Publications:

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Genomic complexity predicts resistance to endocrine therapy and CDK4/6 inhibition in hormone receptor-positive (HR+)/HER2-negative metastatic breast cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Davis, Andrew A AA; Luo, Jingqin J; Zheng, Tiantian T; Dai, Chao C; Dong, Xiaoxi X; Tan, Lu L; Suresh, Rama R; Ademuyiwa, Foluso O FO; Rigden, Caron C; Rearden, Timothy P TP; Clifton, Katherine K; Weilbaecher, Katherine K; Frith, Ashley A; Tandra, Pavankumar K PK; Summa, Tracy T; Haas, Brittney B; Thomas, Shana S; Hernandez-Aya, Leonel F LF; Peterson, Lindsay L LL; Wang, Xiaohong X; Luo, Shujun J SJ; Zhou, Kemin K; Du, Pan P; Jia, Shidong S; King, Bonnie L BL; Krishnamurthy, Jairam J; Ma, Cynthia X CX

Publication Date: 2023-01-24

Variant appearance in text: CYP2B6: 136A>G; Met46Val

PubMed Link: 36693175

Variant Present in the following documents:

• ccr-22-2177_supplementary_data_s1_suppds1.xlsx, sheet 3

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Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.

Npj Genomic Medicine

Lanillos, Javier J; Carcajona, Marta M; Maietta, Paolo P; Alvarez, Sara S; Rodriguez-Antona, Cristina C

Publication Date: 2022-02-18

Variant appearance in text: CYP2B6: M46V

PubMed Link: 35181665

Variant Present in the following documents:

• 41525_2022_283_MOESM4_ESM.xlsx, sheet 1
• 41525_2022_283_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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The correlation between the level of 3-hydroxypropyl mercapturic acid, CYP2B6 polymorphisms, and hematuria occurrences after cyclophosphamide administration and its bioanalytical methods: A systematic review.

Heliyon

Harahap, Yahdiana Y; Nurahman, Farhan F; Purwanto, Denni Joko DJ; Yanuar, Arry A

Publication Date: 2021-10

Variant appearance in text: CYP2B6: M46V

PubMed Link: 34746455

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 34621706

Variant Present in the following documents:

• Main text
• tcp-29-135.pdf
• tcp-29-135-s001.xls, sheet 1

View BVdb publication page

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HIV-1 and human genetic variation.

Nature Reviews. Genetics

McLaren, Paul J PJ; Fellay, Jacques J

Publication Date: 2021-10

Variant appearance in text: rs35303484

PubMed Link: 34168330

Variant Present in the following documents:

• Main text

View BVdb publication page

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Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.

Saudi Journal Of Biological Sciences

Aboul-Soud, Mourad A M MAM; Alzahrani, Alhussain J AJ; Mahmoud, Amer A

Publication Date: 2021-01

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 33424349

Variant Present in the following documents:

• mmc1.xlsx, sheet 1

View BVdb publication page

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Variation in 100 relevant pharmacogenes among emiratis with insights from understudied populations.

Scientific Reports

Al-Mahayri, Zeina N ZN; Patrinos, George P GP; Wattanapokayakit, Sukanya S; Iemwimangsa, Nareenart N; Fukunaga, Koya K; Mushiroda, Taisei T; Chantratita, Wasun W; Ali, Bassam R BR

Publication Date: 2020-12-04

Variant appearance in text: rs35303484

PubMed Link: 33277594

Variant Present in the following documents:

• 41598_2020_78231_MOESM1_ESM.pdf

View BVdb publication page

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Pharmacogenomics of methadone: a narrative review of the literature.

Pharmacogenomics

Packiasabapathy, Senthil S; Aruldhas, Blessed W BW; Horn, Nicole N; Overholser, Brian R BR; Quinney, Sara K SK; Renschler, Janelle S JS; Sadhasivam, Senthilkumar S

Publication Date: 2020-08

Variant appearance in text: rs35303484

PubMed Link: 32705966

Variant Present in the following documents:

• Main text

View BVdb publication page

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Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics

Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR

Publication Date: 2021-01

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 32607875

Variant Present in the following documents:

• 40262_2020_913_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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The GenomeAsia 100K Project enables genetic discoveries across Asia.

