Variant ID: 19-41512841-G-A

NM_000767.4(CYP2B6):c.516G>A;(p.Gln172Gln)

This variant was identified in 177 publications




Publications:


Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study.

Bmc Medicine
RM Turner, EM de Koning, V Fontana, A Thompson, M Pirmohamed
Publication Date: 2020-11-25

Variant appearance in text: rs3745274
PubMed Link: 33234119
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450.

Journal Of Personalized Medicine
V Hlaváč, P Holý, P Souček
Publication Date: 2020-08-28

Variant appearance in text: rs3745274
PubMed Link: 32872162
Variant Present in the following documents:
  • Main text
View BVdb publication page



Analysis of Comprehensive Pharmacogenomic Profiling of VIP Variants Among the Genetically Isolated Chechen Subpopulation from Jordan.

Pharmacogenomics And Personalized Medicine
LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 32765042
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.

International Journal Of Molecular Sciences
CM Hattinger, MP Patrizio, S Luppi, M Serra
Publication Date: 2020-06-30

Variant appearance in text: rs3745274
PubMed Link: 32629971
Variant Present in the following documents:
  • Main text
View BVdb publication page



Minding the gap in HIV host genetics: opportunities and challenges.

Human Genetics
SN Gingras, D Tang, J Tuff, PJ McLaren
Publication Date: 2020-06

Variant appearance in text: rs3745274
PubMed Link: 32409920
Variant Present in the following documents:
  • Main text
View BVdb publication page



Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy.

Frontiers In Pharmacology
ZN Al-Mahayri, GP Patrinos, BR Ali
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 32351390
Variant Present in the following documents:
  • Main text
View BVdb publication page



Toward precision prescribing for methadone: Determinants of methadone deposition.

Plos One
AH Talal, Y Ding, CS Venuto, LM Chakan, A McLeod, A Dharia, GD Morse, LS Brown, M Markatou, ED Kharasch
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 32302325
Variant Present in the following documents:
  • Main text
View BVdb publication page



Importance of genetic polymorphisms in liver transplantation outcomes.

World Journal Of Gastroenterology
T Kelava, P Turcic, A Markotic, A Ostojic, D Sisl, A Mrzljak
Publication Date: 2020-03-28

Variant appearance in text: rs3745274
PubMed Link: 32256016
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration.

Ja Clinical Reports
A Fujita, K Hayamizu, T Yoshihara, M Zaitsu, F Shiraishi, H Arima, K Matsuo, K Shiokawa, H Setoguchi, T Sasaguri
Publication Date: 2018-08-13

Variant appearance in text: rs3745274
PubMed Link: 32025958
Variant Present in the following documents:
  • Main text
View BVdb publication page



Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.

Plos One
T Ahsan, NJ Urmi, AA Sajib
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 31971968
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan.

Journal Of Personalized Medicine
LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani
Publication Date: 2020-01-06

Variant appearance in text: rs3745274
PubMed Link: 31935801
Variant Present in the following documents:
  • Main text
View BVdb publication page



Adverse Drug Reactions Associated with CYP 2B6 Polymorphisms in HIV/AIDS-Treated Patients in Yaoundé, Cameroon.

The Application Of Clinical Genetics
C Nguefeu Nkenfou, B Atogho Tiedeu, C Nguefeu Nkenfou, AM Nji, JP Chedjou, C Tah Fomboh, C Kouanfack, WF Mbacham
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31920362
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial.

Scientific Reports
M Gómez-Silva, E Piñeyro-Garza, R Vargas-Zapata, ME Gamino-Peña, A León-García, MB de León, A Llerena, RBR León-Cachón
Publication Date: 2019-11-28

Variant appearance in text: rs3745274
PubMed Link: 31780765
Variant Present in the following documents:
  • 41598_2019_Article_54436.pdf
  • aaaaaMain text
View BVdb publication page



Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?

Pharmaceutics
Y Cazaubon, Y Talineau, C Feliu, C Konecki, J Russello, O Mathieu, Z Djerada
Publication Date: 2019-10-31

Variant appearance in text: rs3745274
PubMed Link: 31683663
Variant Present in the following documents:
  • Main text
  • pharmaceutics-11-00566.pdf
View BVdb publication page



Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.

