Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study.
Aids Research And Therapy
Buzibye, Allan A; Wools-Kaloustian, Kara K; Olagunju, Adeniyi A; Twinomuhwezi, Ellon E; Yiannoutsos, Constantin C; Owen, Andrew A; Neary, Megan M; Matovu, Joshua J; Banturaki, Grace G; Castelnuovo, Barbara B; Lamorde, Mohammed M; Khoo, Saye S; Waitt, Catriona C; Kiragga, Agnes A
Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain.
Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing
Keat, Karl K; Hui, Daniel D; Xiao, Brenda B; Bradford, Yuki Y; Cindi, Zinhle Z; Daar, Eric S ES; Gulick, Roy R; Riddler, Sharon A SA; Sinxadi, Phumla P; Haas, David W DW; Ritchie, Marylyn D MD
Impact of genetic variants in the nicotine metabolism pathway on nicotine metabolite levels in smokers.
Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Perez-Paramo, Yadira X YX; Watson, Christy J W CJW; Chen, Gang G; Thomas, Claire E CE; Adams-Haduch, Jennifer J; Wang, Renwei R; Khor, Chiea Chuen CC; Koh, Woon-Puay WP; Nelson, Heather H HH; Yuan, Jian-Min JM; Lazarus, Philip P
Next-generation whole exome sequencing to delineate the genetic basis of primary congenital glaucoma.
Scientific Reports
Rauf, Bushra B; Khan, Shahid Y SY; Jiao, Xiaodong X; Irum, Bushra B; Ashfaq, Ramla R; Zehra, Mubashra M; Khan, Asma A AA; Naeem, Muhammad Asif MA; Shahzad, Mohsin M; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA
Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.
Frontiers In Pharmacology
Silgado-Guzmán, Daniel Felipe DF; Angulo-Aguado, Mariana M; Morel, Adrien A; Niño-Orrego, María José MJ; Ruiz-Torres, Daniel-Armando DA; Contreras Bravo, Nora Constanza NC; Restrepo, Carlos Martin CM; Ortega-Recalde, Oscar O; Fonseca-Mendoza, Dora Janeth DJ
A Prognostic and Carboplatin Response Predictive Model in Ovarian Cancer: A Mono-Institutional Retrospective Study Based on Clinics and Pharmacogenomics.
Biomedicines
Staropoli, Nicoletta N; Arbitrio, Mariamena M; Salvino, Angela A; Scionti, Francesca F; Ciliberto, Domenico D; Ingargiola, Rossana R; Labanca, Caterina C; Agapito, Giuseppe G; Iuliano, Eleonora E; Barbieri, Vito V; Cucè, Maria M; Zuccalà, Valeria V; Cannataro, Mario M; Tassone, Pierfrancesco P; Tagliaferri, Pierosandro P
Effects of Cytochrome P450 and Transporter Polymorphisms on the Bioavailability and Safety of Dutasteride and Tamsulosin.
Frontiers In Pharmacology
Villapalos-García, Gonzalo G; Zubiaur, Pablo P; Navares-Gómez, Marcos M; Saiz-Rodríguez, Miriam M; Mejía-Abril, Gina G; Martín-Vílchez, Samuel S; Román, Manuel M; Ochoa, Dolores D; Abad-Santos, Francisco F
Variants in COMT, CYP3A5, CYP2B6, and ABCG2 Alter Quetiapine Pharmacokinetics.
Pharmaceutics
Zubiaur, Pablo P; Fernández-Campos, Paula P; Navares-Gómez, Marcos M; Soria-Chacartegui, Paula P; Villapalos-García, Gonzalo G; Román, Manuel M; Mejía-Abril, Gina G; Ochoa, Dolores D; Abad-Santos, Francisco F
PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics.
Journal Of Clinical Medicine
Zubiaur, Pablo P; Mejía-Abril, Gina G; Navares-Gómez, Marcos M; Villapalos-García, Gonzalo G; Soria-Chacartegui, Paula P; Saiz-Rodríguez, Miriam M; Ochoa, Dolores D; Abad-Santos, Francisco F
Dexketoprofen Pharmacokinetics is not Significantly Altered by Genetic Polymorphism.
Frontiers In Pharmacology
Mejía-Abril, Gina G; Zubiaur, Pablo P; Navares-Gómez, Marcos M; Villapalos-García, Gonzalo G; Román, Manuel M; Ochoa, Dolores D; Abad-Santos, Francisco F
Pharmacogenetic predictors of nevirapine pharmacokinetics in Ghanaian children living with HIV with or without TB coinfection.
