The Influence of Cytochrome P450 Polymorphisms on Pharmacokinetic Profiles and Treatment Outcomes Among Malaria Patients in Sub-Saharan Africa: A Systematic Review.
Pharmacogenomics And Personalized Medicine
Marwa, Karol J KJ; Kapesa, Anthony A; Kamugisha, Erasmus E; Swedberg, Göte G
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: CYP2A6: 479T>A; Leu160His
Kiani, Aysha Karim AK; Medori, Maria Chiara MC; Dhuli, Kristjana K; Donato, Kevin K; Caruso, Paola P; Fioretti, Francesco F; Perrone, Marco Alfonso MA; Ceccarini, Maria Rachele MR; Manganotti, Paolo P; Nodari, Savina S; Codini, Michela M; Beccari, Tommaso T; Bertelli, Matteo M
Association between gene polymorphisms in the cyclophosphamide metabolism pathway with complications after haploidentical hematopoietic stem cell transplantation.
Frontiers In Immunology
Muñiz, Paula P; Andrés-Zayas, Cristina C; Carbonell, Diego D; Chicano, María M; Bailén, Rebeca R; Oarbeascoa, Gillen G; Suárez-González, Julia J; Gómez Centurión, Ignacio I; Dorado, Nieves N; Gallardo, David D; Anguita, Javier J; Kwon, Mi M; Díez-Martín, Jose L JL; Martínez-Laperche, Carolina C; Buño, Ismael I
Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.
Clinical And Translational Science
El-Boraie, Ahmed A; Tanner, Julie-Anne JA; Zhu, Andy Z X AZX; Claw, Katrina G KG; Prasad, Bhagwat B; Schuetz, Erin G EG; Thummel, Kenneth E KE; Fukunaga, Koya K; Mushiroda, Taisei T; Kubo, Michiaki M; Benowitz, Neal L NL; Lerman, Caryn C; Tyndale, Rachel F RF
Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.
Clinical And Translational Science
El-Boraie, Ahmed A; Tanner, Julie-Anne JA; Zhu, Andy Z X AZX; Claw, Katrina G KG; Prasad, Bhagwat B; Schuetz, Erin G EG; Thummel, Kenneth E KE; Fukunaga, Koya K; Mushiroda, Taisei T; Kubo, Michiaki M; Benowitz, Neal L NL; Lerman, Caryn C; Tyndale, Rachel F RF
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma.
Nature Communications
Frontzek, Fabian F; Staiger, Annette M AM; Zapukhlyak, Myroslav M; Xu, Wendan W; Bonzheim, Irina I; Borgmann, Vanessa V; Sander, Philip P; Baptista, Maria Joao MJ; Heming, Jan-Niklas JN; Berning, Philipp P; Wullenkord, Ramona R; Erdmann, Tabea T; Lutz, Mathias M; Veratti, Pia P; Ehrenfeld, Sophia S; Wienand, Kirsty K; Horn, Heike H; Goodlad, John R JR; Wilson, Matthew R MR; Anagnostopoulos, Ioannis I; Lamping, Mario M; Gonzalez-Barca, Eva E; Climent, Fina F; Salar, Antonio A; Castellvi, Josep J; Abrisqueta, Pau P; Menarguez, Javier J; Aldamiz, Teresa T; Richter, Julia J; Klapper, Wolfram W; Tzankov, Alexandar A; Dirnhofer, Stefan S; Rosenwald, Andreas A; Mate, José Luis JL; Tapia, Gustavo G; Lenz, Peter P; Miething, Cornelius C; Hartmann, Wolfgang W; Chapuy, Björn B; Fend, Falko F; Ott, German G; Navarro, José-Tomas JT; Grau, Michael M; Lenz, Georg G
Publication Date: 2021-08-31
Variant appearance in text: CYP2A6: 479T>A; L160H; rs1801272
Individualized Drugs' Selection by Evaluation of Drug Properties, Pharmacogenomics and Clinical Parameters: Performance of a Bioinformatic Tool Compared to a Clinically Established Counselling Process.