Nature

,

Publication Date: 2019-12

Variant appearance in text: CYP2B6: 136A>G; rs35303484

PubMed Link: 31802016

Variant Present in the following documents:

• 41586_2019_1793_MOESM3_ESM.xlsx, sheet 19

View BVdb publication page

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Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Medicine

Rospo, Giuseppe G; Lorenzato, Annalisa A; Amirouchene-Angelozzi, Nabil N; Magrì, Alessandro A; Cancelliere, Carlotta C; Corti, Giorgio G; Negrino, Carola C; Amodio, Vito V; Montone, Monica M; Bartolini, Alice A; Barault, Ludovic L; Novara, Luca L; Isella, Claudio C; Medico, Enzo E; Bertotti, Andrea A; Trusolino, Livio L; Germano, Giovanni G; Di Nicolantonio, Federica F; Bardelli, Alberto A

Publication Date: 2019-06-28

Variant appearance in text: CYP2B6: M46V

PubMed Link: 31253177

Variant Present in the following documents:

• 13073_2019_654_MOESM2_ESM.xlsx, sheet 3

View BVdb publication page

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The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

British Journal Of Clinical Pharmacology

Helsby, N A NA; Yong, M M; van Kan, M M; de Zoysa, J R JR; Burns, K E KE

Publication Date: 2019-09

Variant appearance in text: rs35303484

PubMed Link: 31218720

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted next generation sequencing as a tool for precision medicine.

Bmc Medical Genomics

Gulilat, Markus M; Lamb, Tyler T; Teft, Wendy A WA; Wang, Jian J; Dron, Jacqueline S JS; Robinson, John F JF; Tirona, Rommel G RG; Hegele, Robert A RA; Kim, Richard B RB; Schwarz, Ute I UI

Publication Date: 2019-06-03

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 31159795

Variant Present in the following documents:

• 12920_2019_527_MOESM1_ESM.xlsx, sheet 6

View BVdb publication page

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Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics.

Biochemical Pharmacology

Ahmad, Taha T; Valentovic, Monica A MA; Rankin, Gary O GO

Publication Date: 2018-07

Variant appearance in text: CYP2B6: 136A>G; M46V; rs35303484

PubMed Link: 29458047

Variant Present in the following documents:

• Main text

View BVdb publication page

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Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia.

Scientific Reports

Zakerska-Banaszak, Oliwia O; Skrzypczak-Zielinska, Marzena M; Tamowicz, Barbara B; Mikstacki, Adam A; Walczak, Michal M; Prendecki, Michal M; Dorszewska, Jolanta J; Pollak, Agnieszka A; Lechowicz, Urszula U; Oldak, Monika M; Huminska-Lisowska, Kinga K; Molinska-Glura, Marta M; Szalata, Marlena M; Slomski, Ryszard R

Publication Date: 2017-11-13

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 29133890

Variant Present in the following documents:

• Main text
• 41598_2017_Article_15657.pdf

View BVdb publication page

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Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin.

Plos One

Soeria-Atmadja, Sandra S; Österberg, Emma E; Gustafsson, Lars L LL; Dahl, Marja-Liisa ML; Eriksen, Jaran J; Rubin, Johanna J; Navér, Lars L

Publication Date: 2017

Variant appearance in text: rs35303484

PubMed Link: 28886044

Variant Present in the following documents:

• Main text
• pone.0181316.pdf

View BVdb publication page

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Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

Clinical Pharmacology And Therapeutics

Zhou, Y Y; Ingelman-Sundberg, M M; Lauschke, V M VM

Publication Date: 2017-10

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 28378927

Variant Present in the following documents:

• Main text
• CPT-102-688.pdf

View BVdb publication page

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2

View BVdb publication page

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The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine.

Genome Medicine

Garofalo, Andrea A; Sholl, Lynette L; Reardon, Brendan B; Taylor-Weiner, Amaro A; Amin-Mansour, Ali A; Miao, Diana D; Liu, David D; Oliver, Nelly N; MacConaill, Laura L; Ducar, Matthew M; Rojas-Rudilla, Vanesa V; Giannakis, Marios M; Ghazani, Arezou A; Gray, Stacy S; Janne, Pasi P; Garber, Judy J; Joffe, Steve S; Lindeman, Neal N; Wagle, Nikhil N; Garraway, Levi A LA; Van Allen, Eliezer M EM

Publication Date: 2016-07-26

Variant appearance in text: CYP2B6: 136A>G; M46V; rs35303484

PubMed Link: 27460824

Variant Present in the following documents:

