Publications:

---

Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies.

Medcomm

Shen, Jinze J; Wang, Qurui Q; Mao, Yunan Y; Gao, Wei W; Duan, Shiwei S

Publication Date: 2023-06

Variant appearance in text: p53: W23S

PubMed Link: 37256211

Variant Present in the following documents:

• Main text
• MCO2-4-e288.pdf

View BVdb publication page

---

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.

Nature Communications

Ho, Teresa Lai Fong TLF; Lee, May Yin MY; Goh, Hui Chin HC; Ng, Germaine Yi Ning GYN; Lee, Jane Jia Hui JJH; Kannan, Srinivasaraghavan S; Lim, Yan Ting YT; Zhao, Tianyun T; Lim, Edwin Kok Hao EKH; Phua, Cheryl Zi Jin CZJ; Lee, Yi Fei YF; Lim, Rebecca Yi Xuan RYX; Ng, Perry Jun Hao PJH; Yuan, Ju J; Chan, Dedrick Kok Hong DKH; Lieske, Bettina B; Chong, Choon Seng CS; Lee, Kuok Chung KC; Lum, Jeffrey J; Cheong, Wai Kit WK; Yeoh, Khay Guan KG; Tan, Ker Kan KK; Sobota, Radoslaw M RM; Verma, Chandra S CS; Lane, David P DP; Tam, Wai Leong WL; Venkitaraman, Ashok R AR

Publication Date: 2023-03-28

Variant appearance in text: p53: W23S

PubMed Link: 36977662

Variant Present in the following documents:

• Main text
• 41467_2023_Article_37223.pdf

View BVdb publication page

---

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.

Nature Communications

Hassin, Ori O; Nataraj, Nishanth Belugali NB; Shreberk-Shaked, Michal M; Aylon, Yael Y; Yaeger, Rona R; Fontemaggi, Giulia G; Mukherjee, Saptaparna S; Maddalena, Martino M; Avioz, Adi A; Iancu, Ortal O; Mallel, Giuseppe G; Gershoni, Anat A; Grosheva, Inna I; Feldmesser, Ester E; Ben-Dor, Shifra S; Golani, Ofra O; Hendel, Ayal A; Blandino, Giovanni G; Kelsen, David D; Yarden, Yosef Y; Oren, Moshe M

Publication Date: 2022-05-19

Variant appearance in text: p53: W23S

PubMed Link: 35589715

Variant Present in the following documents:

• Main text
• 41467_2022_Article_30481.pdf

View BVdb publication page

---

The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.

Nature Communications

Vaughan, Catherine A CA; Singh, Shilpa S; Subler, Mark A MA; Windle, Jolene J JJ; Inoue, Kazushi K; Fry, Elizabeth A EA; Pillappa, Raghavendra R; Grossman, Steven R SR; Windle, Brad B; Andrew Yeudall, W W; Deb, Swati Palit SP; Deb, Sumitra S

Publication Date: 2021-01-29

Variant appearance in text: p53: W23S

PubMed Link: 33514736

Variant Present in the following documents:

• Main text
• 41467_2021_Article_20928.pdf

View BVdb publication page

---

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.

Nucleic Acids Research

Biber, Stephanie S; Pospiech, Helmut H; Gottifredi, Vanesa V; Wiesmüller, Lisa L

Publication Date: 2020-12-02

Variant appearance in text: p53: W23S

PubMed Link: 33166398

Variant Present in the following documents:

• Main text
• gkaa974.pdf

View BVdb publication page

---

The Tumor Suppressor, p53, Negatively Regulates Non-Canonical NF-κB Signaling through miRNAInduced Silencing of NF-κB-Inducing Kinase.

Molecules And Cells

Jang, Hanbit H; Park, Seulki S; Kim, Jaehoon J; Kim, Jong Hwan JH; Kim, Seon-Young SY; Cho, Sayeon S; Park, Sung Goo SG; Park, Byoung Chul BC; Kim, Sunhong S; Kim, Jeong-Hoon JH

Publication Date: 2020-01-31

Variant appearance in text: p53: W23S

PubMed Link: 31870133

Variant Present in the following documents:

• Main text
• molce-43-023.pdf

View BVdb publication page

---

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.