Frontiers In Pharmacology
V Gonzalez-Covarrubias, M Morales-Franco, OF Cruz-Correa, A Martínez-Hernández, H García-Ortíz, F Barajas-Olmos, AD Genis-Mendoza, JJ Martínez-Magaña, H Nicolini, L Orozco, X Soberón
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31649539
Variant Present in the following documents:
  • Main text
  • fphar-10-01169.pdf
View BVdb publication page



CYP2B6 genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population.

International Journal Of Chronic Obstructive Pulmonary Disease
Y Ding, Q Li, Q Feng, D Xu, C Wu, J Zhao, X Zhou, Y Yang, H Niu, P He, L Xing
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31564857
Variant Present in the following documents:
  • Main text
View BVdb publication page



Potential role of pharmacogenomics testing in the setting of enhanced recovery pathways after surgery.

Pharmacogenomics And Personalized Medicine
H Awad, A Ahmed, RD Urman, N Stoicea, SD Bergese
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31440074
Variant Present in the following documents:
  • pgpm-12-145.pdf
View BVdb publication page



Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.

Antimicrobial Agents And Chemotherapy
A Enimil, S Antwi, H Yang, A Dompreh, WA Alghamdi, FS Gillani, A Orstin, D Bosomtwe, T Opoku, J Norman, L Wiesner, T Langaee, CA Peloquin, MH Court, DJ Greenblatt, A Kwara
Publication Date: 2019-10

Variant appearance in text: rs3745274
PubMed Link: 31332062
Variant Present in the following documents:
  • Main text
View BVdb publication page



Use of Pharmacogenetic Drugs by the Dutch Population.

Frontiers In Genetics
MA Alshabeeb, VHM Deneer, A Khan, FW Asselbergs
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31312209
Variant Present in the following documents:
  • Main text
View BVdb publication page



A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.

Aids (London, England)
RC Patel, RM Stalter, KK Thomas, B Tamraz, SW Blue, DW Erikson, CJ Kim, EJ Kelly, K Nanda, AP Kourtis, JR Lingappa, N Mugo, JM Baeten, KK Scarsi,
Publication Date: 2019-11-01

Variant appearance in text: rs3745274
PubMed Link: 31306173
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.

The Journal Of Antimicrobial Chemotherapy
M Neary, CA Chappell, KK Scarsi, S Nakalema, J Matovu, SL Achilles, BA Chen, M Siccardi, A Owen, M Lamorde
Publication Date: 2019-10-01

Variant appearance in text: rs3745274
PubMed Link: 31299074
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.

The Journal Of Antimicrobial Chemotherapy
WA Alghamdi, S Antwi, A Enimil, H Yang, A Dompreh, L Wiesner, T Langaee, CA Peloquin, A Kwara
Publication Date: 2019-09-01

Variant appearance in text: rs3745274
PubMed Link: 31243456
Variant Present in the following documents:
  • Main text
View BVdb publication page



Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years.

Journal Of Acquired Immune Deficiency Syndromes (1999)
M Bwakura Dangarembizi, P Samson, EV Capparelli, CB Moore, P Jean-Philippe, SA Spector, N Chakhtoura, A Benns, B Zimmer, L Purdue, C Jackson, C Wallis, JL Libous, EG Chadwick,
Publication Date: 2019-08-01

Variant appearance in text: rs3745274
PubMed Link: 31241542
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics of Nicotine Metabolism: Novel CYP2A6 and CYP2B6 Genetic Variation Patterns in Alaska Native and American Indian Populations.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco
KG Claw, JA Beans, SB Lee, JP Avey, PA Stapleton, SE Scherer, A El-Boraie, RF Tyndale, DA Nickerson, DA Dillard, KE Thummel, RF Robinson
Publication Date: 2020-05-26

Variant appearance in text: rs3745274
PubMed Link: 31241144
Variant Present in the following documents:
  • Main text
View BVdb publication page



The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

British Journal Of Clinical Pharmacology
NA Helsby, M Yong, M van Kan, JR de Zoysa, KE Burns
Publication Date: 2019-09

Variant appearance in text: rs3745274
PubMed Link: 31218720
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes.

Pharmacogenetics And Genomics
S Tshabalala, A Choudhury, N Beeton-Kempen, N Martinson, M Ramsay, D Mancama
Publication Date: 2019-09

Variant appearance in text: rs3745274
PubMed Link: 31162291
Variant Present in the following documents:
  • Main text
  • pgen-29-167-s003.xlsx
  • pgen-29-167.pdf
View BVdb publication page



CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients.

