Publications:

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Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer.

Nature Communications

Cotto, Kelsy C KC; Feng, Yang-Yang YY; Ramu, Avinash A; Richters, Megan M; Freshour, Sharon L SL; Skidmore, Zachary L ZL; Xia, Huiming H; McMichael, Joshua F JF; Kunisaki, Jason J; Campbell, Katie M KM; Chen, Timothy Hung-Po TH; Rozycki, Emily B EB; Adkins, Douglas D; Devarakonda, Siddhartha S; Sankararaman, Sumithra S; Lin, Yiing Y; Chapman, William C WC; Maher, Christopher A CA; Arora, Vivek V; Dunn, Gavin P GP; Uppaluri, Ravindra R; Govindan, Ramaswamy R; Griffith, Obi L OL; Griffith, Malachi M

Publication Date: 2023-03-22

Variant appearance in text: TP53: f19a

PubMed Link: 36949070

Variant Present in the following documents:

• 41467_2023_37266_MOESM8_ESM.xlsx, sheet 1

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Computational Investigation on the p53-MDM2 Interaction Using the Potential of Mean Force Study.

Acs Omega

Das, Pundarikaksha P; Mattaparthi, Venkata Satish Kumar VSK

Publication Date: 2020-04-21

Variant appearance in text: p53: F19A

PubMed Link: 32337406

Variant Present in the following documents:

• Main text
• ao9b03372.pdf

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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology

Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M

Publication Date: 2020-01-07

Variant appearance in text: TP53: f19a

PubMed Link: 31925297

Variant Present in the following documents:

• 42003_2019_736_MOESM3_ESM.xlsx, sheet 1

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Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting.

Journal Of Molecular Cell Biology

Tan, Yaw Sing YS; Mhoumadi, Yasmina Y; Verma, Chandra S CS

Publication Date: 2019-04-01

Variant appearance in text: p53: F19A

PubMed Link: 30726928

Variant Present in the following documents:

• Main text
• mjz009.pdf

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Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma.

The Journal Of Experimental Medicine

Stolte, Björn B; Iniguez, Amanda Balboni AB; Dharia, Neekesh V NV; Robichaud, Amanda L AL; Conway, Amy Saur AS; Morgan, Ann M AM; Alexe, Gabriela G; Schauer, Nathan J NJ; Liu, Xiaoxi X; Bird, Gregory H GH; Tsherniak, Aviad A; Vazquez, Francisca F; Buhrlage, Sara J SJ; Walensky, Loren D LD; Stegmaier, Kimberly K

Publication Date: 2018-08-06

Variant appearance in text: TP53: F19A

PubMed Link: 30045945

Variant Present in the following documents:

• Main text
• JEM_20171066.pdf

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A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53.

Bmc Biology

Wong, Jin Huei JH; Alfatah, Mohammad M; Sin, Mei Fang MF; Sim, Hong May HM; Verma, Chandra S CS; Lane, David P DP; Arumugam, Prakash P

Publication Date: 2017-11-09

Variant appearance in text: p53: F19A

PubMed Link: 29121928

Variant Present in the following documents:

• Main text

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Residue-Specific Interactions of an Intrinsically Disordered Protein with Silica Nanoparticles and their Quantitative Prediction.

The Journal Of Physical Chemistry. C, Nanomaterials And Interfaces

Xie, Mouzhe M; Hansen, Alexandar L AL; Yuan, Jiaqi J; Brüschweiler, Rafael R

Publication Date: 2016-10-27

Variant appearance in text: p53: F19A

PubMed Link: 28337243

Variant Present in the following documents:

• Main text

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Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting.

Oncogene

Wachter, F F; Morgan, A M AM; Godes, M M; Mourtada, R R; Bird, G H GH; Walensky, L D LD

Publication Date: 2017-04

Variant appearance in text: p53: F19A

PubMed Link: 27721413

Variant Present in the following documents:

• Main text
• nihms809995.pdf

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Efficient Atomistic Simulation of Pathways and Calculation of Rate Constants for a Protein-Peptide Binding Process: Application to the MDM2 Protein and an Intrinsically Disordered p53 Peptide.

The Journal Of Physical Chemistry Letters

Zwier, Matthew C MC; Pratt, Adam J AJ; Adelman, Joshua L JL; Kaus, Joseph W JW; Zuckerman, Daniel M DM; Chong, Lillian T LT

Publication Date: 2016-09-01

Variant appearance in text: p53: F19A

PubMed Link: 27532687

Variant Present in the following documents:

• Main text

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Wide-line NMR and DSC studies on intrinsically disordered p53 transactivation domain and its helically pre-structured segment.

Bmb Reports

Tompa, Peter P; Han, Kyou-Hoon KH; Bokor, Mónika M; Kamasa, Pawel P; Tantos, Ágnes Á; Fritz, Beáta B; Kim, Do-Hyoung DH; Lee, Chewook C; Verebélyi, Tamás T; Tompa, Kálmán K

Publication Date: 2016-09

Variant appearance in text: p53: F19A

PubMed Link: 27418282

Variant Present in the following documents:

• Main text
• BMB-49-497.pdf

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The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans.

