Publications:

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Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies.

Medcomm

Shen, Jinze J; Wang, Qurui Q; Mao, Yunan Y; Gao, Wei W; Duan, Shiwei S

Publication Date: 2023-06

Variant appearance in text: p53: L22Q

PubMed Link: 37256211

Variant Present in the following documents:

• Main text
• MCO2-4-e288.pdf

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What Makes a Good Protein-Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism.

Acs Central Science

Chen, Shu-Yu SY; Zacharias, Martin M

Publication Date: 2023-05-24

Variant appearance in text: p53: L22Q

PubMed Link: 37252344

Variant Present in the following documents:

• Main text
• oc3c00003.pdf

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Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition.

Frontiers In Molecular Biosciences

Semenov, Oleg O; Daks, Alexandra A; Fedorova, Olga O; Shuvalov, Oleg O; Barlev, Nickolai A NA

Publication Date: 2022

Variant appearance in text: p53: L22Q

PubMed Link: 35813818

Variant Present in the following documents:

• Main text
• fmolb-09-928399.pdf

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Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.

Nature Communications

Hassin, Ori O; Nataraj, Nishanth Belugali NB; Shreberk-Shaked, Michal M; Aylon, Yael Y; Yaeger, Rona R; Fontemaggi, Giulia G; Mukherjee, Saptaparna S; Maddalena, Martino M; Avioz, Adi A; Iancu, Ortal O; Mallel, Giuseppe G; Gershoni, Anat A; Grosheva, Inna I; Feldmesser, Ester E; Ben-Dor, Shifra S; Golani, Ofra O; Hendel, Ayal A; Blandino, Giovanni G; Kelsen, David D; Yarden, Yosef Y; Oren, Moshe M

Publication Date: 2022-05-19

Variant appearance in text: p53: L22Q

PubMed Link: 35589715

Variant Present in the following documents:

• Main text
• 41467_2022_Article_30481.pdf

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The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.

Nature Communications

Vaughan, Catherine A CA; Singh, Shilpa S; Subler, Mark A MA; Windle, Jolene J JJ; Inoue, Kazushi K; Fry, Elizabeth A EA; Pillappa, Raghavendra R; Grossman, Steven R SR; Windle, Brad B; Andrew Yeudall, W W; Deb, Swati Palit SP; Deb, Sumitra S

Publication Date: 2021-01-29

Variant appearance in text: p53: L22Q

PubMed Link: 33514736

Variant Present in the following documents:

• Main text
• 41467_2021_Article_20928.pdf

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Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.

Nucleic Acids Research

Biber, Stephanie S; Pospiech, Helmut H; Gottifredi, Vanesa V; Wiesmüller, Lisa L

Publication Date: 2020-12-02

Variant appearance in text: p53: L22Q

PubMed Link: 33166398

Variant Present in the following documents:

• Main text
• gkaa974.pdf

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Stat2 stability regulation: an intersection between immunity and carcinogenesis.

Experimental & Molecular Medicine

Lee, Cheol-Jung CJ; An, Hyun-Jung HJ; Cho, Eun Suh ES; Kang, Han Chang HC; Lee, Joo Young JY; Lee, Hye Suk HS; Cho, Yong-Yeon YY

Publication Date: 2020-09

Variant appearance in text: p53: L22Q

PubMed Link: 32973222

Variant Present in the following documents:

• Main text
• 12276_2020_Article_506.pdf

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The Tumor Suppressor, p53, Negatively Regulates Non-Canonical NF-κB Signaling through miRNAInduced Silencing of NF-κB-Inducing Kinase.

Molecules And Cells

Jang, Hanbit H; Park, Seulki S; Kim, Jaehoon J; Kim, Jong Hwan JH; Kim, Seon-Young SY; Cho, Sayeon S; Park, Sung Goo SG; Park, Byoung Chul BC; Kim, Sunhong S; Kim, Jeong-Hoon JH

Publication Date: 2020-01-31

Variant appearance in text: p53: L22Q

PubMed Link: 31870133

Variant Present in the following documents:

• Main text
• molce-43-023.pdf
• molce-43-023_supple.pdf

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How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor.

