

Publication Date: 2017-08-10

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 28783719

Variant Present in the following documents:

• Main text

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Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications

Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ

Publication Date: 2017-08-04

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 28775315

Variant Present in the following documents:

• 41467_2017_289_MOESM7_ESM.xlsx, sheet 1

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AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.

International Journal Of Molecular Sciences

Casado, Jorge J; Iñigo-Chaves, Almudena A; Jiménez-Ruiz, Sergio M SM; Ríos-Arrabal, Sandra S; Carazo-Gallego, Ángel Á; González-Puga, Cristina C; Núñez, María Isabel MI; Ruíz-Extremera, Ángeles Á; Salmerón, Javier J; León, Josefa J

Publication Date: 2017-06-11

Variant appearance in text: TP53: 481G>T

PubMed Link: 28604612

Variant Present in the following documents:

• ijms-18-01251-s001.pdf

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The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer.

Oncotarget

Coaxum, Sonya D SD; Tiedeken, Jessica J; Garrett-Mayer, Elizabeth E; Myers, Jeffrey J; Rosenzweig, Steven A SA; Neskey, David M DM

Publication Date: 2017-04-04

Variant appearance in text: p53: A161S

PubMed Link: 28160562

Variant Present in the following documents:

• Main text
• oncotarget-08-22991.pdf

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Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma.

Oncotarget

Asano, Naofumi N; Yoshida, Akihiko A; Mitani, Sachiyo S; Kobayashi, Eisuke E; Shiotani, Bunsyo B; Komiyama, Motokiyo M; Fujimoto, Hiroyuki H; Chuman, Hirokazu H; Morioka, Hideo H; Matsumoto, Morio M; Nakamura, Masaya M; Kubo, Takashi T; Kato, Mamoru M; Kohno, Takashi T; Kawai, Akira A; Kondo, Tadashi T; Ichikawa, Hitoshi H

Publication Date: 2017-02-21

Variant appearance in text: TP53: A161S

PubMed Link: 28099935

Variant Present in the following documents:

• oncotarget-08-12941-s003.xlsx, sheet 1

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: A161S

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Genetic changes of non-small cell lung cancer under neoadjuvant therapy.

Oncotarget

Warth, Arne A; Endris, Volker V; Stenzinger, Albrecht A; Penzel, Roland R; Harms, Alexander A; Duell, Thomas T; Abdollahi, Amir A; Lindner, Michael M; Schirmacher, Peter P; Muley, Thomas T; Dienemann, Hendrik H; Fink, Ludger L; Morresi-Hauf, Alicia A; Pfarr, Nicole N; Weichert, Wilko W

Publication Date: 2016-05-17

Variant appearance in text: TP53: 481G>T; Ala161Ser

PubMed Link: 27105513

Variant Present in the following documents:

• oncotarget-07-29761-s002.xlsx, sheet 1

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Dynamic changes of driver genes' mutations across clinical stages in nine cancer types.

Cancer Medicine

Li, Xia X

Publication Date: 2016-07

Variant appearance in text: TP53: A161S

PubMed Link: 26992457

Variant Present in the following documents:

• CAM4-5-1556.pdf

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REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer.

Scientific Reports

Zhao, Min M; Rotgans, Bronwyn B; Wang, Tianfang T; Cummins, S F SF

Publication Date: 2016-03-15

Variant appearance in text: TP53: A161S

PubMed Link: 26975833

Variant Present in the following documents:

• srep23167-s9.xls, sheet 1

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: TP53: A161S

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells.

Cell Death & Disease

Fitzgerald, A L AL; Osman, A A AA; Xie, T-X TX; Patel, A A; Skinner, H H; Sandulache, V V; Myers, J N JN

Publication Date: 2015-03-12

Variant appearance in text: TP53: A161S

PubMed Link: 25766317

Variant Present in the following documents:

• Main text
• cddis201544a.pdf

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Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients.