Genes & Development

Coffill, Cynthia R CR; Lee, Alison P AP; Siau, Jia Wei JW; Chee, Sharon M SM; Joseph, Thomas L TL; Tan, Yaw Sing YS; Madhumalar, Arumugam A; Tay, Boon-Hui BH; Brenner, Sydney S; Verma, Chandra S CS; Ghadessy, Farid J FJ; Venkatesh, Byrappa B; Lane, David P DP

Publication Date: 2016-02-01

Variant appearance in text: p53: F19A

PubMed Link: 26798135

Variant Present in the following documents:

• supp_gad.274118.115_SuppMaterial.pdf

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Phosphorylation Regulates the Bound Structure of an Intrinsically Disordered Protein: The p53-TAZ2 Case.

Plos One

Ithuralde, Raúl Esteban RE; Turjanski, Adrián Gustavo AG

Publication Date: 2016

Variant appearance in text: p53: Phe19Ala

PubMed Link: 26742101

Variant Present in the following documents:

• Main text

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A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time.

Cell Reports

Li, Yao-Cheng YC; Rodewald, Luo Wei LW; Hoppmann, Christian C; Wong, Ee Tsin ET; Lebreton, Sylvain S; Safar, Pavel P; Patek, Marcel M; Wang, Lei L; Wertman, Kenneth F KF; Wahl, Geoffrey M GM

Publication Date: 2014-12-11

Variant appearance in text: p53: F19A

PubMed Link: 25464845

Variant Present in the following documents:

• Main text

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MDM4 is a key therapeutic target in cutaneous melanoma.

Nature Medicine

Gembarska, Agnieszka A; Luciani, Flavie F; Fedele, Clare C; Russell, Elisabeth A EA; Dewaele, Michael M; Villar, Stéphanie S; Zwolinska, Aleksandra A; Haupt, Sue S; de Lange, Job J; Yip, Dana D; Goydos, James J; Haigh, Jody J JJ; Haupt, Ygal Y; Larue, Lionel L; Jochemsen, Aart A; Shi, Hubing H; Moriceau, Gatien G; Lo, Roger S RS; Ghanem, Ghanem G; Shackleton, Mark M; Bernal, Federico F; Marine, Jean-Christophe JC

Publication Date: 2012-08

Variant appearance in text: p53: F19A

PubMed Link: 22820643

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• Main text

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Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53·MDM2/MDMX interaction.

The Journal Of Biological Chemistry

Shan, Bing B; Li, Da-Wei DW; Brüschweiler-Li, Lei L; Brüschweiler, Rafael R

Publication Date: 2012-08-31

Variant appearance in text: p53: F19A

PubMed Link: 22807444

Variant Present in the following documents:

• Main text

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Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.

Plos One

Bernard, Xavier X; Robinson, Philip P; Nominé, Yves Y; Masson, Murielle M; Charbonnier, Sebastian S; Ramirez-Ramos, Juan Ramon JR; Deryckere, Francois F; Travé, Gilles G; Orfanoudakis, Georges G

Publication Date: 2011

Variant appearance in text: p53: F19A

PubMed Link: 22046250

Variant Present in the following documents:

• Main text
• pone.0025981.pdf

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A stapled p53 helix overcomes HDMX-mediated suppression of p53.

Cancer Cell

Bernal, Federico F; Wade, Mark M; Godes, Marina M; Davis, Tina N TN; Whitehead, David G DG; Kung, Andrew L AL; Wahl, Geoffrey M GM; Walensky, Loren D LD

Publication Date: 2010-11-16

Variant appearance in text: p53: F19A

PubMed Link: 21075307

Variant Present in the following documents:

• Main text

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p53-based cancer therapy.

Cold Spring Harbor Perspectives In Biology

Lane, David P DP; Cheok, Chit Fang CF; Lain, Sonia S

Publication Date: 2010-09

Variant appearance in text: p53: F19A

PubMed Link: 20463003

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• Main text

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Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.

Journal Of Molecular Biology

Li, Chong C; Pazgier, Marzena M; Li, Changqing C; Yuan, Weirong W; Liu, Min M; Wei, Gang G; Lu, Wei-Yue WY; Lu, Wuyuan W

Publication Date: 2010-04-30

Variant appearance in text: p53: F19A

PubMed Link: 20226197

Variant Present in the following documents:

• Main text

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Gly-Ala repeats induce position- and substrate-specific regulation of 26 S proteasome-dependent partial processing.

The Journal Of Biological Chemistry

Daskalogianni, Chrysoula C; Apcher, Sébastien S; Candeias, Marco M MM; Naski, Nadia N; Calvo, Fabien F; Fåhraeus, Robin R

Publication Date: 2008-10-31

Variant appearance in text: p53: F19A

PubMed Link: 18757367

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• Main text

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Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.

Journal Of The American Chemical Society

Bernal, Federico F; Tyler, Andrew F AF; Korsmeyer, Stanley J SJ; Walensky, Loren D LD; Verdine, Gregory L GL

Publication Date: 2007-03-07

Variant appearance in text: p53: F19A

PubMed Link: 17284038

Variant Present in the following documents:

• Main text

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Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53.

Oncogene

Allende-Vega, N N; Saville, M K MK; Meek, D W DW

Publication Date: 2007-06-21

Variant appearance in text: p53: F19A

PubMed Link: 17237821

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• Main text

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Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.

The Biochemical Journal

Shimizu, Harumi H; Saliba, David D; Wallace, Maura M; Finlan, Lee L; Langridge-Smith, Patrick R R PR; Hupp, Ted R TR

Publication Date: 2006-07-15

Variant appearance in text: p53: F19A

PubMed Link: 16579792

Variant Present in the following documents:

• Main text

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