Publications:

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The Competition of Yin and Yang: Exploring the Role of Wild-Type and Mutant p53 in Tumor Progression.

Biomedicines

Cai, Bi-He BH; Sung, Yu-Te YT; Chen, Chia-Chi CC; Shaw, Jei-Fu JF; Hsin, I-Lun IL

Publication Date: 2023-04-17

Variant appearance in text: p53: S121F

PubMed Link: 37189810

Variant Present in the following documents:

• Main text
• biomedicines-11-01192.pdf

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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience

Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X

Publication Date: 2022-09-16

Variant appearance in text: p53: 362C>T

PubMed Link: 36117989

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

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Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications

Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A

Publication Date: 2022-07-13

Variant appearance in text: TP53: 362C>T; S121F

PubMed Link: 35831314

Variant Present in the following documents:

• 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: TP53: S121F

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Genotyping data of routinely processed matched primary/metastatic tumor samples.

Data In Brief

Kotoula, Vassiliki V; Chatzopoulos, Kyriakos K; Papadopoulou, Kyriaki K; Giannoulatou, Eleni E; Koliou, Georgia-Angeliki GA; Karavasilis, Vasilios V; Pazarli, Elissavet E; Pervana, Stavroula S; Kafiri, Georgia G; Tsoulfas, Georgios G; Chrisafi, Sofia S; Sgouramali, Helen H; Papakostas, Pavlos P; Pectasides, Dimitrios D; Hytiroglou, Prodromos P; Pentheroudakis, George G; Fountzilas, George G

Publication Date: 2021-02

Variant appearance in text: TP53: 362C>T; Ser121Phe

PubMed Link: 33365374

Variant Present in the following documents:

• mmc1.xlsx, sheet 3

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: TP53: S121F

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Durable response of multiple myeloma and non-small cell lung cancer with simultaneous, biologically targeted treatment.

British Journal Of Haematology

Kaiser, Martin F MF; Croft, James J; Shah, Paras P; Yousaf, Nadia N; Popat, Sanjay S

Publication Date: 2020-04

Variant appearance in text: TP53: S121F

PubMed Link: 32022246

Variant Present in the following documents:

• Main text
• BJH-189-e1.pdf

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Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation.

International Journal Of Molecular Sciences

Cai, Bi-He BH; Chao, Chung-Faye CF; Huang, Hsiang-Chi HC; Lee, Hsueh-Yi HY; Kannagi, Reiji R; Chen, Jang-Yi JY

Publication Date: 2019-07-27

Variant appearance in text: p53: S121F

PubMed Link: 31357595

Variant Present in the following documents:

• Main text
• ijms-20-03681.pdf

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Quantifying the two-state facilitated diffusion model of protein-DNA interactions.

Nucleic Acids Research

Leven, Itai I; Levy, Yaakov Y

Publication Date: 2019-06-20

Variant appearance in text: p53: S121F

PubMed Link: 31045207

Variant Present in the following documents:

• Main text
• gkz308.pdf

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Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma.

Nature Communications

Yan, Ting T; Cui, Heyang H; Zhou, Yong Y; Yang, Bin B; Kong, Pengzhou P; Zhang, Yingchun Y; Liu, Yiqian Y; Wang, Bin B; Cheng, Yikun Y; Li, Jiayi J; Guo, Shixing S; Xu, Enwei E; Liu, Huijuan H; Cheng, Caixia C; Zhang, Ling L; Chen, Ling L; Zhuang, Xiaofei X; Qian, Yu Y; Yang, Jian J; Ma, Yanchun Y; Li, Hongyi H; Wang, Fang F; Liu, Jing J; Liu, Xuefeng X; Su, Dan D; Wang, Yan Y; Sun, Ruifang R; Guo, Shiping S; Li, Yaoping Y; Cheng, Xiaolong X; Liu, Zhihua Z; Zhan, Qimin Q; Cui, Yongping Y

Publication Date: 2019-04-11

Variant appearance in text: TP53: 362C>T; S121L

PubMed Link: 30975989

Variant Present in the following documents:

• 41467_2019_9255_MOESM4_ESM.xlsx, sheet 1

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The molecular mechanism of action of methylene quinuclidinone and its effects on the structure of p53 mutants.

