Publications:

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Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types.

Scientific Reports

Sasaki, Keiju K; Takahashi, Shin S; Ouchi, Kota K; Otsuki, Yasufumi Y; Wakayama, Shonosuke S; Ishioka, Chikashi C

Publication Date: 2023-03-24

Variant appearance in text: p53: Q16L

PubMed Link: 36964217

Variant Present in the following documents:

• 41598_2023_32092_MOESM1_ESM.xlsx, sheet 1

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Heterogeneity of the cancer cell line metabolic landscape.

Molecular Systems Biology

Shorthouse, David D; Bradley, Jenna J; Critchlow, Susan E SE; Bendtsen, Claus C; Hall, Benjamin A BA

Publication Date: 2022-11

Variant appearance in text: TP53: 47A>T; Gln16Leu

PubMed Link: 36321551

Variant Present in the following documents:

• MSB-18-e11006-s010.xlsx, sheet 1

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The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME

Publication Date: 2022-10-12

Variant appearance in text: TP53: Q16L

PubMed Link: 36222846

Variant Present in the following documents:

• ccr-22-1914_supplementary_data_2_suppds2.xlsx, sheet 1
• ccr-22-1914_supplementary_data_3_suppds3.xlsx, sheet 1

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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience

Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X

Publication Date: 2022-09-16

Variant appearance in text: p53: 47A>T

PubMed Link: 36117989

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

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Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.

Nature Communications

Bartolacci, Caterina C; Andreani, Cristina C; Vale, Gonçalo G; Berto, Stefano S; Melegari, Margherita M; Crouch, Anna Colleen AC; Baluya, Dodge L DL; Kemble, George G; Hodges, Kurt K; Starrett, Jacqueline J; Politi, Katerina K; Starnes, Sandra L SL; Lorenzini, Daniele D; Raso, Maria Gabriela MG; Solis Soto, Luisa M LM; Behrens, Carmen C; Kadara, Humam H; Gao, Boning B; Wistuba, Ignacio I II; Minna, John D JD; McDonald, Jeffrey G JG; Scaglioni, Pier Paolo PP

Publication Date: 2022-07-26

Variant appearance in text: TP53: 47A>T; Q16L

PubMed Link: 35882862

Variant Present in the following documents:

• 41467_2022_31963_MOESM13_ESM.xlsx, sheet 1

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Establishment and characterization of a novel highly malignant lung cancer cell line ZX2021H derived from a metastatic lymph node lesion.

Thoracic Cancer

Zu, Lingling L; Li, Xuebing X; He, Jinling J; Zhou, Ning N; Meng, Fanrong F; Li, Xiaozhou X; Xu, Song S; Zhang, Lei L

Publication Date: 2022-04

Variant appearance in text: TP53: Q16L

PubMed Link: 35297208

Variant Present in the following documents:

• Main text
• TCA-13-1199.pdf

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A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases.

Scientific Reports

Magraner-Pardo, Lorena L; Laskowski, Roman A RA; Pons, Tirso T; Thornton, Janet M JM

Publication Date: 2021-07-12

Variant appearance in text: TP53: 47A>T; Q16L

PubMed Link: 34253785

Variant Present in the following documents:

• 41598_2021_93715_MOESM2_ESM.xlsx, sheet 9

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Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients.

Breast Cancer Research And Treatment

Nteliopoulos, Georgios G; Page, Karen K; Hills, Allison A; Howarth, Karen K; Emmett, Warren W; Green, Emma E; Martinson, Luke J LJ; Fernadez-Garcia, Daniel D; Hastings, Robert R; Guttery, David S DS; Kenny, Laura L; Stebbing, Justin J; Cleator, Susan S; Rehman, Farah F; Gleason, Kelly L T KLT; Sanela, Andrijac A; Ion, Charlotte C; Rushton, Amelia J AJ; Rosenfeld, Nitzan N; Coombes, R Charles RC; Shaw, Jacqueline A JA

Publication Date: 2021-07

Variant appearance in text: TP53: Q16L

PubMed Link: 34097174

Variant Present in the following documents:

• 10549_2021_6220_MOESM2_ESM.xlsx, sheet 1
• 10549_2021_6220_MOESM2_ESM.xlsx, sheet 2

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Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers.