Pharmacogenomics And Personalized Medicine
Borro, Marina M; Gentile, Giovanna G; Preissner, Sally H SH; Pomes, Leda Marina LM; Gohlke, Björn-Oliver BO; Del Casale, Antonio A; Eckert, Andreas A; Marchetti, Paolo P; Preissner, Saskia S; Preissner, Robert R; Simmaco, Maurizio M
Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study.
International Journal Of Environmental Research And Public Health
Pérez-Rubio, Gloria G; López-Flores, Luis Alberto LA; Cupertino, Ana Paula AP; Cartujano-Barrera, Francisco F; Reynales-Shigematsu, Luz Myriam LM; Ramírez, Mariana M; Ellerbeck, Edward F EF; Rodríguez-Bolaños, Rosibel R; Falfan-Valencia, Ramcés R
Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population.
Diagnostics (Basel, Switzerland)
Pérez-Rubio, Gloria G; Falfán-Valencia, Ramcés R; Fernández-López, Juan Carlos JC; Ramírez-Venegas, Alejandra A; Hernández-Zenteno, Rafael de Jesús RJ; Flores-Trujillo, Fernando F; Silva-Zolezzi, Irma I
Deregulated Immune Pathway Associated with Palbociclib Resistance in Preclinical Breast Cancer Models: Integrative Genomics and Transcriptomics.
Genes
Pandey, Kamal K; Lee, Eunbyeol E; Park, Nahee N; Hur, Jin J; Cho, Young Bin YB; Katuwal, Nar Bahadur NB; Kim, Seung Ki SK; Lee, Seung Ah SA; Kim, Isaac I; An, Hee Jung HJ; Hwang, Sohyun S; Moon, Yong Wha YW
Genetics of 35 blood and urine biomarkers in the UK Biobank.
Nature Genetics
Sinnott-Armstrong, Nasa N; Tanigawa, Yosuke Y; Amar, David D; Mars, Nina N; Benner, Christian C; Aguirre, Matthew M; Venkataraman, Guhan Ram GR; Wainberg, Michael M; Ollila, Hanna M HM; Kiiskinen, Tuomo T; Havulinna, Aki S AS; Pirruccello, James P JP; Qian, Junyang J; Shcherbina, Anna A; , ; Rodriguez, Fatima F; Assimes, Themistocles L TL; Agarwala, Vineeta V; Tibshirani, Robert R; Hastie, Trevor T; Ripatti, Samuli S; Pritchard, Jonathan K JK; Daly, Mark J MJ; Rivas, Manuel A MA
Publication Date: 2021-02
Variant appearance in text: CYP2A6: 479T>A; Leu160His; rs1801272
Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
International Journal Of Medical Sciences
Al-Eitan, Laith N LN; Almasri, Ayah Y AY; Alnaamneh, Adan H AH; Aman, Hatem A HA; Alrabadi, Nasr N NN; Khasawneh, Rame H RH; Alghamdi, Mansour A MA
Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.
Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01
Variant appearance in text: CYP2A6: L160H; rs1801272
Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.
Molecular Psychiatry
Buchwald, Jadwiga J; Chenoweth, Meghan J MJ; Palviainen, Teemu T; Zhu, Gu G; Benner, Christian C; Gordon, Scott S; Korhonen, Tellervo T; Ripatti, Samuli S; Madden, Pamela A F PAF; Lehtimäki, Terho T; Raitakari, Olli T OT; Salomaa, Veikko V; Rose, Richard J RJ; George, Tony P TP; Lerman, Caryn C; Pirinen, Matti M; Martin, Nicholas G NG; Kaprio, Jaakko J; Loukola, Anu A; Tyndale, Rachel F RF
Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.
Molecular Psychiatry
Buchwald, Jadwiga J; Chenoweth, Meghan J MJ; Palviainen, Teemu T; Zhu, Gu G; Benner, Christian C; Gordon, Scott S; Korhonen, Tellervo T; Ripatti, Samuli S; Madden, Pamela A F PAF; Lehtimäki, Terho T; Raitakari, Olli T OT; Salomaa, Veikko V; Rose, Richard J RJ; George, Tony P TP; Lerman, Caryn C; Pirinen, Matti M; Martin, Nicholas G NG; Kaprio, Jaakko J; Loukola, Anu A; Tyndale, Rachel F RF
Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans.