Journal Of Experimental & Clinical Cancer Research : Cr

Thiem, Alexander A; Hesbacher, Sonja S; Kneitz, Hermann H; di Primio, Teresa T; Heppt, Markus V MV; Hermanns, Heike M HM; Goebeler, Matthias M; Meierjohann, Svenja S; Houben, Roland R; Schrama, David D

Publication Date: 2019-09-11

Variant appearance in text: p53: W23S

PubMed Link: 31506076

Variant Present in the following documents:

• Main text
• 13046_2019_Article_1403.pdf

View BVdb publication page

---

appreci8: a pipeline for precise variant calling integrating 8 tools.

Bioinformatics (Oxford, England)

Sandmann, Sarah S; Karimi, Mohsen M; de Graaf, Aniek O AO; Rohde, Christian C; Göllner, Stefanie S; Varghese, Julian J; Ernsting, Jan J; Walldin, Gunilla G; van der Reijden, Bert A BA; Müller-Tidow, Carsten C; Malcovati, Luca L; Hellström-Lindberg, Eva E; Jansen, Joop H JH; Dugas, Martin M

Publication Date: 2018-12-15

Variant appearance in text: TP53: 68G>C; Trp23Ser

PubMed Link: 29945233

Variant Present in the following documents:

• bty518_supplementary_data_s2.xlsx, sheet 9

View BVdb publication page

---

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.

Cell Death And Differentiation

Goiran, Thomas T; Duplan, Eric E; Rouland, Lila L; El Manaa, Wejdane W; Lauritzen, Inger I; Dunys, Julie J; You, Han H; Checler, Frédéric F; Alves da Costa, Cristine C

Publication Date: 2018-05

Variant appearance in text: p53: W23S

PubMed Link: 29352272

Variant Present in the following documents:

• Main text
• 41418_2017_Article_16.pdf

View BVdb publication page

---

Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.

Oncotarget

Boudreau, Howard E HE; Ma, Wei Feng WF; Korzeniowska, Agnieszka A; Park, Jonathan J JJ; Bhagwat, Medha A MA; Leto, Thomas L TL

Publication Date: 2017-07-04

Variant appearance in text: p53: W23S

PubMed Link: 28574838

Variant Present in the following documents:

• Main text
• oncotarget-08-44379.pdf

View BVdb publication page

---

Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy.

Molecular Therapy Oncolytics

Bressy, Christian C; Hastie, Eric E; Grdzelishvili, Valery Z VZ

Publication Date: 2017-06-16

Variant appearance in text: p53: W23S

PubMed Link: 28480326

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.

The Journal Of Clinical Investigation

Singh, Shilpa S; Vaughan, Catherine A CA; Frum, Rebecca A RA; Grossman, Steven R SR; Deb, Sumitra S; Palit Deb, Swati S

Publication Date: 2017-05-01

Variant appearance in text: p53: W23S

PubMed Link: 28394262

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer.

International Journal Of Molecular Sciences

Liu, Guangbo G; Pei, Fen F; Yang, Fengqing F; Li, Lingxiao L; Amin, Amit Dipak AD; Liu, Songnian S; Buchan, J Ross JR; Cho, William C WC

Publication Date: 2017-02-10

Variant appearance in text: p53: W23S

PubMed Link: 28208579

Variant Present in the following documents:

• Main text

View BVdb publication page

---

BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53.

Scientific Reports

Nie, Er E; Jin, Xin X; Wu, Weining W; Yu, Tianfu T; Zhou, Xu X; Zhi, Tongle T; Shi, Zhumei Z; Zhang, Junxia J; Liu, Ning N; You, Yongping Y

Publication Date: 2016-12-21

Variant appearance in text: p53: Trp23Ser

PubMed Link: 28000777

Variant Present in the following documents:

• Main text
• srep39743.pdf

View BVdb publication page

---

The Transactivation Domains of the p53 Protein.

Cold Spring Harbor Perspectives In Medicine

Raj, Nitin N; Attardi, Laura D LD

Publication Date: 2017-01-03

Variant appearance in text: p53: W23S

PubMed Link: 27864306

Variant Present in the following documents:

• Main text

View BVdb publication page

---

iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: W23S

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

View BVdb publication page

---

Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants.

Frontiers In Oncology

Giorgi, Carlotta C; Bonora, Massimo M; Missiroli, Sonia S; Morganti, Claudia C; Morciano, Giampaolo G; Wieckowski, Mariusz R MR; Pinton, Paolo P

Publication Date: 2016

Variant appearance in text: p53: W23S

PubMed Link: 26942128

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter.