Oncotarget

Omar, Sara Ibrahim SI; Tuszynski, Jack J

Publication Date: 2018-12-14

Variant appearance in text: p53: S121F

PubMed Link: 30647850

Variant Present in the following documents:

• Main text
• oncotarget-09-37137.pdf

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NF1 mutations in conjunctival melanoma.

British Journal Of Cancer

Scholz, S L SL; Cosgarea, I I; Süßkind, D D; Murali, R R; Möller, I I; Reis, H H; Leonardelli, S S; Schilling, B B; Schimming, T T; Hadaschik, E E; Franklin, C C; Paschen, A A; Sucker, A A; Steuhl, K P KP; Schadendorf, D D; Westekemper, H H; Griewank, K G KG

Publication Date: 2018-05

Variant appearance in text: TP53: 362C>T; S121F

PubMed Link: 29559732

Variant Present in the following documents:

• 41416_2018_46_MOESM4_ESM.xlsx, sheet 1

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Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells.

Oncotarget

Menendez, Daniel D; Lowe, Julie M JM; Snipe, Joyce J; Resnick, Michael A MA

Publication Date: 2016-09-20

Variant appearance in text: p53: S121F

PubMed Link: 27533082

Variant Present in the following documents:

• Main text
• oncotarget-07-61630.pdf
• oncotarget-07-61630-s002.xlsx, sheet 1
• oncotarget-07-61630-s001.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: S121F

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Lysines in the tetramerization domain of p53 selectively modulate G1 arrest.

Cell Cycle (Georgetown, Tex.)

Beckerman, Rachel R; Yoh, Kathryn K; Mattia-Sansobrino, Melissa M; Zupnick, Andrew A; Laptenko, Oleg O; Karni-Schmidt, Orit O; Ahn, Jinwoo J; Byeon, In-Ja IJ; Keezer, Susan S; Prives, Carol C

Publication Date: 2016-06-02

Variant appearance in text: p53: S121F

PubMed Link: 27210019

Variant Present in the following documents:

• Main text

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Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics

Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y

Publication Date: 2015-12

Variant appearance in text: p53: S121F

PubMed Link: 26502337

Variant Present in the following documents:

• NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 1
• NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 2

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: TP53: S121F

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: S121F

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.

Plos One

Lukman, Suryani S; Lane, David P DP; Verma, Chandra S CS

Publication Date: 2013

Variant appearance in text: p53: S121F

PubMed Link: 24324553

Variant Present in the following documents:

• Main text
• pone.0080221.pdf

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Overexpression of DRAM enhances p53-dependent apoptosis.

Cancer Medicine

Takahashi, Masahiro M; Kakudo, Yuichi Y; Takahashi, Shin S; Sakamoto, Yasuhiro Y; Kato, Shunsuke S; Ishioka, Chikashi C

Publication Date: 2013-02

Variant appearance in text: p53: S121F

PubMed Link: 24133622

Variant Present in the following documents:

• Main text

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Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.

Nucleic Acids Research

Ciribilli, Yari Y; Monti, Paola P; Bisio, Alessandra A; Nguyen, H Thien HT; Ethayathulla, Abdul S AS; Ramos, Ana A; Foggetti, Giorgia G; Menichini, Paola P; Menendez, Daniel D; Resnick, Michael A MA; Viadiu, Hector H; Fronza, Gilberto G; Inga, Alberto A

Publication Date: 2013-10

Variant appearance in text: p53: S121F

PubMed Link: 23892287

Variant Present in the following documents:

• Main text

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Mining differential top-k co-expression patterns from time course comparative gene expression datasets.