Infection, Genetics And Evolution : Journal Of Molecular Epidemiology And Evolutionary Genetics In Infectious Diseases
Langaee, Taimour T; Al-Shaer, Mohammad H MH; Gong, Yan Y; Lima, Elizabeth E; Antwi, Sampson S; Enimil, Anthony A; Dompreh, Albert A; Yang, Hongmei H; Alghamdi, Wael A WA; Wiesner, Lubbe L; Peloquin, Charles A CA; Kwara, Awewura A
SLCO1B1 Phenotype and CYP3A5 Polymorphism Significantly Affect Atorvastatin Bioavailability.
Journal Of Personalized Medicine
Zubiaur, Pablo P; Benedicto, Maria Dolores MD; Villapalos-García, Gonzalo G; Navares-Gómez, Marcos M; Mejía-Abril, Gina G; Román, Manuel M; Martín-Vílchez, Samuel S; Ochoa, Dolores D; Abad-Santos, Francisco F
Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities.
Frontiers In Pharmacology
Hurkmans, Evelien G E EGE; Klumpers, Marije J MJ; Vermeulen, Sita H SH; Hagleitner, Melanie M MM; Flucke, Uta U; Schreuder, H W Bart HWB; Gelderblom, Hans H; Bras, Johannes J; Guchelaar, Henk-Jan HJ; Coenen, Marieke J H MJH; Te Loo, D Maroeska W M DMWM
Efavirenz Pharmacogenetics and Weight Gain Following Switch to Integrase Inhibitor-Containing Regimens.
Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Leonard, Michael A MA; Cindi, Zinhle Z; Bradford, Yuki Y; Bourgi, Kassem K; Koethe, John J; Turner, Megan M; Norwood, Jamison J; Woodward, Beverly B; Erdem, Husamettin H; Basham, Rebecca R; Baker, Paxton P; Rebeiro, Peter F PF; Sterling, Timothy R TR; Hulgan, Todd T; Daar, Eric S ES; Gulick, Roy R; Riddler, Sharon A SA; Sinxadi, Phumla P; Ritchie, Marylyn D MD; Haas, David W DW
Pharmacogenomics of methadone: a narrative review of the literature.
Pharmacogenomics
Packiasabapathy, Senthil S; Aruldhas, Blessed W BW; Horn, Nicole N; Overholser, Brian R BR; Quinney, Sara K SK; Renschler, Janelle S JS; Sadhasivam, Senthilkumar S
Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.
Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Pharmacogenetic interactions between antiretroviral drugs and vaginally administered hormonal contraceptives.
Pharmacogenetics And Genomics
Haas, David W DW; Cramer, Yoninah S YS; Godfrey, Catherine C; Rosenkranz, Susan L SL; Aweeka, Francesca F; Berzins, Baiba B; Coombs, Robert R; Coughlin, Kristine K; Moran, Laura E LE; Gingrich, David D; Zorrilla, Carmen D CD; Baker, Paxton P; Cohn, Susan E SE; Scarsi, Kimberly K KK; ,
Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study.
Cancers
Altieri, Barbara B; Sbiera, Silviu S; Herterich, Sabine S; De Francia, Silvia S; Della Casa, Silvia S; Calabrese, Anna A; Pontecorvi, Alfredo A; Quinkler, Marcus M; Kienitz, Tina T; Mannelli, Massimo M; Canu, Letizia L; Angelousi, Anna A; Chortis, Vasileios V; Kroiss, Matthias M; Terzolo, Massimo M; Fassnacht, Martin M; Ronchi, Cristina L CL
Publication Date: 2020-02-04
Variant appearance in text: CYP2B6: 485-18C>T; rs4803419
Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients.
European Heart Journal. Cardiovascular Pharmacotherapy
Lewis, Joshua P JP; Backman, Joshua D JD; Reny, Jean-Luc JL; Bergmeijer, Thomas O TO; Mitchell, Braxton D BD; Ritchie, Marylyn D MD; Déry, Jean-Pierre JP; Pakyz, Ruth E RE; Gong, Li L; Ryan, Kathleen K; Kim, Eun-Young EY; Aradi, Daniel D; Fernandez-Cadenas, Israel I; Lee, Ming Ta Michael MTM; Whaley, Ryan M RM; Montaner, Joan J; Gensini, Gian Franco GF; Cleator, John H JH; Chang, Kiyuk K; Holmvang, Lene L; Hochholzer, Willibald W; Roden, Dan M DM; Winter, Stefan S; Altman, Russ B RB; Alexopoulos, Dimitrios D; Kim, Ho-Sook HS; Gawaz, Meinrad M; Bliden, Kevin P KP; Valgimigli, Marco M; Marcucci, Rossella R; Campo, Gianluca G; Schaeffeler, Elke E; Dridi, Nadia P NP; Wen, Ming-Shien MS; Shin, Jae Gook JG; Fontana, Pierre P; Giusti, Betti B; Geisler, Tobias T; Kubo, Michiaki M; Trenk, Dietmar D; Siller-Matula, Jolanta M JM; Ten Berg, Jurriën M JM; Gurbel, Paul A PA; Schwab, Matthias M; Klein, Teri E TE; Shuldiner, Alan R AR; ,
A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.