• 13073_2016_333_MOESM5_ESM.xlsx, sheet 1

View BVdb publication page

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Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

Drug Metabolism And Pharmacokinetics

Cho, Doo-Yeoun DY; Shen, Joan H Q JH; Lemler, Suzanne M SM; Skaar, Todd C TC; Li, Lang L; Blievernicht, Julia J; Zanger, Ulrich M UM; Kim, Kwon-Bok KB; Shin, Jae-Gook JG; Flockhart, David A DA; Desta, Zeruesenay Z

Publication Date: 2016-04

Variant appearance in text: CYP2B6: M46V

PubMed Link: 27053325

Variant Present in the following documents:

• Main text

View BVdb publication page

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An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients.

Frontiers In Genetics

Swart, Marelize M; Evans, Jonathan J; Skelton, Michelle M; Castel, Sandra S; Wiesner, Lubbe L; Smith, Peter J PJ; Dandara, Collet C

Publication Date: 2015

Variant appearance in text: CYP2B6: 136A>G; rs35303484

PubMed Link: 26779253

Variant Present in the following documents:

• Main text
• fgene-06-00356.pdf

View BVdb publication page

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs35303484

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

View BVdb publication page

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Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis.

Ebiomedicine

Cummins, Nathan W NW; Neuhaus, Jacqueline J; Chu, Haitao H; Neaton, James J; Wyen, Christoph C; Rockstroh, Jürgen K JK; Skiest, Daniel J DJ; Boyd, Mark A MA; Khoo, Saye S; Rotger, Margalida M; Telenti, Amalio A; Weinshilboum, Richard R; Badley, Andrew D AD; ,

Publication Date: 2015-07

Variant appearance in text: rs35303484

PubMed Link: 26288843

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: CYP2B6: M46V

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 4

View BVdb publication page

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PharmGKB summary: Efavirenz pathway, pharmacokinetics.

Pharmacogenetics And Genomics

McDonagh, Ellen M EM; Lau, Johnathan L JL; Alvarellos, Maria L ML; Altman, Russ B RB; Klein, Teri E TE

Publication Date: 2015-07

Variant appearance in text: CYP2B6: 136A>G; rs35303484

PubMed Link: 25966836

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs35303484

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

View BVdb publication page

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Whole-genome sequencing of the world's oldest people.

Plos One

Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK

Publication Date: 2014

Variant appearance in text: CYP2B6: M46V

PubMed Link: 25390934

Variant Present in the following documents:

• pone.0112430.s004.xlsx, sheet 1

View BVdb publication page

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A probabilistic model to predict clinical phenotypic traits from genome sequencing.

Plos Computational Biology

Chen, Yun-Ching YC; Douville, Christopher C; Wang, Cheng C; Niknafs, Noushin N; Yeo, Grace G; Beleva-Guthrie, Violeta V; Carter, Hannah H; Stenson, Peter D PD; Cooper, David N DN; Li, Biao B; Mooney, Sean S; Karchin, Rachel R

Publication Date: 2014-09

Variant appearance in text: CYP2B6: M46V

PubMed Link: 25188385

Variant Present in the following documents:

• pcbi.1003825.s014.xlsx, sheet 1

View BVdb publication page

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs35303484

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

View BVdb publication page

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Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine.

Colombia Medica (Cali, Colombia)

Isaza, Carlos C; Henao, Julieta J; Beltrán, Leonardo L; Porras, Liliana L; Gonzalez, Martha M; Cruz, Raquel R; Carracedo, Angel A

Publication Date: 2013-01

Variant appearance in text: rs35303484

PubMed Link: 24892317

Variant Present in the following documents:

• Main text

View BVdb publication page

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Evaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulation.

Plos One

Kobayashi, Kana K; Takahashi, Ohgi O; Hiratsuka, Masahiro M; Yamaotsu, Noriyuki N; Hirono, Shuichi S; Watanabe, Yurie Y; Oda, Akifumi A

Publication Date: 2014

Variant appearance in text: CYP2B6: Met46Val

PubMed Link: 24796891

Variant Present in the following documents:

• Main text
• pone.0096789.pdf

View BVdb publication page

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Pharmacogenetic-based efavirenz dose modification: suggestions for an African population and the different CYP2B6 genotypes.

