Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program.
Plos One
M Serper, M Vujkovic, DE Kaplan, RM Carr, KM Lee, Q Shao, DR Miller, PD Reaven, LS Phillips, CJ O'Donnell, JB Meigs, PWF Wilson, R Vickers-Smith, HR Kranzler, AC Justice, JM Gaziano, S Muralidhar, S Pyarajan, SL DuVall, TL Assimes, JS Lee, PS Tsao, DJ Rader, SM Damrauer, JA Lynch, D Saleheen, BF Voight, KM Chang,
Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study.
Genes
A Huerta-Chagoya, H Moreno-Macías, M Sevilla-González, R Rodríguez-Guillén, ML Ordóñez-Sánchez, D Gómez-Velasco, L Muñóz-Hernández, Y Segura-Kato, O Arellano-Campos, I Cruz-Bautista, CA Aguilar-Salinas, T Tusié-Luna
Exome sequencing of Finnish isolates enhances rare-variant association power.
Nature
AE Locke, KM Steinberg, CWK Chiang, SK Service, AS Havulinna, L Stell, M Pirinen, HJ Abel, CC Chiang, RS Fulton, AU Jackson, CJ Kang, KL Kanchi, DC Koboldt, DE Larson, J Nelson, TJ Nicholas, A Pietilä, V Ramensky, D Ray, LJ Scott, HM Stringham, J Vangipurapu, R Welch, P Yajnik, X Yin, JG Eriksson, M Ala-Korpela, MR Järvelin, M Männikkö, H Laivuori, , SK Dutcher, NO Stitziel, RK Wilson, IM Hall, C Sabatti, A Palotie, V Salomaa, M Laakso, S Ripatti, M Boehnke, NB Freimer
Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes.
Hepatology Communications
L Barata, MF Feitosa, LF Bielak, B Halligan, AS Baldridge, X Guo, LM Yerges-Armstrong, AV Smith, J Yao, ND Palmer, LB VanWagner, JJ Carr, YI Chen, M Allison, MJ Budoff, SK Handelman, SLR Kardia, TH Mosley, K Ryan, TB Harris, LJ Launer, V Gudnason, JI Rotter, M Fornage, LJ Rasmussen-Torvik, IB Borecki, JR O'Connell, PA Peyser, EK Speliotes, MA Province
Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.
Genome Biology
FWB Sanders, A Acharjee, C Walker, L Marney, LD Roberts, F Imamura, B Jenkins, J Case, S Ray, S Virtue, A Vidal-Puig, D Kuh, R Hardy, M Allison, N Forouhi, AJ Murray, N Wareham, M Vacca, A Koulman, JL Griffin
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
Nature Genetics
A Mahajan, J Wessel, SM Willems, W Zhao, NR Robertson, AY Chu, W Gan, H Kitajima, D Taliun, NW Rayner, X Guo, Y Lu, M Li, RA Jensen, Y Hu, S Huo, KK Lohman, W Zhang, JP Cook, BP Prins, J Flannick, N Grarup, VV Trubetskoy, J Kravic, YJ Kim, DV Rybin, H Yaghootkar, M Müller-Nurasyid, K Meidtner, R Li-Gao, TV Varga, J Marten, J Li, AV Smith, P An, S Ligthart, S Gustafsson, G Malerba, A Demirkan, JF Tajes, V Steinthorsdottir, M Wuttke, C Lecoeur, M Preuss, LF Bielak, M Graff, HM Highland, AE Justice, DJ Liu, E Marouli, GM Peloso, HR Warren, , , , S Afaq, S Afzal, E Ahlqvist, P Almgren, N Amin, LB Bang, AG Bertoni, C Bombieri, J Bork-Jensen, I Brandslund, JA Brody, NP Burtt, M Canouil, YI Chen, YS Cho, C Christensen, SV Eastwood, KU Eckardt, K Fischer, G Gambaro, V Giedraitis, ML Grove, HG de Haan, S Hackinger, Y Hai, S Han, A Tybjærg-Hansen, MF Hivert, B Isomaa, S Jäger, ME