Frontiers In Pharmacology
JH Ahmed, E Makonnen, G Yimer, D Seifu, A Bekele, M Assefa, A Aseffa, R Howe, A Fotoohi, M Hassan, E Aklillu
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31139078
Variant Present in the following documents:
  • Main text
View BVdb publication page



Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity.

Genes
P Crocco, A Montesanto, S Dato, S Geracitano, F Iannone, G Passarino, G Rose
Publication Date: 2019-05-27

Variant appearance in text: rs3745274
PubMed Link: 31137904
Variant Present in the following documents:
  • Main text
View BVdb publication page



Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans.

Southern African Journal Of Hiv Medicine
J Johnston, L Wiesner, P Smith, G Maartens, C Orrell
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31061724
Variant Present in the following documents:
  • Main text
View BVdb publication page



Secondary actionable findings identified by exome sequencing: expected impact on the organisation of care from the study of 700 consecutive tests.

European Journal Of Human Genetics : Ejhg
C Thauvin-Robinet, J Thevenon, S Nambot, J Delanne, P Kuentz, AL Bruel, A Chassagne, E Cretin, A Pelissier, C Peyron, E Gautier, D Lehalle, N Jean-Marçais, P Callier, AL Mosca-Boidron, A Vitobello, A Sorlin, F Tran Mau-Them, C Philippe, P Vabres, L Demougeot, C Poé, T Jouan, M Chevarin, M Lefebvre, M Bardou, E Tisserant, M Luu, C Binquet, JF Deleuze, C Verstuyft, Y Duffourd, L Faivre
Publication Date: 2019-08

Variant appearance in text: rs3745274
PubMed Link: 31019283
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China.

Molecular Genetics & Genomic Medicine
C Zhang, W Guo, Y Cheng, Q Li, X Yang, R Dai, L Zhu, W Chen
Publication Date: 2019-05

Variant appearance in text: rs3745274
PubMed Link: 30955239
Variant Present in the following documents:
  • Main text
View BVdb publication page



Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL study.

British Journal Of Clinical Pharmacology
C Victorri-Vigneau, C Verstuyft, R Bouquié, EJ Laforgue, JB Hardouin, J Leboucher, B Le Geay, C Dano, G Challet-Bouju, M Grall-Bronnec
Publication Date: 2019-07

Variant appearance in text: rs3745274
PubMed Link: 30907440
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Lower Dose of Efavirenz Can Be Coadministered With Rifampicin and Isoniazid in Tuberculosis Patients.

Open Forum Infectious Diseases
JP Kaboggoza, X Wang, M Neary, P Ayuso, C Sekaggya-Wiltshire, S Nakalema, A Owen, M McClure, M Lamorde, M Boffito
Publication Date: 2019-02

Variant appearance in text: rs3745274
PubMed Link: 30815503
Variant Present in the following documents:
  • Main text
View BVdb publication page



No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein.

Clinical Pharmacology And Therapeutics
C Zahner, E Kruttschnitt, J Uricher, M Lissy, M Hirsch, S Nicolussi, S Krähenbühl, J Drewe
Publication Date: 2019-08

Variant appearance in text: rs3745274
PubMed Link: 30739325
Variant Present in the following documents:
  • CPT-106-432-s003.docx
View BVdb publication page



Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites.

The Journal Of Antimicrobial Chemotherapy
EH Decloedt, PZ Sinxadi, GU van Zyl, L Wiesner, S Khoo, JA Joska, DW Haas, G Maartens
Publication Date: 2019-03-01

Variant appearance in text: rs3745274
PubMed Link: 30535366
Variant Present in the following documents:
  • Main text
  • dky481.pdf
View BVdb publication page



CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis.

Systematic Reviews
M Richardson, J Kirkham, K Dwan, DJ Sloan, G Davies, AL Jorgensen
Publication Date: 2018-11-20

Variant appearance in text: rs3745274
PubMed Link: 30458875
Variant Present in the following documents:
  • 13643_2018_861_MOESM8_ESM.docx
  • aaaaaMain text
View BVdb publication page



Clinical and genetic factors associated with increased risk of severe liver toxicity in a monocentric cohort of HIV positive patients receiving nevirapine-based antiretroviral therapy.

