TP53 c.416A>G ;(p.K139R)

Variant ID: 17-7578514-T-C

NM_000546.5(TP53):c.416A>G;(p.K139R)

This variant was identified in 19 publications

View GRCh38 version.




Publications:


Circulating tumour DNA analysis predicts relapse and improves risk stratification in primary refractory multiple myeloma.

Blood Cancer Journal
Mithraprabhu, Sridurga S; Reynolds, John J; Turner, Rose R; Quach, Hang H; Horvath, Noemi N; Kerridge, Ian I; Kalff, Anna A; Bergin, Krystal K; Hocking, Jay J; Yuen, Flora F; Khong, Tiffany T; Durie, Brian M BM; Spencer, Andrew A
Publication Date: 2023-02-13

Variant appearance in text: TP53: 416A>G; K139R
PubMed Link: 36781844
Variant Present in the following documents:
  • 41408_2023_796_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.

Biology Direct
Peng, Tingwei T; Liu, Mingchuan M; Hu, Lang L; Guo, Dong D; Wang, Di D; Qi, Bingchao B; Ren, Gaotong G; Hu, Chenchen C; Zhang, Feng F; Chun, Hyung J HJ; Song, Liqiang L; Hu, Jianqiang J; Li, Yan Y
Publication Date: 2022-11-16

Variant appearance in text: p53: K139R
PubMed Link: 36384975
Variant Present in the following documents:
  • Main text
  • 13062_2022_Article_346.pdf
View BVdb publication page



CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: 416A>G
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Editorial: Exploring the subcellular proteome and its post-translational modifications.

Frontiers In Molecular Biosciences
Zhang, Shen S; Jiang, Hao H; Wu, Qi Q
Publication Date: 2022

Variant appearance in text: p53: K139R
PubMed Link: 36032683
Variant Present in the following documents:
  • Main text
  • fmolb-09-994961.pdf
View BVdb publication page



mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.

Genes & Development
Kon, Ning N; Ou, Yang Y; Wang, Shang-Jui SJ; Li, Huan H; Rustgi, Anil K AK; Gu, Wei W
Publication Date: 2021-01-01

Variant appearance in text: p53: K139R
PubMed Link: 33303641
Variant Present in the following documents:
  • Main text
  • 59.pdf
View BVdb publication page



The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine
Adashek, Jacob J JJ; Kato, Shumei S; Lippman, Scott M SM; Kurzrock, Razelle R
Publication Date: 2020-02-17

Variant appearance in text: TP53: K139R
PubMed Link: 32066498
Variant Present in the following documents:
  • Main text
View BVdb publication page



Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex.

The Journal Of Biological Chemistry
Masuda, Yuji Y; Saeki, Yasushi Y; Arai, Naoko N; Kawai, Hidehiko H; Kukimoto, Iwao I; Tanaka, Keiji K; Masutani, Chikahide C
Publication Date: 2019-10-11

Variant appearance in text: p53: K139R
PubMed Link: 31492752
Variant Present in the following documents:
  • Main text
View BVdb publication page



Abrogation of FBW7α-dependent p53 degradation enhances p53's function as a tumor suppressor.

The Journal Of Biological Chemistry
Tripathi, Vivek V; Kaur, Ekjot E; Kharat, Suhas Sampat SS; Hussain, Mansoor M; Damodaran, Arun Prasath AP; Kulshrestha, Swati S; Sengupta, Sagar S
Publication Date: 2019-09-06

Variant appearance in text: p53: K139R
PubMed Link: 31346036
Variant Present in the following documents:
  • Main text
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: TP53: K139R
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Germ-line and somatic EPHA2 coding variants in lens aging and cataract.

Plos One
Bennett, Thomas M TM; M'Hamdi, Oussama O; Hejtmancik, J Fielding JF; Shiels, Alan A
Publication Date: 2017

Variant appearance in text: TP53: K139R
PubMed Link: 29267365
Variant Present in the following documents:
  • pone.0189881.s007.xlsx, sheet 1
View BVdb publication page



Mutational landscape reflects the biological continuum of plasma cell dyscrasias.

Blood Cancer Journal
Rossi, A A; Voigtlaender, M M; Janjetovic, S S; Thiele, B B; Alawi, M M; März, M M; Brandt, A A; Hansen, T T; Radloff, J J; Schön, G G; Hegenbart, U U; Schönland, S S; Langer, C C; Bokemeyer, C C; Binder, M M
Publication Date: 2017-02-24

Variant appearance in text: TP53: K139R
PubMed Link: 28234344
Variant Present in the following documents:
  • Main text
  • bcj201719a.pdf
View BVdb publication page



iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: TP53: K139R
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s5.xls, sheet 1
View BVdb publication page



Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer.

Ebiomedicine
Fernandez-Cuesta, Lynnette L; Perdomo, Sandra S; Avogbe, Patrice H PH; Leblay, Noemie N; Delhomme, Tiffany M TM; Gaborieau, Valerie V; Abedi-Ardekani, Behnoush B; Chanudet, Estelle E; Olivier, Magali M; Zaridze, David D; Mukeria, Anush A; Vilensky, Marta M; Holcatova, Ivana I; Polesel, Jerry J; Simonato, Lorenzo L; Canova, Cristina C; Lagiou, Pagona P; Brambilla, Christian C; Brambilla, Elisabeth E; Byrnes, Graham G; Scelo, Ghislaine G; Le Calvez-Kelm, Florence F; Foll, Matthieu M; McKay, James D JD; Brennan, Paul P
Publication Date: 2016-08

Variant appearance in text: TP53: K139R
PubMed Link: 27377626
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



The Conundrum of Genetic "Drivers" in Benign Conditions.

Journal Of The National Cancer Institute
Kato, Shumei S; Lippman, Scott M SM; Flaherty, Keith T KT; Kurzrock, Razelle R
Publication Date: 2016-08

Variant appearance in text: TP53: K139R
PubMed Link: 27059373
Variant Present in the following documents:
  • Main text
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: TP53: K139R
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 1
View BVdb publication page



MTBP inhibits migration and metastasis of hepatocellular carcinoma.

Clinical & Experimental Metastasis
Bi, Qian Q; Ranjan, Atul A; Fan, Rui R; Agarwal, Neeraj N; Welch, Danny R DR; Weinman, Steven A SA; Ding, Jie J; Iwakuma, Tomoo T
Publication Date: 2015-04

Variant appearance in text: p53: K139R
PubMed Link: 25759210
Variant Present in the following documents:
  • Main text
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: TP53: K139R
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Isg15 controls p53 stability and functions.

Cell Cycle (Georgetown, Tex.)
Huang, Yi-Fu YF; Wee, Sheena S; Gunaratne, Jayantha J; Lane, David P DP; Bulavin, Dmitry V DV
Publication Date: 2014

Variant appearance in text: p53: K139R
PubMed Link: 24844324
Variant Present in the following documents:
  • Main text
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: TP53: K139R
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page