Jørgensen, T Jørgensen, A Käräjämäki, BJ Kim, SS Kim, HA Koistinen, P Kovacs, J Kriebel, F Kronenberg, K Läll, LA Lange, JJ Lee, B Lehne, H Li, KH Lin, A Linneberg, CT Liu, J Liu, M Loh, R Mägi, V Mamakou, R McKean-Cowdin, G Nadkarni, M Neville, SF Nielsen, I Ntalla, PA Peyser, W Rathmann, K Rice, SS Rich, L Rode, O Rolandsson, S Schönherr, E Selvin, KS Small, A Stančáková, P Surendran, KD Taylor, TM Teslovich, B Thorand, G Thorleifsson, A Tin, A Tönjes, A Varbo, DR Witte, AR Wood, P Yajnik, J Yao, L Yengo, R Young, P Amouyel, H Boeing, E Boerwinkle, EP Bottinger, R Chowdhury, FS Collins, G Dedoussis, A Dehghan, P Deloukas, MM Ferrario, J Ferrières, JC Florez, P Frossard, V Gudnason, TB Harris, SR Heckbert, JMM Howson, M Ingelsson, S Kathiresan, F Kee, J Kuusisto, C Langenberg, LJ Launer, CM Lindgren, S Männistö, T Meitinger, O Melander, KL Mohlke, M Moitry, AD Morris, AD Murray, R de Mutsert, M Orho-Melander, KR Owen, M Perola, A Peters, MA Province, A Rasheed, PM Ridker, F Rivadineira, FR Rosendaal, AH Rosengren, V Salomaa, WH Sheu, R Sladek, BH Smith, K Strauch, AG Uitterlinden, R Varma, CJ Willer, M Blüher, AS Butterworth, JC Chambers, DI Chasman, J Danesh, C van Duijn, J Dupuis, OH Franco, PW Franks, P Froguel, H Grallert, L Groop, BG Han, T Hansen, AT Hattersley, C Hayward, E Ingelsson, SLR Kardia, F Karpe, JS Kooner, A Köttgen, K Kuulasmaa, M Laakso, X Lin, L Lind, Y Liu, RJF Loos, J Marchini, A Metspalu, D Mook-Kanamori, BG Nordestgaard, CNA Palmer, JS Pankow, O Pedersen, BM Psaty, R Rauramaa, N Sattar, MB Schulze, N Soranzo, TD Spector, K Stefansson, M Stumvoll, U Thorsteinsdottir, T Tuomi, J Tuomilehto, NJ Wareham, JG Wilson, E Zeggini, RA Scott, I Barroso, TM Frayling, MO Goodarzi, JB Meigs, M Boehnke, D Saleheen, AP Morris, JI Rotter, MI McCarthy
Publication Date: 2018-04
Variant appearance in text: NCAN: Pro92Ser; rs2228603
Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey.
Plos Genetics
CN Spracklen, J Shi, S Vadlamudi, Y Wu, M Zou, CK Raulerson, JP Davis, M Zeynalzadeh, K Jackson, W Yuan, H Wang, W Shou, Y Wang, J Luo, LA Lange, EM Lange, BM Popkin, P Gordon-Larsen, S Du, W Huang, KL Mohlke
Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease.
Gastroenterology
J Ma, R Hennein, C Liu, MT Long, U Hoffmann, PF Jacques, AH Lichtenstein, FB Hu, D Levy
High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease.
Cancer
CG Tepper, JHT Dang, SL Stewart, DM Fang, KA Wong, SY Liu, RR Davis, DY Dao, JP Gregg, NJ Török, MS Chen
Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy.
Scientific Reports
A Di Costanzo, F Belardinilli, D Bailetti, M Sponziello, L D'Erasmo, L Polimeni, F Baratta, D Pastori, F Ceci, A Montali, G Girelli, B De Masi, A Angeloni, G Giannini, M Del Ben, F Angelico, M Arca
Publication Date: 2018-02-27
Variant appearance in text: NCAN: Pro92Ser; rs2228603
Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.