Bmc Infectious Diseases
A Giacomelli, A Riva, FS Falvella, ML Oreni, D Cattaneo, S Cheli, G Renisi, V Di Cristo, A Lupo, E Clementi, S Rusconi, M Galli, AL Ridolfo
Publication Date: 2018-11-12

Variant appearance in text: rs3745274
PubMed Link: 30419834
Variant Present in the following documents:
  • Main text
View BVdb publication page



K-variant BCHE and pesticide exposure: Gene-environment interactions in a case-control study of Parkinson's disease in Egypt.

Scientific Reports
TW Rösler, M Salama, AS Shalash, EM Khedr, A El-Tantawy, G Fawi, A El-Motayam, E El-Seidy, M El-Sherif, M El-Gamal, M Moharram, M El-Kattan, M Abdel-Naby, S Ashour, U Müller, A Dempfle, G Kuhlenbäumer, GU Höglinger
Publication Date: 2018-11-08

Variant appearance in text: rs3745274
PubMed Link: 30410011
Variant Present in the following documents:
  • 41598_2018_35003_MOESM1_ESM.pdf
  • aaaaaMain text
View BVdb publication page



Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

Scientific Reports
SE John, D Antony, M Eaaswarkhanth, P Hebbar, AM Channanath, D Thomas, S Devarajan, J Tuomilehto, F Al-Mulla, O Alsmadi, TA Thanaraj
Publication Date: 2018-11-08

Variant appearance in text: rs3745274
PubMed Link: 30409984
Variant Present in the following documents:
  • Main text
View BVdb publication page



Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, Japan November 16-19, 2018.

Pediatric Blood & Cancer
.
Publication Date: 2018-11

Variant appearance in text: rs3745274
PubMed Link: 30240102
Variant Present in the following documents:
  • Main text
View BVdb publication page



User considerations in assessing pharmacogenomic tests and their clinical support tools.

Npj Genomic Medicine
G Mukerjee, A Huston, B Kabakchiev, M Piquette-Miller, R van Schaik, R Dorfman
Publication Date: 2018

Variant appearance in text: rs3745274
PubMed Link: 30210808
Variant Present in the following documents:
  • 41525_2018_65_MOESM1_ESM.docx
View BVdb publication page



Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans.

European Journal Of Drug Metabolism And Pharmacokinetics
J Torgersen, SL Bellamy, B Ratshaa, X Han, M Mosepele, AF Zuppa, M Vujkovic, AP Steenhoff, GP Bisson, R Gross
Publication Date: 2019-04

Variant appearance in text: rs3745274
PubMed Link: 30168000
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cohort Profile: the Predictors of Breast Cancer Recurrence (ProBe CaRE) Premenopausal Breast Cancer Cohort Study in Denmark.

Bmj Open
LJ Collin, DP Cronin-Fenton, TP Ahern, PM Christiansen, P Damkier, B Ejlertsen, S Hamilton-Dutoit, A Kjærsgaard, RA Silliman, HT Sørensen, TL Lash
Publication Date: 2018-08-01

Variant appearance in text: rs3745274
PubMed Link: 30068618
Variant Present in the following documents:
  • Main text
View BVdb publication page



Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype.

Pharmacology Research & Perspectives
P Haage, R Kronstrand, M Josefsson, S Calistri, RHN van Schaik, H Green, FC Kugelberg
Publication Date: 2018-07

Variant appearance in text: rs3745274
PubMed Link: 29992026
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population.

Saudi Pharmaceutical Journal : Spj : The Official Publication Of The Saudi Pharmaceutical Society
O Filiptsova, M Kobets, J Kobets, O Naboka, O Koiro, A Ochkur, L Galiy
Publication Date: 2018-07

Variant appearance in text: rs3745274
PubMed Link: 29991909
Variant Present in the following documents:
  • Main text
View BVdb publication page



From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.

Pharmacogenomics
NC Salloum, ELF Buchalter, S Chanani, G Espejo, MS Ismail, RO Laine, M Nageeb, AB Srivastava, N Trapp, L Trillo, E Vance, M Wenzinger, SM Hartz, SP David, LS Chen
Publication Date: 2018-07-01

Variant appearance in text: rs3745274
PubMed Link: 29914292
Variant Present in the following documents:
  • Main text
View BVdb publication page



Drug metabolism and transport gene polymorphisms and efavirenz adverse effects in Brazilian HIV-positive individuals.

