Publications:

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The Competition of Yin and Yang: Exploring the Role of Wild-Type and Mutant p53 in Tumor Progression.

Biomedicines

Cai, Bi-He BH; Sung, Yu-Te YT; Chen, Chia-Chi CC; Shaw, Jei-Fu JF; Hsin, I-Lun IL

Publication Date: 2023-04-17

Variant appearance in text: p53: S46F

PubMed Link: 37189810

Variant Present in the following documents:

• Main text
• biomedicines-11-01192.pdf

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ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC).

Plos Genetics

Ferrando, Lorenzo L; Vingiani, Andrea A; Garuti, Anna A; Vernieri, Claudio C; Belfiore, Antonino A; Agnelli, Luca L; Dagrada, Gianpaolo G; Ivanoiu, Diana D; Bonizzi, Giuseppina G; Munzone, Elisabetta E; Lippolis, Luana L; Dameri, Martina M; Ravera, Francesco F; Colleoni, Marco M; Viale, Giuseppe G; Magnani, Luca L; Ballestrero, Alberto A; Zoppoli, Gabriele G; Pruneri, Giancarlo G

Publication Date: 2023-01-03

Variant appearance in text: TP53: 137C>T

PubMed Link: 36595552

Variant Present in the following documents:

• pgen.1010563.s004.xlsx, sheet 1

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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience

Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X

Publication Date: 2022-09-16

Variant appearance in text: p53: S46F

PubMed Link: 36117989

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

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Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics

Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS

Publication Date: 2022-08

Variant appearance in text: TP53: S46F

PubMed Link: 35835912

Variant Present in the following documents:

• 41588_2022_1121_MOESM3_ESM.xlsx, sheet 3

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Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.

Nature Communications

Vergara, Ismael A IA; Mintoff, Christopher P CP; Sandhu, Shahneen S; McIntosh, Lachlan L; Young, Richard J RJ; Wong, Stephen Q SQ; Colebatch, Andrew A; Cameron, Daniel L DL; Kwon, Julia Lai JL; Wolfe, Rory R; Peng, Angela A; Ellul, Jason J; Dou, Xuelin X; Fedele, Clare C; Boyle, Samantha S; Arnau, Gisela Mir GM; Raleigh, Jeanette J; Hatzimihalis, Athena A; Szeto, Pacman P; Mooi, Jennifer J; Widmer, Daniel S DS; Cheng, Phil F PF; Amann, Valerie V; Dummer, Reinhard R; Hayward, Nicholas N; Wilmott, James J; Scolyer, Richard A RA; Cho, Raymond J RJ; Bowtell, David D; Thorne, Heather H; Alsop, Kathryn K; Cordner, Stephen S; Woodford, Noel N; Leditschke, Jodie J; O'Brien, Patricia P; Dawson, Sarah-Jane SJ; McArthur, Grant A GA; Mann, Graham J GJ; Levesque, Mitchell P MP; Papenfuss, Anthony T AT; Shackleton, Mark M

Publication Date: 2021-03-04

Variant appearance in text: TP53: Ser46Phe

PubMed Link: 33664264

Variant Present in the following documents:

• 41467_2021_21576_MOESM1_ESM.pdf

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Alignment-free method for functional annotation of amino acid substitutions: Application on epigenetic factors involved in hematologic malignancies.

Plos One

Gemović, Branislava B; Perović, Vladimir V; Davidović, Radoslav R; Drljača, Tamara T; Veljkovic, Nevena N

Publication Date: 2021

Variant appearance in text: TP53: S46F

PubMed Link: 33395407

Variant Present in the following documents:

• Main text
• pone.0244948.pdf

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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery

Shan, Lin L; Yu, Jiao J; He, Zhengjin Z; Chen, Shishuang S; Liu, Mingxian M; Ding, Hongyu H; Xu, Liang L; Zhao, Jie J; Yang, Ailing A; Jiang, Hai H

Publication Date: 2020

Variant appearance in text: p53: S46F

PubMed Link: 32704382

Variant Present in the following documents:

• 41421_2020_177_MOESM4_ESM.xlsx, sheet 1

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Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation.

International Journal Of Molecular Sciences

Cai, Bi-He BH; Chao, Chung-Faye CF; Huang, Hsiang-Chi HC; Lee, Hsueh-Yi HY; Kannagi, Reiji R; Chen, Jang-Yi JY

Publication Date: 2019-07-27

Variant appearance in text: p53: S46F

PubMed Link: 31357595

Variant Present in the following documents:

• Main text
• ijms-20-03681.pdf

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Molecular characterization of low grade and high grade bladder cancer.