Plos One
T Kawaguchi, T Shima, M Mizuno, Y Mitsumoto, A Umemura, Y Kanbara, S Tanaka, Y Sumida, K Yasui, M Takahashi, K Matsuo, Y Itoh, K Tokushige, E Hashimoto, K Kiyosawa, M Kawaguchi, H Itoh, H Uto, Y Komorizono, K Shirabe, S Takami, T Takamura, M Kawanaka, R Yamada, F Matsuda, T Okanoue
Genome-Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys.
The Journal Of Pediatrics
J Wattacheril, JE Lavine, NP Chalasani, X Guo, S Kwon, J Schwimmer, JP Molleston, R Loomba, EM Brunt, YI Chen, MO Goodarzi, KD Taylor, KP Yates, J Tonascia, JI Rotter
Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program.
Circulation. Cardiovascular Genetics
TV Varga, AH Winters, KA Jablonski, ES Horton, P Khare-Ranade, WC Knowler, SM Marcovina, F Renström, KE Watson, R Goldberg, JC Florez, TI Pollin, PW Franks
Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults.
Molecular Biology Reports
YN Flores, R Velázquez-Cruz, P Ramírez, M Bañuelos, ZF Zhang, HF Yee, SC Chang, S Canizales-Quinteros, M Quiterio, G Cabrera-Alvarez, N Patiño, J Salmerón
The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3.
Molecular Genetics And Metabolism
RL Hanson, F Leti, D Tsinajinnie, S Kobes, S Puppala, JE Curran, L Almasy, DM Lehman, J Blangero, R Duggirala, JK DiStefano
The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals.
Plos One
K Nishioji, N Mochizuki, M Kobayashi, M Kamaguchi, Y Sumida, T Nishimura, K Yamaguchi, H Kadotani, Y Itoh
The impact of low-frequency and rare variants on lipid levels.
Nature Genetics
I Surakka, M Horikoshi, R Mägi, AP Sarin, A Mahajan, V Lagou, L Marullo, T Ferreira, B Miraglio, S Timonen, J Kettunen, M Pirinen, J Karjalainen, G Thorleifsson, S Hägg, JJ Hottenga, A Isaacs, C Ladenvall, M Beekman, T Esko, JS Ried, CP Nelson, C Willenborg, S Gustafsson, HJ Westra, M Blades, AJ de Craen, EJ de Geus, J Deelen, H Grallert, A Hamsten, AS Havulinna, C Hengstenberg, JJ Houwing-Duistermaat, E Hyppönen, LC Karssen, T Lehtimäki, V Lyssenko, PK Magnusson, E Mihailov, M Müller-Nurasyid, JP Mpindi, NL Pedersen, BW Penninx, M Perola, TH Pers, A Peters, J Rung, JH Smit, V Steinthorsdottir, MD Tobin, N Tsernikova, EM van Leeuwen, JS Viikari, SM Willems, G Willemsen, H Schunkert, J Erdmann, NJ Samani, J Kaprio, L Lind, C Gieger, A Metspalu, PE Slagboom, L Groop, CM van Duijn, JG Eriksson, A Jula, V Salomaa, DI Boomsma, C Power, OT Raitakari, E Ingelsson, MR Järvelin, U Thorsteinsdottir, L Franke, E Ikonen, O Kallioniemi, V Pietiäinen, CM Lindgren, K Stefansson, A Palotie, MI McCarthy, AP Morris, I Prokopenko, S Ripatti,
Publication Date: 2015-06
Variant appearance in text: NCAN: Pro92Ser; rs2228603
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.
Nature Communications
YL Liu, HL Reeves, AD Burt, D Tiniakos, S McPherson, JB Leathart, ME Allison, GJ Alexander, AC Piguet, R Anty, P Donaldson, GP Aithal, S Francque, L Van Gaal, K Clement, V Ratziu, JF Dufour, CP Day, AK Daly, QM Anstee
Publication Date: 2014-06-30
Variant appearance in text: NCAN: 274C>T; Pro92Ser; rs2228603
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.