Oncotarget

Vaughan, Catherine A CA; Pearsall, Isabella I; Singh, Shilpa S; Windle, Brad B; Deb, Swati P SP; Grossman, Steven R SR; Yeudall, W Andrew WA; Deb, Sumitra S

Publication Date: 2016-03-15

Variant appearance in text: p53: W23S

PubMed Link: 26820293

Variant Present in the following documents:

• oncotarget-07-12426.pdf

View BVdb publication page

---

Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Phang, Beng Hooi BH; Othman, Rashidah R; Bougeard, Gaelle G; Chia, Ren Hui RH; Frebourg, Thierry T; Tang, Choong Leong CL; Cheah, Peh Yean PY; Sabapathy, Kanaga K

Publication Date: 2015-11-17

Variant appearance in text: p53: W23S

PubMed Link: 26578795

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter.

Plos One

Maeda, Ryo R; Suzuki, Hidefumi H; Tanaka, Yuta Y; Tamura, Taka-aki TA

Publication Date: 2014

Variant appearance in text: p53: W23S

PubMed Link: 24594805

Variant Present in the following documents:

• Main text
• pone.0090190.pdf

View BVdb publication page

---

Allosteric conformational barcodes direct signaling in the cell.

Structure (London, England : 1993)

Nussinov, Ruth R; Ma, Buyong B; Tsai, Chung-Jung CJ; Csermely, Peter P

Publication Date: 2013-09-03

Variant appearance in text: p53: W23S

PubMed Link: 24010710

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Negative regulation of p53 by Ras superfamily protein RBEL1A.

Journal Of Cell Science

Lui, Ki K; An, Jie J; Montalbano, Joanne J; Shi, Jingxue J; Corcoran, Chad C; He, Qin Q; Sun, Hong H; Sheikh, M Saeed MS; Huang, Ying Y

Publication Date: 2013-06-01

Variant appearance in text: p53: W23S

PubMed Link: 23572512

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The different ways through which specificity works in orthosteric and allosteric drugs.

Current Pharmaceutical Design

Nussinov, Ruth R; Tsai, Chung-Jung CJ

Publication Date: 2012

Variant appearance in text: p53: W23S

PubMed Link: 22316155

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

Cell

Freed-Pastor, William A WA; Mizuno, Hideaki H; Zhao, Xi X; Langerød, Anita A; Moon, Sung-Hwan SH; Rodriguez-Barrueco, Ruth R; Barsotti, Anthony A; Chicas, Agustin A; Li, Wencheng W; Polotskaia, Alla A; Bissell, Mina J MJ; Osborne, Timothy F TF; Tian, Bin B; Lowe, Scott W SW; Silva, Jose M JM; Børresen-Dale, Anne-Lise AL; Levine, Arnold J AJ; Bargonetti, Jill J; Prives, Carol C

Publication Date: 2012-01-20

Variant appearance in text: p53: W23S

PubMed Link: 22265415

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Gene-specific transcription activation via long-range allosteric shape-shifting.

The Biochemical Journal

Tsai, Chung-Jung CJ; Nussinov, Ruth R

Publication Date: 2011-10-01

Variant appearance in text: p53: W23S

PubMed Link: 21916844

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance.

Archives Of Biochemistry And Biophysics

Sankala, Heidi H; Vaughan, Catherine C; Wang, Jing J; Deb, Sumitra S; Graves, Paul R PR

Publication Date: 2011-08-01

Variant appearance in text: p53: W23S

PubMed Link: 21621504

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization.

The Journal Of Biological Chemistry

Sun, Luyang L; Shi, Lei L; Wang, Feng F; Huangyang, Peiwei P; Si, Wenzhe W; Yang, Jie J; Yao, Zhi Z; Shang, Yongfeng Y

Publication Date: 2011-02-11

Variant appearance in text: p53: W23S

PubMed Link: 21127074

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein.

Biochemistry

Lee, Chul Won CW; Martinez-Yamout, Maria A MA; Dyson, H Jane HJ; Wright, Peter E PE

Publication Date: 2010-11-23

Variant appearance in text: p53: W23S

PubMed Link: 20961098

Variant Present in the following documents:

• Main text

View BVdb publication page

---

p53 activates transcription by directing structural shifts in Mediator.