International Journal Of Molecular Sciences

Ho, Teresa T; Tan, Ban Xiong BX; Lane, David D

Publication Date: 2019-12-18

Variant appearance in text: p53: L22Q

PubMed Link: 31861395

Variant Present in the following documents:

• Main text

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IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.

Journal Of Experimental & Clinical Cancer Research : Cr

Thiem, Alexander A; Hesbacher, Sonja S; Kneitz, Hermann H; di Primio, Teresa T; Heppt, Markus V MV; Hermanns, Heike M HM; Goebeler, Matthias M; Meierjohann, Svenja S; Houben, Roland R; Schrama, David D

Publication Date: 2019-09-11

Variant appearance in text: p53: L22Q

PubMed Link: 31506076

Variant Present in the following documents:

• Main text
• 13046_2019_Article_1403.pdf

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Gain-of-function mutant p53: history and speculation.

Journal Of Molecular Cell Biology

Bargonetti, Jill J; Prives, Carol C

Publication Date: 2019-07-19

Variant appearance in text: p53: L22Q

PubMed Link: 31283823

Variant Present in the following documents:

• Main text
• mjz067.pdf

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Structural Basis for the Interaction between p53 Transactivation Domain and the Mediator Subunit MED25.

Molecules (Basel, Switzerland)

Lee, Min-Sung MS; Lim, Kyungeun K; Lee, Mi-Kyung MK; Chi, Seung-Wook SW

Publication Date: 2018-10-22

Variant appearance in text: p53: L22Q

PubMed Link: 30360415

Variant Present in the following documents:

• Main text
• molecules-23-02726.pdf

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appreci8: a pipeline for precise variant calling integrating 8 tools.

Bioinformatics (Oxford, England)

Sandmann, Sarah S; Karimi, Mohsen M; de Graaf, Aniek O AO; Rohde, Christian C; Göllner, Stefanie S; Varghese, Julian J; Ernsting, Jan J; Walldin, Gunilla G; van der Reijden, Bert A BA; Müller-Tidow, Carsten C; Malcovati, Luca L; Hellström-Lindberg, Eva E; Jansen, Joop H JH; Dugas, Martin M

Publication Date: 2018-12-15

Variant appearance in text: TP53: 65T>A; Leu22Gln

PubMed Link: 29945233

Variant Present in the following documents:

• bty518_supplementary_data_s6.xlsx, sheet 9
• bty518_supplementary_data_s2.xlsx, sheet 9

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Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.

Cell Death And Differentiation

Goiran, Thomas T; Duplan, Eric E; Rouland, Lila L; El Manaa, Wejdane W; Lauritzen, Inger I; Dunys, Julie J; You, Han H; Checler, Frédéric F; Alves da Costa, Cristine C

Publication Date: 2018-05

Variant appearance in text: p53: L22Q

PubMed Link: 29352272

Variant Present in the following documents:

• Main text
• 41418_2017_Article_16.pdf

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Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.

Oncotarget

Boudreau, Howard E HE; Ma, Wei Feng WF; Korzeniowska, Agnieszka A; Park, Jonathan J JJ; Bhagwat, Medha A MA; Leto, Thomas L TL

Publication Date: 2017-07-04

Variant appearance in text: p53: L22Q

PubMed Link: 28574838

Variant Present in the following documents:

• Main text

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HOXA5 and p53 cooperate to suppress lung cancer cell invasion and serve as good prognostic factors in non-small cell lung cancer.

Journal Of Cancer

Chang, Chi-Jen CJ; Chen, Yen-Lin YL; Hsieh, Chia-Hung CH; Liu, Ya-Jung YJ; Yu, Sung-Liang SL; Chen, Jeremy J W JJW; Wang, Chi-Chung CC

Publication Date: 2017

Variant appearance in text: p53: L22Q

PubMed Link: 28529621

Variant Present in the following documents:

• Main text
• jcav08p1071.pdf

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Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.

The Journal Of Clinical Investigation

Singh, Shilpa S; Vaughan, Catherine A CA; Frum, Rebecca A RA; Grossman, Steven R SR; Deb, Sumitra S; Palit Deb, Swati S

Publication Date: 2017-05-01

Variant appearance in text: p53: L22Q

PubMed Link: 28394262

Variant Present in the following documents:

• Main text

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Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer.