Nature Genetics
OL Holmen, H Zhang, Y Fan, DH Hovelson, EM Schmidt, W Zhou, Y Guo, J Zhang, A Langhammer, ML Løchen, SK Ganesh, L Vatten, F Skorpen, H Dalen, J Zhang, S Pennathur, J Chen, C Platou, EB Mathiesen, T Wilsgaard, I Njølstad, M Boehnke, YE Chen, GR Abecasis, K Hveem, CJ Willer
Publication Date: 2014-04
Variant appearance in text: NCAN: Pro92Ser; rs2228603
Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.
Plos Genetics
SK Service, TM Teslovich, C Fuchsberger, V Ramensky, P Yajnik, DC Koboldt, DE Larson, Q Zhang, L Lin, R Welch, L Ding, MD McLellan, M O'Laughlin, C Fronick, LL Fulton, V Magrini, A Swift, P Elliott, MR Jarvelin, M Kaakinen, MI McCarthy, L Peltonen, A Pouta, LL Bonnycastle, FS Collins, N Narisu, HM Stringham, J Tuomilehto, S Ripatti, RS Fulton, C Sabatti, RK Wilson, M Boehnke, NB Freimer
PNPLA3 GG genotype and carotid atherosclerosis in patients with non-alcoholic fatty liver disease.
Plos One
S Petta, L Valenti, G Marchesini, V Di Marco, A Licata, C Cammà, MR Barcellona, D Cabibi, B Donati, A Fracanzani, S Grimaudo, G Parrinello, RM Pipitone, D Torres, S Fargion, G Licata, A Craxì
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.
Hepatology (Baltimore, Md.)
ND Palmer, SK Musani, LM Yerges-Armstrong, MF Feitosa, LF Bielak, R Hernaez, B Kahali, JJ Carr, TB Harris, MA Jhun, SL Kardia, CD Langefeld, TH Mosley, JM Norris, AV Smith, HA Taylor, LE Wagenknecht, J Liu, IB Borecki, PA Peyser, EK Speliotes
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Journal Of Medical Genetics
D Weissglas-Volkov, CA Aguilar-Salinas, E Nikkola, KA Deere, I Cruz-Bautista, O Arellano-Campos, LL Muñoz-Hernandez, L Gomez-Munguia, ML Ordoñez-Sánchez, PM Reddy, AJ Lusis, N Matikainen, MR Taskinen, L Riba, RM Cantor, JS Sinsheimer, T Tusie-Luna, P Pajukanta
Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third National Health and Nutrition Examination Survey.
Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association
R Hernaez, J McLean, M Lazo, FL Brancati, JN Hirschhorn, IB Borecki, TB Harris, , T Nguyen, IR Kamel, S Bonekamp, MS Eberhardt, JM Clark, WH Kao, EK Speliotes
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
American Journal Of Human Genetics
FW Asselbergs, Y Guo, EP van Iperen, S Sivapalaratnam, V Tragante, MB Lanktree, LA Lange, B Almoguera, YE Appelman, J Barnard, J Baumert, AL Beitelshees, TR Bhangale, YD Chen, TR Gaunt, Y Gong, JC Hopewell, T Johnson, ME Kleber, TY Langaee, M Li, YR Li, K Liu, CW McDonough, MF Meijs, RP Middelberg, K Musunuru, CP Nelson, JR O'Connell, S Padmanabhan, JS Pankow, N Pankratz, S Rafelt, R Rajagopalan, SP Romaine, NJ Schork, J Shaffer, H Shen, EN Smith, SE Tischfield, PJ van der Most, JV van Vliet-Ostaptchouk, N Verweij, KA Volcik, L Zhang, KR Bailey, KM Bailey, F Bauer, JM Boer, PS Braund, A Burt, PR Burton, SG Buxbaum, W Chen, RM Cooper-Dehoff, LA Cupples, JS deJong, C Delles, D