Bmc Bioinformatics

Liu, Yu-Cheng YC; Cheng, Chun-Pei CP; Tseng, Vincent S VS

Publication Date: 2013-07-21

Variant appearance in text: TP53: S121F

PubMed Link: 23870110

Variant Present in the following documents:

• Main text
• 1471-2105-14-230.pdf

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Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study.

Blood

Xu-Monette, Zijun Y ZY; Wu, Lin L; Visco, Carlo C; Tai, Yu Chuan YC; Tzankov, Alexander A; Liu, Wei-min WM; Montes-Moreno, Santiago S; Dybkaer, Karen K; Chiu, April A; Orazi, Attilio A; Zu, Youli Y; Bhagat, Govind G; Richards, Kristy L KL; Hsi, Eric D ED; Zhao, X Frank XF; Choi, William W L WW; Zhao, Xiaoying X; van Krieken, J Han JH; Huang, Qin Q; Huh, Jooryung J; Ai, Weiyun W; Ponzoni, Maurilio M; Ferreri, Andrés J M AJ; Zhou, Fan F; Kahl, Brad S BS; Winter, Jane N JN; Xu, Wei W; Li, Jianyong J; Go, Ronald S RS; Li, Yong Y; Piris, Miguel A MA; Møller, Michael B MB; Miranda, Roberto N RN; Abruzzo, Lynne V LV; Medeiros, L Jeffrey LJ; Young, Ken H KH

Publication Date: 2012-11-08

Variant appearance in text: TP53: S121F

PubMed Link: 22955915

Variant Present in the following documents:

• Main text

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Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.

Oncology Letters

Yasuda, Katsuhiro K; Kato, Shunsuke S; Sakamoto, Yasuhiro Y; Watanabe, Gou G; Mashiko, Satsuki S; Sato, Atsuko A; Kakudo, Yuichi Y; Ishioka, Chikashi C

Publication Date: 2012-05

Variant appearance in text: p53: S121F

PubMed Link: 22783376

Variant Present in the following documents:

• Main text

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: TP53: S121F

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Menendez, Daniel D; Inga, Alberto A; Resnick, Michael A MA

Publication Date: 2010-01-26

Variant appearance in text: p53: S121F

PubMed Link: 20080630

Variant Present in the following documents:

• Main text

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Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.

Cell Cycle (Georgetown, Tex.)

Ahn, Jinwoo J; Poyurovsky, Masha V MV; Baptiste, Nicole N; Beckerman, Rachel R; Cain, Christine C; Mattia, Melissa M; McKinney, Kristine K; Zhou, Jianmin J; Zupnick, Andrew A; Gottifredi, Vanesa V; Prives, Carol C

Publication Date: 2009-05-15

Variant appearance in text: p53: S121F

PubMed Link: 19462533

Variant Present in the following documents:

• Main text

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Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts.

Plos Genetics

Noureddine, Maher A MA; Menendez, Daniel D; Campbell, Michelle R MR; Bandele, Omari J OJ; Horvath, Monica M MM; Wang, Xuting X; Pittman, Gary S GS; Chorley, Brian N BN; Resnick, Michael A MA; Bell, Douglas A DA

Publication Date: 2009-05

Variant appearance in text: p53: S121F

PubMed Link: 19424414

Variant Present in the following documents:

• Main text
• pgen.1000462.pdf

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Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain.

The Journal Of Biological Chemistry

Pietsch, E Christine EC; Perchiniak, Erin E; Canutescu, Adrian A AA; Wang, Guoli G; Dunbrack, Roland L RL; Murphy, Maureen E ME

Publication Date: 2008-07-25

Variant appearance in text: p53: S121F

PubMed Link: 18524770

Variant Present in the following documents:

• Main text

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The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.

Molecular And Cellular Biology

Menendez, Daniel D; Inga, Alberto A; Resnick, Michael A MA

Publication Date: 2006-03

Variant appearance in text: p53: S121F

PubMed Link: 16508005

Variant Present in the following documents:

• Main text

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