International Journal Of Molecular Sciences

Liu, Guangbo G; Pei, Fen F; Yang, Fengqing F; Li, Lingxiao L; Amin, Amit Dipak AD; Liu, Songnian S; Buchan, J Ross JR; Cho, William C WC

Publication Date: 2017-02-10

Variant appearance in text: p53: L22Q

PubMed Link: 28208579

Variant Present in the following documents:

• Main text

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TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.

The Journal Of Biological Chemistry

Maeda, Ryo R; Tamashiro, Hiroyuki H; Takano, Kazunori K; Takahashi, Hiro H; Suzuki, Hidefumi H; Saito, Shinta S; Kojima, Waka W; Adachi, Noritaka N; Ura, Kiyoe K; Endo, Takeshi T; Tamura, Taka-Aki TA

Publication Date: 2017-02-24

Variant appearance in text: p53: L22Q

PubMed Link: 28082682

Variant Present in the following documents:

• Main text

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BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53.

Scientific Reports

Nie, Er E; Jin, Xin X; Wu, Weining W; Yu, Tianfu T; Zhou, Xu X; Zhi, Tongle T; Shi, Zhumei Z; Zhang, Junxia J; Liu, Ning N; You, Yongping Y

Publication Date: 2016-12-21

Variant appearance in text: p53: Leu22Gln

PubMed Link: 28000777

Variant Present in the following documents:

• Main text
• srep39743.pdf

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The Transactivation Domains of the p53 Protein.

Cold Spring Harbor Perspectives In Medicine

Raj, Nitin N; Attardi, Laura D LD

Publication Date: 2017-01-03

Variant appearance in text: p53: L22Q

PubMed Link: 27864306

Variant Present in the following documents:

• Main text

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Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.

Cold Spring Harbor Perspectives In Medicine

Pfister, Neil T NT; Prives, Carol C

Publication Date: 2017-02-01

Variant appearance in text: p53: L22Q

PubMed Link: 27836911

Variant Present in the following documents:

• Main text

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: L22Q

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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ARN: analysis and prediction by adipogenic professional database.

Bmc Systems Biology

Huang, Yan Y; Wang, Li L; Zan, And Lin-Sen AL

Publication Date: 2016-08-08

Variant appearance in text: p53: L22Q

PubMed Link: 27503118

Variant Present in the following documents:

• 12918_2016_321_MOESM1_ESM.xlsx, sheet 5

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P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.

The Journal Of Cell Biology

Hashimoto, Ari A; Oikawa, Tsukasa T; Hashimoto, Shigeru S; Sugino, Hirokazu H; Yoshikawa, Ayumu A; Otsuka, Yutaro Y; Handa, Haruka H; Onodera, Yasuhito Y; Nam, Jin-Min JM; Oneyama, Chitose C; Okada, Masato M; Fukuda, Mitsunori M; Sabe, Hisataka H

Publication Date: 2016-04-11

Variant appearance in text: p53: L22Q

PubMed Link: 27044891

Variant Present in the following documents:

• Main text

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Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Krois, Alexander S AS; Ferreon, Josephine C JC; Martinez-Yamout, Maria A MA; Dyson, H Jane HJ; Wright, Peter E PE

Publication Date: 2016-03-29

Variant appearance in text: p53: L22Q

PubMed Link: 26976603

Variant Present in the following documents:

• Main text

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Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants.

Frontiers In Oncology

Giorgi, Carlotta C; Bonora, Massimo M; Missiroli, Sonia S; Morganti, Claudia C; Morciano, Giampaolo G; Wieckowski, Mariusz R MR; Pinton, Paolo P

Publication Date: 2016

Variant appearance in text: p53: L22Q

PubMed Link: 26942128

Variant Present in the following documents:

• Main text

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Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter.