Duggan, M Fornage, CE Furlong, N Glazer, JG Gums, C Hastie, MV Holmes, T Illig, SA Kirkland, M Kivimaki, R Klein, BE Klein, C Kooperberg, K Kottke-Marchant, M Kumari, AZ LaCroix, L Mallela, G Murugesan, J Ordovas, WH Ouwehand, WS Post, R Saxena, H Scharnagl, PJ Schreiner, T Shah, DC Shields, D Shimbo, SR Srinivasan, RP Stolk, DI Swerdlow, HA Taylor, EJ Topol, E Toskala, JL van Pelt, J van Setten, S Yusuf, JC Whittaker, AH Zwinderman, , SS Anand, AJ Balmforth, GS Berenson, CR Bezzina, BO Boehm, E Boerwinkle, JP Casas, MJ Caulfield, R Clarke, JM Connell, KJ Cruickshanks, KW Davidson, IN Day, PI de Bakker, PA Doevendans, AF Dominiczak, AS Hall, CA Hartman, C Hengstenberg, HL Hillege, MH Hofker, SE Humphries, GP Jarvik, JA Johnson, BM Kaess, S Kathiresan, W Koenig, DA Lawlor, W März, O Melander, BD Mitchell, GW Montgomery, PB Munroe, SS Murray, SJ Newhouse, NC Onland-Moret, N Poulter, B Psaty, S Redline, SS Rich, JI Rotter, H Schunkert, P Sever, AR Shuldiner, RL Silverstein, A Stanton, B Thorand, MD Trip, MY Tsai, P van der Harst, E van der Schoot, YT van der Schouw, WM Verschuren, H Watkins, AA Wilde, BH Wolffenbuttel, JB Whitfield, GK Hovingh, CM Ballantyne, C Wijmenga, MP Reilly, NG Martin, JG Wilson, DJ Rader, NJ Samani, AP Reiner, RA Hegele, JJ Kastelein, AD Hingorani, PJ Talmud, H Hakonarson, CC Elbers, BJ Keating, F Drenos
Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases.
Bmc Medical Genetics
S Huhn, M Bevier, A Rudolph, B Pardini, A Naccarati, R Hein, M Hoffmeister, L Vodickova, J Novotny, H Brenner, J Chang-Claude, K Hemminki, P Vodicka, A Försti
Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.
Plos One
T Kawaguchi, Y Sumida, A Umemura, K Matsuo, M Takahashi, T Takamura, K Yasui, T Saibara, E Hashimoto, M Kawanaka, S Watanabe, S Kawata, Y Imai, M Kokubo, T Shima, H Park, H Tanaka, K Tajima, R Yamada, F Matsuda, T Okanoue,
A Demirkan, N Amin, A Isaacs, MR Jarvelin, JB Whitfield, HE Wichmann, KO Kyvik, I Rudan, C Gieger, AA Hicks, Å Johansson, JJ Hottenga, JJ Smith, SH Wild, NL Pedersen, G Willemsen, M Mangino, C Hayward, AG Uitterlinden, A Hofman, J Witteman, GW Montgomery, KH Pietiläinen, T Rantanen, J Kaprio, A Döring, PP Pramstaller, U Gyllensten, EJ de Geus, BW Penninx, JF Wilson, F Rivadeneria, PK Magnusson, DI Boomsma, T Spector, H Campbell, B Hoehne, NG Martin, BA Oostra, M McCarthy, L Peltonen-Palotie, Y Aulchenko, PM Visscher, S Ripatti, AC Janssens, CM van Duijn,
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
Plos Genetics
EK Speliotes, LM Yerges-Armstrong, J Wu, R Hernaez, LJ Kim, CD Palmer, V Gudnason, G Eiriksdottir, ME Garcia, LJ Launer, MA Nalls, JM Clark, BD Mitchell, AR Shuldiner, JL Butler, M Tomas, U Hoffmann, SJ Hwang, JM Massaro, CJ O'Donnell, DV Sahani, V Salomaa, EE Schadt, SM Schwartz, DS Siscovick, , , , BF Voight, JJ Carr, MF Feitosa, TB Harris, CS Fox, AV Smith, WH Kao, JN Hirschhorn, IB Borecki,