Oncogene-like addiction to aneuploidy in human cancers.
Biorxiv : The Preprint Server For Biology
Girish, Vishruth V; Lakhani, Asad A AA; Scaduto, Christine M CM; Thompson, Sarah L SL; Brown, Leanne M LM; Hagenson, Ryan A RA; Sausville, Erin L EL; Mendelson, Brianna E BE; Lukow, Devon A DA; Yuan, Monet Lou ML; Kandikuppa, Pranav K PK; Stevens, Eric C EC; Lee, Sophia N SN; Salovska, Barbora B; Li, Wenxue W; Smith, Joan C JC; Taylor, Alison M AM; Martienssen, Robert A RA; Liu, Yansheng Y; Sun, Ruping R; Sheltzer, Jason M JM
BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification.
Molecular Cancer Research : Mcr
Barnett, Sarah E SE; Kenyani, Jenna J; Tripari, Martina M; Butt, Zohra Z; Grosman, Rudi R; Querques, Francesca F; Shaw, Liam L; Silva, Luisa C LC; Goate, Zoe Z; Marciniak, Stefan J SJ; Rassl, Doris M DM; Jackson, Richard R; Lian, Lu-Yun LY; Szlosarek, Peter W PW; Sacco, Joseph J JJ; Coulson, Judy M JM
Replication stress defines distinct molecular subtypes across cancers.
Cancer Research Communications
Takahashi, Nobuyuki N; Kim, Sehyun S; Schultz, Christopher W CW; Rajapakse, Vinodh N VN; Zhang, Yang Y; Redon, Christophe E CE; Fu, Haiqing H; Pongor, Lorinc L; Kumar, Suresh S; Pommier, Yves Y; Aladjem, Mirit I MI; Thomas, Anish A
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity.
Genome Medicine
Moosavi, Seyed H SH; Eide, Peter W PW; Eilertsen, Ina A IA; Brunsell, Tuva H TH; Berg, Kaja C G KCG; Røsok, Bård I BI; Brudvik, Kristoffer W KW; Bjørnbeth, Bjørn A BA; Guren, Marianne G MG; Nesbakken, Arild A; Lothe, Ragnhild A RA; Sveen, Anita A
Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Chua, Khi Pin KP; Teng, Yvonne H F YHF; Tan, Aaron C AC; Takano, Angela A; Alvarez, Jacob J S JJS; Nahar, Rahul R; Rohatgi, Neha N; Lai, Gillianne G Y GGY; Aung, Zaw Win ZW; Yeong, Joe P S JPS; Lim, Kiat Hon KH; Naeini, Marjan Mojtabavi MM; Kassam, Irfahan I; Jain, Amit A; Tan, Wan Ling WL; Gogna, Apoorva A; Too, Chow Wei CW; Kanesvaran, Ravindran R; Ng, Quan Sing QS; Ang, Mei Kim MK; Rajasekaran, Tanujaa T; Anantham, Devanand D; Phua, Ghee Chee GC; Tan, Bien Soo BS; Lee, Yin Yeng YY; Wang, Lanying L; Teo, Audrey S M ASM; Khng, Alexis Jiaying AJ; Lim, Ming Jie MJ; Suteja, Lisda L; Toh, Chee Keong CK; Lim, Wan-Teck WT; Iyer, N Gopalakrishna NG; Tam, Wai Leong WL; Tan, Eng-Huat EH; Zhai, Weiwei W; Hillmer, Axel M AM; Skanderup, Anders J AJ; Tan, Daniel S W DSW
Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma.
Molecular Systems Biology
O'Connor, Samantha A SA; Feldman, Heather M HM; Arora, Sonali S; Hoellerbauer, Pia P; Toledo, Chad M CM; Corrin, Philip P; Carter, Lucas L; Kufeld, Megan M; Bolouri, Hamid H; Basom, Ryan R; Delrow, Jeffrey J; McFaline-Figueroa, José L JL; Trapnell, Cole C; Pollard, Steven M SM; Patel, Anoop A; Paddison, Patrick J PJ; Plaisier, Christopher L CL
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Morozko, Eva L EL; Smith-Geater, Charlene C; Monteys, Alejandro Mas AM; Pradhan, Subrata S; Lim, Ryan G RG; Langfelder, Peter P; Kachemov, Marketta M; Kulkarni, Jayesh A JA; Zaifman, Josh J; Hill, Austin A; Stocksdale, Jennifer T JT; Cullis, Pieter R PR; Wu, Jie J; Ochaba, Joseph J; Miramontes, Ricardo R; Chakraborty, Anirban A; Hazra, Tapas K TK; Lau, Alice A; St-Cyr, Sophie S; Orellana, Iliana I; Kopan, Lexi L; Wang, Keona Q KQ; Yeung, Sylvia S; Leavitt, Blair R BR; Reidling, Jack C JC; Yang, X William XW; Steffan, Joan S JS; Davidson, Beverly L BL; Sarkar, Partha S PS; Thompson, Leslie M LM
Chemical Characterization of Nanoparticles and Volatiles Present in Mainstream Hookah Smoke.
Aerosol Science And Technology : The Journal Of The American Association For Aerosol Research
Perraud, Véronique V; Lawler, Michael J MJ; Malecha, Kurtis T KT; Johnson, Rebecca M RM; Herman, David D; Staimer, Norbert N; Kleinman, Michael T MT; Nizkorodov, Sergey A SA; Smith, James N JN
Functional genomics identifies new synergistic therapies for retinoblastoma.