Marine Drugs

El-Chaar, Nader N NN; Smith, Thomas E TE; Shrestha, Gajendra G; Piccolo, Stephen R SR; Harper, Mary Kay MK; Van Wagoner, Ryan M RM; Lu, Zhenyu Z; Venancio, Ashlee R AR; Ireland, Chris M CM; Bild, Andrea H AH; Moos, Philip J PJ

Publication Date: 2021-01-18

Variant appearance in text: p53: Q16L

PubMed Link: 33477536

Variant Present in the following documents:

• marinedrugs-19-00041-s001.pdf

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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery

Shan, Lin L; Yu, Jiao J; He, Zhengjin Z; Chen, Shishuang S; Liu, Mingxian M; Ding, Hongyu H; Xu, Liang L; Zhao, Jie J; Yang, Ailing A; Jiang, Hai H

Publication Date: 2020

Variant appearance in text: p53: Q16L

PubMed Link: 32704382

Variant Present in the following documents:

• 41421_2020_177_MOESM4_ESM.xlsx, sheet 1

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NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Oncogene

Luiken, Sarah S; Fraas, Angelika A; Bieg, Matthias M; Sugiyanto, Raisatun R; Goeppert, Benjamin B; Singer, Stephan S; Ploeger, Carolin C; Warsow, Gregor G; Marquardt, Jens U JU; Sticht, Carsten C; De La Torre, Carolina C; Pusch, Stefan S; Mehrabi, Arianeb A; Gretz, Norbert N; Schlesner, Matthias M; Eils, Roland R; Schirmacher, Peter P; Longerich, Thomas T; Roessler, Stephanie S

Publication Date: 2020-04

Variant appearance in text: TP53: 47A>T; Q16L

PubMed Link: 32055024

Variant Present in the following documents:

• 41388_2020_1198_MOESM2_ESM.xlsx, sheet 1

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: TP53: Q16L

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Advantage of Next-Generation Sequencing in Dynamic Monitoring of Circulating Tumor DNA over Droplet Digital PCR in Cetuximab Treated Colorectal Cancer Patients.

Translational Oncology

Zhang, Hangyu H; Liu, Rujiao R; Yan, Cong C; Liu, Lulu L; Tong, Zhou Z; Jiang, Weiqin W; Yao, Ming M; Fang, Weijia W; Chen, Zhiyu Z

Publication Date: 2019-03

Variant appearance in text: TP53: Q16L

PubMed Link: 30562681

Variant Present in the following documents:

• Main text
• main.pdf

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Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients.

Neoplasia (New York, N.Y.)

Xiao, Zhiguang Z; Gaertner, Silvia S; Morresi-Hauf, Alicia A; Genzel, Rebecca R; Duell, Thomas T; Ullrich, Axel A; Knyazev, Pjotr G PG

Publication Date: 2017-05

Variant appearance in text: p53: Q16L

PubMed Link: 28391030

Variant Present in the following documents:

• Main text

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: Q16L

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: TP53: 47A>T; Q16L

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 3
• mmc3.xlsx, sheet 2

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REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer.

Scientific Reports

Zhao, Min M; Rotgans, Bronwyn B; Wang, Tianfang T; Cummins, S F SF

Publication Date: 2016-03-15

Variant appearance in text: TP53: Q16L

PubMed Link: 26975833

Variant Present in the following documents:

• srep23167-s9.xls, sheet 1

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: TP53: Q16L

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.

Elife

Jeay, Sébastien S; Gaulis, Swann S; Ferretti, Stéphane S; Bitter, Hans H; Ito, Moriko M; Valat, Thérèse T; Murakami, Masato M; Ruetz, Stephan S; Guthy, Daniel A DA; Rynn, Caroline C; Jensen, Michael R MR; Wiesmann, Marion M; Kallen, Joerg J; Furet, Pascal P; Gessier, François F; Holzer, Philipp P; Masuya, Keiichi K; Würthner, Jens J; Halilovic, Ensar E; Hofmann, Francesco F; Sellers, William R WR; Graus Porta, Diana D

Publication Date: 2015-05-12

Variant appearance in text: p53: Q16L

PubMed Link: 25965177

Variant Present in the following documents:

• Main text
• elife-06498.pdf

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Protein domain-level landscape of cancer-type-specific somatic mutations.