Oncotarget

Vaughan, Catherine A CA; Pearsall, Isabella I; Singh, Shilpa S; Windle, Brad B; Deb, Swati P SP; Grossman, Steven R SR; Yeudall, W Andrew WA; Deb, Sumitra S

Publication Date: 2016-03-15

Variant appearance in text: p53: L22Q

PubMed Link: 26820293

Variant Present in the following documents:

• Main text
• oncotarget-07-12426.pdf

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Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Phang, Beng Hooi BH; Othman, Rashidah R; Bougeard, Gaelle G; Chia, Ren Hui RH; Frebourg, Thierry T; Tang, Choong Leong CL; Cheah, Peh Yean PY; Sabapathy, Kanaga K

Publication Date: 2015-11-17

Variant appearance in text: p53: L22Q

PubMed Link: 26578795

Variant Present in the following documents:

• Main text

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Structure and apoptotic function of p73.

Bmb Reports

Yoon, Mi-Kyung MK; Ha, Ji-Hyang JH; Lee, Min-Sung MS; Chi, Seung-Wook SW

Publication Date: 2015-02

Variant appearance in text: p53: L22Q

PubMed Link: 25441426

Variant Present in the following documents:

• Main text
• BMB-48-81.pdf

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Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.

Nucleic Acids Research

Loughery, Jayne J; Cox, Miranda M; Smith, Linda M LM; Meek, David W DW

Publication Date: 2014-07

Variant appearance in text: p53: L22Q

PubMed Link: 24928858

Variant Present in the following documents:

• Main text
• gku501.pdf

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Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.

Chemical Reviews

Uversky, Vladimir N VN; Davé, Vrushank V; Iakoucheva, Lilia M LM; Malaney, Prerna P; Metallo, Steven J SJ; Pathak, Ravi Ramesh RR; Joerger, Andreas C AC

Publication Date: 2014-07-09

Variant appearance in text: p53: L22Q

PubMed Link: 24830552

Variant Present in the following documents:

• Main text

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Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter.

Plos One

Maeda, Ryo R; Suzuki, Hidefumi H; Tanaka, Yuta Y; Tamura, Taka-aki TA

Publication Date: 2014

Variant appearance in text: p53: L22Q

PubMed Link: 24594805

Variant Present in the following documents:

• Main text
• pone.0090190.pdf

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Allosteric conformational barcodes direct signaling in the cell.

Structure (London, England : 1993)

Nussinov, Ruth R; Ma, Buyong B; Tsai, Chung-Jung CJ; Csermely, Peter P

Publication Date: 2013-09-03

Variant appearance in text: p53: L22Q

PubMed Link: 24010710

Variant Present in the following documents:

• Main text

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Negative regulation of p53 by Ras superfamily protein RBEL1A.

Journal Of Cell Science

Lui, Ki K; An, Jie J; Montalbano, Joanne J; Shi, Jingxue J; Corcoran, Chad C; He, Qin Q; Sun, Hong H; Sheikh, M Saeed MS; Huang, Ying Y

Publication Date: 2013-06-01

Variant appearance in text: p53: L22Q

PubMed Link: 23572512

Variant Present in the following documents:

• Main text

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Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl.

Genes & Cancer

Vaughan, Catherine A CA; Singh, Shilpa S; Windle, Brad B; Yeudall, W Andrew WA; Frum, Rebecca R; Grossman, Steven R SR; Deb, Swati P SP; Deb, Sumitra S

Publication Date: 2012-07

Variant appearance in text: p53: L22Q

PubMed Link: 23264849

Variant Present in the following documents:

• Main text

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Ubiquitylation of p53 by the APC/C inhibitor Trim39.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Zhang, Liguo L; Huang, Nai-Jia NJ; Chen, Chen C; Tang, Wanli W; Kornbluth, Sally S

Publication Date: 2012-12-18

Variant appearance in text: p53: L22Q

PubMed Link: 23213260

Variant Present in the following documents:

• Main text

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Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53·MDM2/MDMX interaction.

The Journal Of Biological Chemistry

Shan, Bing B; Li, Da-Wei DW; Brüschweiler-Li, Lei L; Brüschweiler, Rafael R

Publication Date: 2012-08-31

Variant appearance in text: p53: L22Q

PubMed Link: 22807444

Variant Present in the following documents:

• Main text

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Mutant p53: one name, many proteins.