Oncogene
Aubry, Arthur A; Pearson, Joel D JD; Huang, Katherine K; Livne-Bar, Izhar I; Ahmad, Mohammad M; Jagadeesan, Madhavan M; Khetan, Vikas V; Ketela, Troy T; Brown, Kevin R KR; Yu, Tao T; Lu, Suying S; Wrana, Jeffrey L JL; Moffat, Jason J; Bremner, Rod R
Enabling large-scale genome editing at repetitive elements by reducing DNA nicking.
Nucleic Acids Research
Smith, Cory J CJ; Castanon, Oscar O; Said, Khaled K; Volf, Verena V; Khoshakhlagh, Parastoo P; Hornick, Amanda A; Ferreira, Raphael R; Wu, Chun-Ting CT; Güell, Marc M; Garg, Shilpa S; Ng, Alex H M AHM; Myllykallio, Hannu H; Church, George M GM
NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.
Oncogene
Luiken, Sarah S; Fraas, Angelika A; Bieg, Matthias M; Sugiyanto, Raisatun R; Goeppert, Benjamin B; Singer, Stephan S; Ploeger, Carolin C; Warsow, Gregor G; Marquardt, Jens U JU; Sticht, Carsten C; De La Torre, Carolina C; Pusch, Stefan S; Mehrabi, Arianeb A; Gretz, Norbert N; Schlesner, Matthias M; Eils, Roland R; Schirmacher, Peter P; Longerich, Thomas T; Roessler, Stephanie S
Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data.
Genome Biology
Holland, Christian H CH; Tanevski, Jovan J; Perales-Patón, Javier J; Gleixner, Jan J; Kumar, Manu P MP; Mereu, Elisabetta E; Joughin, Brian A BA; Stegle, Oliver O; Lauffenburger, Douglas A DA; Heyn, Holger H; Szalai, Bence B; Saez-Rodriguez, Julio J
COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Lindemann, Antje A; Patel, Ameeta A AA; Silver, Natalie L NL; Tang, Lin L; Liu, Zhiyi Z; Wang, Li L; Tanaka, Noriaki N; Rao, Xiayu X; Takahashi, Hideaki H; Maduka, Nakachi K NK; Zhao, Mei M; Chen, Tseng-Cheng TC; Liu, WeiWei W; Gao, Meng M; Wang, Jing J; Frank, Steven J SJ; Hittelman, Walter N WN; Mills, Gordon B GB; Myers, Jeffrey N JN; Osman, Abdullah A AA
Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Kotler, Samuel A SA; Tugarinov, Vitali V; Schmidt, Thomas T; Ceccon, Alberto A; Libich, David S DS; Ghirlando, Rodolfo R; Schwieters, Charles D CD; Clore, G Marius GM
Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin.
Cancer Discovery
Yang, Dian D; Denny, Sarah K SK; Greenside, Peyton G PG; Chaikovsky, Andrea C AC; Brady, Jennifer J JJ; Ouadah, Youcef Y; Granja, Jeffrey M JM; Jahchan, Nadine S NS; Lim, Jing Shan JS; Kwok, Shirley S; Kong, Christina S CS; Berghoff, Anna S AS; Schmitt, Anna A; Reinhardt, H Christian HC; Park, Kwon-Sik KS; Preusser, Matthias M; Kundaje, Anshul A; Greenleaf, William J WJ; Sage, Julien J; Winslow, Monte M MM
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases.
Science (New York, N.Y.)
Pommier, Arnaud A; Anaparthy, Naishitha N; Memos, Nicoletta N; Kelley, Z Larkin ZL; Gouronnec, Alizée A; Yan, Ran R; Auffray, Cédric C; Albrengues, Jean J; Egeblad, Mikala M; Iacobuzio-Donahue, Christine A CA; Lyons, Scott K SK; Fearon, Douglas T DT
Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma.
Science Translational Medicine
Lochmann, Timothy L TL; Powell, Krista M KM; Ham, Jungoh J; Floros, Konstantinos V KV; Heisey, Daniel A R DAR; Kurupi, Richard I J RIJ; Calbert, Marissa L ML; Ghotra, Maninderjit S MS; Greninger, Patricia P; Dozmorov, Mikhail M; Gowda, Madhu M; Souers, Andrew J AJ; Reynolds, C Patrick CP; Benes, Cyril H CH; Faber, Anthony C AC
Vimentin regulates differentiation switch via modulation of keratin 14 levels and their expression together correlates with poor prognosis in oral cancer patients.
Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation.
Embo Reports
Kouwenhoven, Evelyn N EN; Oti, Martin M; Niehues, Hanna H; van Heeringen, Simon J SJ; Schalkwijk, Joost J; Stunnenberg, Hendrik G HG; van Bokhoven, Hans H; Zhou, Huiqing H
Microarray analysis of serum mRNA in patients with head and neck squamous cell carcinoma at whole-genome scale.
Biomed Research International
Čapková, Markéta M; Šáchová, Jana J; Strnad, Hynek H; Kolář, Michal M; Hroudová, Miluše M; Chovanec, Martin M; Čada, Zdeněk Z; Šteffl, Martin M; Valach, Jaroslav J; Kastner, Jan J; Vlček, Čestmír Č; Smetana, Karel K; Plzák, Jan J