Therapeutic and Toxic Effects of Valproic Acid Metabolites.
Metabolites
Shnayder, Natalia A NA; Grechkina, Violetta V VV; Khasanova, Aiperi K AK; Bochanova, Elena N EN; Dontceva, Evgenia A EA; Petrova, Marina M MM; Asadullin, Azat R AR; Shipulin, German A GA; Altynbekov, Kuanysh S KS; Al-Zamil, Mustafa M; Nasyrova, Regina F RF
Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.
Scientific Reports
Chenoweth, Meghan J MJ; Cox, Lisa Sanderson LS; Nollen, Nikki L NL; Ahluwalia, Jasjit S JS; Benowitz, Neal L NL; Lerman, Caryn C; Knight, Jo J; Tyndale, Rachel F RF
Publication Date: 2021-10-01
Variant appearance in text: CYP2A6: V365M; rs28399454
Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations.
Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.
Clinical And Translational Science
El-Boraie, Ahmed A; Tanner, Julie-Anne JA; Zhu, Andy Z X AZX; Claw, Katrina G KG; Prasad, Bhagwat B; Schuetz, Erin G EG; Thummel, Kenneth E KE; Fukunaga, Koya K; Mushiroda, Taisei T; Kubo, Michiaki M; Benowitz, Neal L NL; Lerman, Caryn C; Tyndale, Rachel F RF
Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.
Clinical And Translational Science
El-Boraie, Ahmed A; Tanner, Julie-Anne JA; Zhu, Andy Z X AZX; Claw, Katrina G KG; Prasad, Bhagwat B; Schuetz, Erin G EG; Thummel, Kenneth E KE; Fukunaga, Koya K; Mushiroda, Taisei T; Kubo, Michiaki M; Benowitz, Neal L NL; Lerman, Caryn C; Tyndale, Rachel F RF
Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment.
Antimicrobial Agents And Chemotherapy
Pernaute-Lau, Leyre L; Adegnika, Ayola Akim AA; Zhou, Yitian Y; Zinsou, Jeannot F JF; Gil, Jose Pedro JP; Krishna, Sanjeev S; Kremsner, Peter G PG; Lauschke, Volker M VM; Velavan, Thirumalaisamy P TP
Publication Date: 2021-06-17
Variant appearance in text: CYP2A6: V365M; rs28399454
Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.
Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01
Variant appearance in text: CYP2A6: V365M; rs28399454
Genetic polymorphisms in very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China: A cohort study in the Zhuang population.
Medicine
Li, Jing J; Guo, Chenghao C; Yan, Mengdan M; Niu, Fanglin F; Chen, Peng P; Li, Bin B; Jin, Tianbo T
Publication Date: 2018-04
Variant appearance in text: CYP2A6: Val365Met; rs28399454
Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.
Addiction (Abingdon, England)
Chenoweth, Meghan J MJ; Ware, Jennifer J JJ; Zhu, Andy Z X AZX; Cole, Christopher B CB; Cox, Lisa Sanderson LS; Nollen, Nikki N; Ahluwalia, Jasjit S JS; Benowitz, Neal L NL; Schnoll, Robert A RA; Hawk, Larry W LW; Cinciripini, Paul M PM; George, Tony P TP; Lerman, Caryn C; Knight, Joanne J; Tyndale, Rachel F RF; ,
Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer.
Scientific Reports
Feliubadaló, Lídia L; Tonda, Raúl R; Gausachs, Mireia M; Trotta, Jean-Rémi JR; Castellanos, Elisabeth E; López-Doriga, Adriana A; Teulé, Àlex À; Tornero, Eva E; Del Valle, Jesús J; Gel, Bernat B; Gut, Marta M; Pineda, Marta M; González, Sara S; Menéndez, Mireia M; Navarro, Matilde M; Capellá, Gabriel G; Gut, Ivo I; Serra, Eduard E; Brunet, Joan J; Beltran, Sergi S; Lázaro, Conxi C
Publication Date: 2017-01-04
Variant appearance in text: CYP2A6: 1093G>A; Val365Met
Characterization of ADME gene variation in 21 populations by exome sequencing.
Pharmacogenetics And Genomics
Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR
Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.