The Journal Of Antimicrobial Chemotherapy
TB de Almeida, MCVM de Azevedo, JFDC Pinto, FRA Ferry, GAR da Silva, IJ de Castro, P Baker, A Tanuri, DW Haas, CC Cardoso
Publication Date: 2018-09-01

Variant appearance in text: rs3745274
PubMed Link: 29868865
Variant Present in the following documents:
  • Main text
  • dky190_supplementary_data.docx
View BVdb publication page



Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.

The Pharmacogenomics Journal
M Vujkovic, SL Bellamy, AF Zuppa, MR Gastonguay, GS Moorthy, B Ratshaa, X Han, AP Steenhoff, M Mosepele, BL Strom, GP Bisson, R Aplenc, R Gross
Publication Date: 2018-09

Variant appearance in text: rs3745274
PubMed Link: 29855606
Variant Present in the following documents:
  • Main text
View BVdb publication page



Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events.

Pharmacogenetics And Genomics
DW Haas, Y Bradford, A Verma, SS Verma, JJ Eron, RM Gulick, SA Riddler, PE Sax, ES Daar, GD Morse, EP Acosta, MD Ritchie
Publication Date: 2018-07

Variant appearance in text: rs3745274
PubMed Link: 29847509
Variant Present in the following documents:
  • Main text
View BVdb publication page



Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.

Clinical Pharmacology And Therapeutics
ED Kharasch, A Crafford
Publication Date: 2019-01

Variant appearance in text: rs3745274
PubMed Link: 29756345
Variant Present in the following documents:
  • Main text
  • nihms-968353.pdf
View BVdb publication page



Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.

American Journal Of Medical Genetics. Part A
AM Padula, W Yang, K Schultz, F Lurmann, SK Hammond, GM Shaw
Publication Date: 2018-05

Variant appearance in text: rs3745274
PubMed Link: 29681089
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of Opioid Use Disorder Treatment.

Cns Drugs
RC Crist, TK Clarke, WH Berrettini
Publication Date: 2018-04

Variant appearance in text: rs3745274
PubMed Link: 29623639
Variant Present in the following documents:
  • Main text
View BVdb publication page



Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes.

Scientific Reports
L Tawe, T Motshoge, P Ramatlho, N Mutukwa, CW Muthoga, GBD Dongho, A Martinelli, E Peloewetse, G Russo, IK Quaye, GM Paganotti
Publication Date: 2018-03-20

Variant appearance in text: rs3745274
PubMed Link: 29559695
Variant Present in the following documents:
  • Main text
View BVdb publication page



Variations in plasma concentrations of tamoxifen metabolites and the effects of genetic polymorphisms on tamoxifen metabolism in Korean patients with breast cancer.

Oncotarget
HI Woo, SK Lee, J Kim, SW Kim, J Yu, SY Bae, JE Lee, SJ Nam, SY Lee
Publication Date: 2017-11-21

Variant appearance in text: rs3745274
PubMed Link: 29245979
Variant Present in the following documents:
  • oncotarget-08-100296-s002.doc
View BVdb publication page



Antituberculosis Drug-Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors.

Clinical Pharmacology And Therapeutics
X Hu, M Zhang, H Bai, L Wu, Y Chen, L Ding, Z Zhao, W Peng, T Liu, J Song, Y Li, X Lu, X Chen, Y Zhou, B Ying
Publication Date: 2018-08

Variant appearance in text: rs3745274
PubMed Link: 29071720
Variant Present in the following documents:
  • CPT-104-326-s001.docx
View BVdb publication page



Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients.

Plos One
SL Chan, APG Chua, F Aminkeng, CBE Chee, S Jin, M Loh, SH Gan, YT Wang, LR Brunham
Publication Date: 2017

Variant appearance in text: rs3745274
PubMed Link: 29036176
Variant Present in the following documents:
  • pone.0186200.s006.docx
View BVdb publication page



Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.

Antimicrobial Agents And Chemotherapy
P Eloy, A Tessier, P Fan-Havard, M Chou, C Verstuyft, AM Taburet, DW Haas, J Bertrand,
Publication Date: 2017-12

Variant appearance in text: rs3745274
PubMed Link: 28947469
Variant Present in the following documents:
  • Main text
View BVdb publication page



Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.

The Journal Of Infectious Diseases
KR Mollan, C Tierney, JN Hellwege, JJ Eron, MG Hudgens, RM Gulick, R Haubrich, PE Sax, TB Campbell, ES Daar, KR Robertson, D Ventura, Q Ma, DRV Edwards, DW Haas,
Publication Date: 2017-09-01

Variant appearance in text: rs3745274
PubMed Link: 28931220
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin.