Genes & Development

Freed-Pastor, William A WA; Prives, Carol C

Publication Date: 2012-06-15

Variant appearance in text: p53: L22Q

PubMed Link: 22713868

Variant Present in the following documents:

• Main text

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The different ways through which specificity works in orthosteric and allosteric drugs.

Current Pharmaceutical Design

Nussinov, Ruth R; Tsai, Chung-Jung CJ

Publication Date: 2012

Variant appearance in text: p53: L22Q

PubMed Link: 22316155

Variant Present in the following documents:

• Main text

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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

Cell

Freed-Pastor, William A WA; Mizuno, Hideaki H; Zhao, Xi X; Langerød, Anita A; Moon, Sung-Hwan SH; Rodriguez-Barrueco, Ruth R; Barsotti, Anthony A; Chicas, Agustin A; Li, Wencheng W; Polotskaia, Alla A; Bissell, Mina J MJ; Osborne, Timothy F TF; Tian, Bin B; Lowe, Scott W SW; Silva, Jose M JM; Børresen-Dale, Anne-Lise AL; Levine, Arnold J AJ; Bargonetti, Jill J; Prives, Carol C

Publication Date: 2012-01-20

Variant appearance in text: p53: L22Q

PubMed Link: 22265415

Variant Present in the following documents:

• Main text

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Gene-specific transcription activation via long-range allosteric shape-shifting.

The Biochemical Journal

Tsai, Chung-Jung CJ; Nussinov, Ruth R

Publication Date: 2011-10-01

Variant appearance in text: p53: L22Q

PubMed Link: 21916844

Variant Present in the following documents:

• Main text

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ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.

Plos One

Sirbu, Bianca M BM; Lachmayer, Sarah J SJ; Wülfing, Verena V; Marten, Lara M LM; Clarkson, Katie E KE; Lee, Linda W LW; Gheorghiu, Liliana L; Zou, Lee L; Powell, Simon N SN; Dahm-Daphi, Jochen J; Willers, Henning H

Publication Date: 2011

Variant appearance in text: p53: L22Q

PubMed Link: 21857991

Variant Present in the following documents:

• Main text
• pone.0023053.pdf

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Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance.

Archives Of Biochemistry And Biophysics

Sankala, Heidi H; Vaughan, Catherine C; Wang, Jing J; Deb, Sumitra S; Graves, Paul R PR

Publication Date: 2011-08-01

Variant appearance in text: p53: L22Q

PubMed Link: 21621504

Variant Present in the following documents:

• Main text

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Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer.

Journal Of Molecular Biology

Natan, Eviatar E; Baloglu, Cetin C; Pagel, Kevin K; Freund, Stefan M V SM; Morgner, Nina N; Robinson, Carol V CV; Fersht, Alan R AR; Joerger, Andreas C AC

Publication Date: 2011-06-10

Variant appearance in text: p53: L22Q

PubMed Link: 21457718

Variant Present in the following documents:

• Main text

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p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb.

Cancer Research

Zeng, Yaxue Y; Kotake, Yojiro Y; Pei, Xin-Hai XH; Smith, Matthew D MD; Xiong, Yue Y

Publication Date: 2011-04-01

Variant appearance in text: p53: L22Q

PubMed Link: 21447739

Variant Present in the following documents:

• Main text

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p53-dependent repression of polo-like kinase-1 (PLK1).

Cell Cycle (Georgetown, Tex.)

McKenzie, Lynsey L; King, Sharon S; Marcar, Lynnette L; Nicol, Sam S; Dias, Sylvia S SS; Schumm, Katie K; Robertson, Pamela P; Bourdon, Jean-Christophe JC; Perkins, Neil N; Fuller-Pace, Frances F; Meek, David W DW

Publication Date: 2010-10-15

Variant appearance in text: p53: L22Q

PubMed Link: 20962589

Variant Present in the following documents:

• Main text

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Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein.

Biochemistry

Lee, Chul Won CW; Martinez-Yamout, Maria A MA; Dyson, H Jane HJ; Wright, Peter E PE

Publication Date: 2010-11-23

Variant appearance in text: p53: L22Q

PubMed Link: 20961098

Variant Present in the following documents:

• Main text

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