TP53 c.52A>G ;(p.T18A)

Variant ID: 17-7579861-T-C

NM_000546.5(TP53):c.52A>G;(p.T18A)

This variant was identified in 26 publications

View GRCh38 version.




Publications:


Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types.

Scientific Reports
Sasaki, Keiju K; Takahashi, Shin S; Ouchi, Kota K; Otsuki, Yasufumi Y; Wakayama, Shonosuke S; Ishioka, Chikashi C
Publication Date: 2023-03-24

Variant appearance in text: p53: T18A
PubMed Link: 36964217
Variant Present in the following documents:
  • 41598_2023_32092_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Whole-transcriptome-based skin virome profiling in typical epidermodysplasia verruciformis reveals α-, β- and γ-HPV infections.

Jci Insight
Saeidian, Amir Hossein AH; Youssefian, Leila L; Naji, Mahtab M; Mahmoudi, Hamidreza H; Barnada, Samantha M SM; Huang, Charles Y CY; Naghipoor, Karim K; Hozhabrpour, Amir A; Park, Jason S JS; Manzo Margiotta, Flavia F; Vahidnezhad, Fatemeh F; Saffarian, Zahra Z; Kamyab-Hesari, Kambiz K; Tolouei, Mohammad M; Faraji, Niloofar N; Azimi, Seyyede Zeinab SZ; Namdari, Ghazal G; Mansouri, Parvin P; Casanova, Jean-Laurent JL; Béziat, Vivien V; Jouanguy, Emmanuelle E; Uitto, Jouni J; Vahidnezhad, Hassan H
Publication Date: 2023-01-05

Variant appearance in text: p53: 52A>G
PubMed Link: 36602881
Variant Present in the following documents:
  • jciinsight-8-162558.pdf
View BVdb publication page



A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma.

Scientific Reports
Warrick, Joshua I JI; Knowles, Margaret A MA; Hurst, Carolyn D CD; Shuman, Lauren L; Raman, Jay D JD; Walter, Vonn V; Putt, Jeffrey J; Dyrskjøt, Lars L; Groeneveld, Clarice C; Castro, Mauro A A MAA; Robertson, A Gordon AG; DeGraff, David J DJ
Publication Date: 2022-10-03

Variant appearance in text: TP53: 52A>G; T18A
PubMed Link: 36192513
Variant Present in the following documents:
  • 41598_2022_20927_MOESM14_ESM.xlsx, sheet 1
View BVdb publication page



CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: 52A>G
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.

Aging
Su, Xiaofan X; Jin, Haoxuan H; Wang, Jiaqian J; Lu, Huiping H; Gu, Tiantian T; Gao, Zhibo Z; Li, Manxiang M
Publication Date: 2022-05-25

Variant appearance in text: TP53: 52A>G; T18A
PubMed Link: 35613927
Variant Present in the following documents:
  • aging-14-204101-s004.xlsx, sheet 1
View BVdb publication page



Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.

Clinical And Translational Gastroenterology
Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD
Publication Date: 2021-11-18

Variant appearance in text: TP53: 52A>G; T18A
PubMed Link: 34797250
Variant Present in the following documents:
  • ct9-12-e00431-s006.xlsx, sheet 1
  • ct9-12-e00431-s005.xlsx, sheet 1
View BVdb publication page



Defining relative mutational difficulty to understand cancer formation.

Cell Discovery
Shan, Lin L; Yu, Jiao J; He, Zhengjin Z; Chen, Shishuang S; Liu, Mingxian M; Ding, Hongyu H; Xu, Liang L; Zhao, Jie J; Yang, Ailing A; Jiang, Hai H
Publication Date: 2020

Variant appearance in text: p53: T18A
PubMed Link: 32704382
Variant Present in the following documents:
  • 41421_2020_177_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation.

The Journal Of Biological Chemistry
Österlund, Nicklas N; Lundqvist, Martin M; Ilag, Leopold L LL; Gräslund, Astrid A; Emanuelsson, Cecilia C
Publication Date: 2020-06-12

Variant appearance in text: p53: T18A
PubMed Link: 32350108
Variant Present in the following documents:
  • zbc8135.pdf
View BVdb publication page



The role of myoglobin in epithelial cancers: Insights from transcriptomics.