Plos One
S Soeria-Atmadja, E Österberg, LL Gustafsson, ML Dahl, J Eriksen, J Rubin, L Navér
Publication Date: 2017

Variant appearance in text: rs3745274
PubMed Link: 28886044
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228).

British Journal Of Cancer
F Lévi, A Karaboué, R Saffroy, C Desterke, V Boige, D Smith, M Hebbar, P Innominato, J Taieb, C Carvalho, R Guimbaud, C Focan, M Bouchahda, R Adam, M Ducreux, G Milano, A Lemoine
Publication Date: 2017-09-26

Variant appearance in text: rs3745274
PubMed Link: 28817838
Variant Present in the following documents:
  • bjc2017278x1.docx
View BVdb publication page



Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant.

Blood
E Karaesmen, AA Rizvi, LM Preus, PL McCarthy, MC Pasquini, K Onel, X Zhu, S Spellman, CA Haiman, DO Stram, L Pooler, X Sheng, Q Zhu, L Yan, Q Liu, Q Hu, A Webb, G Brock, AI Clay-Gilmour, S Battaglia, D Tritchler, S Liu, T Hahn, LE Sucheston-Campbell
Publication Date: 2017-09-28

Variant appearance in text: rs3745274
PubMed Link: 28811306
Variant Present in the following documents:
  • blood784637-suppl2.xlsx
View BVdb publication page



Impact of Single Nucleotide Polymorphisms on Plasma Concentrations of Efavirenz and Lopinavir/Ritonavir in Chinese Children Infected with the Human Immunodeficiency Virus.

Pharmacotherapy
X Liu, Q Ma, Y Zhao, W Mu, X Sun, Y Cheng, H Zhang, Y Ma, F Zhang
Publication Date: 2017-09

Variant appearance in text: rs3745274
PubMed Link: 28718515
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacokinetics of Efavirenz at a High Dose of 25 Milligrams per Kilogram per Day in Children 2 to 3 Years Old.

Antimicrobial Agents And Chemotherapy
C Pressiat, M Amorissani-Folquet, C Yonaba, JM Treluyer, DL Dahourou, F Eboua, S Blanche, V Mea-Assande, N Bouazza, F Foissac, K Malateste, S Ouedraogo, G Lui, V Leroy, D Hirt
Publication Date: 2017-07

Variant appearance in text: rs3745274
PubMed Link: 28483965
Variant Present in the following documents:
  • Main text
View BVdb publication page



Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana.

Journal Of Acquired Immune Deficiency Syndromes (1999)
M Vujkovic, SL Bellamy, AF Zuppa, M Gastonguay, GS Moorthy, BR Ratshaa, X Han, AP Steenhoff, M Mosepele, BL Strom, R Aplenc, GP Bisson, R Gross
Publication Date: 2017-08-01

Variant appearance in text: rs3745274
PubMed Link: 28481785
Variant Present in the following documents:
  • Main text
View BVdb publication page



CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction.

The Pharmacogenomics Journal
S de Denus, JL Rouleau, DL Mann, GS Huggins, NL Pereira, SH Shah, TP Cappola, R Fouodjio, I Mongrain, MP Dubé
Publication Date: 2018-04

Variant appearance in text: rs3745274
PubMed Link: 28440343
Variant Present in the following documents:
  • NIHMS856822-supplement-1.docx
View BVdb publication page



A de novo splice site mutation in EHMT1 resulting in Kleefstra syndrome with pharmacogenomics screening and behavior therapy for regressive behaviors.

Molecular Genetics & Genomic Medicine
AK Mitra, J Dodge, J Van Ness, I Sokeye, B Van Ness
Publication Date: 2017-03

Variant appearance in text: rs3745274
PubMed Link: 28361099
Variant Present in the following documents:
  • Main text
View BVdb publication page



CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection.

Aids (London, England)
C Bolton Moore, EV Capparelli, P Samson, M Bwakura-Dangarembizi, P Jean-Philippe, C Worrell, B Heckman, L Purdue, SA Spector, A Benns, W Borkowsky, A Loftis, E Hawkins, C Wallis, EG Chadwick,
Publication Date: 2017-05-15

Variant appearance in text: rs3745274
PubMed Link: 28323755
Variant Present in the following documents:
  • Main text
View BVdb publication page



Relationship between clopidogrel-related polymorphisms and variable platelet reactivity at 1 year: A cohort study from Han Chinese.