Plos One

Apollo, Alessandro A; Ortenzi, Valerio V; Scatena, Cristian C; Zavaglia, Katia K; Aretini, Paolo P; Lessi, Francesca F; Franceschi, Sara S; Tomei, Sara S; Sepich, Carlo Alberto CA; Viacava, Paolo P; Mazzanti, Chiara Maria CM; Naccarato, Antonio Giuseppe AG

Publication Date: 2019

Variant appearance in text: TP53: S46F

PubMed Link: 30650148

Variant Present in the following documents:

• Main text
• pone.0210635.s002.xlsx, sheet 3
• pone.0210635.pdf

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Locus-specific concordance of genomic alterations between tissue and plasma circulating tumor DNA in metastatic melanoma.

Molecular Oncology

Calapre, Leslie L; Giardina, Tindaro T; Robinson, Cleo C; Reid, Anna L AL; Al-Ogaili, Zeyad Z; Pereira, Michelle R MR; McEvoy, Ashleigh C AC; Warburton, Lydia L; Hayward, Nicholas K NK; Khattak, Muhammad A MA; Meniawy, Tarek M TM; Millward, Michael M; Amanuel, Benhur B; Ziman, Melanie M; Gray, Elin S ES

Publication Date: 2019-02

Variant appearance in text: TP53: S46F

PubMed Link: 30312528

Variant Present in the following documents:

• Main text
• MOL2-13-171-s003.xlsx, sheet 1
• MOL2-13-171.pdf

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ELAS1 induces apoptotic death in adenocarcinoma DU145 and squamous-cell carcinoma SAS cancer cells, but not in normal KD cells.

Oncotarget

Uchihashi, Toshihiro T; Ota, Kaori K; Yabuno, Yusuke Y; Ohno, Shouichi S; Fukushima, Kohshiro K; Naito, Yoko Y; Kogo, Mikihiko M; Yabuta, Norikazu N; Nojima, Hiroshi H

Publication Date: 2017-10-17

Variant appearance in text: p53: S46F

PubMed Link: 29156763

Variant Present in the following documents:

• Main text
• oncotarget-08-85868-s001.pdf
• oncotarget-08-85868.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: S46F

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Lysines in the tetramerization domain of p53 selectively modulate G1 arrest.

Cell Cycle (Georgetown, Tex.)

Beckerman, Rachel R; Yoh, Kathryn K; Mattia-Sansobrino, Melissa M; Zupnick, Andrew A; Laptenko, Oleg O; Karni-Schmidt, Orit O; Ahn, Jinwoo J; Byeon, In-Ja IJ; Keezer, Susan S; Prives, Carol C

Publication Date: 2016-06-02

Variant appearance in text: p53: S46F

PubMed Link: 27210019

Variant Present in the following documents:

• Main text

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Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics

Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y

Publication Date: 2015-12

Variant appearance in text: p53: S46F

PubMed Link: 26502337

Variant Present in the following documents:

• NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 2

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: TP53: S46F

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: S46F

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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A highly recurrent RPS27 5'UTR mutation in melanoma.

Oncotarget

Dutton-Regester, Ken K; Gartner, Jared J JJ; Emmanuel, Rafi R; Qutob, Nouar N; Davies, Michael A MA; Gershenwald, Jeffrey E JE; Robinson, William W; Robinson, Steven S; Rosenberg, Steven A SA; Scolyer, Richard A RA; Mann, Graham J GJ; Thompson, John F JF; Hayward, Nicholas K NK; Samuels, Yardena Y

Publication Date: 2014-05-30

Variant appearance in text: p53: S46F

PubMed Link: 24913145

Variant Present in the following documents:

• oncotarget-05-2912-s003.xlsx, sheet 1

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: TP53: S46F

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies.

Biophysical Journal

Rigacci, Stefania S; Bucciantini, Monica M; Relini, Annalisa A; Pesce, Alessandra A; Gliozzi, Alessandra A; Berti, Andrea A; Stefani, Massimo M

Publication Date: 2008-05-01

Variant appearance in text: p53: S46F

PubMed Link: 18199664

Variant Present in the following documents:

• Main text

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Requirement of clathrin heavy chain for p53-mediated transcription.

Genes & Development

Enari, Masato M; Ohmori, Kazuji K; Kitabayashi, Issay I; Taya, Yoichi Y

Publication Date: 2006-05-01

Variant appearance in text: p53: S46F

PubMed Link: 16618797

Variant Present in the following documents:

• Main text

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