International Journal Of Molecular Medicine
Bicker, Anne A; Nauth, Theresa T; Gerst, Daniela D; Aboouf, Mostafa Ahmed MA; Fandrey, Joachim J; Kristiansen, Glen G; Gorr, Thomas Alexander TA; Hankeln, Thomas T
Publication Date: 2020-02

Variant appearance in text: TP53: Thr18Ala
PubMed Link: 31894249
Variant Present in the following documents:
  • Supplementary_Data2.xlsx, sheet 10
  • Supplementary_Data2.xlsx, sheet 4
  • Supplementary_Data2.xlsx, sheet 2
  • Supplementary_Data2.xlsx, sheet 3
View BVdb publication page



appreci8: a pipeline for precise variant calling integrating 8 tools.

Bioinformatics (Oxford, England)
Sandmann, Sarah S; Karimi, Mohsen M; de Graaf, Aniek O AO; Rohde, Christian C; Göllner, Stefanie S; Varghese, Julian J; Ernsting, Jan J; Walldin, Gunilla G; van der Reijden, Bert A BA; Müller-Tidow, Carsten C; Malcovati, Luca L; Hellström-Lindberg, Eva E; Jansen, Joop H JH; Dugas, Martin M
Publication Date: 2018-12-15

Variant appearance in text: TP53: 52A>G; Thr18Ala
PubMed Link: 29945233
Variant Present in the following documents:
  • bty518_supplementary_data_s6.xlsx, sheet 8
View BVdb publication page



Emerging proteomics biomarkers and prostate cancer burden in Africa.

Oncotarget
Adeola, Henry A HA; Blackburn, Jonathan M JM; Rebbeck, Timothy R TR; Zerbini, Luiz F LF
Publication Date: 2017-06-06

Variant appearance in text: p53: T18A
PubMed Link: 28388542
Variant Present in the following documents:
  • Main text
  • oncotarget-08-37991.pdf
View BVdb publication page



iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: TP53: T18A
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s5.xls, sheet 1
View BVdb publication page



Novel method for the high-throughput production of phosphorylation site-specific monoclonal antibodies.

Scientific Reports
Kurosawa, Nobuyuki N; Wakata, Yuka Y; Inobe, Tomonao T; Kitamura, Haruki H; Yoshioka, Megumi M; Matsuzawa, Shun S; Kishi, Yoshihiro Y; Isobe, Masaharu M
Publication Date: 2016-04-29

Variant appearance in text: p53: T18A
PubMed Link: 27125496
Variant Present in the following documents:
  • Main text
  • srep25174.pdf
View BVdb publication page



Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer.

Oncotarget
Bhattacharya, Bhaskar B; Low, Sarah Hong Hui SH; Chong, Mei Ling ML; Chia, Dilys D; Koh, King Xin KX; Sapari, Nur Sabrina NS; Kaye, Stanley S; Hung, Huynh H; Benoukraf, Touati T; Soong, Richie R
Publication Date: 2016-05-17

Variant appearance in text: TP53: T18A
PubMed Link: 27081080
Variant Present in the following documents:
  • Main text
View BVdb publication page



Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort.

Oncotarget
Adeola, Henry A HA; Smith, Muneerah M; Kaestner, Lisa L; Blackburn, Jonathan M JM; Zerbini, Luiz F LF
Publication Date: 2016-03-22

Variant appearance in text: p53: T18A
PubMed Link: 26885621
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phosphorylation Regulates the Bound Structure of an Intrinsically Disordered Protein: The p53-TAZ2 Case.

Plos One
Ithuralde, Raúl Esteban RE; Turjanski, Adrián Gustavo AG
Publication Date: 2016

Variant appearance in text: p53: Thr18Ala
PubMed Link: 26742101
Variant Present in the following documents:
  • Main text
  • pone.0144284.pdf
View BVdb publication page



Protein domain-level landscape of cancer-type-specific somatic mutations.

Plos Computational Biology
Yang, Fan F; Petsalaki, Evangelia E; Rolland, Thomas T; Hill, David E DE; Vidal, Marc M; Roth, Frederick P FP
Publication Date: 2015-03

Variant appearance in text: TP53: T18A
PubMed Link: 25794154
Variant Present in the following documents:
  • pcbi.1004147.s001.xlsx, sheet 1
View BVdb publication page



A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.