Journal Of Research In Medical Sciences : The Official Journal Of Isfahan University Of Medical Sciences
X Wang, Y Lai, Y Luo, X Zhang, H Zhou, Z Ye, J Tang, X Liu
Publication Date: 2016

Variant appearance in text: rs3745274
PubMed Link: 28255319
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Effect of Gene Variants on Levonorgestrel Pharmacokinetics When Combined With Antiretroviral Therapy Containing Efavirenz or Nevirapine.

Clinical Pharmacology And Therapeutics
M Neary, M Lamorde, A Olagunju, KM Darin, C Merry, P Byakika-Kibwika, DJ Back, M Siccardi, A Owen, KK Scarsi
Publication Date: 2017-09

Variant appearance in text: rs3745274
PubMed Link: 28187506
Variant Present in the following documents:
  • Main text
  • NIHMS851773-supplement-Supp_info.docx
View BVdb publication page



Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.

Oncotarget
SH Kuo, SY Yang, SL You, HC Lien, CH Lin, PH Lin, CS Huang
Publication Date: 2017-03-28

Variant appearance in text: rs3745274
PubMed Link: 28178648
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.

Molecular Psychiatry
AH Smith, KP Jensen, J Li, Y Nunez, LA Farrer, H Hakonarson, SD Cook-Sather, HR Kranzler, J Gelernter
Publication Date: 2017-03

Variant appearance in text: rs3745274
PubMed Link: 28115739
Variant Present in the following documents:
  • NIHMS851849-supplement-Supplemental_Material.docx
View BVdb publication page



Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202.

Pharmacogenetics And Genomics
A Verma, Y Bradford, SS Verma, SA Pendergrass, ES Daar, C Venuto, GD Morse, MD Ritchie, DW Haas
Publication Date: 2017-03

Variant appearance in text: rs3745274
PubMed Link: 28099408
Variant Present in the following documents:
  • Main text
View BVdb publication page



Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics
DH Hovelson, Z Xue, M Zawistowski, MG Ehm, EC Harris, SL Stocker, AS Gross, IJ Jang, I Ieiri, JE Lee, LR Cardon, SL Chissoe, G Abecasis, MR Nelson
Publication Date: 2017-03

Variant appearance in text: rs3745274
PubMed Link: 27984508
Variant Present in the following documents:
  • fpc-27-089-s004.xlsx
  • fpc-27-089-s005.xlsx
View BVdb publication page



Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p'-dde levels in a population-based sample.

Environment International
L Lind, E Ng, E Ingelsson, C Lindgren, S Salihovic, B van Bavel, A Mahajan, E Lampa, AP Morris, PM Lind
Publication Date: 2017-01

Variant appearance in text: rs3745274
PubMed Link: 27839851
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetic Optimization of Smoking Cessation Treatment.

Trends In Pharmacological Sciences
MJ Chenoweth, RF Tyndale
Publication Date: 2017-01

Variant appearance in text: rs3745274
PubMed Link: 27712845
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children.

The Journal Of Antimicrobial Chemotherapy
A Bienczak, A Cook, L Wiesner, V Mulenga, C Kityo, A Kekitiinwa, AS Walker, A Owen, DM Gibb, D Burger, H McIlleron, P Denti
Publication Date: 2017-01

Variant appearance in text: rs3745274
PubMed Link: 27707991
Variant Present in the following documents:
  • Main text
View BVdb publication page



Single Nucleotide Polymorphisms in Cellular Drug Transporters Are Associated with Intolerance to Antiretroviral Therapy in Brazilian HIV-1 Positive Individuals.

Plos One
MB Arruda, F Campagnari, TB de Almeida, JC Couto-Fernandez, A Tanuri, CC Cardoso
Publication Date: 2016

Variant appearance in text: rs3745274
PubMed Link: 27648838
Variant Present in the following documents:
  • Main text
  • pone.0163170.s001.xlsx
View BVdb publication page



Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma.

Oncotarget
CM Hattinger, P Biason, E Iacoboni, S Gagno, M Fanelli, E Tavanti, S Vella, S Ferrari, A Roli, R Roncato, L Giodini, K Scotlandi, P Picci, G Toffoli, M Serra
Publication Date: 2016-09-20

Variant appearance in text: rs3745274
PubMed Link: 27566557
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of efavirenz discontinuation for reported central nervous system symptoms appears to differ by race.