Aids (London, England)
Patel, Rena C RC; Stalter, Randy M RM; Thomas, Katherine K KK; Tamraz, Bani B; Blue, Steven W SW; Erikson, David W DW; Kim, Christina J CJ; Kelly, Edward J EJ; Nanda, Kavita K; Kourtis, Athena P AP; Lingappa, Jairam R JR; Mugo, Nelly N; Baeten, Jared M JM; Scarsi, Kimberly K KK; ,
Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.
The Journal Of Antimicrobial Chemotherapy
Neary, Megan M; Chappell, Catherine A CA; Scarsi, Kimberly K KK; Nakalema, Shadia S; Matovu, Joshua J; Achilles, Sharon L SL; Chen, Beatrice A BA; Siccardi, Marco M; Owen, Andrew A; Lamorde, Mohammed M
Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.
The Journal Of Antimicrobial Chemotherapy
Alghamdi, Wael A WA; Antwi, Sampson S; Enimil, Anthony A; Yang, Hongmei H; Dompreh, Albert A; Wiesner, Lubbe L; Langaee, Taimour T; Peloquin, Charles A CA; Kwara, Awewura A
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.
Clinical Pharmacology And Therapeutics
Desta, Zeruesenay Z; Gammal, Roseann S RS; Gong, Li L; Whirl-Carrillo, Michelle M; Gaur, Aditya H AH; Sukasem, Chonlaphat C; Hockings, Jennifer J; Myers, Alan A; Swart, Marelize M; Tyndale, Rachel F RF; Masimirembwa, Collen C; Iwuchukwu, Otito F OF; Chirwa, Sanika S; Lennox, Jeffrey J; Gaedigk, Andrea A; Klein, Teri E TE; Haas, David W DW
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.
Cell Death & Disease
Grassi, Ludovica L; Alfonsi, Romina R; Francescangeli, Federica F; Signore, Michele M; De Angelis, Maria Laura ML; Addario, Antonio A; Costantini, Manuela M; Flex, Elisabetta E; Ciolfi, Andrea A; Pizzi, Simone S; Bruselles, Alessandro A; Pallocca, Matteo M; Simone, Giuseppe G; Haoui, Mustapha M; Falchi, Mario M; Milella, Michele M; Sentinelli, Steno S; Di Matteo, Paola P; Stellacci, Emilia E; Gallucci, Michele M; Muto, Giovanni G; Tartaglia, Marco M; De Maria, Ruggero R; Bonci, Désirée D
A likely pathogenic variant putatively affecting splicing of PIGA identified in a multiple congenital anomalies hypotonia-seizures syndrome 2 (MCAHS2) family pedigree via whole-exome sequencing.
CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies.
Aids Research And Human Retroviruses
Chang, Jonathan L JL; Lee, Sulggi A SA; Tsai, Alexander C AC; Musinguzi, Nicholas N; Muzoora, Conrad C; Bwana, Bosco B; Boum, Yap Y; Haberer, Jessica E JE; Hunt, Peter W PW; Martin, Jeff J; Bangsberg, David R DR; Kroetz, Deanna L DL; Siedner, Mark J MJ
Drug metabolism and transport gene polymorphisms and efavirenz adverse effects in Brazilian HIV-positive individuals.
The Journal Of Antimicrobial Chemotherapy
de Almeida, Tailah Bernardo TB; de Azevedo, Marcelo Costa Velho Mendes MCVM; Pinto, Jorge Francisco da Cunha JFDC; Ferry, Fernando Rafael de Almeida FRA; da Silva, Guilherme Almeida Rosa GAR; de Castro, Izana Junqueira IJ; Baker, Paxton P; Tanuri, Amilcar A; Haas, David W DW; Cardoso, Cynthia C CC
Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.
The Pharmacogenomics Journal
Vujkovic, Marijana M; Bellamy, Scarlett L SL; Zuppa, Athena F AF; Gastonguay, Marc R MR; Moorthy, Ganesh S GS; Ratshaa, Bakgaki B; Han, Xiaoyan X; Steenhoff, Andrew P AP; Mosepele, Mosepele M; Strom, Brian L BL; Bisson, Gregory P GP; Aplenc, Richard R; Gross, Robert R