Plos One

Mukonzo, Jackson K JK; Owen, Joel S JS; Ogwal-Okeng, Jasper J; Kuteesa, Ronald B RB; Nanzigu, Sarah S; Sewankambo, Nelson N; Thabane, Lehana L; Gustafsson, Lars L LL; Ross, Colin C; Aklillu, Eleni E

Publication Date: 2014

Variant appearance in text:

PubMed Link: 24497997

Variant Present in the following documents:

• Main text

View BVdb publication page

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CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes.

Plos One

Bloom, A Joseph AJ; Martinez, Maribel M; Chen, Li-Shiun LS; Bierut, Laura J LJ; Murphy, Sharon E SE; Goate, Alison A

Publication Date: 2013

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 24260284

Variant Present in the following documents:

• Main text
• pone.0079700.pdf

View BVdb publication page

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Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy.

Plos One

Glass, Tracy R TR; Rotger, Margalida M; Telenti, Amalio A; Decosterd, Laurent L; Csajka, Chantal C; Bucher, Heiner C HC; Günthard, Huldrych F HF; Rickenbach, Martin M; Nicca, Dunja D; Hirschel, Bernard B; Bernasconi, Enos E; Wandeler, Gilles G; Battegay, Manuel M; Marzolini, Catia C; ,

Publication Date: 2012

Variant appearance in text: rs35303484

PubMed Link: 22235271

Variant Present in the following documents:

• Main text
• pone.0029186.pdf

View BVdb publication page

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Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267.

Journal Of Acquired Immune Deficiency Syndromes (1999)

Dooley, Kelly E KE; Park, Jeong-Gun JG; Swindells, Susan S; Allen, Reena R; Haas, David W DW; Cramer, Yoninah Y; Aweeka, Francesca F; Wiggins, Ilene I; Gupta, Amita A; Lizak, Patricia P; Qasba, Sonia S; van Heeswijk, Rolf R; Flexner, Charles C; ,

Publication Date: 2012-04-15

Variant appearance in text: rs35303484

PubMed Link: 22126739

Variant Present in the following documents:

• Main text

View BVdb publication page

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CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

Addiction Biology

Levran, Orna O; Peles, Einat E; Hamon, Sara S; Randesi, Matthew M; Adelson, Miriam M; Kreek, Mary Jeanne MJ

Publication Date: 2013-07

Variant appearance in text: CYP2B6: M46V; rs35303484

PubMed Link: 21790905

Variant Present in the following documents:

• Main text

View BVdb publication page

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Analysis of pharmacogenetic traits in two distinct South African populations.

Human Genomics

Ikediobi, Ogechi O; Aouizerat, Bradley B; Xiao, Yuanyuan Y; Gandhi, Monica M; Gebhardt, Stefan S; Warnich, Louise L

Publication Date: 2011-05

Variant appearance in text: rs35303484

PubMed Link: 21712189

Variant Present in the following documents:

• Main text

View BVdb publication page

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Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.

The Journal Of Infectious Diseases

Lubomirov, Rubin R; Colombo, Sara S; di Iulio, Julia J; Ledergerber, Bruno B; Martinez, Raquel R; Cavassini, Matthias M; Hirschel, Bernard B; Bernasconi, Enos E; Elzi, Luigia L; Vernazza, Pietro P; Furrer, Hansjakob H; Günthard, Huldrych F HF; Telenti, Amalio A; ,

Publication Date: 2011-01-15

Variant appearance in text: rs35303484

PubMed Link: 21288825

Variant Present in the following documents:

• Main text

View BVdb publication page

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A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.

British Journal Of Clinical Pharmacology

Mukonzo, Jackson K JK; Röshammar, Daniel D; Waako, Paul P; Andersson, Maria M; Fukasawa, Takashi T; Milani, Lili L; Svensson, Jan Olof JO; Ogwal-Okeng, Jasper J; Gustafsson, Lars L LL; Aklillu, Eleni E

Publication Date: 2009-11

Variant appearance in text: rs35303484

PubMed Link: 19916993

Variant Present in the following documents:

• Main text

View BVdb publication page

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Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.

Drug Metabolism And Disposition: The Biological Fate Of Chemicals

Talakad, Jyothi C JC; Kumar, Santosh S; Halpert, James R JR

Publication Date: 2009-03

Variant appearance in text: CYP2B6: M46V

PubMed Link: 19074527

Variant Present in the following documents:

• Main text

View BVdb publication page

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