Pharmacogenetics And Genomics
P Leger, S Chirwa, M Turner, DM Richardson, P Baker, M Leonard, H Erdem, L Olson, DW Haas
Publication Date: 2016-10

Variant appearance in text: rs3745274
PubMed Link: 27509478
Variant Present in the following documents:
  • Main text
View BVdb publication page



The use of machine learning for the identification of peripheral artery disease and future mortality risk.

Journal Of Vascular Surgery
EG Ross, NH Shah, RL Dalman, KT Nead, JP Cooke, NJ Leeper
Publication Date: 2016-11

Variant appearance in text: rs3745274
PubMed Link: 27266594
Variant Present in the following documents:
  • Main text
View BVdb publication page



SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study.

Bmc Cancer
T Reimer, S Kempert, B Gerber, HJ Thiesen, S Hartmann, D Koczan
Publication Date: 2016-05-27

Variant appearance in text: rs3745274
PubMed Link: 27234217
Variant Present in the following documents:
  • 12885_2016_2373_MOESM3_ESM.docx
View BVdb publication page



Rapid and Complete Remission of Metastatic Adrenocortical Carcinoma Persisting 10 Years After Treatment With Mitotane Monotherapy: Case Report and Review of the Literature.

Medicine
N El Ghorayeb, G Rondeau, M Latour, C Cohade, H Olney, A Lacroix, P Perrotte, A Sabourin, TL Mazzuco, I Bourdeau
Publication Date: 2016-03

Variant appearance in text: rs3745274
PubMed Link: 27043680
Variant Present in the following documents:
  • Main text
View BVdb publication page



Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents.

Environmental Health : A Global Access Science Source
KN Kim, JH Kim, K Jung, YC Hong
Publication Date: 2016-03-25

Variant appearance in text: rs3745274
PubMed Link: 27015811
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.

Plos Genetics
HC Yang, SK Chu, CL Huang, HW Kuo, SC Wang, SW Liu, IK Ho, YL Liu
Publication Date: 2016-03

Variant appearance in text: rs3745274
PubMed Link: 27010727
Variant Present in the following documents:
  • Main text
View BVdb publication page



Glutathione S Transferases Polymorphisms Are Independent Prognostic Factors in Lupus Nephritis Treated with Cyclophosphamide.

Plos One
A Audemard-Verger, N Martin Silva, C Verstuyft, N Costedoat-Chalumeau, A Hummel, V Le Guern, K Sacré, O Meyer, E Daugas, C Goujard, A Sultan, T Lobbedez, L Galicier, J Pourrat, C Le Hello, M Godin, R Morello, M Lambert, E Hachulla, P Vanhille, G Queffeulou, J Potier, JJ Dion, P Bataille, D Chauveau, G Moulis, D Farge-Bancel, P Duhaut, B Saint-Marcoux, A Deroux, J Manuzak, C Francès, O Aumaitre, H Bezanahary, L Becquemont, B Bienvenu
Publication Date: 2016

Variant appearance in text: rs3745274
PubMed Link: 27002825
Variant Present in the following documents:
  • Main text
View BVdb publication page



The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children.

British Journal Of Clinical Pharmacology
A Bienczak, A Cook, L Wiesner, A Olagunju, V Mulenga, C Kityo, A Kekitiinwa, A Owen, AS Walker, DM Gibb, H McIlleron, D Burger, P Denti
Publication Date: 2016-07

Variant appearance in text: rs3745274
PubMed Link: 26991336
Variant Present in the following documents:
  • Main text
View BVdb publication page



Impact of Cytochrome P450 2D6 Function on the Chiral Blood Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine (MDMA) and Its Phase I and II Metabolites in Humans.

Plos One
AE Steuer, C Schmidhauser, EH Tingelhoff, Y Schmid, A Rickli, T Kraemer, ME Liechti
Publication Date: 2016

Variant appearance in text: rs3745274
PubMed Link: 26967321
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000324071.4 c.516G>A p.Gln172= synonymous_variant 4/9 -
ENST00000330446.5 c.364+2490G>A - intron_variant - 2/4
ENST00000593831.1 c.256+2490G>A - intron_variant - 2/4
ENST00000594187.1 n.100G>A - non_coding_transcript_exon_variant 2/2 -
ENST00000598834.1 n.418G>A - non_coding_transcript_exon_variant 4/5 -
NM_000767.5 c.516G>A p.Gln172= synonymous_variant 4/9 -