Cancer Research
Patel, Yesha M YM; Park, Sunghim L SL; Han, Younghun Y; Wilkens, Lynne R LR; Bickeböller, Heike H; Rosenberger, Albert A; Caporaso, Neil N; Landi, Maria Teresa MT; Brüske, Irene I; Risch, Angela A; Wei, Yongyue Y; Christiani, David C DC; Brennan, Paul P; Houlston, Richard R; McKay, James J; McLaughlin, John J; Hung, Rayjean R; Murphy, Sharon S; Stram, Daniel O DO; Amos, Christopher C; Le Marchand, Loïc L
Evidence for extensive pleiotropy among pharmacogenes.
Pharmacogenomics
Oetjens, Matthew T MT; Bush, William S WS; Denny, Joshua C JC; Birdwell, Kelly K; Kodaman, Nuri N; Verma, Anurag A; Dilks, Holli H HH; Pendergrass, Sarah A SA; Ritchie, Marylyn D MD; Crawford, Dana C DC
An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients.
Frontiers In Genetics
Swart, Marelize M; Evans, Jonathan J; Skelton, Michelle M; Castel, Sandra S; Wiesner, Lubbe L; Smith, Peter J PJ; Dandara, Collet C
Publication Date: 2015
Variant appearance in text: CYP2A6: 1093G>A; rs28399454
Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study.
Clinical Pharmacokinetics
Dickinson, Laura L; Amin, Janaki J; Else, Laura L; Boffito, Marta M; Egan, Deirdre D; Owen, Andrew A; Khoo, Saye S; Back, David D; Orrell, Catherine C; Clarke, Amanda A; Losso, Marcelo M; Phanuphak, Praphan P; Carey, Dianne D; Cooper, David A DA; Emery, Sean S; Puls, Rebekah R
Pharmacokinetic and Pharmacodynamic Comparison of Once-Daily Efavirenz (400 mg vs. 600 mg) in Treatment-Naïve HIV-Infected Patients: Results of the ENCORE1 Study.
Clinical Pharmacology And Therapeutics
Dickinson, L L; Amin, J J; Else, L L; Boffito, M M; Egan, D D; Owen, A A; Khoo, S S; Back, D D; Orrell, C C; Clarke, A A; Losso, M M; Phanuphak, P P; Carey, D D; Cooper, D A DA; Emery, S S; Puls, R R; ,
CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe.
Bmc Pharmacology & Toxicology
Dhoro, Milcah M; Zvada, Simbarashe S; Ngara, Bernard B; Nhachi, Charles C; Kadzirange, Gerald G; Chonzi, Prosper P; Masimirembwa, Collen C
The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.
Disease Markers
Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N
Whole-genome sequencing of the world's oldest people.
Plos One
Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK
Publication Date: 2014
Variant appearance in text: CYP2A6: V365M; rs28399454
Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes.
The Journal Of Antimicrobial Chemotherapy
Haas, David W DW; Kwara, Awewura A; Richardson, Danielle M DM; Baker, Paxton P; Papageorgiou, Ioannis I; Acosta, Edward P EP; Morse, Gene D GD; Court, Michael H MH
Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6 15, CYP2A6 16, CYP2A6 21 and CYP2A6 22: differential susceptibility due to different sequence locations of the mutations.
Plos One
Tiong, Kai Hung KH; Mohammed Yunus, Nafees Ahemad NA; Yiap, Beow Chin BC; Tan, Eng Lai EL; Ismail, Rusli R; Ong, Chin Eng CE
Multiple genetic variants predict steady-state nevirapine clearance in HIV-infected Cambodians.
Pharmacogenetics And Genomics
Bertrand, Julie J; Chou, Monidarin M; Richardson, Danielle M DM; Verstuyft, Céline C; Leger, Paul D PD; Mentré, France F; Taburet, Anne-Marie AM; Haas, David W DW; ,
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
Pharmacogenetics And Genomics
Holzinger, Emily R ER; Grady, Benjamin B; Ritchie, Marylyn D MD; Ribaudo, Heather J HJ; Acosta, Edward P EP; Morse, Gene D GD; Gulick, Roy M RM; Robbins, Gregory K GK; Clifford, David B DB; Daar, Eric S ES; McLaren, Paul P; Haas, David W DW
Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.
Human Molecular Genetics
Bloom, A Joseph AJ; Harari, Oscar O; Martinez, Maribel M; Madden, Pamela A F PA; Martin, Nicholas G NG; Montgomery, Grant W GW; Rice, John P JP; Murphy, Sharon E SE; Bierut, Laura J LJ; Goate, Alison A