Cell Cycle (Georgetown, Tex.)
ElSawy, Karim M KM; Sim, Adelene A; Lane, David P DP; Verma, Chandra S CS; Caves, Leo Sd LS
Publication Date: 2015

Variant appearance in text: p53: Thr18Ala
PubMed Link: 25584963
Variant Present in the following documents:
  • Main text
View BVdb publication page



Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Drosten, Matthias M; Sum, Eleanor Y M EY; Lechuga, Carmen G CG; Simón-Carrasco, Lucía L; Jacob, Harrys K C HK; García-Medina, Raquel R; Huang, Sidong S; Beijersbergen, Roderick L RL; Bernards, Rene R; Barbacid, Mariano M
Publication Date: 2014-10-21

Variant appearance in text: p53: T18A
PubMed Link: 25288756
Variant Present in the following documents:
  • Main text
View BVdb publication page



Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.

Nature
Morin, Ryan D RD; Mendez-Lago, Maria M; Mungall, Andrew J AJ; Goya, Rodrigo R; Mungall, Karen L KL; Corbett, Richard D RD; Johnson, Nathalie A NA; Severson, Tesa M TM; Chiu, Readman R; Field, Matthew M; Jackman, Shaun S; Krzywinski, Martin M; Scott, David W DW; Trinh, Diane L DL; Tamura-Wells, Jessica J; Li, Sa S; Firme, Marlo R MR; Rogic, Sanja S; Griffith, Malachi M; Chan, Susanna S; Yakovenko, Oleksandr O; Meyer, Irmtraud M IM; Zhao, Eric Y EY; Smailus, Duane D; Moksa, Michelle M; Chittaranjan, Suganthi S; Rimsza, Lisa L; Brooks-Wilson, Angela A; Spinelli, John J JJ; Ben-Neriah, Susana S; Meissner, Barbara B; Woolcock, Bruce B; Boyle, Merrill M; McDonald, Helen H; Tam, Angela A; Zhao, Yongjun Y; Delaney, Allen A; Zeng, Thomas T; Tse, Kane K; Butterfield, Yaron Y; Birol, Inanç I; Holt, Rob R; Schein, Jacqueline J; Horsman, Douglas E DE; Moore, Richard R; Jones, Steven J M SJ; Connors, Joseph M JM; Hirst, Martin M; Gascoyne, Randy D RD; Marra, Marco A MA
Publication Date: 2011-07-27

Variant appearance in text: TP53: T18A
PubMed Link: 21796119
Variant Present in the following documents:
  • NIHMS313098-supplement-6.xls, sheet 1
View BVdb publication page



High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex.

Chembiochem : A European Journal Of Chemical Biology
Henchey, Laura K LK; Porter, Jason R JR; Ghosh, Indraneel I; Arora, Paramjit S PS
Publication Date: 2010-10-18

Variant appearance in text: p53: T18A
PubMed Link: 20821791
Variant Present in the following documents:
  • Main text
View BVdb publication page



Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.

Journal Of Molecular Biology
Li, Chong C; Pazgier, Marzena M; Li, Changqing C; Yuan, Weirong W; Liu, Min M; Wei, Gang G; Lu, Wei-Yue WY; Lu, Wuyuan W
Publication Date: 2010-04-30

Variant appearance in text: p53: T18A
PubMed Link: 20226197
Variant Present in the following documents:
  • Main text
View BVdb publication page



Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2.

Oncogene
Teufel, D P DP; Bycroft, M M; Fersht, A R AR
Publication Date: 2009-05-21

Variant appearance in text: p53: T18A
PubMed Link: 19363523
Variant Present in the following documents:
  • Main text
View BVdb publication page



TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.

Molecular And Cellular Biology
Huang, Yi-Fu YF; Chang, Margaret Dah-Tsyr MD; Shieh, Sheau-Yann SY
Publication Date: 2009-06

Variant appearance in text: p53: T18A
PubMed Link: 19332559
Variant Present in the following documents:
  • Main text
View BVdb publication page



The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.

Plos One
Valbuena, Alberto A; Blanco, Sandra S; Vega, Francisco M FM; Lazo, Pedro A PA
Publication Date: 2008-07-09

Variant appearance in text: p53: T18A
PubMed Link: 18612383
Variant Present in the following documents:
  • Main text
  • pone.0002649.pdf
View BVdb publication page



p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.

Molecular And Cellular Biology
Vega, Francisco M FM; Sevilla, Ana A; Lazo, Pedro A PA
Publication Date: 2004-12

Variant appearance in text: p53: Thr18Ala
PubMed Link: 15542844
Variant Present in the following documents:
  • Main text
View BVdb publication page