Plos Computational Biology

Yang, Fan F; Petsalaki, Evangelia E; Rolland, Thomas T; Hill, David E DE; Vidal, Marc M; Roth, Frederick P FP

Publication Date: 2015-03

Variant appearance in text: TP53: Q16L

PubMed Link: 25794154

Variant Present in the following documents:

• pcbi.1004147.s001.xlsx, sheet 1

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: Q16L

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Proteomic signatures associated with p53 mutational status in lung adenocarcinoma.

Proteomics

Taguchi, Ayumu A; Delgado, Oliver O; Celiktaş, Müge M; Katayama, Hiroyuki H; Wang, Hong H; Gazdar, Adi F AF; Hanash, Samir M SM

Publication Date: 2014-12

Variant appearance in text: p53: Q16L

PubMed Link: 25331784

Variant Present in the following documents:

• Main text

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MBASED: allele-specific expression detection in cancer tissues and cell lines.

Genome Biology

Mayba, Oleg O; Gilbert, Houston N HN; Liu, Jinfeng J; Haverty, Peter M PM; Jhunjhunwala, Suchit S; Jiang, Zhaoshi Z; Watanabe, Colin C; Zhang, Zemin Z

Publication Date: 2014-08-07

Variant appearance in text: TP53: Q16L

PubMed Link: 25315065

Variant Present in the following documents:

• 13059_2014_405_MOESM3_ESM.xlsx, sheet 2

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Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours.

British Journal Of Cancer

Singh, R R RR; Patel, K P KP; Routbort, M J MJ; Aldape, K K; Lu, X X; Manekia, J J; Abraham, R R; Reddy, N G NG; Barkoh, B A BA; Veliyathu, J J; Medeiros, L J LJ; Luthra, R R

Publication Date: 2014-11-11

Variant appearance in text: TP53: Q16L

PubMed Link: 25314059

Variant Present in the following documents:

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Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs.

International Journal Of Molecular Sciences

Ji, Xiaona X; Huang, Qiang Q; Yu, Long L; Nussinov, Ruth R; Ma, Buyong B

Publication Date: 2014-07-29

Variant appearance in text: p53: Q16L

PubMed Link: 25075982

Variant Present in the following documents:

• Main text
• ijms-15-13275.pdf

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Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.

Oncogene

Zaganjor, E E; Osborne, J K JK; Weil, L M LM; Diaz-Martinez, L A LA; Gonzales, J X JX; Singel, S M SM; Larsen, J E JE; Girard, L L; Minna, J D JD; Cobb, M H MH

Publication Date: 2014-11-20

Variant appearance in text: TP53: 47A>T; Q16L

PubMed Link: 24240690

Variant Present in the following documents:

• NIHMS550264-supplement-2.xlsx, sheet 1

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miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.

Oncogene

Du, L L; Zhao, Z Z; Ma, X X; Hsiao, T-H TH; Chen, Y Y; Young, E E; Suraokar, M M; Wistuba, I I; Minna, J D JD; Pertsemlidis, A A

Publication Date: 2014-08-21

Variant appearance in text: TP53: Q16L

PubMed Link: 24037530

Variant Present in the following documents:

• NIHMS560248-supplement-3.xlsx, sheet 1

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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics

Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z

Publication Date: 2013

Variant appearance in text: TP53: Q16L

PubMed Link: 23819521

Variant Present in the following documents:

• 1471-2164-14-S3-S7-S1.xlsx, sheet 1

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A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy.

Plos One

Zhou, Jun J; Chen, Zhengming Z; Malysa, Agnes A; Li, Xin X; Oliveira, Paula P; Zhang, Yingtao Y; Bepler, Gerold G

Publication Date: 2013

Variant appearance in text: p53: Q16L

PubMed Link: 23483975

Variant Present in the following documents:

• Main text
• pone.0058091.pdf

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: TP53: Q16L

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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Modulation of the ribonucleotide reductase-antimetabolite drug interaction in cancer cell lines.

Journal Of Nucleic Acids

Zhou, Jun J; Oliveira, Paula P; Li, Xueli X; Chen, Zhengming Z; Bepler, Gerold G

Publication Date: 2010-09-28

Variant appearance in text: p53: Q16L

PubMed Link: 20976259

Variant Present in the following documents:

• JNA2010-597098.pdf

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Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Plos One

Chen, Zhenbin Z; Feng, Jinong J; Buzin, Carolyn H CH; Sommer, Steve S SS

Publication Date: 2008

Variant appearance in text: TP53: Q16L

PubMed Link: 19005564

Variant Present in the following documents:

• pone.0003714.s004.xls, sheet 1

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