Constructing a polygenic risk score for childhood obesity using functional data analysis.
Econometrics And Statistics
Craig, Sarah J C SJC; Kenney, Ana M AM; Lin, Junli J; Paul, Ian M IM; Birch, Leann L LL; Savage, Jennifer S JS; Marini, Michele E ME; Chiaromonte, Francesca F; Reimherr, Matthew L ML; Makova, Kateryna D KD
Simulated distributions from negative experiments highlight the importance of the body mass index distribution in explaining depression-body mass index genetic risk score interactions.
International Journal Of Epidemiology
Casanova, Francesco F; O'Loughlin, Jessica J; Lewis, Cathryn C; Frayling, Timothy M TM; Wood, Andrew R AR; Tyrrell, Jessica J
The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease.
Obesity (Silver Spring, Md.)
Kalaoja, Marita M; Corbin, Laura J LJ; Tan, Vanessa Y VY; Ahola-Olli, Ari V AV; Havulinna, Aki S AS; Santalahti, Kristiina K; Pitkänen, Niina N; Lehtimäki, Terho T; Lyytikäinen, Leo-Pekka LP; Raitoharju, Emma E; Seppälä, Ilkka I; Kähönen, Mika M; Ripatti, Samuli S; Palotie, Aarno A; Perola, Markus M; Viikari, Jorma S JS; Jalkanen, Sirpa S; Maksimow, Mikael M; Salomaa, Veikko V; Salmi, Marko M; Raitakari, Olli T OT; Kettunen, Johannes J; Timpson, Nicholas J NJ
Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.
Jama Psychiatry
Kappelmann, Nils N; Arloth, Janine J; Georgakis, Marios K MK; Czamara, Darina D; Rost, Nicolas N; Ligthart, Symen S; Khandaker, Golam M GM; Binder, Elisabeth B EB
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses.
Bmj (Clinical Research Ed.)
Sun, Yi-Qian YQ; Burgess, Stephen S; Staley, James R JR; Wood, Angela M AM; Bell, Steven S; Kaptoge, Stephen K SK; Guo, Qi Q; Bolton, Thomas R TR; Mason, Amy M AM; Butterworth, Adam S AS; Di Angelantonio, Emanuele E; Vie, Gunnhild Å GÅ; Bjørngaard, Johan H JH; Kinge, Jonas Minet JM; Chen, Yue Y; Mai, Xiao-Mei XM
Phenome-wide association studies across large population cohorts support drug target validation.
Nature Communications
Diogo, Dorothée D; Tian, Chao C; Franklin, Christopher S CS; Alanne-Kinnunen, Mervi M; March, Michael M; Spencer, Chris C A CCA; Vangjeli, Ciara C; Weale, Michael E ME; Mattsson, Hannele H; Kilpeläinen, Elina E; Sleiman, Patrick M A PMA; Reilly, Dermot F DF; McElwee, Joshua J; Maranville, Joseph C JC; Chatterjee, Arnaub K AK; Bhandari, Aman A; Nguyen, Khanh-Dung H KH; Estrada, Karol K; Reeve, Mary-Pat MP; Hutz, Janna J; Bing, Nan N; John, Sally S; MacArthur, Daniel G DG; Salomaa, Veikko V; Ripatti, Samuli S; Hakonarson, Hakon H; Daly, Mark J MJ; Palotie, Aarno A; Hinds, David A DA; Donnelly, Peter P; Fox, Caroline S CS; Day-Williams, Aaron G AG; Plenge, Robert M RM; Runz, Heiko H
Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study.
Bmj (Clinical Research Ed.)
Wootton, Robyn E RE; Lawn, Rebecca B RB; Millard, Louise A C LAC; Davies, Neil M NM; Taylor, Amy E AE; Munafò, Marcus R MR; Timpson, Nicholas J NJ; Davis, Oliver S P OSP; Davey Smith, George G; Haworth, Claire M A CMA
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses.
Plos Genetics
Baranski, Thomas J TJ; Kraja, Aldi T AT; Fink, Jill L JL; Feitosa, Mary M; Lenzini, Petra A PA; Borecki, Ingrid B IB; Liu, Ching-Ti CT; Cupples, L Adrienne LA; North, Kari E KE; Province, Michael A MA
Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.
Aging
Pilling, Luke C LC; Kuo, Chia-Ling CL; Sicinski, Kamil K; Tamosauskaite, Jone J; Kuchel, George A GA; Harries, Lorna W LW; Herd, Pamela P; Wallace, Robert R; Ferrucci, Luigi L; Melzer, David D
Prediction of Adulthood Obesity Using Genetic and Childhood Clinical Risk Factors in the Cardiovascular Risk in Young Finns Study.
Circulation. Cardiovascular Genetics
Seyednasrollah, Fatemeh F; Mäkelä, Johanna J; Pitkänen, Niina N; Juonala, Markus M; Hutri-Kähönen, Nina N; Lehtimäki, Terho T; Viikari, Jorma J; Kelly, Tanika T; Li, Changwei C; Bazzano, Lydia L; Elo, Laura L LL; Raitakari, Olli T OT
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.
Plos Medicine
Noyce, Alastair J AJ; Kia, Demis A DA; Hemani, Gibran G; Nicolas, Aude A; Price, T Ryan TR; De Pablo-Fernandez, Eduardo E; Haycock, Philip C PC; Lewis, Patrick A PA; Foltynie, Thomas T; Davey Smith, George G; , ; Schrag, Anette A; Lees, Andrew J AJ; Hardy, John J; Singleton, Andrew A; Nalls, Mike A MA; Pearce, Neil N; Lawlor, Debbie A DA; Wood, Nicholas W NW
Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study.
Scientific Reports
Konttinen, Hanna H; Llewellyn, Clare C; Wardle, Jane J; Silventoinen, Karri K; Joensuu, Anni A; Männistö, Satu S; Salomaa, Veikko V; Jousilahti, Pekka P; Kaprio, Jaakko J; Perola, Markus M; Haukkala, Ari A
Genetic studies of body mass index yield new insights for obesity biology.
Nature
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