Data In Brief
Boronat, Anna A; Mateus, Julian J; Soldevila-Domenech, Natalia N; Guerra, Mercè M; Rodríguez-Morató, Jose J; Varon, Carlota C; Muñoz, Daniel D; Barbosa, Francina F; Morales, Juan Carlos JC; Gaedigk, Andreas A; Langohr, Klaus K; Covas, Maria-Isabel MI; Pérez-Mañá, Clara C; Fitó, Montserrat M; Tyndale, Rachel F RF; de la Torre, Rafael R
Publication Date: 2019-12
Variant appearance in text: CYP2A6: Leu160His; rs1801272
POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas.
Journal Of The American Heart Association
Calvete, Oriol O; Garcia-Pavia, Pablo P; Domínguez, Fernando F; Mosteiro, Lluc L; Pérez-Cabornero, Lucía L; Cantalapiedra, Diego D; Zorio, Esther E; Ramón Y Cajal, Teresa T; Crespo-Leiro, Maria G MG; Teulé, Álex Á; Lázaro, Conxi C; Morente, Manuel M MM; Urioste, Miguel M; Benitez, Javier J
Association of genetic polymorphisms CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 with tobacco-induced lung Cancer: case-control study in an Egyptian population.
Bmc Cancer
Ezzeldin, Nada N; El-Lebedy, Dalia D; Darwish, Amira A; El Bastawisy, Ahmed A; Abd Elaziz, Shereen Hamdy SH; Hassan, Mirhane Mohamed MM; Saad-Hussein, Amal A
Genetic polymorphisms in very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China: A cohort study in the Zhuang population.
Medicine
Li, Jing J; Guo, Chenghao C; Yan, Mengdan M; Niu, Fanglin F; Chen, Peng P; Li, Bin B; Jin, Tianbo T
Publication Date: 2018-04
Variant appearance in text: CYP2A6: Leu160His; rs1801272
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Nature Communications
Schrader, A A; Crispatzu, G G; Oberbeck, S S; Mayer, P P; Pützer, S S; von Jan, J J; Vasyutina, E E; Warner, K K; Weit, N N; Pflug, N N; Braun, T T; Andersson, E I EI; Yadav, B B; Riabinska, A A; Maurer, B B; Ventura Ferreira, M S MS; Beier, F F; Altmüller, J J; Lanasa, M M; Herling, C D CD; Haferlach, T T; Stilgenbauer, S S; Hopfinger, G G; Peifer, M M; Brümmendorf, T H TH; Nürnberg, P P; Elenitoba-Johnson, K S J KSJ; Zha, S S; Hallek, M M; Moriggl, R R; Reinhardt, H C HC; Stern, M-H MH; Mustjoki, S S; Newrzela, S S; Frommolt, P P; Herling, M M
Publication Date: 2018-02-15
Variant appearance in text: CYP2A6: L160H; rs1801272
Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.
Pharmacogenetics And Genomics
Tanner, Julie-Anne JA; Zhu, Andy Z AZ; Claw, Katrina G KG; Prasad, Bhagwat B; Korchina, Viktoriya V; Hu, Jianhong J; Doddapaneni, HarshaVardhan H; Muzny, Donna M DM; Schuetz, Erin G EG; Lerman, Caryn C; Thummel, Kenneth E KE; Scherer, Steven E SE; Tyndale, Rachel F RF
Data on polymorphisms in CYP2A6 associated to risk and predispose to smoking related variables.
Data In Brief
López-Flores, Luis A LA; Pérez-Rubio, Gloria G; Ramírez-Venegas, Alejandra A; Ambrocio-Ortiz, Enrique E; Sansores, Raúl H RH; Falfán-Valencia, Ramcés R