Nature Structural & Molecular Biology

Meyer, Krista D KD; Lin, Shih-Chieh SC; Bernecky, Carrie C; Gao, Yuefeng Y; Taatjes, Dylan J DJ

Publication Date: 2010-06

Variant appearance in text: p53: W23S

PubMed Link: 20453859

Variant Present in the following documents:

• Main text

View BVdb publication page

---

p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.

Anticancer Research

Bocangel, Dora D; Sengupta, Shiladitya S; Mitra, Sankar S; Bhakat, Kishor K KK

Publication Date: 2009-10

Variant appearance in text: p53: Trp23Ser

PubMed Link: 19846904

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.

Molecular Cancer Therapeutics

Zheng, Mingzhong M; Bocangel, Dora D; Ramesh, Rajagopal R; Ekmekcioglu, Suhendan S; Poindexter, Nancy N; Grimm, Elizabeth A EA; Chada, Sunil S

Publication Date: 2008-12

Variant appearance in text: p53: Trp23Ser

PubMed Link: 19056673

Variant Present in the following documents:

• Main text

View BVdb publication page

---

A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Baptiste-Okoh, Nicole N; Barsotti, Anthony M AM; Prives, Carol C

Publication Date: 2008-02-12

Variant appearance in text: p53: W23S

PubMed Link: 18238895

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.

Nucleic Acids Research

Zaky, Amira A; Busso, Carlos C; Izumi, Tadahide T; Chattopadhyay, Ranajoy R; Bassiouny, Ahmad A; Mitra, Sankar S; Bhakat, Kishor K KK

Publication Date: 2008-03

Variant appearance in text: p53: Trp23Ser

PubMed Link: 18208837

Variant Present in the following documents:

• Main text

View BVdb publication page

---

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop.

Molecular And Cellular Biology

Valbuena, Alberto A; Vega, Francisco M FM; Blanco, Sandra S; Lazo, Pedro A PA

Publication Date: 2006-07

Variant appearance in text: p53: W23S

PubMed Link: 16782868

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.

Molecular Systems Biology

Tabach, Yuval Y; Milyavsky, Michael M; Shats, Igor I; Brosh, Ran R; Zuk, Or O; Yitzhaky, Assif A; Mantovani, Roberto R; Domany, Eytan E; Rotter, Varda V; Pilpel, Yitzhak Y

Publication Date: 2005

Variant appearance in text: p53: W23S

PubMed Link: 16729057

Variant Present in the following documents:

• msb4100030.pdf

View BVdb publication page

---

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling.

The Journal Of Cell Biology

Wang, Xueying X; Kua, Hui-Yi HY; Hu, Yuanyu Y; Guo, Ke K; Zeng, Qi Q; Wu, Qiang Q; Ng, Huck-Hui HH; Karsenty, Gerard G; de Crombrugghe, Benoit B; Yeh, James J; Li, Baojie B

Publication Date: 2006-01-02

Variant appearance in text: p53: W23S

PubMed Link: 16380437

Variant Present in the following documents:

• Main text
• jcb1720115.pdf

View BVdb publication page

---

Sequestration of p53 in the cytoplasm by adenovirus type 12 E1B 55-kilodalton oncoprotein is required for inhibition of p53-mediated apoptosis.

Journal Of Virology

Zhao, Lisa Y LY; Liao, Daiqing D

Publication Date: 2003-12

Variant appearance in text: p53: W23S

PubMed Link: 14645574

Variant Present in the following documents:

• Main text

View BVdb publication page

---

P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Asher, Gad G; Lotem, Joseph J; Tsvetkov, Peter P; Reiss, Veronica V; Sachs, Leo L; Shaul, Yosef Y

Publication Date: 2003-12-09

Variant appearance in text: p53: W23S

PubMed Link: 14634213

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53.

The Journal Of Biological Chemistry

Watcharasit, Piyajit P; Bijur, Gautam N GN; Song, Ling L; Zhu, Jianhui J; Chen, Xinbin X; Jope, Richard S RS

Publication Date: 2003-12-05

Variant appearance in text: p53: W23S

PubMed Link: 14523002

Variant Present in the following documents:

• Main text

View BVdb publication page

---

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.

Molecular And Cellular Biology

Gaiddon, C C; Lokshin, M M; Ahn, J J; Zhang, T T; Prives, C C

Publication Date: 2001-03

Variant appearance in text: p53: W23S

PubMed Link: 11238924

Variant Present in the following documents:

• Main text

View BVdb publication page

---