Cancer Research

Osman, Abdullah A AA; Neskey, David M DM; Katsonis, Panagiotis P; Patel, Ameeta A AA; Ward, Alexandra M AM; Hsu, Teng-Kuei TK; Hicks, Stephanie C SC; McDonald, Thomas O TO; Ow, Thomas J TJ; Alves, Marcus Ortega MO; Pickering, Curtis R CR; Skinner, Heath D HD; Zhao, Mei M; Sturgis, Eric M EM; Kies, Merrill S MS; El-Naggar, Adel A; Perrone, Federica F; Licitra, Lisa L; Bossi, Paolo P; Kimmel, Marek M; Frederick, Mitchell J MJ; Lichtarge, Olivier O; Myers, Jeffrey N JN

Publication Date: 2015-04-01

Variant appearance in text: p53: A161S

PubMed Link: 25691460

Variant Present in the following documents:

• Main text

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Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.

Cancer Research

Neskey, David M DM; Osman, Abdullah A AA; Ow, Thomas J TJ; Katsonis, Panagiotis P; McDonald, Thomas T; Hicks, Stephanie C SC; Hsu, Teng-Kuei TK; Pickering, Curtis R CR; Ward, Alexandra A; Patel, Ameeta A; Yordy, John S JS; Skinner, Heath D HD; Giri, Uma U; Sano, Daisuke D; Story, Michael D MD; Beadle, Beth M BM; El-Naggar, Adel K AK; Kies, Merrill S MS; William, William N WN; Caulin, Carlos C; Frederick, Mitchell M; Kimmel, Marek M; Myers, Jeffrey N JN; Lichtarge, Olivier O

Publication Date: 2015-04-01

Variant appearance in text: TP53: A161S

PubMed Link: 25634208

Variant Present in the following documents:

• Main text

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: A161S

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

Plos One

Chuang, Hui-Ching HC; Yang, Liang Peng LP; Fitzgerald, Alison L AL; Osman, Abdullah A; Woo, Sang Hyeok SH; Myers, Jeffrey N JN; Skinner, Heath D HD

Publication Date: 2014

Variant appearance in text: p53: A161S

PubMed Link: 25119136

Variant Present in the following documents:

• Main text
• pone.0104821.pdf

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Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss.

Nature Genetics

Gross, Andrew M AM; Orosco, Ryan K RK; Shen, John P JP; Egloff, Ann Marie AM; Carter, Hannah H; Hofree, Matan M; Choueiri, Michel M; Coffey, Charles S CS; Lippman, Scott M SM; Hayes, D Neil DN; Cohen, Ezra E EE; Grandis, Jennifer R JR; Nguyen, Quyen T QT; Ideker, Trey T

Publication Date: 2014-09

Variant appearance in text: TP53: 481G>T; A161S

PubMed Link: 25086664

Variant Present in the following documents:

• NIHMS612904-supplement-2.xlsx, sheet 8

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Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing.

Oncotarget

Janku, Filip F; Kaseb, Ahmed O AO; Tsimberidou, Apostolia M AM; Wolff, Robert A RA; Kurzrock, Razelle R

Publication Date: 2014-05-30

Variant appearance in text: TP53: A161S

PubMed Link: 24931142

Variant Present in the following documents:

• Main text

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Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53.

Molecular Cancer Therapeutics

Gadhikar, Mayur A MA; Sciuto, Maria Rita MR; Alves, Marcus Vinicius Ortega MV; Pickering, Curtis R CR; Osman, Abdullah A AA; Neskey, David M DM; Zhao, Mei M; Fitzgerald, Alison L AL; Myers, Jeffrey N JN; Frederick, Mitchell J MJ

Publication Date: 2013-09

Variant appearance in text: p53: A161S

PubMed Link: 23839309

Variant Present in the following documents:

• Main text

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: TP53: A161S

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.

Nucleic Acids Research

Ryu, Gil-Mi GM; Song, Pamela P; Kim, Kyu-Won KW; Oh, Kyung-Soo KS; Park, Keun-Joon KJ; Kim, Jong Hun JH

Publication Date: 2009-03

Variant appearance in text: TP53: A161S

PubMed Link: 19139070

Variant Present in the following documents:

• gkn1008_nar-01723-s-2008-File009.xls, sheet 2
• gkn1008_nar-01723-s-2008-File011.xls, sheet 2
• gkn1008_nar-01723-s-2008-File008.xls, sheet 2

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